Possible impact of use of a ketogenic diet in pregnancy on the fetus: Review of animal and human studies by Agata Miłosz, Justyna Michalczyk, Iwona Morawik, Klaudia Długoborska, Monika Gesek

“…In addition, it may lead to epigenetic changes in the fetus that affect the child's health and functioning in adulthood [2]. …”
Get full text

Cellular senescence-associated genes in rheumatoid arthritis: Identification and functional analysis. by You Ao, Qing Lan, Tianhua Yu, Zhichao Wang, Jing Zhang

“…Rheumatoid arthritis (RA), a long-term autoinflammatory condition causing joint damage and deformities, involves a multifaceted pathogenesis with genetic, epigenetic, and immune factors, including early immune aging. …”
Get full text

Chidamide Suppresses the Growth of Cholangiocarcinoma by Inhibiting HDAC3 and Promoting FOXO1 Acetylation by Yongpan Li, Jujia Zheng, Qiang Huo, Zhongchao Chen, Jun Chen, Xiangwei Xu

“…Inhibitors for histone deacetylases (HDACs) have been identified as epigenetic drug targets to treat a variety of malignancies through several molecular mechanisms. …”
Get full text

Molecular techniques for cancer diagnostics by Vimal Kishor Singh, Ramesh Chandra

“…Recent research reported vast genetic and epigenetic heterogeneity, differences in the gene-expression profiles, and signal transduction networks in a broad range of cancers. …”
Get full text

Triplet Therapy with PD-1 Blockade, Histone Deacetylase Inhibitor, and DNA Methyltransferase Inhibitor Achieves Radiological Response in Refractory Double-Expressor Diffuse Large B... by Runhui Zheng, Xiaobo Chen, Chunyan Wang, Pengfei Qin, Huo Tan, Xiaodan Luo

“…Immune checkpoint blockade and epigenetic drugs have been widely used, but the efficacy of different combined applications varied. …”
Get full text

RIP mutated ITS genes in populations of Ophiocordyceps sinensis and their implications for molecular systematics by Yi Li, Lan Jiang, Ke Wang, Hai-Jun Wu, Rui-Heng Yang, Yu-Jing Yan, Kathryn E. Bushley, David L. Hawksworth, Zujian Wu, Yi-Jian Yao

“…This is a process that detects and mutates repetitive DNA and frequently leads to epigenetic silencing, and these mutations have been interpreted as pseudogenes. …”
Get full text

JK-1, a useful erythroleukemic cell line model to study a controlled erythroid differentiation from progenitors to terminal erythropoiesis by Sylvain Metral, Sandrine Genetet, Benoît Gamain, Isabelle Mouro-Chanteloup

“…Here, we characterize the JK-1 CML-derived cell line, previously shown to spontaneously differentiate without cytokines. Using an epigenetic differentiation inhibitor that keeps JK-1 in an early differentiation phase, we characterized 2 progenitor stages: BFU-E JK-1 and CFU-E JK-1 with CD34+/CD36− and CD34−/CD36 + phenotypes respectively. …”
Get full text

The Polycystic Ovary Syndrome and the Metabolic Syndrome: A Possible Chronobiotic-Cytoprotective Adjuvant Therapy by Eduardo Spinedi, Daniel P. Cardinali

“…., chronodisruption) and genetic/epigenetic factors may also play relevant roles in syndrome development. …”
Get full text

Mechanism of Inflammation in Age-Related Macular Degeneration by Francesco Parmeggiani, Mario R. Romano, Ciro Costagliola, Francesco Semeraro, Carlo Incorvaia, Sergio D’Angelo, Paolo Perri, Paolo De Palma, Katia De Nadai, Adolfo Sebastiani

“…Risk factors of AMD are heterogeneous, mainly including increasing age and different genetic predispositions, together with several environmental/epigenetic factors, that is, cigarette smoking, dietary habits, and phototoxic exposure. …”
Get full text

Clinical Features and Genetic Background of the Periodic Fever Syndrome with Aphthous Stomatitis, Pharyngitis, and Adenitis: A Single Center Longitudinal Study of 81 Patients by Daša Perko, Maruša Debeljak, Nataša Toplak, Tadej Avčin

“…Our data suggest that PFAPA could be the result of multiple low-penetrant variants in different genes in combination with epigenetic and environmental factors leading to uniform clinical picture.…”
Get full text

