Patient‐derived acellular ascites fluid affects drug responses in ovarian cancer cell lines through the activation of key signalling pathways by Katharina Bischof, Andrea Cremaschi, Lena Eroukhmanoff, Johannes Landskron, Lise‐Lotte Flage‐Larsen, Alexandra Gade, Line Bjørge, Alfonso Urbanucci, Kjetil Taskén

“…Malignant ascites is commonly produced in advanced epithelial ovarian cancer (EOC) and serves as unique microenvironment for tumour cells. …”
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Attenuated titin protein expression is associated with advanced stages of ovarian cancer by Harvey Sharma, Jaskaran Aujla, Asad Nawaz, Thabet Khasawneh, Ayesha Alvero, Robert T. Morris, Asma Basha, Laila Tutunji, Toshima Z. Parris, Khalil Helou, Ghassan M. Saed

“…This study explores the role of titin, a giant muscle protein, in the progression of epithelial ovarian cancer (EOC). We examined titin levels in tissues and sera from EOC patients across stages I–IV and in chemoresistant EOC cells. …”
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Efficacy and safety of NeoAdjuvant chemotherapy with or without tIslelizumab followed by debulking surgery for oVarian cancEr (NAIVE study) in China: study protocol of an open-labe... by Ying Zhu, Jianwei Zhou, Zhigang Zhang, Jiaojiao Zhang, Jing Fei, Xiaoqing Zhu

“…Introduction The prognosis for epithelial ovarian cancer (EOC) is exceedingly poor, with patients diagnosed with stage III/IV tumours typically offered cytoreductive surgery in conjunction with chemotherapy as a standard treatment option. …”
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Efficacy and Safety of Low-Dose Lenvatinib and Toripalimab in Patients With Recurrent Platinum-Resistant Ovarian Cancer: Study Protocol of a Multicenter, Open-Label, Single-Arm, Ph... by Su H, Shang X, Liu H, Wang Y, Yu Y, Xu Y, Jiang K, Feng F

“…Patients with recurrent epithelial ovarian cancer who have disease progression either during or within 6 months after completion of platinum-based therapy will be included. …”
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Cisplatin resistance alters ovarian cancer spheroid formation and impacts peritoneal invasion by Lydia C. Powell, Marcos Quintela, David W. James, Emenike Onyido, David Howard, Kadie Edwards, Jordan L. Turney, Charlotte R. Morgan, Jenny Worthington, Nicole Williams, Alexander Dulebo, Heiko Haschke, Deyarina Gonzalez, R. Steven Conlan, Lewis W. Francis

“…Epithelial ovarian cancer (EOC) is an aggressive and lethal gynaecologic malignancy due to late diagnosis and acquired resistance to chemotherapeutic drugs, such as cisplatin. …”
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Characterizing tumor biology and immune microenvironment in high-grade serous ovarian cancer via single-cell RNA sequencing: insights for targeted and personalized immunotherapy st... by Fu Zhao, Fu Zhao, Xiaojing Jiang, Yumeng Li, Tianjiao Huang, Zhikai Xiahou, Wenyang Nie, Qian Li

“…BackgroundHigh-grade serous ovarian cancer (HGSOC), the predominant subtype of epithelial ovarian cancer, is frequently diagnosed at an advanced stage due to its nonspecific early symptoms. …”
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