Differences in physicochemical properties and proteomics analysis of spray- and freeze-dried milk powders from bovine, goat, and horse sources by Shichu Zhou, Xin Zhang, Junyu Zhang, Changjiang Zang, Rongbo Fan, Jun Wang, Tongjun Guo, Rongwei Han, Yongxin Yang

“…Proteomic analysis indicated that freeze-dried milk powder exhibited higher levels of immune-related proteins, including complement C3, C7, and complement factor B, and antimicrobial enzymes such as lysozyme and lactoperoxidase compared with spray-dried milk powder. …”
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An in-vivo herb-drug interaction study of IME-9 and glimepiride in nicotinamide-STZ-induced diabetic rats by Archana K. Thikekar, Asha B. Thomas, Sohan S. Chitlange

“…In silico molecular docking investigations were conducted using Autodock Vina 1.2.3 to assess the binding affinity of the 46 primary phytoconstituents present in IME 9 with CYP2C9 enzymes. Toxicity assessments were carried out utilizing the MTT assay. …”
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Molting of laying hens can activate AMPK- lipophagy - lipid metabolism pathway and improve intestinal digestion and absorption by Meiwei Lv, Chenxin Liu, Xiaowen Jiang, Ming Ge, Haibin Wang, Wenhui Yu

“…Serological analysis and detection of enzymes involved in digestion and absorption, showed upregulated expression of GLUT2, FABP (P<0.05 and P<0.001) and CD36 (P<0.01), and the activities of amylase, chymotrypsin and Lipase also increased significantly (P<0.05, P<0.01 and P<0.001). …”
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Opposing Effects of Omega-3 and Omega-6 Long Chain Polyunsaturated Fatty Acids on the Expression of Lipogenic Genes in Omental and Retroperitoneal Adipose Depots in the Rat by B. S. Muhlhausler, R. Cook-Johnson, M. James, D. Miljkovic, E. Duthoit, R. Gibson

“…Samples from distinct adipose depots (omental and retroperitoneal) were collected and mRNA expression of the pro-lipogenic transcription factors Sterol-Retinoid-Element-Binding-Protein1c (SREBP1c) and Peroxisome Proliferator Activated Receptor-γ (PPARγ), lipogenic enzymes Sterol-coenzyme Desaturase1 (SCD-1), Fatty Acid Synthase (FAS), lipoprotein lipase (LPL) and glycerol-3-phosphate dehydrogenase (G3PDH) and adipokines leptin and adiponectin determined by qRT-PCR. …”
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Co-inoculation of Trichoderma viride with Azospirillum brasilense could suppress the development of Harpophora maydis-infected maize in Egypt by Rasha M. Elmeihy, Omar A. Hewedy, Maryam S. Alhumaidi, Khadijah A. Altammar, Eman O. Hassan, Samah A. El-Debaiky

“…T. viride showed high mycoparasitic potential against H. maydis via various antagonistic activities, including the production of lytic enzymes, secondary metabolites, volatile compounds, and siderophores. …”
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New Genomic Approaches to Enhance Biomass Degradation by the Industrial Fungus Trichoderma reesei by Renato Graciano de Paula, Amanda Cristina Campos Antoniêto, Liliane Fraga Costa Ribeiro, Cláudia Batista Carraro, Karoline Maria Vieira Nogueira, Douglas Christian Borges Lopes, Alinne Costa Silva, Mariana Taíse Zerbini, Wellington Ramos Pedersoli, Mariana do Nascimento Costa, Roberto Nascimento Silva

“…It is the most important fungus for the industrial production of enzymes to biomass deconstruction being widely used in the biotechnology industry, mainly in the production of biofuels. …”
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Exploration of the Role of Cyclophilins in Established Hepatitis B and C Infections by Jennifer Molle, Sarah Duponchel, Jennifer Rieusset, Michel Ovize, Alexander V. Ivanov, Fabien Zoulim, Birke Bartosch

