Effects of Corporal Punishments on Pupils Learning of English in Selected Primary Schools in Kyanamira Sub-County Kabale District Western Uganda. by Tumwijukye, Wencesilous

“…On the other hand, the respondents who disagreed with the corporal punishment being used in schools argued that the punishment made learners lose their freedom when interacting with teachers hence absconding and escaping from school Fearing the corporal punishment. …”
Get full text

Shed antigen-induced blocking effect on CAR-T cells targeting Glypican-3 in Hepatocellular Carcinoma by Wei Gao, Tong Ding, Beicheng Sun, Nan Li, Fang Gao, Meng Jia, Mitchell Ho, Na Li, Luan Sun, Zhanhui Gao, Lei Ao, Sujuan Ma, Peihua Lu, Shaochang Jia

“…Therefore, sGPC3 acted as dominant negative regulators when competed with cell surface GPC3 to bind anti-GPC3 CAR-T cells, leading to an inhibitory effect on CAR-T cells in HCC.Conclusions We provide a proof-of-concept study demonstrating that GPC3 shedding might cause worse response to CAR-T cell treatment by competing with cell surface GPC3 for CAR-T cell binding, which revealed a new mechanism of tumor immune escape in HCC, providing a novel biomarker for patient enrolment in future clinical trials and/or treatments with GPC3-targeted CAR-T cells.…”
Get full text

NUAK1 acts as a novel regulator of PD-L1 via activating GSK-3β/β-catenin pathway in hepatocellular carcinoma by Chao-Yan Yao, Hang-Tian Tao, Jin-Jin He, Feng-Yi Zhu, Cui-Qing Xie, Yu-Na Cheng, Ji-Qin Li, Zhuang-Zhuang Liu, Chun-Yu Hou, Xue-Li Liu, Yong-Li Fan, Dong Fang, Xin-Rui Lv

“…Conclusions This study revealed a novel role for NUAK1, which promotes the transcriptional expression of PD-L1 by activating GSK3β/β-catenin signaling pathway, leading to immune escape of hepatocellular carcinoma. Registry and the registration no. of the study/trial: Not applicable.…”
Get full text

Avatares de la energía nuclear en Argentina by Milagros Rodríguez

“…Its study shows a special concern as the attitude of the government self-defined “Proceso de Reorganización Nacional” towards the National Atomic Energy Commission (CNEA - Comisión Nacional de Energía Atómica) escaped from the characteristic guidelines of the period. …”
Get full text

Stochastic Modeling of Adaptive Trait Evolution in Phylogenetics: A Polynomial Regression and Approximate Bayesian Computation Approach by Dwueng-Chwuan Jhwueng, Chia-Hua Chang

“…In light of this complexity and concerning the phenomenon of trait relationships that escape line measurement, we introduce a novel general adaptive optimal regression model, grounded on polynomial relationships. …”
Get full text

Entre espaces domestiques et « espaces domestiqués » : « L’autonomisation intime » des étudiantes en Turquie by Tuğba Gökduman

“…The article makes the hypothesis that this mobility into the city, which is considered at first sight as an escape from the dominant sexual norms and from parental control, does not however mean a linear journey towards sexual emancipation. …”
Get full text

In silico analysis of the effect of HCV genotype-specific polymorphisms in Core, NS3, NS5A, and NS5B proteins on T-cell epitope processing and presentation by Samina Baig, Samina Baig, Assel Berikkara, Ramsha Khalid, Syed A. Subhan, Tanveer Abbas, Syed Hani Abidi

“…Although previous studies have shown the immune escape potential of several mutations within the HCV proteins, little is known about the effect of genotype/subtype-specific gene polymorphism on T-cell immunity. …”
Get full text

Exploring the role of ESR1 mutations in metastatic hormone receptor-positive breast cancer T cell immune surveillance disruption by Morgane Lopez, Laurie Spehner, Fabrice André, Julien Viot, Evan Seffar, Amélie Marguier, Elsa Curtit, Guillaume Meynard, Erion Dobi, Sylvain Ladoire, Romain Boidot, Romain Loyon, Valentin Derangere, François-Clément Bidard, Christophe Borg, Laura Mansi, Marie Kroemer

“…If ESR1 peptides-restricted lymphocytes were detectable in BC patients, ESR1 mutations promote immune escape at advanced stages. Trial registration ClinicalTrials.gov, NCT02838381. …”
Get full text

Impact of Financial Literacy on Saving Decisions: Insight from Aseman Project Operated by Barkat Foundation by VAhid Moghadam, Hadi Amiri, Sahar Baharipour, Fatemeh Bagheri, Parisa GHasemian

“…IntroductionOne of the key debates around poverty alleviation centers on the "poverty trap" - the idea that increasing the incomes of the poor is essential for helping them escape this cycle (Easterly, 2006). Some believe that global aid can effectively lift people out of poverty, allowing them to solve their own problems (Sachs, 2005; Banerjee & Duflo, 2011). …”
Get full text

Persistent Gender and Racial Hierarchies: Marriage Migration and Mixedness in Morocco from the French Protectorate to the Present by Catherine Therrien, Catherine Phipps

“…In the 20th century, in the colonial and post-independence period, many Moroccan men used mixed marriage as a way to escape traditional pressures to pay a bride price (sdaq) to a Moroccan woman’s family. …”
Get full text

