Macrophage Polarisation in the Tumour Microenvironment: Recent Research Advances and Therapeutic Potential of Different Macrophage Reprogramming by Rongqi Guo PhD, Rui Wang PhD, Weisong Zhang PhD, Yangyang Li PhD, Yihao Wang PhD, Hao Wang PhD, Xia Li PhD, Jianxiang Song PhD

“…These processes are influenced by M1/M2 polarisation, metabolic and epigenetic reprogramming, and various signalling pathways. …”
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Pituitary adenoma: important genetic factors and clinical diagnostic issues by G. Juknytė, E. Karinauskė, R. Liutkevičienė

“…Since the development of pituitary adenomas can be significantly influenced by epigenetic changes in pituitary cells, there is currently an increasing focus on the study of epigenetic mechanisms such as DNA methylation, histone modifications, and micro-RNA studies. …”
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Neurological impact of HIV/AIDS and substance use alters brain function and structure by James Haorah, Samikkannu Malaroviyam, Hemavathi Iyappan, Thangavel Samikkannu

“…The impairment of the microglial proteins that are involved in neural circuit function appears to contribute to the breakdown of cellular communication and neurodegeneration in HANDs. The epigenetic modification of N-terminal acetylation is currently understudied, which is discussed in brief to demonstrate the important role of this epigenetic modification in infected microglia within specific brain regions. …”
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NHÂN DÒNG VÀ NGHIÊN CỨU MỨC ĐỘ METHYL HÓA VÙNG ICR (Imprinting control region) TRÊN LOCUS Igf2/H19 Ở CHUỘT (Mus musculus) by Trần Văn Giang

“…Epigenetic (ngoại di truyền) là hiện tượng trong quá trình in dấu hệ gen (genome imprinting) mà chỉ một allele bố mẹ được biểu hiện tùy thuộc vào nguồn gốc allele đó. …”
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Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response in pancreatic cancer by Lukas Klein, Mengyu Tu, Niklas Krebs, Laura Urbach, Daniela Grimm, Muhammad Umair Latif, Frederike Penz, Anna Blandau, Xueyan Wu, Rebecca Diya Samuel, Stefan Küffer, Florian Wegwitz, Nathan Chan, Kazeera Aliar, Foram Vyas, Uday Kishore, Elisabeth Hessmann, Andreas Trumpp, Elisa Espinet, Argyris Papantonis, Rama Khokha, Volker Ellenrieder, Barbara T. Grünwald, Shiv K. Singh

“…Hence, tumor cell-intrinsic epigenetic programs, together with extrinsic microenvironmental cues, facilitate intratumoral subtype heterogeneity and disease progression.…”
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Mechanisms and environmental factors shaping the ecosystem of brain macrophages by Silvia Penati, Simone Brioschi, Zhangying Cai, Claudia Z. Han, Claudia Z. Han, Marco Colonna, Marco Colonna

“…Microglia and BAMs are phenotypically and epigenetically distinct and exhibit highly specialized functions tailored to their environmental niches. …”
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In Vitro Cytotoxicity of Fluorinated Quaternary Ammonium Salts in Colorectal Cancer Cells and In Silico Pharmacology by Adriana Milena Olarte Aponte, Victoria Ospina, Sergio A. Pulido, Luz Amalia Ríos-Vásquez, Luz Adriana Betancur Jaramillo, Carlos Mario Muñetón Peña, Rogelio Ocampo-Cardona, Sara M. Robledo

“…Colorectal cancer (CRC) is a multifactorial disease driven by genetic and epigenetic alterations that modulate specific metabolic pathways. …”
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Quantification and Gene Expression Analysis of Histone Deacetylases in Common Bean during Rust Fungal Inoculation by Kalpalatha Melmaiee, Venu (Kal) Kalavacharla, Adrianne Brown, Antonette Todd, Yaqoob Thurston, Sathya Elavarthi

“…Histone deacetylases (HDACs) play an important role in plant growth, development, and defense processes and are one of the primary causes of epigenetic modifications in a genome. There was only one study reported on epigenetic modifications of the important legume crop, common bean, and its interaction with the fungal rust pathogen Uromyces appendiculatus prior to this project. …”
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PRMT5-Mediated ALKBH5 Methylation Promotes Colorectal Cancer Immune Evasion via Increasing CD276 Expression by Sen Meng, Hao Liu, Jiayu Xu, Chuyin Deng, Xingyou Qian, Sufang Chu, Wei-Guo Zhu, Jiuling Zhu, Hongmei Yong, Zhongwei Li, Jin Bai

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Enigma of Retrotransposon Biology in Mammalian Early Embryos and Embryonic Stem Cells by Ying Yin, Liquan Zhou, Shuiqiao Yuan

“…Retrotransposons are epigenetically silenced in most somatic tissues and become reactivated in early embryos. …”
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The Kat in the HAT: The Histone Acetyl Transferase Kat6b (MYST4) Is Downregulated in Murine Macrophages in Response to LPS by Smita Shukla, Carly Levine, Roopa Payanur Sripathi, Genie Elson, Carol Susan Lutz, Samuel Joseph Leibovich

