Central Hypogonadotropic Hypogonadism: Genetic Complexity of a Complex Disease by Marco Marino, Valeria Moriondo, Eleonora Vighi, Elisa Pignatti, Manuela Simoni

“…Indeed, all detected gene variants may explain a small proportion of the affected patients (43%), indicating that other genes or epigenetic mechanisms are involved in the onset of CHH. …”
Get full text

Dietary, Metabolic, and Potentially Environmental Modulation of the Lysine Acetylation Machinery by Go-Woon Kim, Goran Gocevski, Chao-Jung Wu, Xiang-Jiao Yang

“…A number of scientific studies support the notion that external stimuli regulate an individual's epigenomic profile. Epigenetic changes play a key role in defining gene expression patterns under both normal and pathological conditions. …”
Get full text

The role of KLF4 in human primordial germ cell development by Sun-Min Lee, Merrick Pierson Smela, M. Azim Surani

“…Cut-and-run and transcriptomic analyses reveal that KLF4 represses somatic markers involved in neuronal and endodermal differentiation while promoting the expression of genes associated with PGC specification, such as PAX5, and epigenetic regulators, including DNMT3L and REST. KLF4 targets in hPGCLCs showed significant co-enrichment of motifs for SP and STAT factors, which are known to regulate cell cycle and migration genes. …”
Get full text

Isolation and Identification of Individual Intestinal Bacteria Associated with Waist Circumference Increase by Sahar Salih Hussein, Asal Aziz Tawfeeq

“…Since the origin of obesity is multifactorial and complex, resulting from the interaction between genetic/epigenetic, environmental, and socio-psychological determinants, in addition to the bacterial composition of the intestinal flora could be a third element involved in the development of excess weight. …”
Get full text

Mechanistic insight of curcumin: a potential pharmacological candidate for epilepsy by Saima Khatoon, Nida Kalam

“…Further, curcumin can persuade epigenetic alterations, including histone modifications (acetylation/deacetylation), which are the changes responsible for the altered expression of genes facilitating the process of epileptogenesis. …”
Get full text

Mitochondrial DNA: A New Predictor of Diabetic Kidney Disease by Yajing Huang, Jingwei Chi, Fanxiang Wei, Yue Zhou, Yihai Cao, Yangang Wang

“…The occurrence and development of DKD is closely related to epigenetic changes and the interaction between mtDNA, ROS, inflammatory factors, and endothelial damage, which continuously aggravates kidney. …”
Get full text

PLncWX: A Machine-Learning Algorithm for Plant lncRNA Identification Based on WOA-XGBoost by Fei Guo, Zhixiang Yin, Kai Zhou, Jiasi Li

“…Studies have shown that lncRNAs can regulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels, which are not only closely related to the occurrence, development, and prevention of human diseases, but also can regulate plant flowering and participate in plant abiotic stress responses such as drought and salt. …”
Get full text

Miniature-inverted-repeat transposable elements contribute to phenotypic variation regulation of rice induced by space environment by Lishan Chen, Qing Yang, Yan Zhang, Yeqing Sun

“…These analyses were conducted to investigate the effects of MITEs related epigenetic and genetic variations on space-mutagenic phenotypes.Results and discussionStudies have indicated that MITEs within gene regulatory regions might contribute to the formation and differentiation of space-mutagenic phenotypes. …”
Get full text

Microfacies and Reservoir Space Characteristics of Carbonate Reservoir of the Ordovician Yingshan Formation in Northern Slope of Tazhong Uplift, Tarim Basin by Ping Ren

“…The low-energy microfacies associations mostly appear as original strata or interlayer, but after the superposition of structural cracks, buried karsts, or epigenetic karsts, low-energy microfacies associations may form relatively small-scale fractured and fracture-dissolution pore types of reservoirs in this area.…”
Get full text

Deciphering the effect of UM171 on human hematopoietic progenitor cell fate through clonal analysis by Patrick Coulombe, Elisa Tomellini, Jalila Chagraoui, Nadine Mayotte, Guy Sauvageau

“…This can be achieved via exposure to UM171 which leads to the degradation of chromatin modifiers and prevents the loss of key epigenetic marks. However, the chromatin landscape varies across populations within the hematopoietic system and the effect of UM171 on self-renewal and differentiation potential of different hematopoietic progenitor cells is less characterized. …”
Get full text

