Genome-wide DNA methylation and transcriptome sequencing analyses of lens tissue in an age-related mouse cataract model. by Yuzhu Hu, Dongmei Su, Yue Zhang, Yanjiang Fu, Sijia Li, Xiaoya Chen, Xiao Zhang, Shunfei Zheng, Xu Ma, Shanshan Hu

“…In this study, we used a mouse model and performed DNA methylation and transcriptome sequencing analyses to find epigenetic indicators for age-related cataracts (ARC). …”
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Changes in Lysine Methylation Contribute to the Cytotoxicity of Curcumin in Colon Cancer Cells by Roberta Santarelli, Paola Currà, Michele Di Crosta, Roberta Gonnella, Maria Saveria Gilardini Montani, Mara Cirone

“…Epigenetic abnormalities play a critical role in colon carcinogenesis, making them a promising target for therapeutic interventions. …”
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Ticam2 ablation facilitates monocyte exhaustion recovery after sepsis by Blake A. Caldwell, Susanti Ie, Amy Lucas, Liwu Li

“…To determine the impact of TICAM2 ablation on innate epigenetic memory in sepsis, we measured genome-wide DNA methylation in bone marrow monocytes and found that Ticam2 -/- cells exhibit a unique profile of altered methylation at CEBPE binding sites and regulatory features for key immune genes such as Dmkn and Btg1. …”
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Trachoma and Ocular Chlamydial Infection in the Era of Genomics by Tamsyn Derrick, Chrissy h. Roberts, Anna R. Last, Sarah E. Burr, Martin J. Holland

“…We focus on the contribution of host and pathogen genetic variation, bacterial ecology of the conjunctiva, and host epigenetic imprinting including small RNA regulation by both host and pathogen in the development of ocular pathology. …”
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Targeted intervention of tumor microenvironment with HDAC inhibitors and their combination therapy strategies by Wanli Zhang, Luqi Ge, Yiwen Zhang, Zhentao Zhang, Wen Zhang, Feifeng Song, Ping Huang, Tong Xu

“…Abstract Histone deacetylation represents a significant epigenetic mechanism that involves the removal of acetyl groups from histones, subsequently influencing gene transcription. …”
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On the human nature (following in the steps of Belyaev) by A. L. Markel

“…In fact, we are talking about epigenetic inheritance in the evolution of culture and morality. …”
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Human microbiome, applied to clinical practice by V. T. Ivashkin, K. V. Ivashkin

“…The Human Genome Project assumes: development of the human genome variations database (HapMap; Human Variome Project), interpretation of human phenotype differences (Encyclopedia Of DNA Elements), modeling of human phenomenon (RECON), interpretation of epigenetic variants and hereditary changes in phenotypical manifestations. …”
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Brd7 loss reawakens dormant metastasis initiating cells in lung by forging an immunosuppressive niche by Jayanta Mondal, Junfeng Zhang, Feng Qing, Shunping Li, Dhiraj Kumar, Jason T. Huse, Filippo G. Giancotti

“…Abstract Metastasis in cancer is influenced by epigenetic factors. Using an in vivo screen, we demonstrate that several subunits of the polybromo-associated BAF (PBAF) chromatin remodeling complex, particularly Brd7, are required for maintaining breast cancer metastatic dormancy in the lungs of female mice. …”
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Multiomic machine learning on lactylation for molecular typing and prognosis of lung adenocarcinoma by Mengmeng Hua, Tao Li

“…LRG mRNA and long non-coding RNA transcriptomes, epigenetic methylation data, and somatic mutation data from The Cancer Genome Atlas LUAD cohort were analyzed to identify lactylation cancer subtypes (CSs) using 10 multiomics ensemble clustering techniques. …”
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Second-generation BRAF inhibitor Encorafenib resistance is regulated by NCOA4-mediated iron trafficking in the drug-resistant malignant melanoma cells by Ceyda Colakoglu Bergel, Isil Ezgi Eryilmaz, Gulsah Cecener, Unal Egeli

“…RNA-Seq results also exhibited altered epigenetic regulation of resistance; particularly ferritin family members, ion transport pathways. …”
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METTL14 modulates the progression and ferroptosis of colitis by regulating the stability of m6A-modified GPX4 by Yuhua Chen, Weicong Fan, Ying Lyu, Jingsheng Liao, Ying Zhou

