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521
Non-coding RNAs and exosomal ncRNAs in colorectal cancer
Published 2025-02-01“…Abstract Colorectal cancer (CRC) is a complex disease with many genetic and epigenetic changes leading to dysregulation of cell signaling pathways. …”
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522
Implications of intratumoral microbiota in tumor metastasis: a special perspective of microorganisms in tumorigenesis and clinical therapeutics
Published 2025-02-01“…Intratumoral microbiota can modulate tumor progression through multiple mechanisms, including regulating immune responses, inducing genomic instability and gene mutations, altering metabolic pathways, controlling epigenetic pathways, and disrupting cancer-related signaling pathways. …”
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523
Prmt5 is essential for intestinal stem cell maintenance and homeostasis
Published 2025-02-01“…Abstract Intestinal homeostasis relies on the continuous renewal of intestinal stem cells (ISCs), which could be epigenetically regulated. While protein arginine methyltransferase 5 (Prmt5) is known to play a key role in multiple organs as an epigenetic modifier, its specific function in maintaining intestinal homeostasis remains to be elucidated. …”
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524
ATP-Dependent Chromatin Remodeling Complex in the Lineage Specification of Mesenchymal Stem Cells
Published 2020-01-01“…ATP-dependent chromatin alteration is one form of epigenetic modifications that can regulate the transcriptional level of specific genes by utilizing the energy from ATP hydrolysis to reorganize chromatin structure. …”
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525
Periconceptional Folate Deficiency and Implications in Neural Tube Defects
Published 2012-01-01“…Nutritional deficiencies are preventable etiological and epigenetic factors causing congenital abnormalities, first cause of infant mortality. …”
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526
Molecular and Cellular Pathways Contributing to Joint Damage in Rheumatoid Arthritis
Published 2020-01-01“…Rheumatoid arthritis is a chronic autoimmune syndrome associated with several genetic, epigenetic, and environmental factors affecting the articular joints contributing to cartilage and bone damage. …”
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527
Theoretical underpinnings and future research on academic stress in biological and educational perspectives
Published 2025-02-01“…The review identifies four key theoretical foundations: the neurocognitive aspects of stress and performance, the neurophysiology of stress, epigenetic regulation of stress, and stress and genetic variations. …”
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528
Glioblastoma Multiforme Stem Cells
Published 2011-01-01“…There are promising mounting data on providing new molecular targets and predictive markers of response, leading to more effective therapies of GBM, guided by patient-specific genetic and epigenetic profiling. However, the achievement of efficient GBMSC targeting also requires an adequate understanding of the unique microenvironment, and the relationship with the immune system in the central nervous system (CNS) and CNS tumors. …”
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529
Stress Response and Perinatal Reprogramming: Unraveling (Mal)adaptive Strategies
Published 2016-01-01“…These changes are likely driven by epigenetic factors that lie at the core of the stress-response reprogramming in individuals with a history of perinatal stress. …”
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530
The DNA Polymerase _-Primase Complex: Multiple Functions and Interactions
Published 2003-01-01“…However, pol-prim seems to play additional roles in other complex cellular processes, such as the response to DNA damage, telomere maintenance, and the epigenetic control of higher order chromatin assembly.…”
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531
Post infectious fatigue and circadian rhythm disruption in long-COVID and other infections: a need for further research
Published 2025-02-01“…., interleukin-6, tumor necrosis factor-alpha). Epigenetic changes, including DNA methylation at clock-related loci, particularly in peripheral tissues, further contribute to systemic circadian dysregulation. …”
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532
Biological functions of 5-methylcytosine RNA-binding proteins and their potential mechanisms in human cancers
Published 2025-02-01“…The 5-methylcytosine (m5C) modification is a crucial epigenetic RNA modification, which is involved in the post-transcriptional regulation of genes. …”
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533
The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic Review
Published 2018-01-01“…Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Genetic and epigenetic alterations play a decisive role in the onset of several human neoplasms. …”
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534
Non-metric variations in individuals who died during the perinatal period in past populations: recording protocol and comparative data
Published 2023-08-01“…Non-metric variations, also referred to as "epigenetic variations" or asymptomatic bone variants, are bone or dental phenotypic variants of unknown origin, with no known pathological etiology. …”
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535
Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres
Published 2025-01-01“…Changes in epigenetic processes such as histone acetylation are proposed as key events influencing cancer cell function and the initiation and progression of pediatric brain tumors. …”
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536
A conserved element in the first intron of Cd4 has a lineage specific, TCR signal-responsive, canonical enhancer function that matches the timing of cell surface CD4 upregulation r...
Published 2025-01-01“…However, the mechanisms of genetic and epigenetic regulation are complex, and their interplay not entirely understood. …”
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537
Implications of noncoding RNAs for cancer therapy: Are we aiming at the right targets?
Published 2025-01-01“…It now appears that dual epigenetic regulatory systems exist in higher eukaryotic cells: a ncRNA network that governs essential cell functions, like cell fate decision and maintenance of homeostasis, and a protein-based system that presides over core physiological processes, like cell division and genomic maintenance. …”
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538
Spatial stochastic models of cancer: Fitness, migration, invasion
Published 2013-03-01“…Cancer progression is driven by genetic and epigenetic events giving rise to heterogeneity of cellphenotypes, and by selection forces that shape the changingcomposition of tumors. …”
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539
Facioscapulohumeral muscular dystrophy: a review of pathogenesis, clinical symptoms, and treatment
Published 2023-10-01“…The first type is characterised by a reduction in D4Z4 repeats, while the second type is characterised by mutations in genes encoding epigenetic regulators such as SMCHD1. In recent years, significant progress has been made in understanding the pathogenesis, clinical features, and progression of the disease, but there is still no specific treatment due to the obstacles in the development of gene therapy. …”
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540
Cashmere cyclic growth affected by different photoperiods alters DNA methylation patterns
Published 2024-12-01“…Whole-genome bisulfite sequencing was used to study epigenetic differences in hair follicles from Inner Mongolia Albas cashmere goats during long and short photoperiods. …”
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