Behavioral, biochemical, immune, and histological responses of Nile tilapia (Oreochromis niloticus Linnaeus, 1758) to lead, mercury, and pendimethalin exposure: individual and comb... by Rasha M. Reda, Eman M. Zaki, Ahmed A. A. Aioub, Mohamed M. M. Metwally, Aya M. Yassin, Fatma Mahsoub

“…The MIX group had higher levels of serum creatinine and urea, as well as the liver enzymes alanine aminotransferase, aspartate transaminase, and alkaline phosphatase. …”
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Exploring Zinc C295 as a Dual HIV-1 Integrase Inhibitor: From Strand Transfer to 3′-Processing Suppression by Sharif Karim Sayyed, Marzuqa Quraishi, D. S. Prabakaran, Balaji Chandrasekaran, Thiyagarajan Ramesh, Satish Kumar Rajasekharan, Chaitany Jayprakash Raorane, Tareeka Sonawane, Vinothkannan Ravichandran

“…Computational analyses revealed key interactions of Zinc C295 within the enzyme’s allosteric site, providing insights into its dual inhibitory mechanism. …”
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Protective effects of peptide KSPLY derived from Hericium erinaceus on H2O2-induced oxidative damage in HepG2 cells by Zhengli Xu, Qiuhui Hu, Minhao Xie, Jianhui Liu, Anxiang Su, Hui Xu, Wenjian Yang

“…Erinaceus-derived peptide KSPLY pretreatment promoted the expression of detoxification and antioxidant enzymes via the Keap1/Nrf2 signal pathway, thereby inhibiting the generation of ROS and MDA. …”
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Feruloyl-amides as natural antimicrobials for crop and food protection by Denise Dozio, Sharmila Ghosh, Daniele Alessandro Consolini, Josè Luis Ermini Starna, Loris Pinto, Federico Baruzzi, Martina Letizia Contente, Andrea Pinto, Paolo Cortesi, Salvatore Princiotto, Andrea Kunova, Sabrina Dallavalle

“…The main mechanism of defence is based on a rapid transcriptional reprogramming of genes encoding biosynthetic enzymes that synthesize specific secondary metabolites. …”
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Immunization of cattle with a Rhipicephalus microplus chitinase peptide containing predicted B-cell epitopes reduces tick biological fitness by María Martina Esperanza Perez-Soria, Daniel Gustavo López-Díaz, Rafael Jiménez-Ocampo, Gabriela Aguilar-Tipacamú, Massaro W. Ueti, Juan Mosqueda, Ala Tabor

“…To develop novel tick vaccines, it is crucial to identify and evaluate antigens capable of generating protection in cattle. Chitinases are enzymes that degrade older chitin at the time of moulting, therefore allowing interstadial metamorphosis. …”
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Research Progress of Bacteriocin Combined with Physical Technology in the Prevention and Control of Foodborne Pathogens and Spoilage Microorganisms by Mingzhu WANG, Zihao TIAN, Zhongmei TAN, Jie REN, Gaoyun WU, Jinqi GUO, Yuchang YAO, Yuan YIN, Bailiang LI, Jiage MA, Wei YU

“…However, bacteriocins may have some limitations when used individually, such as the narrow inhibitory spectrum and easy degradation by enzymes. Previous studies found that the combined use of bacteriocins and physical technologies may exhibit synergistic antimicrobial effects. …”
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Treatment of a mutant KRAS lung cancer cell line with polyisoprenylated cysteinyl amide inhibitors activates the MAPK pathway, inhibits cell migration and induces apoptosis. by Matthew D Gregory, Kweku Ofosu-Asante, Jassy Mary S Lazarte, Pablo E Puente, Nada Tawfeeq, Nadine Belony, Yong Huang, Ite A Offringa, Nazarius S Lamango

“…Western blotting was used to determine the effect of the PCAIs on the phosphorylation levels of MAPK pathway enzymes. After 48 h exposure to 5 μM of the PCAIs, NSL-YHJ-2-46, the MAPK proteins BRAF, MEK1/2, ERK1/2, and p90RSK were activated through phosphorylation by 90, 190, 150 and 120%, respectively. …”
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Synthesis and Evaluation of N-[1-(((3,4-Diphenylthiazol-2(3H)-ylidene)amino)methyl)cyclopentyl]acetamide Derivatives for the Treatment of Diseases Belonging to MAOs by Gülhan Turan-Zitouni, Aouatef Tabbi, Weiam Hussein, Abdullah Burak Karaduman, Begüm Nurpelin Sağlık, Yusuf Özkay

