Acromegaly: Is earlier diagnosis possible? Exploration of a screening algorithm to select high-risk patients by Tessa N.A. Slagboom, David de Jong, Peter H. Bisschop, Madeleine L. Drent

“…The same algorithm identified 0.1 % of the hospital population as potentially having acromegaly, which is approximately 10 times higher than the estimated worldwide prevalence. These results seem promising but need further improvement and validation.…”
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Radon on Mars and the Moon derived from Martian and lunar meteorites by Frédéric Girault, Ludovic Ferrière, Carine Sadaka, Íñigo de Loyola Chacartegui Rojo, Rémi Losno, Frédéric Moynier, Frédéric Perrier, Pierre-Yves Meslin

“…Radon emanation coefficient values are 2.1–17% (mean: 8.1 ± 2.5%) for Martian meteorites and 0.43–11% (mean: 5.5 ± 1.0%) for lunar meteorites. Mean estimated surface radon fluxes for Mars and the Moon are 0.16–0.60 and 0.33–0.44 mBq m−2 s−1 (78–280 and 160–210 atoms m−2 s−1), respectively, much lower than on Earth (21 mBq m−2 s−1 or 104 atoms m−2 s−1). …”
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Reduction of chickens use to perform in vitro pre-screening of novel anticoccidials by miniaturisation and increased throughput of the current Eimeria tenella compound-screening mo... by Virginia Marugan-Hernandez, Javier Regidor-Cerrillo, Luis Ortega-Mora, Sara Arias-Maroto, Kelsilandia Aguiar-Martins

“…In this study, we describe how further optimisation of this in vitro model by miniaturisation can have an additional impact in reduction of the number of chickens used for the generation of parasite stocks for provision of the in vitro model. We have estimated that the use of one chicken could support the evaluation of 10 compounds with a 96-well plate format versus only two compounds with a 24-well plate format, which means an 80% reduction in chicken use. …”
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Comprehensive study for radiation shielding features for Bi2O3–B2O3–ZnO composite using computational radioanalytical Phy-X/PSD, MCNP5, and SRIM software by Y. S. Alajerami, M. H. A. Mhareb, M. I. Sayyed, M. Kh. Hamad, F. Kodeh, M. Rashad, M. Mitwalli

“…The investigations' findings demonstrate a strong agreement between the theoretical and simulation-derived estimates of the mass attenuation coefficient. The relative difference of MAC results lie in the range 0.106–2.941% for BBZ0, 0.105–4.348% for BBZ1, 0.105–3.398% for BBZ2, and 0.105–2.032% for BBZ3. …”
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Optimal timing of organs-at-risk-sparing adaptive radiation therapy for head-and-neck cancer under re-planning resource constraints by Fatemeh Nosrat, Cem Dede, Lucas B. McCullum, Raul Garcia, Abdallah S.R. Mohamed, Jacob G. Scott, James E. Bates, Brigid A. McDonald, Kareem A. Wahid, Mohamed A. Naser, Renjie He, Aysenur Karagoz, Amy C. Moreno, Lisanne V. van Dijk, Kristy K. Brock, Jolien Heukelom, Seyedmohammadhossein Hosseinian, Mehdi Hemmati, Andrew J. Schaefer, Clifton D. Fuller

“…The MDP parameters were derived from a dataset comprising 52 HNC patients treated between 2007 and 2013. Kernel density estimation was used to smooth the sample distributions. …”
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Bioanalytical method development, in-vivo pharmacokinetic evaluation, ex-vivo platelet aggregation inhibition activity of a novel solid dispersion formulation of ticagrelor by Abhishek Srivastava, Abhishek Srivastava, Simrata Bedi, Abhishesh Kumar Mehata, Datta Maroti Pawde, Ketan Vinayakrao Hatware, Mohammad Ahmad Khan, M. S. Muthu, Uma Bhandari

“…The developed formulation (SD1) showed more significant inhibition of ADP-induced platelet aggregation compared to the marketed ticagrelor (RLD) formulation.ConclusionIn conclusion, we have successfully developed a validated analytical method for estimating Ticagrelor plasma concentration. Additionally, our study successfully enhanced Ticagrelor's oral bioavailability, and the developed formulation has more significant inhibition of ADP-induced platelet aggregation relative to the marketed formulation, indicating its substantial therapeutic potential.…”
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Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Peripheral Blood Leukocytes and Plasma of Children with Nonalcoholic Fatty Liver Disease by Joanna B. Trojanek, Jacek Michałkiewicz, Renata Grzywa-Czuba, Wojciech Jańczyk, Lidia Gackowska, Izabela Kubiszewska, Anna Helmin-Basa, Aldona Wierzbicka-Rucińska, Mieczysław Szalecki, Piotr Socha