MethylBERT enables read-level DNA methylation pattern identification and tumour deconvolution using a Transformer-based model by Yunhee Jeong, Clarissa Gerhäuser, Guido Sauter, Thorsten Schlomm, Karl Rohr, Pavlo Lutsik

“…Abstract DNA methylation (DNAm) is a key epigenetic mark that shows profound alterations in cancer. …”
Get full text

CHD7 Regulates Osteogenic Differentiation of Human Dental Follicle Cells via PTH1R Signaling by Caojie Liu, Qiwen Li, Qingyue Xiao, Ping Gong, Ning Kang

“…Chromodomain helicase DNA-binding protein 7 (CHD7) is an ATP-dependent chromatin remodeling enzyme, functioning as chromatin reader to conduct epigenetic modification. Its effect on osteogenic differentiation of human dental follicle cells (hDFCs) remains unclear. …”
Get full text

Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer by Daniela Trisciuoglio, Marta Di Martile, Donatella Del Bufalo

“…In this context, different hematological and solid tumors are characterized by deregulation of the protein acetylation pattern as a result of genetic or epigenetic changes. The imbalance between acetylation and deacetylation of histone or nonhistone proteins is also involved in the modulation of the self-renewal and differentiation ability of stem cells, including cancer stem cells. …”
Get full text

Naturally Occurring Canine Invasive Urinary Bladder Cancer: A Complementary Animal Model to Improve the Success Rate in Human Clinical Trials of New Cancer Drugs by Christopher M. Fulkerson, Deepika Dhawan, Timothy L. Ratliff, Noah M. Hahn, Deborah W. Knapp

“…Therapies aimed at specific genetic and epigenetic targets in cancer cells as well as expanded development of immunotherapies are placing increased demands on animal models. …”
Get full text

Molecular and Cellular Mechanisms of Immunosenescence: Modulation Through Interventions and Lifestyle Changes by Luca Pangrazzi, Andreas Meryk

“…Recent advances in molecular biology have shed light on the underlying mechanisms of immunosenescence, including telomere attrition, epigenetic alterations, mitochondrial dysfunction, and changes in key signaling pathways such as NF-κB and mTOR. …”
Get full text

Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation by Gaia Favero, Lorenzo Franceschetti, Francesca Bonomini, Luigi Fabrizio Rodella, Rita Rezzani

“…The exact aetiology leading to the development of inflammation is not known, but a combination of genetic, epigenetic, and environmental factors seems to play an important role in the pathogenesis of many inflammation-related clinical conditions. …”
Get full text

The Effect and Related Mechanism of Action of Astragalus Compatible with Curcumin against Colon Cancer Metastasis in Mice by Jiafei Wu, Decai Tang

“…The initiation and progression of colon cancer may be influenced by epigenetic processes. Cancer metastasis is a multistep process involving several genes and their products. …”
Get full text

The emerging roles of aberrant alternative splicing in glioma by Reda Ben Mrid, Sara El Guendouzi, Marco Mineo, Rachid El Fatimy

“…Despite successful advances in understanding glioma, several genetic, epigenetic, and post-transcriptional alterations leave various targeted therapies ineffective, leading to a poor prognosis for high-grade glioma. …”
Get full text

Prenatal Detection of Silver–Russell Syndrome: A First Trimester Suspicion and Diagnostic Approach by Slavyana Galeva, Giuliana Diglio, Boris Stoilov, Ekaterina Uchikova, Lucian Pop

“…Parental testing excluded the maternal uniparental disomy of chromosome 7, suggesting an epigenetic mechanism. The findings were consistent with a clinical diagnosis of SRS, and appropriate counseling and multidisciplinary management were initiated. …”
Get full text

Cancer-Associated Immune Resistance and Evasion of Immune Surveillance in Colorectal Cancer by Pietro Parcesepe, Guido Giordano, Carmelo Laudanna, Antonio Febbraro, Massimo Pancione

“…The development of cancer-specific “immune resistance” can be orchestrated either by cooperation with tumor microenvironment or by successive rounds of genetic/epigenetic changes. Recognition of the applicability of this model may provide effective therapeutic avenues for complete elimination of immune-resistant metastatic cells and for enhanced antitumor immunity as part of a combinatorial strategy.…”
Get full text