Pro-Inflammatory Cytokine-Mediated Anemia: Regarding Molecular Mechanisms of Erythropoiesis by F. Morceau, M. Dicato, M. Diederich

“…The deficiency in erythropoietin production results from pro-inflammatory cytokines effect. …”
Get full text

Associates of Cardiopulmonary Arrest in the Perihemodialytic Period by Jennifer E. Flythe, Nien-Chen Li, Shu-Fang Lin, Steven M. Brunelli, Jeffrey Hymes, Eduardo Lacson

“…Of these, lower albumin, hemoglobin, and body mass index; higher erythropoietin stimulating agent dose; and greater missed sessions had the strongest associations with outcome. …”
Get full text

An Update on the Controversies in Anemia Management in Chronic Kidney Disease: Lessons Learned and Lost by Geoffrey Teehan, Robert L. Benz

“…Background. Erythropoietin deficiency and anemia occur in Chronic Kidney Disease (CKD) and may be treated with Erythropoietin Stimulating Agents (ESAs). …”
Get full text

Antierythropoietin Antibody Production Is Not Associated with Malaria and Malaria-Related Anaemia in Humans by Otchere Addai-Mensah, Daniel Gyamfi, Francis Agyei Amponsah, Max Efui Annani-Akollor, Kwabena Owusu Danquah, Lillian Boateng, Eddie-Williams Owiredu, Edward Y. Afriyie, Richard Vikpebah Duneeh, Renate Asare, David Ofosu Ntiamoah, Richard Boateng

“…Antierythropoietin antibodies are not associated with malaria infection and malaria-related anaemia in humans. Erythropoietin concentration is associated with malaria-related anaemia.…”
Get full text

A Case of Myomatous Erythrocytosis Syndrome Associated with a Large Uterine Leiomyoma by Yosuke Ono, Takao Hidaka, Kaori Fukuta, Keiko Kouchi, Kuniaki Yasoshima, Kiyoshi Takagawa, Takashi Arai

“…We report a case of erythrocytosis associated with a large uterine leiomyoma, in which specific immunostaining for erythropoietin was positive. A 55-year-old woman, gravida 0, para 0, was referred to our hospital for treatment for a large uterine myoma and erythrocytosis. …”
Get full text

Parameter estimation in a structured erythropoiesis model by Azmy S. Ackleh, Jeremy J. Thibodeaux

“…Numerical results for estimating the growthrate of precursor cells as a function of the erythropoietinconcentration and the decay rate of erythropoietin as a function ofthe total number of precursor cells from computationally generateddata are provided. …”
Get full text

Contribution of vitamin B 6 deficiency to anemia in children on regular hemodialysis by Fatma Atia, Hafez Bazaraa, Yara Abdelatty, Sarah Lotfy, Eman Eryan

“…Clinical data were collected, including anthropometric measurements, blood pressure, iron, and erythropoietin therapy. Laboratory investigations included hemoglobin (Hb) indices, iron profile, and vitamin B6 level. …”
Get full text

Effects of Oral L-Carnitine Supplementation on Lipid Profile, Anemia, and Quality of Life in Chronic Renal Disease Patients under Hemodialysis: A Randomized, Double-Blinded, Placeb... by Afsoon Emami Naini, Mahnaz Moradi, Mojgan Mortazavi, Asghar Amini Harandi, Mehdi Hadizadeh, Farhad Shirani, Hamed Basir Ghafoori, Pardis Emami Naini

“…There was no statistically significant changes in LDL in any group (P>0.05). Erythropoietin dose was significantly decreased in both the carnitine (-4750±5772 mg, P=0.001) and the placebo group (-2000±4296 mg, P<0.05). …”
Get full text

NeuroEPO influence on the fetal heart in a placental insufficiency model of rats by Nìnive Nùñez Lòpez, Julito Dos Santos Dos Santos, Aida María Suàrez Aguiar, María Antonia Cruz García, Claudia Joffre Frías, Carmen Inés Morales Paneque, Laura López Marín

“…<strong>Foundation:</strong> placental insufficiency is the most common cause of intrauterine growth retardation, which can cause cardiovascular alterations. Recently, erythropoietin therapies have been developed that protect hypoxic cardiac tissues.…”
Get full text

Targeting the Hepcidin-Ferroportin Axis in the Diagnosis and Treatment of Anemias by Elizabeta Nemeth

“…Deficient production of hepcidin causes systemic iron overload in iron-loading anemias such as beta-thalassemia; whereas hepcidin excess contributes to the development of anemia in inflammatory disorders and chronic kidney disease, and may cause erythropoietin resistance. The diagnosis of different forms of anemia will be facilitated by improved hepcidin assays, and the treatment will be enhanced by the development of hepcidin agonists and antagonists.…”
Get full text

Sigmoid Venous Thrombosis in JAK2 V617F Mutated Polycythemia Vera by Cilomar Martins De Oliveira Filho, Alexander Gavralidis