“…Plasma concentrations of MMP-9, TIMP-1, MMP-9/TIMP-1 ratio, MMP-2/TIMP-2 ratio, sCD14, leptin, resistin, IL-1 beta, and IL-6 and serum markers of liver injury were estimated by ELISA. The MMP-9, TIMP-2 expression levels, plasma amounts of MMP-9, TIMP-1, and the MMP-9/TIMP-1 ratio were increased in children with NAFLD. …”
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On the behavior of a granular soil deposit subjected to horizontal vibration. A discrete element modeling by Derbane, Said, Mansouri, Mouloud, Messast, Salah,  El Malki Alaoui, Aboulghit

“…The resonance frequency estimated from this analysis is close to the fundamental frequency for low excitation amplitudes, but becomes smaller as the excitation amplitude increases. …”
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Kanuka honey versus aciclovir for the topical treatment of herpes simplex labialis: a randomised controlled trial by Nick Shortt, Alex Semprini, Mark Weatherall, Richard Beasley, Irene Braithwaite, Angela Liu, Melanie McConnell, Joseph Singer, Darmiga Thayabaran, Abbie Copinga, Abigail Cadwallader, Ahmad Zareh, Aidan Kortegast, Al-Sheibani Saif, Alaina van Zyl, Alex Graham, Alice Liu, Alice Manch, Alison van Wyke, Amanda Barkley, Amy Zhuang, Andrew Mcglashen, Androulla Kotrotsos, Angela Blackwood, Angeline Day-Mesuré, Annabel Turley, Anne Lim, Anne Marie-Nimmo, Anstey Harsant, Anthony Roberts, Ashley Cronin, Barbara Mcrae, Blair Finlayson, Bob Kim, Brandon, Brendon Mcintosh, Brian Johnston, Carina Soeteman, Carla Mcinness, Carrol Newman, Cassie Butler, Catherine Hosler, Cathy Hight, Chantel Kissick, Charlotte Schimanski, Chau Ly, Cheryl Mabbett, Chris Wrapson, Christy Biju, Chuck Varghese, Claire Livingston, Corry Bezems, Danielle Stewart, Daryl Sayer, David Postlewaight, Deb Lawrence, Debora Ngny, Deborah Ellison, Debra Clutterback, Delphine Destrez, Diana Montelli, Dipika Parmar, Dixie Howard, Donnie Loh, Eddie See, Elda Lubbe, Eric Li, Evan Tan, Fiona Mclachlan, Fiona Srush, Fran Chen, Garth Mitchinson, Gina Azer-Iskander, Glenn Summerville, Grace O’conner, Grant Bell, Hayley Garvin, Helen Jarvie, Henriette Meyer, Ingrid Nickson, Ingrid Reed, Irene Nicks, Jackie Jamieson, Jacqui Brus, Jacqui Craw, James Westbury, Jan Green, Janet Downing, Jayne Lewis, Jenna Ludlow, Jenni Puckley, Jennifer Gerbes, Jenny Sparks, Jenny Wu, Jess Barton, Jessica Ensor, Jilly Alexander, Jim Sherborne, Joanna Topliss, Jordan Jeffray, Jordon Hinton, Joseph Tsou, Joy Birch, Julia Mcdonald, Julie Earwaker, Julie Lamb, Julie Summers, Kadyn Lowe, Kaleigh Mackel, Karen Rich, Karen Chen, Karen Wainman, Karena Hall, Kate Adams, Kate Griffin, Kayleigh Mackel, Kelly Burgess, Kelly Harvey, Kelly Shearer, Kelsi Burns, Kerry Dean, Kerry Oxenham, Kritika Singh, Lara Blaikie, Leanne Hall, Leanne Herbert, Leanne Hosking, Leanne Steele, Leigh Vaughan, Lesley Robertson, Levi Bian, Linda Herman, Linda Joe, Linda Southby, Lisa Josephs, Lisa Mitchell, Lorina Lu, Lorraine Brunton, Lucy Armstrong, Lynda Bell, Malinda Ouk, Malli Kotali, Marcus Liddle, Margaret Helms, Marion Gray, Mark Arundel, Mark Webster, Martin Boyle, Maryanne Smyth, Mate Hegedus-Gaspar, Matthew Grey, Maureen Raju, Melanie Wong, Michelle Hwang, Michelle Nawisielski, Michelle Speirs, Natascha Roughton, Navjot Kaw, Neha Chand, Nehad Kamel, Neville Puckey, Nicholas Tee, Nimmi Gnanasekaran, Nolan Mcrae, Noor Al-Rawe, Oliver Rew, Olivia Haslam, Outi Kolju, Palak Mehta, Patrick Lim, Peter Neal, Rachael Gerretzen, Rachael Munns, Rachel Yang, Rachelle Smith, Raksha Goundar, Rav Singh, Ravniel Singh, Rebecca Coley, Rebecca Hesom, Rebekah Beard, Reece Olsen, Renee Belling, Robyn Morrison, Roseanna Mcdonald, Ruby Willing, Saif Al-Sherbeni, Sally Purdie, Sam Betty, Sam Appleford, Samantha Fordham, Samit Patel, Sara Preston, Sarah Wallace, Sascha Ion, Shahlaa Al Salih, Sharon Sullivan, Shazeel Rauf, Sheryl Montgomerie, Shilpa Narain, Shirin Namjou, Shuji Zhang, Simerjeet Singh, Sjaani Stanley, Sonia Schwaum, Steve Jo, Sultana Zannat, Tanya Baker, Tyler Pornchaisuksiri, Utsav Sharma, Vicki Douglas, Victoria Rameke, Vincent Ho, Vioky Usher, Violet Harley, Vishwatej Gangapuri, Warren Greene, Wendy Parkes, William Gia, Wilma Gordon, Yalun Weng, Yasmin Razoki, Yolanda Savage, Zheng Li

