Exercise Training Prevents Decrease in Luminal Capillary Diameter of Skeletal Muscles in Rats with Type 2 Diabetes by Takeshi Morifuji, Shinichiro Murakami, Naoto Fujita, Hiroyo Kondo, Hidemi Fujino

“…The purpose of this study was to examine whether exercise training can prevent microangiopathy of skeletal muscles in rats with type 2 diabetes and if succinate dehydrogenase (SDH) activity, an indicator of mitochondrial oxidative enzyme activity, is involved in the prevention of microangiopathy. …”
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Physicochemical properties and biological activities of polysaccharides from the peel of Dioscorea opposita Thunb. extracted by four different methods by Zuowei Zhao, Li Wang, Yuan Ruan, Chunnan Wen, Menghuan Ge, Yanyan Qian, Bingji Ma

“…The influences of 4 extraction methods, namely hot water extraction (W), acidic extraction (HA), hot-compressed water extraction (HCW) and enzyme-assisted extraction (EAE), on the yields, physicochemical properties, hypoglycemic and antioxidant activities of polysaccharides from DTTP were studied and compared. …”
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PRMT5 promotes ovarian cancer growth through enhancing Warburg effect by methylating ENO1 by Fei Xie, Han Zhang, Kongkai Zhu, Cheng‐Shi Jiang, Xiaoya Zhang, Hongkai Chang, Yaya Qiao, Mingming Sun, Jiyan Wang, Mukuo Wang, Junzhen Tan, Tao Wang, Lianmei Zhao, Yuan Zhang, Jianping Lin, Chunze Zhang, Shuangping Liu, Jianguo Zhao, Cheng Luo, Shuai Zhang, Changliang Shan

“…Abstract Protein arginine methyltransferase 5 (PRMT5) is a major type II enzyme responsible for symmetric dimethylation of arginine (SDMA), and plays predominantly roles in human cancers, including in ovarian cancer. …”
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Short-term airborne ultrasound induced cell death in tobacco cells and changed their wall components by Mahsa Sardari, Faezeh Ghanati, Hamid Mobasheri, Abazar Hajnorouzi

“…Alteration of covalently bound peroxidase and other wall-modifying enzyme activities was accompanied by reduced cellulose, pectin, and hemicellulose B but increased lignin and hemicellulose A. …”
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From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 Pathogenesis by Sara Ahmadi Badi, Samira Tarashi, Abolfazl Fateh, Pejman Rohani, Andrea Masotti, Seyed Davar Siadat

“…Additionally, the gut microbiota composition affects (and is affected by) the expression of angiotensin-converting enzyme-2 (ACE2), which is the main receptor for SARS-CoV-2 and contributes to regulate inflammation. …”
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Chicken collagen hydrolysates differentially mediate anti-inflammatory activity and type I collagen synthesis on human dermal fibroblasts by Marina Offengenden, Subhadeep Chakrabarti, Jianping Wu

“…We found that the use of two rather than one enzyme for hydrolysis generates a greater abundance of low molecular weight peptides with consequent improvement in bioactive properties. …”
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Antibacterial and Pharmacological Evaluation of Fluoroquinolones: A Chemoinformatics Approach by Damini Sood, Neeraj Kumar, Aarushi Singh, Meena Kishore Sakharkar, Vartika Tomar, Ramesh Chandra

“…We found that among all four FQ molecules, ofloxacin showed the highest antibacterial activity through in silico assays with a strong interaction (−38.52 kJ/mol) with the antibacterial target protein (topoisomerase-II DNA gyrase enzyme). The pharmacological and pharmacokinetic analysis also showed that the compounds ciprofloxacin, ofloxacin, lomefloxacin and norfloxacin have good pharmacological properties. …”
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Effect of Endotoxemia in Suckling Rats on Pancreatic Integrity and Exocrine Function in Adults: A Review Report by Jolanta Jaworek, Barbara Tudek, Paweł Kowalczyk, Michalina Kot, Joanna Szklarczyk, Anna Leja-Szpak, Piotr Pierzchalski, Joanna Bonior, Artur Dembiński, Piotr Ceranowicz, Zygmunt Warzecha, Katarzyna Nawrot-Porąbka, Krzysztof Gil

“…Signal for the CCK1 receptor was reduced and pancreatic secretory responses to caerulein were diminished, whereas basal enzyme secretion was unaffected. These pioneer studies have shown that exposition of suckling rats to endotoxin has an impact on the pancreas in the adult organism.…”
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Characterization of a Y-Family DNA Polymerase eta from the Eukaryotic Thermophile Alvinella pompejana by Sayo Kashiwagi, Isao Kuraoka, Yoshie Fujiwara, Kenichi Hitomi, Quen J. Cheng, Jill O. Fuss, David S. Shin, Chikahide Masutani, John A. Tainer, Fumio Hanaoka, Shigenori Iwai

“…Moreover, the activity of this enzyme was retained in the presence of a higher concentration of organic solvents. …”
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Podocyturia: A Clue for the Rational Use of Amiloride in Alport Renal Disease by H. Trimarchi, R. Canzonieri, A. Muryan, A. Schiel, A. Araoz, M. Paulero, J. Andrews, T. Rengel, M. Forrester, F. Lombi, V. Pomeranz, R. Iriarte, E. Zotta

