Identification of selective SWI/SNF dependencies in enzalutamide-resistant prostate cancer by Bengul Gokbayrak, Umut Berkay Altintas, Shreyas Lingadahalli, Tunc Morova, Chia-Chi Flora Huang, Betul Ersoy Fazlioglu, Ivan Pak Lok Yu, Batuhan M. Kalkan, Paloma Cejas, Sonia H. Y. Kung, Ladan Fazli, Akane Kawamura, Henry W. Long, Ceyda Acilan, Tamer T. Onder, Tugba Bagci-Onder, James T. Lynch, Nathan A. Lack

“…To explore how resistance arises, we systematically test all epigenetic modifiers in several models of castration-resistant and enzalutamide-resistant prostate cancer with a custom epigenetic CRISPR library. …”
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Integrated analysis of chromatin and transcriptomic profiling of the striatum after cerebral hypoperfusion in mice by Shijia Le, Fengyiyang Xu, Zhi Luo, Weihao Shi, Shuangshuang Lu, Zengyu Zhang, Zimin Guo, Wenshi Xu, Mingqi Yang, Tianyi Li, Xu Li, Kun Liang, Lei Zhu

“…This study investigated the molecular and epigenetic changes in the striatum, a brain region critical for motor function and cognition, following chronic hypoperfusion using a bilateral common carotid artery stenosis (BCAS) model in mice. …”
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Histone demethylases in autophagy and inflammation by Yaoyao Ma, Wenting Lv, Yi Guo, Tong Yin, Yujie Bai, Ziqi Liu, Chao Chen, WenjuanYang, Jiayi Feng, Wenbin Qian, Ruiling Tang, Yanting Su, Shigang Shan, Huifen Dong, Yongfen Bao, Lihua Qu

“…There are over 30 members of histone lysine demethylases (KDMs), which act as epigenetic regulators in physiological processes and diseases. …”
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NHÂN DÒNG VÀ NGHIÊN CỨU MỨC ĐỘ METHYL HÓA VÙNG ICR (Imprinting control region) TRÊN LOCUS Igf2/H19 Ở CHUỘT (Mus musculus) by Trần Văn Giang

“…Epigenetic (ngoại di truyền) là hiện tượng trong quá trình in dấu hệ gen (genome imprinting) mà chỉ một allele bố mẹ được biểu hiện tùy thuộc vào nguồn gốc allele đó. …”
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Macrophage Polarisation in the Tumour Microenvironment: Recent Research Advances and Therapeutic Potential of Different Macrophage Reprogramming by Rongqi Guo PhD, Rui Wang PhD, Weisong Zhang PhD, Yangyang Li PhD, Yihao Wang PhD, Hao Wang PhD, Xia Li PhD, Jianxiang Song PhD

“…These processes are influenced by M1/M2 polarisation, metabolic and epigenetic reprogramming, and various signalling pathways. …”
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Anticonvulsant valproic acid and other short-chain fatty acids as novel anticancer therapeutics: Possibilities and challenges by Lipska Katarzyna, Gumieniczek Anna, Filip Agata A.

“…The present manuscript summarizes the most important information from the literature about their potent anticancer activities to show some future perspectives related to epigenetic therapy.…”
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Pituitary adenoma: important genetic factors and clinical diagnostic issues by G. Juknytė, E. Karinauskė, R. Liutkevičienė

“…Since the development of pituitary adenomas can be significantly influenced by epigenetic changes in pituitary cells, there is currently an increasing focus on the study of epigenetic mechanisms such as DNA methylation, histone modifications, and micro-RNA studies. …”
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Biomarkers as Key Contributors in Treating Malignant Melanoma Metastases by Camila Ferreira de Souza, Alice Santana Morais, Miriam Galvonas Jasiulionis

“…Fortunately, there are now evidences sustaining the importance of genetic, epigenetic, and metabolomic alterations as biomarkers for classification, staging, and better management of melanoma patients. …”
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Helicobacter pylori-Induced Chronic Gastritis and Assessing Risks for Gastric Cancer by Gonzalo Carrasco, Alejandro H. Corvalan

“…Here we discuss the pathological alterations induced by Helicobacter pylori (HP) leading to chronic gastritis and the epigenetic bases underlying these changes. We review the histology of the normal gastric mucosa and overview the role of HP in the multistep cascade of GC. …”
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A DNA-Methylated Sight on Autoimmune Inflammation Network across RA, pSS, and SLE by Xingqiang Wang, Dongyun Lei, Jie Ding, Shuang Liu, Li Tao, Fan Zhang, Jiangyun Peng, Jian Xu

