Peripheral nerve injury induces dystonia-like movements and dysregulation in the energy metabolism: A multi-omics descriptive study in Thap1+/− mice by Colette Reinhold, Susanne Knorr, Rhonda L. McFleder, Lisa Harder-Rauschenberger, Tom Gräfenhan, Andreas Schlosser, Michael Sendtner, Jens Volkmann, Chi Wang Ip

“…The incomplete penetrance of DYT-THAP1 dystonia, estimated at 40 to 60 %, suggests that an environmental trigger may be required for the manifestation of the disease in genetically predisposed individuals. …”
Get full text

Detection of exhaled methane levels for monitoring trauma-related haemorrhage following blunt trauma: study protocol for a prospective observational study by Péter Jávor, Ferenc Rárosi, Tamara Horváth, László Török, Endre Varga, Petra Hartmann

“…Blood loss will be detected with CT and estimated with CT-linked radiologic software. Exhaled CH4 concentrations will be monitored by attaching a near-infrared laser technique-based photoacoustic spectroscopy apparatus to the exhalation outlet of the ventilator on patient arrival. …”
Get full text

Identification of Potential Type II Diabetes in a Large-Scale Chinese Population Using a Systematic Machine Learning Framework by Mingyue Xue, Yinxia Su, Chen Li, Shuxia Wang, Hua Yao

“…Background. An estimated 425 million people globally have diabetes, accounting for 12% of the world’s health expenditures, and the number continues to grow, placing a huge burden on the healthcare system, especially in those remote, underserved areas. …”
Get full text

Increase in blood pressure precedes distress behavior in nursing home residents with dementia. by Kenneth S Boockvar, Tianwen Huan, Kimberly Curyto, Sei Lee, Orna Intrator

“…We then calculated the change in BP between the DBD incident day and, as baseline, the 7-day average of BP 1 week prior, and tested for differences between DBD and comparison groups in a generalized estimating equations multivariate model.<h4>Results</h4>The DBD and comparison groups consisted of 707 and 2328 individuals, respectively. …”
Get full text

Benefit Analysis of Precursor Emission Reduction on PM2.5: Using CMAQ-RSM to Evaluate Control Strategies in Different Seasons by Chih-Rung Chen, Hsin-Chih Lai, Min-Chuan Hsiao, Hwong-wen Ma

“…The RSM model was used to calculate the decreased concentration of PM2.5 under the reduction of primary PM2.5, NOx, SOx, and NH3 emissions, and then to estimate the impact of emission reduction on PM2.5 concentration per ton of precursor. …”
Get full text

Infant Feeding Practices of HIV Positive Mothers and Its Association with Counseling and HIV Disclosure Status in Ethiopia: A Systematic Review and Meta-Analysis by Getaneh Mulualem Belay, Chalachew Adugna Wubneh

“…Therefore, this systematic review and meta-analysis aimed to estimate the national prevalence of exclusive breastfeeding and mixed feeding practices among HIV positive mothers and its association with counseling and HIV disclosure status to the spouse in Ethiopia. …”
Get full text

HISTOLOGICAL ANALYSIS OF LYMPHOID MASSES OF THE STOMACH AND SMALL INTESTINE IN THE CLINICAL AND PATHOGENETIC PROFILE OF BABESIOSIS by I. I. Torianyk

“…This fact accentuates the morpho-functional estimation of the lymphoid tissue condition with the purpose of timely diagnostics of starting deviations and preventing the development of decompensated changes. …”
Get full text

Obesity and Cardiometabolic Risk Stratification in Schoolchildren from Santa Clara by Elizabeth Fernández Martínez, Clara Luz Rodríguez Cervera, Emilio González Rodríguez, Yosvani García Nóbrega, Alianny Rodríguez Urrutia, Merlin Gari Llanes

“…Cardiometabolic risk estimates were developed in Android and WEB formats.…”
Get full text

Effectiveness, toxicity and impact on quality of life of high-dose-rate brachytherapy delivered in two fractions as monotherapy in patients with prostate cancer by Johan Staby Olsén, Antonis Valachis, Bengt Johansson

“…Results: In total, 175 patients with prostate cancer (94 % classified as low- or intermediate-risk) were treated with HDR-BT during the study period with a median age of 68 years (range: 51–80), and a median follow-up of 60 months (range: 0–174). The estimated five-year cumulative BCR rate was 3.0 % (95 % Confidence Interval (CI): 0 %–13.3 %) for low-risk patients and 9.6 % (95 % CI: 4.7 %–16.7 %) for intermediate-risk patients. …”
Get full text

NT5E (CD73) as a prognostic biomarker and therapeutic target associated with immune infiltration in lung adenocarcinoma by Leyan Chen, Tuoya Qi, Bishu Zhang, Xuelong Wang, Mingfeng Zheng

“…Multiple computational algorithms, including CIBERSORT, ESTIMATE, and xCell, were employed to assess the correlation between NT5E expression and immune cell infiltration. …”
Get full text

