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361
DNA methylation, histone acetylation in the regulation of memory and its modulation during aging
Published 2025-01-01“…These epigenetic modifications, in turn, are regulated by physiology and metabolism. …”
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DNA Methylation in Skeletal Muscle Stem Cell Specification, Proliferation, and Differentiation
Published 2016-01-01“…An unresolved and critically important question in skeletal muscle biology is how muscle stem cells initiate and regulate the genetic program during muscle development. Epigenetic dynamics are essential for cellular development and organogenesis in early life and it is becoming increasingly clear that epigenetic remodeling may also be responsible for the cellular adaptations that occur in later life. …”
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364
A SuperLearner-based pipeline for the development of DNA methylation-derived predictors of phenotypic traits.
Published 2025-02-01“…<h4>Background</h4>DNA methylation (DNAm) provides a window to characterize the impacts of environmental exposures and the biological aging process. Epigenetic clocks are often trained on DNAm using penalized regression of CpG sites, but recent evidence suggests potential benefits of training epigenetic predictors on principal components.…”
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365
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366
The cell autonomous and non-autonomous roles of itaconate in immune response
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367
Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney Injury
Published 2018-01-01“…Over the years, the epigenetic landscape has grown increasingly complex. …”
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368
Methods of massive parallel reporter assays for investigation of enhancers
Published 2021-06-01“…The development of high-throughput genomic assays has made it possible to significantly accelerate the accumulation of information about the characteristic epigenetic properties of regulatory elements. In combination with high-throughput studies focused on the genome-wide distribution of epigenetic marks, regulatory proteins and the spatial structure of chromatin, this significantly expands the understanding of the principles of epigenetic regulation of genes and allows potential regulatory elements to be searched for in silico. …”
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369
Oxidative Stress and DNA Methylation in Prostate Cancer
Published 2010-01-01“…Epigenetics affects genetic regulation, cellular differentiation, embryology, aging, cancer, and other diseases. …”
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370
Chromatin Modifying Agents in the In Vitro Production of Bovine Embryos
Published 2011-01-01“…Therefore, proper knowledge of epigenetic reprogramming is necessary to prevent possible epigenetic errors and to improve efficiency and the use of in vitro fertilization and cloning technologies in cattle and other species.…”
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371
regionalpcs improve discovery of DNA methylation associations with complex traits
Published 2025-01-01“…Abstract We have developed the regionalpcs method, an approach for summarizing gene-level methylation. regionalpcs addresses the challenge of deciphering complex epigenetic mechanisms in diseases like Alzheimer’s disease. …”
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372
Romidepsin Promotes Osteogenic and Adipocytic Differentiation of Human Mesenchymal Stem Cells through Inhibition of Histondeacetylase Activity
Published 2018-01-01“…Herein, we investigated the epigenetic effect of romidepsin, a small molecule dual inhibitor targeting HDAC1 and HDAC2 identified through an epigenetic library functional screen. …”
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373
Genomic Imprinting and Cancer: From Primordial Germ Cells to Somatic Cells
Published 2006-01-01“…Cancer is a disease of aberrant cell growth and is characterised by genetic mutations and epigenetic changes such as DNA methylation. The mechanisms whereby imprinting is maintained in somatic cells and then erased and reset in the germline parallels epigenetic changes that cancer cells undergo. …”
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374
Longitudinal genetic studies of cognitive characteristics
Published 2020-03-01“…The appropriate correction of epigenetic factors related to environmental differences in cognitive abilities requires to determine the mechanisms of chromatin modifications and variations in DNA methylation. …”
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375
IL-13 Augments Histone Demethylase JMJD2B/KDM4B Expression Levels, Activity, and Nuclear Translocation in Airway Fibroblasts in Asthma
Published 2021-01-01“…Asthma is one of the most common obstructive pulmonary diseases worldwide. Epigenetic alterations, including DNA methylation and histone modifications, have been reported to contribute to asthma pathogenesis. …”
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Role of Cold atmospheric plasma in cancer management
Published 2024-03-01“…This article discusses the impact of CAP on epigenetic changes, non-coding RNA expression, and DNA damage, and its synergy with conventional pharmaceuticals. …”
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378
Allele-specific methylation of SSTR4 associated with aging and cognitive functions in patients with schizophrenia.
Published 2025-01-01“…However, the role of genetic-epigenetic interactions involving SSTR4 in patients with schizophrenia remains unexplored. …”
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379
Genetic background and embryonic temperature affect DNA methylation and expression of myogenin and muscle development in Atlantic salmon (Salmo salar).
Published 2017-01-01“…Here we studied the epigenetic effects of embryonic temperature and genetic background on body growth, muscle cellularity and myogenin expression in farmed Atlantic salmon (Salmo salar). …”
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380
Long Noncoding RNAs, Chromatin, and Development
Published 2010-01-01“…This differential expression is regulated at the epigenetic level by chromatin modifications, such as DNA and histone methylation, which interact with structural and enzymatic proteins, resulting in the activation or silencing of any given gene. …”
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