Correlation Between Learning and Memory Impairment and Changes in Cerebral White Matter Nerve Fibers and Pericytes in Rats with Chronic Cerebral Ischemia by HUANG Jia, WANG Mengxue, NI Jinglei, LIANG Shengxiang, LIN Bingbing

“…At 28 d and 56 d after operation, morris water maze was used to detect spatial learning and memory ability; diffusion tensor imaging was used to observe the fractional anisotropy (FA) and mean diffusivity (MD) rate of white matter nerve fibers in corpus callosum and hippocampus; luxol fast blue (LFB) staining was used to observe demyelination in corpus callosum; Western blot was used to detect the expression of myelin basic protein (MBP) and pericyte marker platelet-derived growth factor receptor β (PDGFR-β) in corpus callosum and hippocampus.Results(1) Learning and memory ability: compared with the sham operation group, the escape latency prolonged significantly from day 2 to day 4 after operation in the 28 days after operation group and on the 3rd day in the 56 days after operation group (<italic>P</italic>&lt;0.05). …”
Get full text

Bispecific antibody-mediated redirection of NKG2D-CAR natural killer cells facilitates dual targeting and enhances antitumor activity by Congcong Zhang, Anja Waldmann, Winfried S Wels, Jasmin Röder, Anne Scherer, Malena Bodden, Jordi Pfeifer Serrahima, Anita Bhatti, Nina Müller, Pranav Oberoi

“…However, shedding or downregulation of NKG2D ligands (NKG2DL) can prevent NKG2D activation, resulting in escape of cancer cells from NKG2D-dependent immune surveillance.Methods To enable tumor-specific targeting of NKG2D-expressing effector cells independent of membrane-anchored NKG2DLs, we generated a homodimeric recombinant antibody which harbors an N-terminal single-chain fragment variable (scFv) antibody domain for binding to NKG2D, linked via a human IgG4 Fc region to a second C-terminal scFv antibody domain for recognition of the tumor-associated antigen ErbB2 (HER2). …”
Get full text

Regarder au-delà des élections : l’historicité complexe de la participation politique dans la Libye contemporaine by Chiara Loschi, Chiara Pagano

“…However, these perspectives have been rarely applied to the analysis of post-Gaddafi Libya, where the axiomatic acquisition that a positive link exists between elections and democratic transition has obscured the potentialities of engaging into a scholarly debate encompassing all the “politics of becoming” that might be detected by looking even at those mobilisations that escape and often contest the electoral dynamic. The choice of individuating elections as the top priority of post-Gaddafi Libya and the means to end rivalries between interim authorities, in fact, has never been critically interrogated. …”
Get full text

The History of Miss Jane Pittman by Christopher Mulvey

“…That appeared in 1853, and up to that date Brown, like Equiano, Douglass, Bibb, Henson, Pennington, and the many others who wrote an account of their life as a slave and their escape from the South had had to contend with the Southern cry that everything the fugitive slaves was saying was lies, and that they did not write their own stories but got white Northerners to write them for them. …”
Get full text

Anti-SARS-CoV-2 serology based on ancestral RBD antigens does not correlate with the presence of neutralizing antibodies against Omicron variants by Léa Dépéry, Isabelle Bally, Axelle Amen, Benjamin Némoz, Marlyse Buisson, Laurence Grossi, Aurélie Truffot, Raphaële Germi, Delphine Guilligay, Mélanie Veloso, Antoine Vilotitch, Olivier Epaulard, Patrice Morand, Winfried Weissenhorn, Pascal Poignard, Julien Lupo

“…The clinical utility of serology should be reevaluated in light of the emergence of escape variants, as commercial antibody-binding assays have not been adapted to the virus’ antigenic evolution. …”
Get full text

Investigating the relationship between customer experience components on commitment and customer engagement behaviors in the retail industry by Alireza Naalchi Kashi

“…Affective commitment mediates the relationship between entertainment experiences, escape from reality, electronic word of mouth and revisit intention. …”
Get full text

In vitro functional validation of anti-CD19 chimeric antigen receptor T cells expressing lysine-specific demethylase 1 short hairpin RNA for the treatment of diffuse large B cell l... by Zhi Guo, Zhi Guo, Mingxin He, Ning Liu, Yiqing Yang, Rui Sun, Jianxun Wang, Qiang Wang

“…BackgroundChimeric antigen receptor T (CAR-T) cell therapy is more effective in relapsed or refractory diffuse large B cell lymphoma (DLBCL) than other therapies, but a high proportion of patients relapse after CAR-T cell therapy owing to antigen escape, limited persistence of CAR-T cells, and immunosuppression in the tumor microenvironment. …”
Get full text

Determination of the physicochemical and microbiological quality of buffalo milk in the south of lake Maracaibo by Luis Álvarez, Alexis Zambrano, Datty Rosales-Zambrano

“… The determination of quality parameters in the food industry is a critical point in the transformation process in aspects such as safety and quality attributes required by the market for a product, the cheese making industry does not escape this. In Venezuela, the standards for raw materials (raw milk) and dairy derivatives are established by COVENIN (Venezuelan Commission of Industrial Standards), which determine variables of great importance in milk such as: lipids, proteins, lactose, mineral salts, load microbial, among others. …”
Get full text

Osiąganie kompromisu potrzeb człowieka i przyrody by Karol Lewandowski

“…There are existing also wide possibilities to explore, discover, and research spontaneous ecoengineering effects, that so far have escaped researchers' notice. Similar site surveys can be run in other parts of Poland or other lands. …”
Get full text