“…Cyclophilin (Cyp) inhibitors are of clinical interest in respect to their antiviral activities in the context of many viral infections including chronic hepatitis B and C. Cyps are a group of enzymes with peptidyl-prolyl isomerase activity (PPIase), known to be required for replication of diverse viruses including hepatitis B and C viruses (HBV and HCV). …”
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Exposure of Mesenchymal Stem Cells to an Alzheimer’s Disease Environment Enhances Therapeutic Effects by Sang Eon Park, Hyeong Seop Kim, Soo Jin Kwon, Min-Jeong Kim, Suk-joo Choi, Soo-young Oh, Gyu Ha Ryu, Hong Bae Jeon, Duk L. Na, Jong Wook Chang

“…Previous studies suggested that the coculture of human MSCs with AD in an in vitro model reduced the expression of amyloid-beta 42 (Aβ42) in the medium as well as the overexpression of amyloid-beta- (Aβ-) degrading enzymes such as neprilysin (NEP). We focused on the role of primed MSCs (human Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) exposed to an AD cell line via a coculture system) in reducing the levels of Aβ and inhibiting cell death. …”
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Smac127 Has Proapoptotic and Anti-Inflammatory Effects on Rheumatoid Arthritis Fibroblast-Like Synoviocytes by D. Lattuada, R. Gualtierotti, K. Crotta, P. Seneci, F. Ingegnoli, C. Corradini, R. Viganò, O. Marelli, C. Casnici

“…Fibroblast-like synoviocytes (FLSs) are apoptosis-resistant and contribute to the pathogenesis of RA by producing cytokines and proteolytic enzymes, which degrade the extracellular matrix. We evaluated the proapoptotic and anti-inflammatory activity of the small molecule Smac127 on RA-FLSs cultured in synovial fluid (SF), in order to reproduce the physiopathological environmental characteristic of RA joints. …”
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The structure–activity relationship and computational studies of 1,3-thiazole derivatives as cholinesterase inhibitors with anti-inflammatory activity by Modrić, Marina, Božičević, Marin, Odak, Ilijana, Talić, Stanislava, Barić, Danijela, Mlakić, Milena, Raspudić, Anamarija, Škorić, Irena

“…According to these experimental results, the cholinesterase inhibitory and anti-inflammatory activity of 1,3-thiazoles were correlated and confirmed that the same compounds inhibited LPS-stimulated TNF$\alpha $ cytokine production in PBMCs and enzymes cholinesterases.…”
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M2 Macrophages as a Potential Target for Antiatherosclerosis Treatment by Ying Bi, Jixiang Chen, Feng Hu, Jing Liu, Man Li, Lei Zhao

“…Inhibiting or activating some kinds of enzymes, affecting transcription factors, or acting on several membrane receptors could regulate the polarization of the M2 phenotype. …”
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Continuous Consumption of Reused Palm Oil Induced Hepatic Injury, Depletion of Glutathione Stores, and Modulation of Cytochrome P450 Profiles in Mice by Waranya Chatuphonprasert, Yollada Sriset, Kanokwan Jarukamjorn

“…The expression of Cyp4a10 and Cyp4a14 , the key enzymes in lipid metabolism, were expectedly up-regulated by both. …”
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α-Amylase and α-Glucosidase Inhibitory Activities of Chemical Constituents from Wedelia chinensis (Osbeck.) Merr. Leaves by Nguyen Phuong Thao, Pham Thanh Binh, Nguyen Thi Luyen, Ta Manh Hung, Nguyen Hai Dang, Nguyen Tien Dat

“…Other compounds showed weak or did not show any effect on both enzymes. The results suggested that the antidiabetic properties from the leaves of W. chinensis are not simply a result of each isolated compound but are due to other components such as the accessibility of polyphenolic groups to α-amylase and α-glucosidase activities.…”
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Taxonomic and ecophysiological characteristics of actinobacteria in soils of the dry steppe zone of the Selenga Highlands (Western Transbaikalia) by E. P. Nikitina, L. B. Buyantueva, E. Yu. Abidueva, C. H. Sun

