Golgi scaffold protein PAQR11 in pan-cancer landscape: A comprehensive bioinformatics exploration of expression patterns, prognostic significance, and potential immunological funct... by Zhu Liu, Zhi-Qiang Ling

“…The analysis further revealed PAQR11's involvement in immunological and epigenetic processes, underscoring its critical role in cancer progression and treatment response. …”
Get full text

The Lyn/RUVBL1 Complex Promotes Colorectal Cancer Liver Metastasis by Regulating Arachidonic Acid Metabolism Through Chromatin Remodeling by Zhenyu Zhang, Yina Gao, Yuanyuan Qian, Bowen Wei, Kexin Jiang, Zhiwei Sun, Feifan Zhang, Mingming Yang, Salem Baldi, Xiaoqi Yu, Yunfei Zuo, Shuangyi Ren

“…Abstract Liver metastasis is a common cause of death in colorectal cancer (CRC) patients, but epigenetic remodeling and metabolic reprogramming for CRC liver metastasis remain unclear. …”
Get full text

Insights into <i>Solea senegalensis</i> Reproduction Through Gonadal Tissue Methylation Analysis and Transcriptomic Integration by Daniel Ramírez, Marco Anaya-Romero, María Esther Rodríguez, Alberto Arias-Pérez, Robert Mukiibi, Helena D’Cotta, Diego Robledo, Laureana Rebordinos

“…The complexity of this epigenetic mechanism is evident from the varying levels of methylation and correlation rates observed in different CpGs neighboring specific genes linked to reproduction. …”
Get full text

Aberrant Hepatic Methionine Metabolism and Gene Methylation in the Pathogenesis and Treatment of Alcoholic Steatohepatitis by Charles H. Halsted, Valentina Medici

“…The pathogenesis of alcoholic steatohepatitis (ASH) involves ethanol-induced aberrations in hepatic methionine metabolism that decrease levels of S-adenosylmethionine (SAM), a compound which regulates the synthesis of the antioxidant glutathione and is the principal methyl donor in the epigenetic regulation of genes relevant to liver injury. …”
Get full text

Angelman-Like Syndrome: A Genetic Approach to Diagnosis with Illustrative Cases by Ho-Ming Luk

“…Epigenetic abnormalities in 15q11-13 imprinted region and UBE3A mutation are the two major mechanisms for molecularly confirmed Angelman Syndrome. …”
Get full text

Chromatin-based memory as a self-stabilizing influence on cell identity by Charles C. Bell, Geoffrey J. Faulkner, Omer Gilan

“…Deeper appreciation of this self-stabilizing role for chromatin broadens our perspective of Waddington’s epigenetic landscape from a static surface with islands of stability shaped by evolution, to a plasticine surface molded by experience. …”
Get full text

A novel case of glial transdifferentiation in renal medullary carcinoma brain metastasis by Maria A. Gubbiotti, Ian E. McCutcheon, Priya Rao, Giannicola Genovese, Linghua Wang, Artem Tarasov, Vladislav Putintsev, Amber Berlinski, Danil Stupichev, Kirill Kriukov, Suren Davitavyan, Basim Salem, Alexander Sarachakov, Dmitry Lebedev, Michael Hensley, Alexander Bagaev, Francesca Paradiso, Vladimir Kushnarev, Gleb Khegai, Nizar M. Tannir, Pavlos Msaouel

“…Therefore, given the common genetic signatures in the brain metastasis and the patient’s prior tumor, this case represents a rare event of glial transdifferentiation in a brain metastasis of renal medullary carcinoma following the use of an epigenetic modulator. As renal medullary carcinoma has been known to cleverly utilize adaptive mechanisms for survival, we propose that such cell plasticity seen in this case may have been provoked by the use of a drug that alters the epigenetic signature of the tumor cells. …”
Get full text

Enhanced Generation of Human Induced Pluripotent Stem Cells from Peripheral Blood and Using Their Mesoderm Differentiation Ability to Regenerate Infarcted Myocardium by Ju-Young Kim, Han-Mo Yang, Joo-Eun Lee, Mika Jeon, Sang-Bum Bang, Jihye You, Joonoh Kim, Jaewon Lee, Jin Hur, Hyo-Soo Kim

“…Our study showed a new method to isolate human heart-derived stem cells from human peripheral blood and to generate iPSCs efficiently. Due to epigenetic memory, these CiMS-iPSCs easily differentiated into cardiovascular lineage cells, resulting in improved efficiency in vivo. …”
Get full text

Heat shock transcription factor 1 facilitates liver cancer progression by driving super‐enhancer‐mediated transcription of MYCN by Yizhe Liu, Qili Shi, Yue Su, Zhiao Chen, Xianghuo He