“…Moreover, functional epigenetic module (FEM) algorithm showed that different inflammatory networks are involved in different AIDs; 5 hotspots were identified as biologically plausible pathways in inducing or perpetuating of inflammation which are epigenetically deregulated in AIDs. …”
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The Roles of PPARs in the Fetal Origins of Metabolic Health and Disease by William D. Rees, Christopher J. McNeil, Christopher A. Maloney

“…PPAR-α is expressed at low levels in the fetal liver, however, this expression may be important, as changes in the methylation of DNA in its promoter region are reported to take place during this period of development. This epigenetic modification then programmes subsequent expression. …”
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Melatonin influence on miRNA expression in sperm, hypothalamus, pre-frontal cortex and cerebellum of Wistar rats. by Mísia Helena da Silva Ferro, Ingrid Morante, Fernanda Akane Nishino, Camila Estevam, Fernanda Gaspar do Amaral, José Cipolla-Neto, Taiza Stumpp

“…Its action on sperm is of particular interest, since they transfer genetic and epigenetic information to the offspring, including microRNAs, configuring a mechanism of paternal epigenetic inheritance. …”
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The Role of Plant DNA Methylation in Development, Stress Response, and Crop Breeding by Shuai Qiao, Wei Song, Wentao Hu, Fang Wang, Anzhong Liao, Wenfang Tan, Songtao Yang

“…DNA methylation, an evolutionarily conserved epigenetic mechanism, is crucial for controlling gene activity and ensuring genomic integrity. …”
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Classification of Colon Cancer Patients Based on the Methylation Patterns of Promoters by Wonyoung Choi, Jungwoo Lee, Jin-Young Lee, Sun-Min Lee, Da-Won Kim, Young-Joon Kim

“…Recently, it has also been reported that epigenetic regulation is closely related to cancer development. …”
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Plant Polyphenols and Oxidative Metabolites of the Herbal Alkenylbenzene Methyleugenol Suppress Histone Deacetylase Activity in Human Colon Carcinoma Cells by Isabel Anna Maria Groh, Chen Chen, Claudia Lüske, Alexander Thomas Cartus, Melanie Esselen

“…Evidence has been provided that diet and environmental factors directly influence epigenetic mechanisms associated with cancer development in humans. …”
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In Vitro Cytotoxicity of Fluorinated Quaternary Ammonium Salts in Colorectal Cancer Cells and In Silico Pharmacology by Adriana Milena Olarte Aponte, Victoria Ospina, Sergio A. Pulido, Luz Amalia Ríos-Vásquez, Luz Adriana Betancur Jaramillo, Carlos Mario Muñetón Peña, Rogelio Ocampo-Cardona, Sara M. Robledo

“…Colorectal cancer (CRC) is a multifactorial disease driven by genetic and epigenetic alterations that modulate specific metabolic pathways. …”
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Quantification and Gene Expression Analysis of Histone Deacetylases in Common Bean during Rust Fungal Inoculation by Kalpalatha Melmaiee, Venu (Kal) Kalavacharla, Adrianne Brown, Antonette Todd, Yaqoob Thurston, Sathya Elavarthi

“…Histone deacetylases (HDACs) play an important role in plant growth, development, and defense processes and are one of the primary causes of epigenetic modifications in a genome. There was only one study reported on epigenetic modifications of the important legume crop, common bean, and its interaction with the fungal rust pathogen Uromyces appendiculatus prior to this project. …”
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Behavioral phenotyping of Kaiso-deficient mice by V. S. Korostina, A. V. Kulikov

“…The Kaiso-deficient strain is a new and promising model of the genetic, molecular, and neuronal mechanisms mediating the epigenetic regulation of brain functions and behavior.…”
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Involvement of transposable elements in neurogenesis by R. N. Mustafin, E. K. Khusnutdinova

“…Therefore, transposons, through their own processed transcripts, take an active part in the epigenetic regulation of differentiation of neurons. …”
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Intratumor heterogeneity: models of malignancy emergence and evolution by R. A. Ivanov, S. A. Lashin

“…By uncovering the mechanisms that determine tumor heterogeneity, researchers can identify key genetic and epigenetic changes that contribute to tumor progression and resistance to treatment. …”
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