Gestational Age at Delivery Is an Independent Predictor of Neonatal Outcome for Maternal HELLP Syndrome by Yan Shi, Xiaoli Yang, Chengqin Wang, Luosong Zhuoga, Dongmei Xu

“…Abstract Hemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome is a severe complication of preeclampsia (PE), with a higher incidence rate in people living at high altitudes, such as Tibet area. …”
Get full text

Effect and Safety of Mycophenolate Mofetil in Idiopathic Pulmonary Fibrosis by Argyris Tzouvelekis, Evangelos Bouros, Anastasia Oikonomou, Paschalis Ntolios, George Zacharis, George Kolios, Demosthenes Bouros

“…No cases of clinically significant infection, leucopenia, or elevated liver enzymes were recorded. Conclusions. MMF is a safe therapeutic modality which failed to show a beneficial effect both in functional and radiological parameters in a small cohort of IPF patients.…”
Get full text

The histone methyltransferase DOT1B is dispensable for stage differentiation and macrophage infection of Leishmania mexicana by Nicole Eisenhuth, Elisa Theres Rauh, Melina Mitnacht, Andrea Debus, Ulrike Schleicher, Falk Butter, Katerina Pruzinova, Petr Volf, Christian J. Janzen

“…However, the specific functions of these enzymes depend on the host evasion strategies of the parasites. …”
Get full text

Strenuous Exercise-Induced Tremendously Elevated Transaminases Levels in a Healthy Adult: A Diagnostic Dilemma by Prabin Khatri, Aryan Neupane, Suman Raj Sapkota, Bibhav Bashyal, Dipesh Sharma, Ashmita Chhetri, K. C. Chirag, Ashish Banjade, Priyanka Sapkota, Subarna. Bhandari

“…The liver function test (LFT) is a commonly performed test in clinical practice in order to assess well-being of the liver; however, derangement in liver enzymes, however, may not necessarily imply an underlying liver pathology. …”
Get full text

Two Unrelated Iranian Patients with Adenosine Deaminase 2 Deficiency: A Case Report and Review of Treatment by Parvaneh Karimzade, Aziz Eghbali, Mohammad Keramatipour, Reza Shiari, Zahra Golchehre, Mahdieh Taghizadeh, Mazdak Fallahi, Shahrzad Fallah, Nasrin Khakbazan Fard, Narges Eslami, Narges Bazgir, Mahnaz Jamee, Zahra Chavoshzadeh

“…The second patient was a 6-year-old female who had recurrent fever and bicytopenia, aphthous lesions, cervical lymphadenopathy, and elevated liver enzymes. We also discussed the strategies used to manage the clinical manifestations in these two DADA2 patients. …”
Get full text

Probiotic Bacterium-Derived p40, p75, and HM0539 Proteins as Novel Postbiotics and Gut-Associated Immune System (GAIS) Modulation: Postbiotic-Gut-Health Axis by Feray Gençer Bingöl, Duygu Ağagündüz, Ferenc Budán

“…Postbiotics are bioactive metabolites such as organic acids, peptides/proteins, cell wall components, functional enzymes, short-chain fatty acids, vitamins, and phenols. …”
Get full text

Dimerization-dependent serine protease activity of FAM111A prevents replication fork stalling at topoisomerase 1 cleavage complexes by Sowmiya Palani, Yuka Machida, Julia R. Alvey, Vandana Mishra, Allison L. Welter, Gaofeng Cui, Benoît Bragantini , Maria Victoria Botuyan, Anh T. Q. Cong, Georges Mer, Matthew J. Schellenberg, Yuichi J. Machida

“…Missense mutations in the catalytic domain cause hyper-autocleavage and are associated with genetic disorders with developmental defects. Despite the enzyme’s biological significance, the molecular architecture of the FAM111A serine protease domain (SPD) is unknown. …”
Get full text

Optimization of Protease and Amylase Production by Rhizopus oryzae Cultivated on Bread Waste Using Solid-State Fermentation by Olfa Benabda, Sana M’hir, Mariam Kasmi, Wissem Mnif, Moktar Hamdi

“…This research was carried for the coproduction of two industrial enzymes: α-amylase and protease via SSF by Rhizopus oryzae on humidified bread waste. …”
Get full text

Sequence Analysis of Hypothetical Proteins from 26695 to Identify Potential Virulence Factors by Ahmad Abu Turab Naqvi, Farah Anjum, Faez Iqbal Khan, Asimul Islam, Faizan Ahmad, Md. Imtaiyaz Hassan

“…All the predicted HPs contain representative members of diverse functional classes of proteins such as enzymes, transporters, binding proteins, regulatory proteins, proteins involved in cellular processes and other proteins with miscellaneous functions. …”
Get full text

IL-34 aggravates myocardial ischemia-reperfusion injury by upregulating the HMGB1-IL-17A-IL-6 axis through the JAK signaling pathway. by Ruisong Ma, Xiaochun Hu, Wenwen Fu, Xiaorong Hu

“…We also observed increased serum cardiac enzymes and a larger myocardial injury area. Treatment with a Janus kinase (JAK) pathway inhibitor, however, partially reduced the expression of these proteins and attenuated myocardial injury. …”
Get full text