“…Secondary outcomes included time from randomisation to stage 4 (open wound), time from stage 4 to 7, maximal pain, time to pain resolution and treatment acceptability.Results Primary outcome variable: Kaplan-Meier-based estimates (95% CI) for the median time in days for return to normal skin were 8 (8 to 9) days for aciclovir and 9 (8 to 9) for honey; HR (95% CI) 1.06 (0.92 to 1.22), p=0.56. …”
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Combining Individual‐Based Radio‐Tracking With Whole‐Genome Sequencing Data Reveals Candidate for Genetic Basis of Partial Migration in a Songbird by Matthias H. Weissensteiner, Kira Delmore, Valentina Peona, Juan Sebastian Lugo Ramos, Gregoire Arnaud, Julio Blas, Bruno Faivre, Ivan Pokrovsky, Martin Wikelski, Jesko Partecke, Miriam Liedvogel

“…These individuals were sampled across the species' distribution range, including resident populations (Spain and France), obligate migrants (Russia), and a partial migratory population with equal numbers of migratory and resident individuals in Germany. We estimated genetic differentiation (FST) of single‐nucleotide variants (SNVs) in 2.5 kb windows between all possible population and migratory phenotype combinations, and focused our characterization on birds from the partial migratory population in Germany. …”
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Detecting the Black Hole Candidate Population in M51’s Young Massive Star Clusters: Constraints on Accreting Intermediate-mass Black Holes by Kristen C. Dage, Evangelia Tremou, Bolivia Cuevas Otahola, Eric W. Koch, Kwangmin Oh, Richard M. Plotkin, Vivian L. Tang, Muhammad Ridha Aldhalemi, Zainab Bustani, Mariam Ismail Fawaz, Hans J. Harff, Amna Khalyleh, Timothy McBride, Jesse Mason, Anthony Preston, Cortney Rinehart, Ethan Vinson, Gemma Anderson, Edward M. Cackett, Shih Ching Fu, Sebastian Kamann, Teresa Panurach, Renuka Pechetti, Payaswini Saikia, Susmita Sett, Ryan Urquhart, Christopher Usher

“…We explore the optical properties of the remaining 17 sources, including cluster age and mass estimates, and search for radio counterparts in the 8–12 GHz band. …”
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Impact of shear wave elastography and attenuation imaging for predicting life-threatening event in patients with metabolic dysfunction-associated steatotic liver disease by Yudai Fujiwara, Hidekatsu Kuroda, Tamami Abe, Tomoaki Nagasawa, Ippeki Nakaya, Asami Ito, Takuya Watanabe, Kenji Yusa, Hiroki Sato, Akiko Suzuki, Kei Endo, Yuichi Yoshida, Takayoshi Oikawa, Keisuke Kakisaka, Kei Sawara, Toshifumi Tada, Akio Miyasaka, Takuma Oguri, Naohisa Kamiyama, Takayuki Matsumoto