“…Commonly drug-based approaches include angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, which are employed to reduce proteinuria and thus retard kidney disease progression and cardiovascular morbidity and mortality. …”
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Microbial phenolic metabolites 3-(3′,4′-dihydroxyphenyl)propanoic acid and 3′,4′-dihydroxyphenylacetic acid prevent obesity in mice fed with high-fat diet by Wanbing Chen, Ruonan Liu, Xiaoling Zhu, Qun Lu, Hong Yang, Rui Liu

“…Correlation analysis revealed that the differential metabolites are strongly associated with body weight, blood glucose, insulin level, and superoxide dismutase (SOD) enzyme activity. Our results revealed that DHPA and DHAA exert their anti-obesity effect by regulating important metabolites in the glucose, lipid and tyrosine metabolism pathways.…”
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The Anti-Inflammatory Role of Vitamin E in Prevention of Osteoporosis by A. S. Nazrun, M. Norazlina, M. Norliza, S. Ima Nirwana

“…Vitamin E has also been shown to inhibit COX-2, the enzyme involved in inflammatory reactions. Of the two types of vitamin E studied, tocotrienol seemed to be better than tocopherol in terms of its ability to suppress bone-resorbing cytokines.…”
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The Assessment of Cholinesterase from the Liver of Puntius Javanicus as Detection of Metal Ions by Mohd Khalizan Sabullah, Mohd Rosni Sulaiman, Mohd Yunus Abd Shukor, Mohd Arif Syed, Nor Aripin Shamaan, Ariff Khalid, Siti Aqlima Ahmad

“…Screening of heavy metals shows that chromium, copper, and mercury strongly inhibited P. javanicus ChE by lowering the activity below 50%, while several pairwise combination of metal ions exhibited synergistic inhibiting effects on the enzyme which is greater than single exposure especially chromium, copper, and mercury. …”
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Catalpol alleviates the lipopolysaccharide-induced inflammatory response of BV2 cells by Sijie Liu, Jiayi Zhu, Hao Huang, Jiaxiang Xu, Biao Zhang, Yi Luo

“…The inflammatory factors interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) were detected by enzyme‐linked immunosorbent assay (ELISA). Reactive oxygen species (ROS) were detected by flow cytometry. …”
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Effects of Mulberry Pomace Addition and Transglutaminase Treatment on the Quality of Pasta Enriched with Antioxidants and Dietary Fiber by Thi Minh Ngoc Ta, Chi Hieu Hoang, Thao Mi Nguyen, Thi Thu Tra Tran, Nu Minh Nguyet Ton, Le Van Viet Man

“…The quality improvement of 10% mulberry pomace fortified pasta was investigated by adding a transglutaminase preparation with enzyme dosage from 0.25 to 1.00 U/g protein. The fortified pasta treated with transglutaminase at 0.50 U/g protein showed a significant improvement in chewiness, tensile strength and elongation rate but was not significantly affected in terms of the swelling index and water absorption. …”
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Oral Administration of Semicarbazide Limits Weight Gain together with Inhibition of Fat Deposition and of Primary Amine Oxidase Activity in Adipose Tissue by Josep Mercader, Zsuzsa Iffiú-Soltész, Sandy Bour, Christian Carpéné

“…An enzyme hitherto named semicarbazide-sensitive amine oxidase (SSAO), involved in the oxidation of primary amines, is abundantly expressed in adipocytes. …”
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How endocrine disruptors affect fish reproduction on multiple levels: A review by Socha Magdalena, Chyb Jarosław, Suder Aleksandra, Bojarski Bartosz

“…These substances, including bisphenols, heavy metals, pesticides, phthalates, and polychlorinated biphenyls (PCBs), act as hormone mimics, receptor blockers, or enzyme inhibitors that affect hormonal regulation in the hypothalamic-pituitary-gonadal (HPG) axis. …”
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Mesenchymal Stem Cells in Renal Fibrosis: The Flame of Cytotherapy by Quan Zhuang, Ruoyu Ma, Yanshuang Yin, Tianhao Lan, Meng Yu, Yingzi Ming

“…Yet, the current method of treating renal fibrosis is fairly limited, including angiotensin-converting enzyme inhibition, angiotensin receptor blockade, optimal blood pressure control, and sodium bicarbonate for metabolic acidosis. …”
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Inhibition of Cathepsin S Produces Neuroprotective Effects after Traumatic Brain Injury in Mice by Jianguo Xu, Handong Wang, Ke Ding, Xinyu Lu, Tao Li, Jiawei Wang, Chunxi Wang, Jian Wang

“…It has long been regarded as an enzyme that is primarily involved in general protein degradation. …”
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Computer-aided approaches reveal trihydroxychroman and pyrazolone derivatives as potential inhibitors of SARS-CoV-2 virus main protease by Atatreh Noor, Hasan Shaima, Ali Bassam R., Ghattas Mohammad A.

“…Interestingly, the top compounds showed favorable binding energies and binding patterns to the protease enzyme, forming interactions with several key residues. …”
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