“…UC development and progression were closely associated with epigenetic modifications. Nevertheless, the specific relationship between N6-methyladenosine (m6A) modification at RNA transcription levels and UC pathogenesis remains unclear. …”
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A new dimensionality reduction technique based on the Wavelet Transform for cancer classification by Lisardo Fernández, Mariano Pérez, Juan M. Orduña, José M. Alcaraz

“…Abstract Problem DNA methylation and hydroxymethylation have become important epigenetic markers for early detection of cancer. In recent years, there has been a significant increase in both the number of research works on this topic and the number and size of labeled databases with some type of cancer. …”
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Comprehensive Analysis of microRNA Methylation Profiles and Determination of Their Functional Significance in Colorectal Cancer: A Study Protocol by Nurul Syakima Ab Mutalib, Imilia Ismail, Muhammad Redha Abdullah Zawawi, Nadiah Abu, Siti Aishah Sulaiman, Loh Teng-Hern Tan, Learn-Han Lee

“…Methylation signifies a major transformation in cancer detection, as widespread epigenetic changes could potentially provide superior early-stage cancer detection and classification compared to somatic mutations. …”
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Research progress of DNA methylation in the screening of cervical cancer and precancerous lesions by Yunge Wang, Xueping Ma, Tao Zhang, Lingfei Wang, Yunlong Liu, Guohua Zhou, Haiping Wu

“…DNA methylation is a common epigenetic modification and is considered to be closely related to the occurrence and development of tumors. …”
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Gut Microbiota Secondary Metabolites: Key Roles in GI Tract Cancers and Infectious Diseases by Eman K. E. Anwer, Muhammad Ajagbe, Moustafa Sherif, Abobaker S. Musaibah, Shuaib Mahmoud, Ali ElBanbi, Anwar Abdelnaser

“…Recent research has highlighted the significant role of these metabolites, particularly short-chain fatty acids, indoles, and bile acids, in modulating immune responses, impacting epigenetic mechanisms, and contributing to disease processes. …”
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Single cell RNA sequencing improves the next generation of approaches to AML treatment: challenges and perspectives by Zahra Khosroabadi, Samaneh Azaryar, Hassan Dianat-Moghadam, Zohreh Amoozgar, Mohammadreza Sharifi

“…Abstract Acute myeloid leukemia (AML) is caused by altered maturation and differentiation of myeloid blasts, as well as transcriptional/epigenetic alterations, all leading to excessive proliferation of malignant blood cells in the bone marrow. …”
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Altered Immune Regulation in Type 1 Diabetes by András Zóka, Györgyi Műzes, Anikó Somogyi, Tímea Varga, Barbara Szémán, Zahra Al-Aissa, Orsolya Hadarits, Gábor Firneisz

“…Genomewide association studies have helped to understand the congenital susceptibility, and hand-in-hand with the immunological research novel paths of immune dysregulation were described in central tolerance, apoptotic pathways, or peripheral tolerance mediated by regulatory T-cells. Epigenetic factors are contributing to the immune dysregulation. …”
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Research of the Methylation Status of miR-124a Gene Promoter among Rheumatoid Arthritis Patients by Qiao Zhou, Li Long, Guixiu Shi, Jing Zhang, Tong Wu, Bin Zhou

“…The methylation status of miR-124a seen in this study concurs with that reported in tumor cells, indicating epigenetic dysregulation constituents, a mechanism in the development of rheumatoid arthritis.…”
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Induction of tyrosine aminotransferase in mice is inhibited by activated metabolites of ortho- aminoazotoluene by V. I. Kaledin, S. I. Ilnitskaya, N. A. Popova, O. A. Koval, I. A. Pyshnaya, L. F. Gulyaeva

“…The wide occurrence (practically in each TAT-expressing  hepatocyte) and rapidly reversible inhibition of enzyme induction by the carcinogen point to the epigenetic nature of this phenomenon.…”
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DNA methylation biomarker analysis from low-survival-rate cancers based on genetic functional approaches by Yi-Hsuan Tsai, Prasenjit Mitra, David Taniar, Tun-Wen Pai, Tun-Wen Pai

“…Identifying cancer biomarkers through DNA methylation analysis is an efficient approach toward the detection of aberrant changes in epigenetic regulation associated with early-stage cancer types. …”
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