“…Epigenetic modulators, including histone methylases, demethylases, and deacetylases, have been implicated previously in the regulation of classical and alternative macrophage activation pathways. …”
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Maintenance of Self-Renewal and Pluripotency in J1 Mouse Embryonic Stem Cells through Regulating Transcription Factor and MicroRNA Expression Induced by PD0325901 by Zhiying Ai, Jingjing Shao, Xinglong Shi, Mengying Yu, Yongyan Wu, Juan Du, Yong Zhang, Zekun Guo

“…Embryonic stem cells (ESCs) have the ability to grow indefinitely and retain their pluripotency in culture, and this self-renewal capacity is governed by several crucial molecular pathways controlled by specific regulatory genes and epigenetic modifications. It is reported that multiple epigenetic regulators, such as miRNA and pluripotency factors, can be tightly integrated into molecular pathways and cooperate to maintain self-renewal of ESCs. …”
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Helicobacter pylori reduces METTL14-mediated VAMP3 m6A modification and promotes the development of gastric cancer by regulating LC3C-mediated c-Met recycling by Xixi Cui, Mingjie Chang, Yuqiong Wang, Jiayi Liu, Zenghui Sun, Qiyu Sun, Yundong Sun, Juchao Ren, Wenjuan Li

“…However, the mechanisms underlying the epigenetic regulation of gastric carcinogenesis mediated by H. pylori remain unclear. …”
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Regulation of Shade Avoidance Under Low‐Blue‐Light by MTA in Soybean by Liya Zhang, Jun Liu, Jiaqi Chen, Yanyan Zhang, Chao Qin, Xiangguang Lyu, Zhuang Li, Ronghuan Ji, Bin Liu, Hongyu Li, Tao Zhao

“…Recently, mRNA modification by N6‐methyladenosine (m6A) has emerged as a crucial epigenetic mechanism regulating plant biological processes; however, its impact on shade avoidance remains unexplored. …”
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The Roles of PPARs in the Fetal Origins of Metabolic Health and Disease by William D. Rees, Christopher J. McNeil, Christopher A. Maloney

“…PPAR-α is expressed at low levels in the fetal liver, however, this expression may be important, as changes in the methylation of DNA in its promoter region are reported to take place during this period of development. This epigenetic modification then programmes subsequent expression. …”
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A novel case of glial transdifferentiation in renal medullary carcinoma brain metastasis by Maria A. Gubbiotti, Ian E. McCutcheon, Priya Rao, Giannicola Genovese, Linghua Wang, Artem Tarasov, Vladislav Putintsev, Amber Berlinski, Danil Stupichev, Kirill Kriukov, Suren Davitavyan, Basim Salem, Alexander Sarachakov, Dmitry Lebedev, Michael Hensley, Alexander Bagaev, Francesca Paradiso, Vladimir Kushnarev, Gleb Khegai, Nizar M. Tannir, Pavlos Msaouel

“…Therefore, given the common genetic signatures in the brain metastasis and the patient’s prior tumor, this case represents a rare event of glial transdifferentiation in a brain metastasis of renal medullary carcinoma following the use of an epigenetic modulator. As renal medullary carcinoma has been known to cleverly utilize adaptive mechanisms for survival, we propose that such cell plasticity seen in this case may have been provoked by the use of a drug that alters the epigenetic signature of the tumor cells. …”
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Quantification of Free Circulating DNA and Differential Methylation Profiling of Selected Genes as Novel Non-Invasive Biomarkers for Endometriosis Diagnosis by Moncef Benkhalifa, Pierre Alain Menoud, David Piquemal, Jack Y. Hazout, Sami Mahjoub, Mohammed Zarquaoui, Noureddine Louanjli, Rosalie Cabry, Andre Hazout

“…Endometriosis is a chronic, estrogen-dependent disorder associated with the presence of endometrial cells mainly in the pelvic cavity, causing systemic immune inflammation, infertility, epigenetic dysregulation of differential DNA methylation, coelomic metaplasia, and pain. …”
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New therapies in pulmonary arterial hypertension: Recent insights by Giulia Guglielmi, Konstantinos Dimopoulos, S. John Wort

“…Current therapies primarily focus on pulmonary vasodilation; however, novel approaches that target the underlying pathophysiological mechanisms—such as TGF-β signalling, epigenetic alterations, growth factors, inflammation, and extracellular matrix remodelling—are promising alternatives for improving treatment outcomes. …”
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Molecular pathways in reproductive cancers: a focus on prostate and ovarian cancer by Ayodeji Folorunsho Ajayi, Mega Obukohwo Oyovwi, Oyedayo Phillips Akano, Grace Bosede Akanbi, Florence Bukola Adisa

“…PI3K and MAPK pathways are frequently activated, promoting cell proliferation and survival. Epigenetic alterations, including DNA methylation and histone modifications, are also prevalent in both cancer types. …”
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The Lyn/RUVBL1 Complex Promotes Colorectal Cancer Liver Metastasis by Regulating Arachidonic Acid Metabolism Through Chromatin Remodeling by Zhenyu Zhang, Yina Gao, Yuanyuan Qian, Bowen Wei, Kexin Jiang, Zhiwei Sun, Feifan Zhang, Mingming Yang, Salem Baldi, Xiaoqi Yu, Yunfei Zuo, Shuangyi Ren

“…Abstract Liver metastasis is a common cause of death in colorectal cancer (CRC) patients, but epigenetic remodeling and metabolic reprogramming for CRC liver metastasis remain unclear. …”
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