“…Discussion Our study sheds light on previously unexplored aspects of HSF1 biology, identifying it as a transcription factor capable of shaping the epigenetic landscape in the context of HCC. Given HSF1's potential as an epigenetic regulator, targeting the HSF1‐MYCN axis could open up new therapeutic possibilities for HCC treatment. …”
Get full text

Structures and mechanisms of the RNA m⁶A writer by Deng Ting, Ma Jinbiao

“…N⁶-methyladenosine (m⁶A) is the most prevalent epigenetic modification found in eukaryotic mRNAs and plays a crucial role in regulating gene expression by influencing numerous aspects of mRNA metabolism. …”
Get full text

Retrotransposons and the brain: Exploring a complex relationship between mobile elements, stress, and neurological health by Amelia Cuarenta

“…Early life stress (ELS) is linked to an increased risk for various psychiatric disorders including anxiety, depression, and substance use disorders. Epigenetic mechanisms have increasingly been of interest to understand how environmental factors contribute to reprogramming the brain and alter risk and resilience to developing psychiatric disorders. …”
Get full text

Markers of Field Cancerization: Proposed Clinical Applications in Prostate Biopsies by Kristina A. Trujillo, Anna C. Jones, Jeffrey K. Griffith, Marco Bisoffi

“…Field cancerization denotes the occurrence of genetic, epigenetic, and biochemical aberrations in structurally intact cells in histologically normal tissues adjacent to cancerous lesions. …”
Get full text

Molecular Mechanisms and Functions of lncRNAs in the Inflammatory Reaction of Diabetes Mellitus by Linjuan Huang, Xiaolei Hu

“…Recent studies have shown that lncRNAs are associated with the regulation of inflammatory responses in various ways, including at the epigenetic, transcriptional, and posttranscriptional levels. …”
Get full text

Exploring oncogenic roles and clinical significance of EZH2: focus on non-canonical activities by Michal Wozniak, Malgorzata Czyz

“…The enhancer of zeste homolog 2 (EZH2) is a catalytic component of Polycomb repressive complex 2 (PRC2) mediating the methylation of histone 3 lysine 27 (H3K27me3) and hence the epigenetic repression of target genes, known as canonical function. …”
Get full text

Identification of as a Hypermethylated Gene in Colorectal Cancers by Jongbum Kim, Sangsoo Kim

“…Aberrant DNA methylation, as an epigenetic marker of cancer, influences tumor development and progression. …”
Get full text

IDH Mutant Cholangiocarcinoma: Pathogenesis, Management, and Future Therapies by Alexander Bray, Vaibhav Sahai

“…These neomorphic point mutations endow mutant IDH (mIDH) with the ability to generate an R-enantiomer of 2-hydroxyglutarate (R2HG), a metabolite that drives malignant transformation through aberrant epigenetic signaling. As a result, pharmacologic inhibition of mIDH has become an attractive therapeutic strategy in CCAs harboring this mutation. …”
Get full text

Mechanisms of Alcohol-Induced Endoplasmic Reticulum Stress and Organ Injuries by Cheng Ji

“…Potential mechanisms that trigger the alcoholic ER stress response are directly or indirectly related to alcohol metabolism, which includes toxic acetaldehyde and homocysteine, oxidative stress, perturbations of calcium or iron homeostasis, alterations of S-adenosylmethionine to S-adenosylhomocysteine ratio, and abnormal epigenetic modifications. Interruption of the ER stress triggers is anticipated to have therapeutic benefits for alcoholic disorders.…”
Get full text

Alternative Splicing in Self-Renewal of Embryonic Stem Cells by Clara Y. Cheong, Thomas Lufkin

“…In alignment with our present understanding on the genetic, protein, and epigenetic factors that may direct cell fate, we present a short overview of the often overlooked contribution of alternative splice variants to regulatory diversity. …”
Get full text

Delineating Novel Signature Patterns of Altered Gene Expression in Schizophrenia Using Gene Microarrays by Karoly Mirnics, Frank A. Middleton, David A. Lewis, Pat Levitt

“…The etiology of schizophrenia is unknown, but appears to be multifaceted, with genetic and epigenetic developmental factors all implicated. A convergence of observations from clinical, neuroimaging, and anatomical studies has implicated the dorsal prefrontal cortex as a major locus of alterations in schizophrenia.…”
Get full text

Characterization of subcutaneous and visceral de-differentiated fat cells by Yan Li, Houyu Zhang, Carlos F. Ibáñez, Meng Xie

“…Moreover, HFD deposits epigenetic changes in DFAT cells and ASPCs that are not reversed after returning to CD. …”
Get full text