“…We compared the incidence of events between the groups, and estimated the hazard ratios (HRs) with 95% confidence intervals (CIs). …”
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Meta-analysis on the entomological effects of differentially treated ITNs in a multi-site experimental hut study in sub-Saharan Africa by Natalie Lissenden, John Bradley, Benjamin Menze, Charles Wondji, Constant Edi, Benjamin Koudou, Raphael N’Guessan, Koama Bayili, Abdoulaye Diabaté, Njelembo Mbewe, Basiliana Emidi, Jacklin Mosha, Alphaxard Manjurano, Graham Small, Welbeck Oumbouke, Sarah Jane Moore, Derric Nimmo, Janneke Snetselaar

“…The combined data from these trials were analysed in a meta-analysis, and odds ratios for the effect of the different net designs on mortality and blood-feeding were estimated using mixed effects logistic regression. …”
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Thermodynamic properties of iron, aluminum, boron and phosphorus in dilute silicon solutions by molecular interaction volume model by Li S.-Y., Liu K., Yang F., Xi F.-S., Wu J.-J., Ma W.-H., Lei Y., Wang Y.-J., Zhang X.-N.

“…In this paper, the component activity coefficients and interaction parameters of dilute silicon solutions were estimated by the molecular interaction volume model (MIVM). …”
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Genetic Rescue of the Dinaric Lynx Population: Insights for Conservation From Genetic Monitoring and Individual‐Based Modelling by Elena Pazhenkova, Matej Bartol, Barbara Boljte, Urša Fležar, Andrea Gazzola, Tomislav Gomerčić, Marjeta Konec, Ivan Kos, Miha Krofel, Jakub Kubala, Ladislav Paule, Mihai Pop, Hubert Potočnik, Barbara Promberger, Robin Rigg, Teodora Sin, Magda Sindičić, Vedran Slijepčević, Astrid Vik Stronen, Ira Topličanec, Tomaž Skrbinšek

“…We conducted comprehensive genetic monitoring in this area, gathering 588 non‐invasive and tissue samples, which were used for individual identification and estimation of population genetic parameters. We used stochastic modelling to assess the long‐term viability of the Dinaric lynx population post‐translocation and formulate effective conservation strategies. …”
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The Prevalence of Star-forming Clumps as a Function of Environmental Overdensity in Local Galaxies by Dominic Adams, Hugh Dickinson, Lucy Fortson, Kameswara Mantha, Vihang Mehta, Jürgen Popp, Claudia Scarlata, Chris Lintott, Brooke Simmons, Mike Walmsley

“…We then select a volume-limited sample of 9964 galaxies and estimate the density of their local environment using the distance to their projected fifth nearest neighbor. …”
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Riverine microplastic discharge along the southern Black Sea coast of Türkiye by Yahya Terzi, Rafet Çağrı Öztürk, Ahmet Raif Eryaşar, İlhan Yandi, Ahmet Şahin, Fatih Yılmaz, Kenan Gedik, Sedat Gündoğdu

“…Annual MP discharge to the Black Sea was estimated at 1.49 × 10 ^11 particles. Polyethylene terephthalate (PET, 59.3% ± 2.66%), polyethylene (PE, 20.8% ± 2.04%), and polypropylene (PP, 14.1% ± 2.36%) were the most common polymers, with PET and PE being significantly dominant. …”
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Feasibility of Screening Primary Aldosteronism by Aldosterone-to-Direct Renin Concentration Ratio Derived from Chemiluminescent Immunoassay Measurement: Diagnostic Accuracy and Cut... by Tianqi Li, Yeshuo Ma, Ying Zhang, Yue Liu, Tingting Fu, Ri Zhang, Kai Kang, Yingchao Yang, Lixin Wang, Yinong Jiang, Yan Lu

“…The purpose of the present study was to estimate the diagnostic accuracy and cutoff value of ADRR as screening test for PA. …”
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Prediction of Final Phosphorus Content of Steel in a Scrap-Based Electric Arc Furnace Using Artificial Neural Networks by Riadh Azzaz, Mohammad Jahazi, Samira Ebrahimi Kahou, Elmira Moosavi-Khoonsari

“…This study aims to develop a machine learning model to estimate steel phosphorus content at the end of the process based on input parameters. …”
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Simultaneous Inference of Past Demography and Selection from the Ancestral Recombination Graph under the Beta Coalescent by Korfmann, Kevin, Sellinger, Thibaut Paul Patrick, Freund, Fabian, Fumagalli, Matteo, Tellier, Aurélien

“…We first give proof of the accuracy of our methods to estimate the multiple merger parameter and past demographic history using simulated data under the β-coalescent model. …”
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