The Activity of Metalloproteases and Serine Proteases in Various Organs after Leiurus macroctenus Envenomation by Valery Gunas, Oleksandr Maievskyi, Nataliia Raksha, Tetiana Vovk, Oleksiy Savchuk, Serhii Shchypanskyi, Igor Gunas

“…Scorpion stings may be life-threatening since their venoms are comprised of a wide range of toxins and other bioactive molecules, such as enzymes. At the same time, scorpion envenomation may increase matrix metalloproteases (MMPs) levels, which enhance proteolytic tissue destruction by venom. …”
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A Young Male with Severe Myocarditis and Skeletal Muscle Myositis by Abdalla Ibrahim, Eoghan Meagher, Alexander Fraser, Thomas J. Kiernan

“…He had elevated troponin T, normal skeletal muscle enzymes, and negative inflammatory markers. Cardiac magnetic resonance imaging (MRI) confirmed active myocarditis with extensive myocardial fibrosis and normal left ventricular ejection fraction (LVEF). …”
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Identifying Allosteric Small-Molecule Binding Sites of Inactive NS2B-NS3 Proteases of Pathogenic <i>Flaviviridae</i> by Hovakim Grabski, Siranuysh Grabska, Ruben Abagyan

“…The development of new therapeutic strategies based on inhibiting essential viral enzymes or viral–host protein interactions is problematic due to the fast mutation rate and rapid emergence of drug resistance. …”
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Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice by Lubna Danish, Riffat Siddiq, Sarwat Jahan, Mehwish Taneez, Manzoor Khan, Marva Sandhu

“…Cimetidine by inhibiting the cytochromal enzymes and reducing the production of the toxic metabolite can reduce the hepatotoxic potential while Verapamil can act as a hepatoprotective by maintaining calcium homeostasis. …”
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Effect of Activation Energy on Magnetized Couple Stress Fluid over an Inclined Stretching Permeable Cylinder by Suman Sharma, Shalini Jain

“…Activation energy is of considerable significance in diverse applications such as chemical kinetics, catalyst development, enzymes, semiconductors, and systems sensitive to temperature, such as chemical reactors and engines. …”
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Pharmacokinetic evaluation of the interaction between oral kaempferol and ethanol in rats by Zhou Zhaoxiang, Wang Meng, Guo Zengjun, Zhang Xiaoying

“…Increased permeability of cell membrane and ethanolkaempferol interactions on CYP450 enzymes may enhance the oral bioavailability of kaempferol in rats.…”
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Luteolin Pretreatment Attenuates Hepatic Ischemia-Reperfusion Injury in Mice by Inhibiting Inflammation, Autophagy, and Apoptosis via the ERK/PPARα Pathway by Yuhui Jiang, Wenjuan Yang, Jiameng Ding, Jie Ji, Liwei Wu, Yuanyuan Zheng, Yan Li, Ziqi Cheng, Jie Zhang, Qiang Yu, Jiao Feng, Jingjing Li, Jianye Wu, Yingqun Zhou, Chuanyong Guo

“…Serum and tissue samples were collected at 6 and 24 h after reperfusion to assay liver enzymes, inflammatory factors, expression of proteins associated with apoptosis and autophagy, and factors associated with the extracellular signal-regulated kinase/peroxisome proliferator-activated receptor alpha (ERK/PPARα) pathway. …”
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Absorption and Metabolism Characteristics of Rutin in Caco-2 Cells by Xiaofang Zhang, Jinhui Song, Xiaopeng Shi, Shan Miao, Yan Li, Aidong Wen

“…These results suggest that a specific transport system mediates rutin movement across the apical membrane in Caco-2 cells and that metabolic enzymes are important for this process.…”
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Cadmium Tolerance and Detoxification Mechanisms of <i>Lentinula edodes</i>: Physiology, Subcellular Distribution, and Chemical Forms by Gaigai Chen, Bowen Han, Wene Nan, Xiaobo Dong

“…Enhanced antioxidant enzyme activities, reduced cadmium accumulation, and increased HAc-extractable cadmium with less toxicity promoted stronger cadmium tolerance and detoxification abilities in L130 compared to 1504. …”
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Design, Synthesis, Molecular Docking, and Antibacterial Evaluation of Some Novel Flouroquinolone Derivatives as Potent Antibacterial Agent by Mehul M. Patel, Laxman J. Patel

“…To understand the interaction of binding sites with bacterial protein receptor, the docking study was performed using topoisomerase II DNA gyrase enzymes (PDB ID: 2XCT) by Schrodinger’s Maestro program. …”
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Mechanistic Studies with DNA Polymerases Reveal Complex Outcomes following Bypass of DNA Damage by Robert L. Eoff, Jeong-Yun Choi, F. Peter Guengerich