“…The inhibitory activity of compounds (4a-4i) against hMAO-A and hMAO-B enzymes was elucidated by using in vitro fluorometric method using Amplex Red® reagent. …”
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Investigating the role of cathepsins in breast cancer progression: a Mendelian randomization study by Shengyi Zhou, Shengyi Zhou, Shengyi Zhou, Yizhou Sun, Yizhou Sun, Wenzhang Zha, Wenzhang Zha, Guangjun Zhou, Guangjun Zhou

“…Within the human lysosomal system, a class of enzymes known as cathepsins exhibit elevated expression levels in various malignant tumors, suggesting that they may play key roles in cancer progression.MethodsThis study employed the two-sample Mendelian randomization (MR) approach to investigate the potential causal relationship between cathepsin levels and the risk of developing breast cancer. …”
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Draft genome dataset of Streptomyces griseoincarnatus strain R-35 isolated from tidal pool sedimentsMendeley DataNCBI by Danielle Dana Mitchell, Jo-Marie Vreulink, Alaric Prins, Marilize Le Roes-Hill

“…The CARD RGI algorithm on Proksee predicted the presence of 6,107 antimicrobial resistance (AMR) features, 27 biosynthetic gene clusters (BGCs) were predicted using antiSMASH, while 189 carbohydrate-active enzymes (CAZymes) were predicted using dbCAN3. The raw genome sequencing data has been submitted to the National Center for Biotechnology (NCBI) under the BioProject ID PRJNA1129156 (BioSample ID Accession Number: SAMN42145163; Short Read Archive (SRA) Accession: SRR29633055; https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1129156).…”
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PPARα: A Master Regulator of Bilirubin Homeostasis by Cyril Bigo, Jenny Kaeding, Diala El Husseini, Iwona Rudkowska, Mélanie Verreault, Marie Claude Vohl, Olivier Barbier

“…Human umbilical vein epithelial cells (HUVEC) and coronary artery smooth muscle cells (CASMC) were cultured in the absence or presence of the 3 activators, and mRNA, protein, and/or activity levels of the bilirubin synthesizing heme oxygenase- (HO-) 1 and biliverdin reductase (BVR) enzymes were determined. Human hepatocytes (HH) and HepG2 cells sustained similar treatments, except that the expression of the bilirubin conjugating UDP-glucuronosyltransferase (UGT) 1A1 enzyme and multidrug resistance-associated protein (MRP) 2 transporter was analyzed. …”
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Integrative proteomic-transcriptomic analysis revealed the lifestyles of Lactobacillus paracasei H4-11 and Kluyveromyces marxianus L1-1 under co-cultivation conditions by Na Liu, Likang Qin, Haiying Zeng, Anyan Wen, Song Miao

“…The above up-regulation and down-regulation synergistically promoted the formation of characteristic flavor compounds (mainly L-lactic acid and ethyl acetate). Enzyme-linked immunoassay (ELISA) and parallel reaction monitoring (PRM) quantitative analysis respectively verified that 5 key metabolic enzymes and 27 proteins in L. paracasei H4-11 and K. marxianus L1-1 were associated with the characteristic flavor of rice-acid soup, as confirmed by the quantitative results of 4D LFQ.…”
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Enhancement of Cognitive Benefits and Anti-Anxiety Effects of <i>Phytolacca americana</i> Fruits in a Zebrafish (<i>Danio rerio</i>) Model of Scopolamine-Induced Memory Impairment by Lucia-Florina Popovici, Ion Brinza, Florentina Gatea, Georgiana Ileana Badea, Emanuel Vamanu, Simona Oancea, Lucian Hritcu