“…Her workup revealed an elevated hematocrit, thrombocytosis, high ferritin, and normal erythropoietin. She was diagnosed with polycythemia vera with the JAK2 V617F mutation. …”
Get full text

THALIDOMIDE AMELIORATES ERYTHROPOIESIS AND IRON HOMEOSTASIS IN TRANSFUSION-DEPENDENT β-THALASSEMIA by Kun Yang, Jian Xiao

“…Thalidomide significantly improved anemia endpoints, including increases in hemoglobin (p<0.001), red blood cells (p<0.001), and hematocrit (p<0.001), as well as reducing erythropoietin levels (p=0.033) and ameliorating erythropoiesis. …”
Get full text

Autologous Cord Blood Therapy for Infantile Cerebral Palsy: From Bench to Bedside by A. Jensen

“…Particularly, since the first published double-blind randomized placebo-controlled trial in a paradigm using allogeneic cord blood and erythropoietin to treat cerebral palsy under immunosuppression showed beneficial therapeutic effects in infantile cerebral palsy, long-held doubts about the efficacy of this new cell therapy are dispelled and a revision of therapeutic views upon an ailment, for which there is no cure at present, is warranted. …”
Get full text

Overview of preclinical and phase II clinical studies on Pegmolesatide’s long-term erythropoiesis stimulating effect via EPOR-mediated signal transduction by Xiaoying Ma, Zhen Li, Lu Zhang, Hui Qian, Qinkai Chen, Ye Tao, Yunfan Li, Dandan Wang, Zhizhen Hu, Weili Luo, Ping Li, Hai Yu, Changlin Mei, Xueqing Yu, Yuanfeng Zhou

“…Abstract Introduction Anemia is a prevalent complication of chronic kidney disease (CKD), primarily due to insufficient erythropoietin (EPO). Pegmolesatide (by Hansoh Pharma) is currently the only marketed long-acting EPO mimetic peptide (EMP) for the treatment of anemia in both dialysis and non-dialysis CKD patients. …”
Get full text

Durable Red Blood Cell Transfusion Independence in a Patient with an MDS/MPN Overlap Syndrome Following Discontinuation of Iron Chelation Therapy by Harpreet Kochhar, Chantal S. Leger, Heather A. Leitch

“…There was no response to a six-month course of study medication or to erythropoietin for three months. At 27 months of transfusion dependence, she started deferasirox and within 6 weeks became RBC transfusion independent, with the hemoglobin normalizing by 10 weeks of chelation. …”
Get full text

Nitric Oxide in Cerebral Vasospasm: Theories, Measurement, and Treatment by Michael Siuta, Scott L. Zuckerman, J. Mocco

“…Recent evidence indicates that targeting NOS dysfunction, for example, through erythropoietin or statin administration, also shows promise at preventing vasospasm and neurotoxicity. …”
Get full text

Research progress of hypoxia-inducible factor-1α and zinc in the mechanism of diabetic kidney disease by Wei Qin, Ping Nie, Xuejun Hui, Fei Chen, Xingbao Hu, Wenjiao Shi, Manyu Luo, Bing Li

“…This article provides a detailed review of the multiple roles of hypoxia-inducible factor-1α in the pathogenesis of diabetic kidney disease, including: regulating angiogenesis, increasing the expression of erythropoietin, modulating oxidative stress through the PI3K/AKT and HIF-1α/HO-1 pathways, promoting inflammatory cell infiltration and the release of inflammatory factors to induce inflammatory responses, facilitating epithelial-mesenchymal transition, pathological angiogenesis, and promoting the release of fibrotic factors, ultimately leading to renal fibrosis. …”
Get full text

The Haematological Effects of Oleanolic Acid in Streptozotocin-Induced Diabetic Rats: Effects on Selected Markers by Charity M. Baloyi, A. Khathi, Ntethelelo H. Sibiya, Phikelelani S. Ngubane

“…Untreated diabetic rats exhibited hyperglycaemia, elevated glycated haemoglobin (HbA1c), oxidative stress, and a reduced erythropoietin (EPO) concentration when compared to ND rats. …”
Get full text

Treatment Inertia and Symptom Burden in Anemia of CKD: Insights from the SATISFY Survey in the Middle East, South Africa, and T&uuml;rkiye by Arici M, Al-Ghamdi SMG, Assounga AG, El-Koraie AF, McMillan A, Camidge LJ, Sumarsono B, Blogg M, Ng DB, Lansang EP

“…A high proportion of patients had never received treatment for their anemia (n = 701, 39.2%); the most common treatment was erythropoietin-stimulating agents (ESAs) + intravenous iron (n = 457, 50.3%). …”
Get full text

Renal Anemia Control in Lithuania: Influence of Local Conditions and Local Guidelines by Edita Ziginskiene, Vytautas Kuzminskis, Kristina Petruliene, Ruta Vaiciuniene, Asta Stankuviene, Inga Arune Bumblyte

“…Erythropoietin stimulating agents had a long haul in Lithuania—we had no epoetin till 1994 and there was no intravenous iron in 2001–2004. …”
Get full text