Phytochemical Analysis and Cholinesterase Inhibitory and Antioxidant Activities of Enhydra fluctuans Relevant in the Management of Alzheimer’s Disease by Simin Shabnam Lopa, Md. Yusuf Al-Amin, Md. Kamrul Hasan, Md. Salim Ahammed, KM Monirul Islam, A. H. M. Khurshid Alam, Toshihisa Tanaka, Md. Golam Sadik

“…Among the four tested extracts, the chloroform extract was found to exert the highest inhibition against both the acetylcholinesterase and butyrylcholinesterase enzymes with the IC50 (concentration required for 50% inhibition) values of 83.90 μg/mL and 48.14 μg/mL, respectively. …”
Get full text

Effect of Diets Supplemented With Yeast, Chitin, and Chitosan on the Growth, Immune, and Antioxidant Responses of the Freshwater Prawn Cryphiops (Cryphiops) caementarius by Walter Reyes-Avalos, Carlos Azañero-Díaz, Gladis Melgarejo-Velasquez, Carmen Yzásiga-Barrera, Brian Alegre-Calvo, Roberto Lezama-Salazar

“…However, activated yeast is not effective in increasing the activity of antioxidant enzymes SOD and GST. Therefore, the activated yeast diet can be useful to improve the aquaculture production of C. …”
Get full text

Enhancing the efficacy of low doses of N-acetyl-L-cysteine in mitigating CCl4-induced hepatotoxicity in animal model using physical cold plasma by Masume Farhadi, Farshad Sohbatzadeh, Akbar Hajizadeh Moghaddam, Yasaman Firouzjaei, Cheng Cheng

“…Also, the antioxidant enzymes and oxidative stress activities improved after receiving PTN. …”
Get full text

The Mitochondria-Targeted Antioxidant SkQ1 Downregulates Aryl Hydrocarbon Receptor-Dependent Genes in the Retina of OXYS Rats with AMD-Like Retinopathy by M. L. Perepechaeva, A. Yu. Grishanova, E. A. Rudnitskaya, N. G. Kolosova

“…These data suggest that the Cyp1a2 and Cyp1b1 enzymes are involved in the pathogenesis of AMD-like retinopathy of OXYS rats and are possible therapeutic targets of SkQ1.…”
Get full text

Bactericide, Immunomodulating, and Wound Healing Properties of Transgenic Kalanchoe pinnata Synergize with Antimicrobial Peptide Cecropin P1 In Vivo by A. A. Lebedeva, N. S. Zakharchenko, E. V. Trubnikova, O. A. Medvedeva, T. V. Kuznetsova, G. A. Masgutova, M. V. Zylkova, Y. I. Buryanov, A. S. Belous

“…It included incubation of leaves at +4°C for 7 days, mechanical homogenization of leaves using water as extraction solvent, and heating at +70°C for inactivating plant enzymes. Yield of CecP1 (after heating and sterilizing filtration) was 0.3% of total protein in the extract. …”
Get full text

Whole-Body Cryotherapy Decreases the Levels of Inflammatory, Oxidative Stress, and Atherosclerosis Plaque Markers in Male Patients with Active-Phase Ankylosing Spondylitis in the A... by Agata Stanek, Armand Cholewka, Tomasz Wielkoszyński, Ewa Romuk, Aleksander Sieroń

“…Additionally, in the WBC group, we observed a decrease in oxidative stress markers, changes in the activity of some antioxidant enzymes and nonenzymatic antioxidant parameters. In both groups, the total cholesterol and LDL cholesterol, triglycerides, sCD40L, PAPP-A, and PLGF levels decreased, but the parameter changes were higher in the WBC group. …”
Get full text

Heterologous and High Production of Ergothioneine in <i>Bacillus licheniformis</i> by Using Genes from Anaerobic Bacteria by Zhe Liu, Fengxu Xiao, Yupeng Zhang, Jiawei Lu, Youran Li, Guiyang Shi

“…Given the value of EGT and the application of <i>Bacillus licheniformis</i> in enzyme preparation production, we cloned the key enzymes (EanA and EanB) from <i>Chlorbium limicola</i>. …”
Get full text

Mechanistic insight into human milk extracellular vesicle‐intestinal barrier interactions by Xiang Luo, Yunyue Zhang, Ning Ding, Jana Javorovic, Bahijja Tolulope Raimi‐Abraham, Steven Lynham, Xiaoping Yang, Natalie Shenker, Driton Vllasaliu

“…Here, we studied the interaction of human milk EVs with the gut barrier components, including intestinal biofluids, enzymes, mucus and epithelium. Additionally, we probed the endocytic mechanisms mediating the EV intestinal uptake. …”
Get full text

Heterologous Expression of Laccase1 from Cryphonectria parasitica in Saccharomyces cerevisiae by Kum-Kang So, Fatima Alejandra Hernandez Alvarado, Gui-Hwan Han, Jeong-Won Kim, Tae-Geum Kim, Dae-Hyuk Kim

“…Laccases are enzymes capable of oxidizing phenolic compounds and are important tools in different industrial processes. …”
Get full text

GENOME POLITICS: STRATEGY AND TACTICS by Jonas Rubikas

“…This is clearly seen when the comparison between the information content (the gene number) and the life cycle of small genomes (plasmids, viruses, singlecellular prokaryotic organisms) is made: large space is occupied by information on replication enzymes and the sequence of replication origin. In higher eukaryotic multicellular organisms the increased complexity of the genome could be expressed as plus function information: for metabolism, for relations with environment, for nervous system. …”
Get full text