Helicobacter pylori-Induced Chronic Gastritis and Assessing Risks for Gastric Cancer by Gonzalo Carrasco, Alejandro H. Corvalan

“…Here we discuss the pathological alterations induced by Helicobacter pylori (HP) leading to chronic gastritis and the epigenetic bases underlying these changes. We review the histology of the normal gastric mucosa and overview the role of HP in the multistep cascade of GC. …”
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A DNA-Methylated Sight on Autoimmune Inflammation Network across RA, pSS, and SLE by Xingqiang Wang, Dongyun Lei, Jie Ding, Shuang Liu, Li Tao, Fan Zhang, Jiangyun Peng, Jian Xu

“…Moreover, functional epigenetic module (FEM) algorithm showed that different inflammatory networks are involved in different AIDs; 5 hotspots were identified as biologically plausible pathways in inducing or perpetuating of inflammation which are epigenetically deregulated in AIDs. …”
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PRMT5-Mediated ALKBH5 Methylation Promotes Colorectal Cancer Immune Evasion via Increasing CD276 Expression by Sen Meng, Hao Liu, Jiayu Xu, Chuyin Deng, Xingyou Qian, Sufang Chu, Wei-Guo Zhu, Jiuling Zhu, Hongmei Yong, Zhongwei Li, Jin Bai

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The Roles of PPARs in the Fetal Origins of Metabolic Health and Disease by William D. Rees, Christopher J. McNeil, Christopher A. Maloney

“…PPAR-α is expressed at low levels in the fetal liver, however, this expression may be important, as changes in the methylation of DNA in its promoter region are reported to take place during this period of development. This epigenetic modification then programmes subsequent expression. …”
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Conserved features of recombination control in vertebrates. by Linda Odenthal-Hesse

“…A recent study in PLOS Biology on the epigenetic recombination regulator PRDM9 in salmonid fish reveals that its function has been preserved across vertebrates for hundreds of millions of years, with rapidly evolving DNA-binding domains being a defining attribute.…”
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Virtual screening and molecular dynamics simulations identify repurposed drugs as potent inhibitors of Histone deacetylase 1: Implication in cancer therapeutics. by Mohammed Alrouji, Sabina Yasmin, Mohammed S Alshammari, Fahad A Alhumaydhi, Sharaf E Sharaf, Moyad Shahwan, Anas Shamsi

“…Epigenetic processes are the critical events in carcinogenesis. …”
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Melatonin influence on miRNA expression in sperm, hypothalamus, pre-frontal cortex and cerebellum of Wistar rats. by Mísia Helena da Silva Ferro, Ingrid Morante, Fernanda Akane Nishino, Camila Estevam, Fernanda Gaspar do Amaral, José Cipolla-Neto, Taiza Stumpp

“…Its action on sperm is of particular interest, since they transfer genetic and epigenetic information to the offspring, including microRNAs, configuring a mechanism of paternal epigenetic inheritance. …”
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The Role of Plant DNA Methylation in Development, Stress Response, and Crop Breeding by Shuai Qiao, Wei Song, Wentao Hu, Fang Wang, Anzhong Liao, Wenfang Tan, Songtao Yang

“…DNA methylation, an evolutionarily conserved epigenetic mechanism, is crucial for controlling gene activity and ensuring genomic integrity. …”
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Classification of Colon Cancer Patients Based on the Methylation Patterns of Promoters by Wonyoung Choi, Jungwoo Lee, Jin-Young Lee, Sun-Min Lee, Da-Won Kim, Young-Joon Kim

“…Recently, it has also been reported that epigenetic regulation is closely related to cancer development. …”
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Plant Polyphenols and Oxidative Metabolites of the Herbal Alkenylbenzene Methyleugenol Suppress Histone Deacetylase Activity in Human Colon Carcinoma Cells by Isabel Anna Maria Groh, Chen Chen, Claudia Lüske, Alexander Thomas Cartus, Melanie Esselen

“…Evidence has been provided that diet and environmental factors directly influence epigenetic mechanisms associated with cancer development in humans. …”
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In Vitro Cytotoxicity of Fluorinated Quaternary Ammonium Salts in Colorectal Cancer Cells and In Silico Pharmacology by Adriana Milena Olarte Aponte, Victoria Ospina, Sergio A. Pulido, Luz Amalia Ríos-Vásquez, Luz Adriana Betancur Jaramillo, Carlos Mario Muñetón Peña, Rogelio Ocampo-Cardona, Sara M. Robledo

“…Colorectal cancer (CRC) is a multifactorial disease driven by genetic and epigenetic alterations that modulate specific metabolic pathways. …”
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Quantification and Gene Expression Analysis of Histone Deacetylases in Common Bean during Rust Fungal Inoculation by Kalpalatha Melmaiee, Venu (Kal) Kalavacharla, Adrianne Brown, Antonette Todd, Yaqoob Thurston, Sathya Elavarthi

“…Histone deacetylases (HDACs) play an important role in plant growth, development, and defense processes and are one of the primary causes of epigenetic modifications in a genome. There was only one study reported on epigenetic modifications of the important legume crop, common bean, and its interaction with the fungal rust pathogen Uromyces appendiculatus prior to this project. …”
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Behavioral phenotyping of Kaiso-deficient mice by V. S. Korostina, A. V. Kulikov

“…The Kaiso-deficient strain is a new and promising model of the genetic, molecular, and neuronal mechanisms mediating the epigenetic regulation of brain functions and behavior.…”
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Involvement of transposable elements in neurogenesis by R. N. Mustafin, E. K. Khusnutdinova

“…Therefore, transposons, through their own processed transcripts, take an active part in the epigenetic regulation of differentiation of neurons. …”
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Intratumor heterogeneity: models of malignancy emergence and evolution by R. A. Ivanov, S. A. Lashin

“…By uncovering the mechanisms that determine tumor heterogeneity, researchers can identify key genetic and epigenetic changes that contribute to tumor progression and resistance to treatment. …”
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Scrutinizing neurodegenerative diseases: decoding the complex genetic architectures through a multi-omics lens by Relu Cocoș, Bogdan Ovidiu Popescu

“…We explore the roles of common and rare genetic variants, gene-gene and gene-environment interactions, and epigenetic influences in shaping disease phenotypes. …”
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Molecular pathways in reproductive cancers: a focus on prostate and ovarian cancer by Ayodeji Folorunsho Ajayi, Mega Obukohwo Oyovwi, Oyedayo Phillips Akano, Grace Bosede Akanbi, Florence Bukola Adisa

“…PI3K and MAPK pathways are frequently activated, promoting cell proliferation and survival. Epigenetic alterations, including DNA methylation and histone modifications, are also prevalent in both cancer types. …”
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Ribosomes: An Exciting Avenue in Stem Cell Research by Zhenzhen Han, Qi Zhang, Yanbo Zhu, Jingcheng Chen, Wei Li

“…However, recent evidence has indicated the involvement of epigenetic regulation in determining the fate of stem cells. …”
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Involvement of transposable elements in Alzheimer’s disease pathogenesis by R. N. Mustafin, E. K. Khusnutdinova

“…Possible participants in these mechanisms are transposons, which serve as drivers of epigenetic regulation, since they form species-specific distributions of non-coding RNA genes in genomes in evolution. …”
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Phenotypic plasticity plays an essential role in the confrontation between plants and herbivorous insects by Xianzhong Wang, Jieyu Kang, Huizhong Wang, Shigui Wang, Bin Tang, Jiangjie Lu

“…Throughout this process, phenotypic plasticity has continuously helped both groups adapt to new environments and niches. Epigenetic changes play an important role in the formation of plastic phenotype. …”
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