Recent progress on anti-cancer activity of thiadiazoles: A review by C.R. Santhosh, Sampath Chinnam, Nagaraju Kottam, S Amreen, Guddekoppa S. Ananthnag, G.M. Madhu, Samata Gadde, Viola Tressa Fernandes, Haritha Arnipalli

“…Thiadiazoles acts as inhibitors against several specific enzymes or signaling pathways. These compounds are frequently utilized when combined with other anti-cancer drugs to improve their efficacy. …”
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From micro to macro, nanotechnology demystifies acute pancreatitis: a new generation of treatment options emerges by Wei Du, Xinyue Wang, Yuyan Zhou, Wencheng Wu, Haojie Huang, Zhendong Jin

“…This is caused by the abnormal activation of pancreatic enzymes by a variety of etiologic factors, which results in a localized inflammatory response. …”
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Inhibitory Mechanism of Epsilon-poly-L-Lysine against Botrytis cinerea in Apples by Yong DOU, Jing DONG, Cheng CHEN, Peihong HU, Xinchi LIU, Lingwei KONG

“…The changes in cell permeability, antioxidant enzyme activities, cellular soluble protein and nucleic acid leakage, malonaldehyde content, and reactive oxygen species of B. cinerea were also investigated. …”
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L-selenomethionine inhibits small intestinal ferroptosis caused by ammonia exposure through regulating ROS-mediated iron metabolism by Xinxin Zhang, Lepeng Gu, Ying Chen, Tianqi Wang, Houjuan Xing

“…The results showed that ammonia exposure up-regulated the levels of iron, ROS, MDA, and LPO in the small intestinal tissue and the IPEC-J2 cell, down-regulated the activities of antioxidant enzymes and the content of GSH, inhibited the Nrf2 pathway, significantly altered the expression of ferroptosis (TFR-1, FPN-1, FTH1, SLC7A11, GPX4, ACSL4) and intestine tight junctions (Claudin-1, Occludin, ZO-1) genes. …”
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Liraglutide Attenuates Nonalcoholic Fatty Liver Disease through Adjusting Lipid Metabolism via SHP1/AMPK Signaling Pathway by Peng Yu, Xi Xu, Jing Zhang, Xuan Xia, Fen Xu, Jianping Weng, Xiaoyang Lai, Yunfeng Shen

“…LR administration significantly lowered the serum lipid profile and lipid disposition in vitro and in vivo because of the altered expression of enzymes on hepatic gluconeogenesis and lipid metabolism. …”
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Characteristics and bioinformatics of peptides from natural and cultured sandfish (Holothuria scabra) by Pawitporn Daopa, Chakkapat Aenglong, Sittiruk Roytrakul, Teerasak E-kobon, Xue Zhao, Wanwimol Klaypradit

“…LC-MSMS analysis, coupled with bioinformatics database comparisons, indicated that sandfish from natural and cultured sources, as well as different enzymes used in the hydrolysis process, significantly affect protein and peptide pattern. …”
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An orally administered gold nanocluster with ROS scavenging for inflammatory bowel disease treatment by Fei Wang, Qianhui Li, Tingting Xu, Zhu Li, Yongxin Jiang, Yan Ma, Xiaohu Li, Wanni Wang, Haisheng Qian

“…Au25 NCs can eliminate ROS such as ABTS radicals, superoxide free radicals (•O2−), and hydroxyl free radicals (•OH), upregulate the expression level of antioxidant enzymes, inhibit the expression of proinflammatory cytokines, and finally interrupt the inflammatory circuit of IBD to achieve the effective prevention and delayed treatment of IBD. …”
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Intestinal oxygen utilisation and cellular adaptation during intestinal ischaemia–reperfusion injury by Paraschos Archontakis‐Barakakis, Theodoros Mavridis, David‐Dimitris Chlorogiannis, Georgios Barakakis, Eleni Laou, Daniel I. Sessler, George Gkiokas, Athanasios Chalkias

“…Upon reperfusion, intestinal hypoxia may persist because microcirculatory flow remains impaired and/or because available oxygen is consumed by enzymes, intestinal cells and neutrophils.…”
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Winery By-Products In Vitro and In Vivo Effects on Atherothrombotic Markers: Focus on Platelet-Activating Factor by Maria Choleva, Smaragdi Antonopoulou, Elizabeth Fragopoulou

“…Although wine extracts and phenolic compounds have been reported to inhibit PAF’s actions and reduce the activity of its biosynthetic enzymes, no data exist concerning the influence of winery by-product extracts. …”
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Enhancing Miscanthus floridulus remediation of soil cadmium using Beauveria bassiana FE14: Plant growth promotion and microbial interactions by Ying Wang, Sha Xiang, Rui Chen, Liang Chen, Wendi Lan, Jun Fang, Yunhua Xiao