N7-methylguanosine modification in cancers: from mechanisms to therapeutic potential by Qihui Wu, Xiaodan Fu, Guoqian Liu, Xiaoyun He, Yimin Li, Chunlin Ou

“…Abstract N7-methylguanosine (m7G) is an important RNA modification involved in epigenetic regulation that is commonly observed in both prokaryotic and eukaryotic organisms. …”
Get full text

Structure and evolution of metapolycentromeres by E. O. Grishko, P. M. Borodin

“…The metapolycentromeres may vary in the number of centromeric domains and in their genetic content and epigenetic modifications. However, these variations do not seem to affect their function. …”
Get full text

Effect of The Duration of The Diagnosis on DNA Methylation Changes in Three Different Diabetic Genes in Type 2 Diabetes Mellitus by Harem Othman Smail

“… The primary epigenetic alteration is DNA methylation. This study examined variations in DNA methylation in patients with type 2 diabetes at various time intervals, concentrating on the  Calpain-10 (CAPN10), ATP binding cassette subfamily C member 8 (ABCC8), and  Transcription factor 7-like 2 (TCF7L2) genes. …”
Get full text

Whole Exome Sequencing Reveals Rare Variants in Genes Associated with Metabolic Disorders in Women with PCOS by Priyal Sharma, Ashutosh Halder, Manish Jain, Manish Tripathi

“…Background: Polycystic ovary syndrome (PCOS) is a complex genetic trait, the pathogenesis of which is governed by an interplay of genetic and epigenetic factors. However, the aetiology of PCOS is not fully understood. …”
Get full text

m5C‐TNKmer: Identification of 5‐Methylated Base Cytosine of Ribonucleic Acid Using Supervised Machine Learning Techniques by Shahid Qazi, Dilawar Shah, Mohammad Asmat Ullah Khan, Shujaat Ali, Mohammad Abrar, Asfandyar Khan, Muhammad Tahir

“…ABSTRACT 5‐Methylcytosine (m5C) is a widely recognized epigenetic modification in ribonucleic acid (RNA), catalyzed by methyltransferases. …”
Get full text

Endothelial Progenitor Cells in Diabetic Microvascular Complications: Friends or Foes? by Cai-Guo Yu, Ning Zhang, Sha-Sha Yuan, Yan Ma, Long-Yan Yang, Ying-Mei Feng, Dong Zhao

“…In this review, we first illustrate how hyperglycemia induces metabolic and epigenetic changes in EPCs, which exerts deleterious impact on their number and function. …”
Get full text

siRNA therapeutics for effective management of rheumatoid arthritis by Vishakha R. Chakole, Tathagata Dutta, Priyankar Sen

“…Several treatments are available for RA, including analgesics, corticosteroids, DMARDs, biological agents, combinational therapy, epigenetic and cell therapies which play a crucial role in preventing joint function deterioration, inflammation, synovial edema, etc. …”
Get full text

Intercellular communication is crucial in the regulation of healthy aging via exosomes by Huifang Sun, Tengyuan Xia, Shuting Ma, Tao Lv, Yuhong Li

“…The hallmarks of aging encompass a variety of molecular categories (genomic, telomeric, and epigenetic), organelles (proteostasis, autophagy, and mitochondria), cellular components (including stem cells), systems (such as intercellular communication and chronic inflammation), and environmental factors (dysbiosis and nutrient sensing). …”
Get full text

Genome-wide DNA methylation and transcriptome sequencing analyses of lens tissue in an age-related mouse cataract model. by Yuzhu Hu, Dongmei Su, Yue Zhang, Yanjiang Fu, Sijia Li, Xiaoya Chen, Xiao Zhang, Shunfei Zheng, Xu Ma, Shanshan Hu

“…In this study, we used a mouse model and performed DNA methylation and transcriptome sequencing analyses to find epigenetic indicators for age-related cataracts (ARC). …”
Get full text

Changes in Lysine Methylation Contribute to the Cytotoxicity of Curcumin in Colon Cancer Cells by Roberta Santarelli, Paola Currà, Michele Di Crosta, Roberta Gonnella, Maria Saveria Gilardini Montani, Mara Cirone

“…Epigenetic abnormalities play a critical role in colon carcinogenesis, making them a promising target for therapeutic interventions. …”
Get full text