Class-Specific Histone Deacetylase Inhibitors Promote 11-Beta Hydroxysteroid Dehydrogenase Type 2 Expression in JEG-3 Cells by Katie L. Togher, Louise C. Kenny, Gerard W. O’Keeffe

“…Placental 11β-HSD2 is known to be reduced in a number of adverse pregnancy complications, possibly through an epigenetic mechanism. As a result, a number of pan-HDAC inhibitors have been examined for their ability to promote 11β-HSD2 expression. …”
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Circular RNAs as a novel class of potential therapeutic and diagnostic biomarkers in reproductive biology/diseases by Wanyu Song, Xiuli Chen, Haiying Wu, Neda Rahimian

“…In this aspect, Circular RNAs (circRNAs) play a crucial role as epigenetic modifiers in a wide range of biological and pathological activities, including problems with fertility. …”
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Differential Effects of Calorie Restriction and Exercise on the Adipose Transcriptome in Diet-Induced Obese Mice by Karrie E. Wheatley, Leticia M. Nogueira, Susan N. Perkins, Stephen D. Hursting

“…Chromatin immunoprecipitation assays of the Glut4 promoter revealed that, relative to the DIO controls, CR significantly increased histone 4 acetylation, suggesting epigenetic regulation may underlie some of the differential effects of CR versus EX on the adipose transcriptome.…”
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Structural and functional divergence of homoeologous genes in allopolyploid plant genomes by A. Y. Glagoleva, O. Y. Shoeva, E. K. Khlestkina

“…Changes of individual copies can be associated with epigenetic features of the gene organization (the methylation status of the promoter region or the presence of copy-specific small interfering RNA) or can affect structure of the coding or regulatory regions of the gene. …”
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Measuring Measuring iron concentration in the blood samples of some autistic children from Baghdad City by Ezzuldin sulaiman, Hind Suhail Abdulhay

“…Without a doubt, toxic metal overload or key element shortages can cause epigenetic modifications that impair neuronal maturation and lead to neurodevelopmental abnormalities in the form of developmental disorders in children. …”
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Signaling Crosstalk between PPARγ and BMP2 in Mesenchymal Stem Cells by Ichiro Takada, Yoshiko Yogiashi, Shigeaki Kato

“…We examined the effect of BMP2 and PPARγ in ST2 cells and found that PPARγ activation affected BMP2’s signaling pathway through epigenetic regulation. Although BMP2 did not interfere with PPARγ-mediated adipogenesis, BMP2 increased mRNA expression levels of PPARγ target genes (such as Fabp4 and Nr1h3) when cells were first treated with troglitazone (TRO). …”
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Synthetic genomics in crop breeding: Evidence, opportunities and challenges by Yuhan Zhou, Ziqi Zhou, Qingyao Shu

“…Despite these advancements, the integration of synthetic genomics into crop breeding encounters hurdles, including the intricacies of complex crop genomes, the unpredictability introduced by epigenetic modification, and the limitations in achieving robust transformation processes. …”
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The role of transposable elements in the ecological morphogenesis under the influence of stress by R. N. Mustafin, E. K. Khusnutdinova

“…These genes contain nucleotide sequences that interact with non-coding RNAs processed from transposons transcripts, and therefore they are under the control of epigenetic regulatory networks involving transposons. …”
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Transposable Elements and Genome Size Variations in Plants by Sung-Il Lee, Nam-Soo Kim

“…The activity of LTR retrotransposons is under the control of epigenetic suppressing mechanisms. Also, genome-purging mechanisms have been adopted to counter-balance the genome size amplification. …”
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Decitabine-Induced Changes in Human Myelodysplastic Syndrome Cell Line SKM-1 Are Mediated by FOXO3A Activation by Wen Zeng, Hanjun Dai, Ming Yan, Xiaojun Cai, Hong Luo, Min Ke, Zeming Liu

“…The epigenetic silencing of tumor suppressor genes in myelodysplastic syndromes (MDS) can potentially confer a growth advantage to individual cellular clones. …”
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Decoding the Methylation Patterns of ABC Transporters in Colorectal Cancer by Nurul Nabilah Norhisan, Rashidah Baharudin, Nurul Qistina Rus Bakarurraini, Nur Alyaa Afifah Md Shahri, Francis Yew Fu Tieng, Imilia Ismail, Muhammad-Redha Abdullah-Zawawi, Learn-Han Lee, Nurul Syakima Ab Mutalib

“…The study provides insights into the epigenetic landscape of ABC genes in CRC, highlighting their potential roles in drug resistance, disease initiation, and progression. …”
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Mechanisms and Emerging Regulators of Neuroinflammation: Exploring New Therapeutic Strategies for Neurological Disorders by Mi Eun Kim, Jun Sik Lee