“…Part of this so-called DNA damage tolerance pathway involves the recruitment of specialized DNA polymerases to sites of stalled or collapsed replication forks. These enzymes have unique structural and functional attributes that often allow bypass of adducted template DNA and successful completion of genomic replication. …”
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High-resolution fleezers reveal duplex opening and stepwise assembly by an oligomer of the DEAD-box helicase Ded1p by Eric M. Patrick, Rajeev Yadav, Kasun Senanayake, Kyle Cotter, Andrea A. Putnam, Eckhard Jankowsky, Matthew J. Comstock

“…DEAD-box ATPases with helicase activity unwind RNA duplexes by local opening of helical regions without directional movement through the duplexes and some of these enzymes, including Ded1p from Saccharomyces cerevisiae, oligomerize to effectively unwind RNA duplexes. …”
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Functional Development of the Human Gastrointestinal Tract: Hormone- and Growth Factor-Mediated Regulatory Mechanisms by Daniel Ménard

“…In the third section, emphasis is placed on the functional development of human fetal stomach and its various epithelial cell types; in particular, the glandular chief cells responsible for the synthesis and secretion of gastric enzymes such as pepsinogen-5 and gastric lipase. Bearing in mind that limitations of available cell models have, until now, greatly impeded the comprehension of molecular mechanisms regulating human gastric epithelial cell functions, the last section focuses on new human gastric epithelial cell models recently developed in the author's laboratory. …”
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Antibacterial Effect of Dihydromyricetin on Specific Spoilage Organisms of Hybrid Grouper by Wenbo Huang, Jing Xie

“…Through analyzing cell permeability, enzyme activity, and images of the confocal laser scanning microscope (CLSM), we further studied the antibacterial mechanism of DMY emulsion on specific spoilage bacteria. …”
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Enzymatic functionalization of bacterial nanocellulose: current approaches and future prospects by Monika Kaczmarek, Aneta Monika Białkowska

“…An alternative to these procedures is the highly specific enzymatic modification of bacterial nanocellulose, which perfectly fits into the assumptions of green technologies, making the process eco-friendly and not limiting any outlooks for further usage of the obtained biocomposites. The employment of enzymes for the targeted alteration of this material’s properties is based on either a direct method, such as controlled hydrolysis and nanofication [i.e., synthesis of different morphological forms of bacterial cellulose (e.g., rod-shaped nanocrystals)] using cellulases, and/or attachment of reactive functional groups into the polymer structure via oxidation (e.g., utilizing a laccase/TEMPO catalytic system or lytic polysaccharide monooxygenases) and esterification catalyzed by lipases; or an indirect procedure involving the application of bacterial nanocellulose as a matrix for enzyme immobilization (e.g., laccase, glucose oxidase, horseradish peroxidase, lysozyme, bromelain, lipase, papain), thus creating a specific catalytic system. …”
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Pyogenic Liver Abscess Caused by Methicillin-Susceptible Staphylococcus aureus in a 21-Year-Old Male by Samuel Igbinedion, Meher S. Mavuram, Moheb Boktor, John Bienvenu

“…Labs were significant for leukocytosis with predominant neutrophilia and elevated liver enzymes. CT abdomen with contrast revealed an 8.4 cm multiloculated right hepatic mass extending to the kidney. …”
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Case Report: Necrotizing pneumonia in pediatric patients: a rare case of unilateral necrosis in two entire lobe tissues by Jingli Zhang, Yingqian Zhang, Longfei Gao, Huifang Wu, Xiaojuan Liu, Fan Yang, Yingxue Wang

“…Laboratory investigations revealed elevated white blood cell count, increased inflammatory markers, elevated liver enzymes, coagulation dysfunction, and hypoalbuminemia. …”
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Recapitulation of previously reported associations for type 2 diabetes and metabolic traits in the 126K East Asians by Ji-Young Choi, Hye-Mi Jang, Sohee Han, Mi Yeong Hwang, Bong-Jo Kim, Young Jin Kim

“…In this study, we validated 422 variants independently associated with glycemic indexes, liver enzymes, and type 2 diabetes in 125,872 samples from a Korean population, and further validated the results by assessing publicly available summary statistics from European GWAS (n = 898,130). …”
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Unraveling cerebroprotective potential of fenchone: A combined in vivo and in silico exploration of nitric oxide synthase modulation by Bangaru Mamatha, Anka Rao Areti, DSNBK Prasanth, Narender Malothu

“…Additionally, FEN restored the activity of antioxidant enzymes (catalase and superoxide dismutase) and decreased malondialdehyde (MDA) and nitric oxide (NO) levels and infarct size compared to those in untreated ischemic rats. …”
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