“…Results revealed that B. bassiana FE14 significantly enhanced the growth of M. floridulus, substantially decreased Cd content in soil by 79.39 %, and modified enzyme activities (superoxide dismutase, peroxidase, and catalase) to alleviate Cd-induced oxidative stress in plants, determined by the physical and chemical indicators and enzyme activities of soil and plant. …”
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Comparative Transcriptional Profiling of Two Contrasting Barley Genotypes under Salinity Stress during the Seedling Stage by Runhong Gao, Ke Duan, Guimei Guo, Zhizhao Du, Zhiwei Chen, Liang Li, Ting He, Ruiju Lu, Jianhua Huang

“…Notably, a LysM RLK was firstly found involved in salt stress response. Moreover, key enzymes in the pathways of jasmonic acid biosynthesis, lipid metabolism and indole-3-acetic acid homeostasis were specifically affected by salt stress in salt tolerance genotype. …”
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Polymeric nanoreactors for catalytic applications by Abou-Fayssal, Chantal Joseph, Poli, Rinaldo, Philippot, Karine, Riisager, Anders, Manoury, Eric

“…Mimicking Nature is one drive for chemists to design efficient architectures matching the activity and selectivity of natural catalytic systems, such as enzymes. To this extent, the developed architectures need to have a selective and active site for the transformation of a given substrate to a target product. …”
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Cobalt-induced oxidative stress and defense responses of Adhatoda vasica proliferated shoots by Abeer A. Radi, Fatma A. Farghaly, Fatma A. Al-Kahtany, Ahmed M. Zaher, Afaf M. Hamada

“…While cobalt (Co) can be toxic to plants at high levels and isn’t considered essential, it plays a beneficial role in many enzymes and is critical for various biological functions. …”
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Zinc oxide seed priming enhances drought tolerance in wheat seedlings by improving antioxidant activity and osmoprotection by Rasha M. El-Shazoly, A. A. Othman, Muhammad Saqlain Zaheer, Ahmed F. Al-Hossainy, Dalia A. Abdel-Wahab

“…Zinc is an essential element for several enzymes involved in metabolism, cell elongation, preservation of the strength and integrity of cell membranes, seed development, and resistance to environmental stress. …”
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Comparative study for assessment of two different minimally invasive caries removal techniques by Ahmed M. Elmarakby, Shaimaa F K Habib, Ibrahim M. Alkhaldy, Rahaf M. AlJasser, Labib Mohamed Labib Elsebaey

“…Infected carious dentin for each group was removed using Smart prep bur II (polymer bur) or Brix 3000 (caries dissolving enzymes). Conventional carbide bur was used to remove carious dentin in the control group. …”
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Metabolic and Hepatic Effects of Energy-Reduced Anti-Inflammatory Diet in Younger Adults with Obesity by Gordana Kenđel Jovanović, Ines Mrakovcic-Sutic, Sandra Pavičić Žeželj, Indira Benjak Horvat, Lucia Šuša, Dario Rahelić, Sanja Klobučar Majanović

“…Metabolic status was determined with glycaemic and lipid status, inflammatory status with hs-CRP, IL-6, and TNF-α, and liver status with liver enzymes, NAFLD-FLS, FLI, and FIB-4 indices. The inflammatory potential of the diet was assessed by the Dietary Inflammatory Index, DII®. …”
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Cross-Linking Mast Cell Specific Gangliosides Stimulates the Release of Newly Formed Lipid Mediators and Newly Synthesized Cytokines by Edismauro Garcia Freitas Filho, Elaine Zayas Marcelino da Silva, Camila Ziliotto Zanotto, Constance Oliver, Maria Célia Jamur

“…The effect of cross-linking these gangliosides on the activation of enzymes in the arachidonate cascade was then investigated. …”
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Transcriptomic Analysis of Pathogenicity Genes in Sclerotinia sclerotiorum Affecting Brassica napus by Hengameh Taheri, Mohamad Hamed Ghodoum Parizipour

“…., cell wall-degrading enzymes, biosynthesis of secondary metabolites & metabolic pathways) to infect its host plant.…”
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Inhibition of transcriptional regulation of detoxification genes contributes to insecticide resistance management in Spodoptera exigua by Bo Hu, Yuping Deng, Tao Lu, Miaomiao Ren, Kuitun Liu, Cong Rao, Hailiang Guo, Jianya Su

“…Finally, we demonstrate that sofalcone can greatly improve the susceptibility of S. exigua larvae to insecticides by inhibiting the activity of the ROS/CncC-dependent detoxifying enzymes and downregulating the expression levels of detoxification genes. …”
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Effects of aluminum on metabolism of reactive oxygen species and reactive nitrogen species in root tips of different Eucalyptus species by Zilong Ouyang, Bing Liu, Tangkan Li, Tiandao Bai, Weichao Teng

“…By observing the occurrence and distribution of the main reactive oxygen species (ROS) and reactive nitrogen species (RNS) in root tips of Eucalyptus seedlings under Al stress, this study analyzed change in the growth and physiological indexes of Eucalyptus seedlings under Al stress. The antioxidant enzymes activities of the root tips of different Eucalyptus species induced by Al stress resulted in different ROS and RNS contents, ultimately resulting in differing degrees of membrane lipid peroxidation. …”
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