“…Key signaling pathways, including NF-κB, JAK-STAT, and the NLRP3 inflammasome, are discussed alongside emerging regulators such as non-coding RNAs, epigenetic modifications, and the gut–brain axis. The therapeutic landscape is evolving, with traditional anti-inflammatory drugs like NSAIDs and corticosteroids offering limited efficacy in chronic conditions. …”
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Machine Learning-Devised Immune-Related lncRNA Signature Panel Predicts the Prognosis and Immune Landscape in Breast Cancer Novel IRLP Signature in BRCA by Jun-Yu Zhu, An-Qi Lyu, Zhang-Ting Wang, Wai-Yee Chan, Tao Qin, Kai-Kei Miu, He-Rui Yao

“…Long noncoding RNAs (lncRNAs) actively participate in breast cancer (BRCA) tumorigenesis via epigenetic mechanisms. Our study identified immune-related lncRNA (irlncRNA) pairs and compiled them into a set of noncoding gene signatures able to stratify subtypes of BRCA associated with variable degrees of survival and immune cell infiltration. …”
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Methylation Marks of Blood Leukocytes of Native Hucul Mares Differentiated in Age by T. Ząbek, E. Semik-Gurgul, T. Szmatoła, A. Gurgul, A. Fornal, M. Bugno-Poniewierska

“…In the recent years, the research on aging includes studies of age-related epigenetic effects observed on the DNA methylation level. …”
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Transgenic plants as a model for studying еpigenetic regulation of gene expression by T. V. Marenkova, E. V. Deineko

“…In this review, we briefly discuss the currently known components of epigenetic regulation.…”
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Label-Free Surface-Enhanced Raman Scattering for Genomic DNA Cytosine Methylation Reading by Kazi Morshed Alom, Anastasiia Tukova, Nana Lyu, Alison Rodger, Yuling Wang

“…DNA methylation has been widely studied with the goal of correlating the genome profiles of various diseases with epigenetic mechanisms. Multiple approaches have been developed that employ extensive steps, such as bisulfite treatments, polymerase chain reactions (PCR), restriction digestion, sequencing, mass analysis, etc., to identify DNA methylation. …”
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Maternal asthma imprints fetal lung ILC2s via glucocorticoid signaling leading to worsened allergic airway inflammation in murine adult offspring by Tomoaki Takao, Ako Matsui, Chie Kikutake, Keiko Kan-o, Azusa Inoue, Mikita Suyama, Isamu Okamoto, Minako Ito

“…Furthermore, these offspring carry overlapping chromatin-accessible altered regions, including glucocorticoid receptor-binding regions in their lung ILC2s both at the fetal stage and adulthood, suggesting persistent prenatal epigenetic changes. Moreover, maternal exposure to glucocorticoids has similar effects on fetal lung ILC2s and contributes to allergen-induced lung inflammation during adulthood. …”
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lncRNA GAU1 Induces GALNT8 Overexpression and Potentiates Colorectal Cancer Progression by Xuemei Tang, Haoyu Ruan, Liu Dong, Sihan Li, Zhiyuan Wu, Ming Guan

“…lncRNA is a key epigenetic regulator in biological processes. In the human cancer transcriptome library MiTranscriptome, we identified GAU1 as the top upregulated lncRNA in colorectal cancer (CRC) by sample set enrichment analysis (overexpression ranking percentile=99.75%, P<10−50), which is coexpressed with the potential oncogene GALNT8 (Spearman rho=0.67, P=2.44×10−23, TCGA dataset n=184). …”
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Twist-Induced Epithelial-to-Mesenchymal Transition Confers Specific Metabolic and Mitochondrial Alterations by Haleigh N. Parker, Kayla L. Haberman, Tolulope Ojo, Juli Watkins, Adhwaitha Nambiar, Kayla Morales, Bernd Zechmann, Joseph H. Taube

“…Cells undergo significant epigenetic and phenotypic change during the epithelial-to-mesenchymal transition (EMT), a process observed in development, wound healing, and cancer metastasis. …”
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Application of fractal models for determining the relationship between REEs and faults in North Kochakali coal deposit, Central Iran by Mojtaba Bazargani Golshan, Mehran Arian, Peyman Afzal, Lili Daneshvar Saein, Mohsen Aleali

“…So, the mineralization of REEs in North Kochakali coal deposit is epigenetic. Finally, the Concentration-Distance fractal model can be used as a suitable method to isolate the main mineralization and detect the relationship between faults and mineralized zones.…”
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