“…The examinations of extracellular enzymes showed that all isolates were capable of producing catalase and amylase; 78.6 % of the total number of isolates produced protease and lipase; 53.6 %, cellulase; and 28.6 %, urease. …”
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Perspectives on Structural, Physiological, Cellular, and Molecular Responses to Desiccation in Resurrection Plants by Yathisha Neeragunda Shivaraj, Plancot Barbara, Bruno Gugi, Maïté Vicré-Gibouin, Azeddine Driouich, Sharatchandra Ramasandra Govind, Akash Devaraja, Yogendra Kambalagere

“…Cleavages by xyloglucan-modifying enzymes release the tightly bound xyloglucan-cellulose network, thus increasing cell wall flexibility required for cell wall folding upon desiccation. …”
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In vivo anti-aging properties on fat diet-induced high fat Drosophila melanogaster of n-butanol extract from Paecilomyces hepiali by Akang Dan, Yushi Chen, Yongqi Tian, Shaoyun Wang

“…Further research showed that PHE reduced the accumulation of peroxide products and increased the activity of antioxidant enzymes. Then, through antioxidant activity tracking, dimerumic acid (compound 1, the IC50 value of 3.4 μg/mL on DPPH free radicals scavenging activity), 4,5-dihydroxy-3-methoxypentanoic acid (compound 2, new compound), and thymidine (compound 3) were isolated from PHE. …”
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Ugochukwu, Oliver Ukachi by Maduabuchi , Patrick Aja, Chukwu, Chinecherem Adanna, Okechukwu, Ugwu Paul Chima, Anthony, Boniface Ale, Chinedu , Peter Agu, Deusdedi, Tusubira, Chukwu, Darlington C, Onyedika, Gabriel Ani, Ugbala, Ezebuilo Ekpono, Akobi , Hilary Ogwoni, Awoke , Joshua Nonso, Ogbu, Patience N, Aja, Lucy, Orji, Obasi Uche, Nweke, Chinoso Peter, Egwu, Chinedu, Ekpono, Ejike Ugbala, Ewa, Gift Onyinyechi, Igwenyi, Ikechuku Okorie, Esther, Alum Ugo, Uti, Daniel Ejim, Offor, Christian Emeka, Ifie, Josiah E., Njoku, Amaobichukwu, Kenneth, Ekenechukwu, Ejike, Daniel Eze

“…Malondialdehyde, liver enzymes, reactive oxygen species, total bilirubin, and direct bilirubin levels were all significantly elevated by BPA (p 0.05). …”
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Transcriptome analysis and cytochrome P450 monooxygenase reveal the molecular mechanism of Bisphenol A degradation by Pseudomonas putida strain YC-AE1 by Adel, Eltoukhy, Yang, Jia, Imane, Lamraoui, M. A., Abo‑Kadoum, Omar, Mohammad Atta, Ruth, Nahurira, Junhuan, Wang, Yanchun, Yan

“…The degradation pathway of BPA in YC‑AE1 was proposed with specific enzymes and encoded genes. The role of cytochrome P450 (CYP450) in BPA degradation was further verified. …”
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Endocrine disruptors and cancers. [Perturbateurs endocriniens et cancers] by Souhila AOUICHAT BOUGUERRA, Saliha BOUMAZA, Khouloud HEMILA, Samia NEGGAZI, Nadjiba HAMLAT, Sihem BERDJA, Leïla SMAIL, Besma MOHAMMEDI, Kenza REGUOUAT, Amina BOUDJLIDA, Sofiane KACI, Fatima BOUACHRIA-BOUSMAHA

“…They act by binding to receptors or enzymes and modulate, through their agonist or antagonist activity, the effectiveness or metabolism of natural hormones. …”
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Dietary DHA Regulated the Androgen Production in Male Chinese Tongue Sole Cynoglossus semilaevis by Jiahao Liu, Qiang Ma, Feiran Zhang, Qingyan Gao, Zhijun Zhang, Yuliang Wei, Mengqing Liang, Houguo Xu

“…In conclusion, dietary DHA may promote the synthesis of T and 11-KT through the regulation of protein (Hsd17b1 and P450c17) and gene (p450c17, hsd17b1, hsd3b1, aromatase, hsd11b2, and p45011b) expression of a series of key steroid hormone biosynthetic enzymes in male Chinese tongue sole.…”
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