“…Furthermore, these extracts demonstrated the ability to mitigate cholinergic deficits by inhibiting AChE activity and supporting antioxidant defense mechanisms through increased activity of antioxidant enzymes and reduced lipid and protein peroxidation. …”
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Direct and Indirect Protein Interactions Link FUS Aggregation to Histone Post-Translational Modification Dysregulation and Growth Suppression in an ALS/FTD Yeast Model by Seth A. Bennett, Samantha N. Cobos, Raven M. A. Fisher, Elizaveta Son, Rania Frederic, Rianna Segal, Huda Yousuf, Kaitlyn Chan, David K. Dansu, Mariana P. Torrente

“…We show that the histone-modifying enzymes Ipl1 and Rtt109—responsible for installing H3S10ph and H3K56ac—are excluded from the nucleus in the context of FUS proteinopathy. …”
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Allograft tolerance after adult living donor liver transplantation: a case-control study by Mohamed S. Habl, Moataz Maher Emara, Reham A. Zayed, Ahmed M. Sultan, Ahmed Elsabagh, Ahmed Marwan Elsaid, Ehab E. Abdel-khalek, Mohamed M. El-Saadany, Mohamed Abdel Wahab, Ahmed Shehta

“…During follow-up, Group 1 showed lower serum levels of bilirubin, liver enzymes, alkaline phosphatase, and gamma-glutamyl transferase. …”
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Functional Prediction of Hypothetical Proteins from and Validation of the Predicted Models by Using ROC Curve Analysis by Md. Amran Gazi, Sultan Mahmud, Shah Mohammad Fahim, Mohammad Golam Kibria, Parag Palit, Md. Rezaul Islam, Humaira Rashid, Subhasish Das, Mustafa Mahfuz, Tahmeed Ahmeed

“…These HPs were found to belong to various classes of proteins such as enzymes, binding proteins, signal transducers, lipoprotein, transporters, virulence and other proteins. …”
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Spermine Enhances the Peroxidase Activities of Multimeric Antiparallel G-quadruplex DNAzymes by Raphael I. Adeoye, Theresia K. Ralebitso-Senior, Amanda Boddis, Amanda J. Reid, Francesca Giuntini, Amos A. Fatokun, Andrew K. Powell, Adaoha Ihekwaba-Ndibe, Sylvia O. Malomo, Femi J. Olorunniji

“…While these nanozymes are easy to assemble, they are not as efficient as natural peroxidase enzymes. Several approaches are being used to better understand the structural basis of their reaction mechanisms, with a view to designing constructs with improved catalytic activities. …”
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Carbon Dioxide Micro-Nano Bubbles Aeration Improves Carbon Fixation Efficiency for Succinic Acid Synthesis by <i>Escherichia coli</i> by Ying Chen, Hao Wu, Qianqian Huang, Jingwen Liao, Liuqing Wang, Yue Pan, Anming Xu, Wenming Zhang, Min Jiang

“…The activities of key enzymes within the SA synthesis pathway were also maintained or enhanced in the fermentation process with MNB aeration. …”
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Complete Genome Sequence and Comparative Genome Analysis of Variovorax sp. Strains PAMC28711, PAMC26660, and PAMC28562 and Trehalose Metabolic Pathways in Antarctica Isolates by Prasansah Shrestha, Jayram Karmacharya, So-Ra Han, Jun Hyuck Lee, Hyun Park, Tae-Jin Oh

“…Likewise, CAZyme annotation (dbCAN2 Meta server) was performed to predict the CAZyme family responsible for trehalose biosynthesis and degradation enzymes. Trehalose has been found to respond to osmotic stress and extreme temperatures. …”
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Cellular Responses in Human Dental Pulp Stem Cells Treated with Three Endodontic Materials by Alejandro Victoria-Escandell, José Santiago Ibañez-Cabellos, Sergio Bañuls-Sánchez de Cutanda, Ester Berenguer-Pascual, Jesús Beltrán-García, Eva García-López, Federico V. Pallardó, José Luis García-Giménez, Antonio Pallarés-Sabater, Ignacio Zarzosa-López, Manuel Monterde

“…Levels of antioxidant enzymes were evaluated by Western blot. Genotoxicity was studied by quantifying the expression levels of DNA damage sensors such as ATM and RAD53 genes and DNA damage repair sensors such as RAD51 and PARP-1. …”
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