Once-weekly semaglutide doubles the five-year risk of nonarteritic anterior ischemic optic neuropathy in a Danish cohort of 424,152 persons with type 2 diabetes by Jakob Grauslund, Andreas Abou Taha, Laleh Dehghani Molander, Ryo Kawasaki, Sören Möller, Kurt Højlund, Lonny Stokholm

“…Patients were stratified according to exposure (n = 106,454) or non-exposure (n = 317,698) to once-weekly semaglutide, and incidence rates and hazard ratios (HR) of NAION were estimated in a multivariable Cox proportional hazard regression model. …”
Get full text

Temporal shifts in dengue epidemic in Guangdong Province before and during the COVID-19 pandemic: a Bayesian model study from 2012 to 2022. by Jiaqing Xu, Xiaohua Tan, Yi Quan, Dexin Gong, Hui Deng, Jianguo Zhao, Xing Huang, Yingtao Zhang, Zhoupeng Ren, Zuhua Rong, Weilin Zeng, Xing Li, Wenyuan Zheng, Shu Xiao, Jianpeng Xiao, Meng Zhang

“…According to BSTS model estimates, 6557 local dengue cases may have been reduced in Guangdong Province from 2020 to 2022, with a relative reduction of 99.91% (95%CI: 98.85-99.99%).…”
Get full text

Association between prior tuberculosis disease and dysglycemia within an HIV-endemic, rural South African population. by Alison C Castle, Susanne S Hoeppner, Itai M Magodoro, Urisha Singh, Yumna Moosa, Ingrid V Bassett, Emily B Wong, Mark J Siedner, Vukuzazi Study Team

“…We fitted sex-specific logistic regression models, adjusted for potential clinical and demographic confounders, to estimate relationships between dysglycemia (HBA1c ≥6.5%) and prior TB. …”
Get full text

Use of the LCM Model in the prospective simulation of land use in the Nafoun watershed (Northern Ivory Coast) by Kamagate Anzoumanan, Koffi Ehouman Serge, Koffi Yao Blaise

“…Environmental change assessment is the most accurate method for understanding land use, the types of change to be estimated, and the forces and evolutions driving these changes. …”
Get full text

Cost-effectiveness Analysis of Lorlatinib in Patients Previously Treated with Anaplastic Lymphoma Kinase Inhibitors for Non-small Cell Lung Cancer in Greece by George Gourzoulidis, Oresteia Zisimopoulou, Nadia Boubouchairopoulou, Christina Michailidi, Chrissy Lowry, Charalampos Tzanetakos, Georgia Kourlaba

“…**Results:** The analysis showed that, over a lifetime horizon, the estimated total costs of lorlatinib and P-ChT were €81&#8239;754 and €12&#8239;343, respectively. …”
Get full text

Gonad Maturity of Coconut Crab (Birgus latro) in Pasoso Island, Central Sulawesi by . Sulistiono, Suzana Refiani, Fadly Y. Tantu, . Muslihuddin

“…Observation was done to know sex ratio, gonad maturity and eggs diameter, while analysis was employed to estimate condition factor, gonado somatic index and fecundity.  …”
Get full text

Optimal distribution modeling and multifractal analysis of wind speed in the complex terrain of Sichuan Province, China by Cun Zhan, Renjuan Wei, Lu Zhao, Shijun Chen, Chunying Shen

“…Accordingly, we evaluated maximum likelihood estimation and three goodness-of-fit tests to identify the optimal distribution model of daily wind speed records during 1961–2017 across 156 weather stations in Sichuan Province among six commonly used probability density distributions. …”
Get full text

Viability of black currant pollen before and after cryopreservation in liquid nitrogen, and its morphological features by O. A. Tikhonova, O. A. Gavrilova, E. A. Radchenko, V. G. Verzhuk, A. V. Pavlov

“…Learning about morphological and biological features of pollen is very important to make correct estimations of plant productivity and breeding efficiency.Materials and methods. …”
Get full text

Injury mortality in South Africa: a 2009 and 2017 comparison to track progress to meeting sustainable development goal targets by Megan Prinsloo, Shibe Mhlongo, Rifqah A. Roomaney, Lea Marineau, Thakadu A. Mamashela, Bianca Dekel, Debbie Bradshaw, Lorna J. Martin, Carl Lombard, Rachel Jewkes, Naeemah Abrahams, Richard Matzopoulos

“…Objective Two nationally representative surveys for 2009 and 2017 are utilised to assess SA’s progress towards SDG targets for violence and road traffic injuries, alongside changes in suicide and under-5 mortality rates for childhood injuries, and compare these estimates with those of the Global Burden of Disease for SA. …”
Get full text

The Effectiveness and Safety of Tibial-Sided Osteotomy for Fibula Untethering in Lateral Close-Wedge High Tibial Osteotomy: A Novel Technique with Video Illustration by Keun Young Choi, Man Soo Kim, Yong In

“…These values were compared with estimates of the distance between the PTFJ and neurovascular structures in the radiographic virtual PTFJD group. …”
Get full text