Kidney damage associated with COVID-19: from the acute to the chronic phase by Yannick Mayamba Nlandu, Elliot Koranteng Tannor, Titilope Adetoun Bamikefa, Jean-Robert Rissassi Makulo

“…The entry point into the renal cell remains the angiotensin-converting enzyme 2 (ACE-2) receptor and the spectrum of renal lesions is broad, with a clear predominance of structural and functional tubular lesions. …”
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The Use of Antisense-Mediated Inhibition to Delineate The Role of Inflammatory Agents in The Pathophysiology of Spinal Cord Injury by Damien D. Pearse, Francisco C. Pereira, Katina Chatzipanteli, Francisco W. Dalton Dietrich, Mary Bartlett Bunge

“…Hybridization of the oligonucleotide to the mRNA then interferes with the normal processing of that mRNA at the ribosome or targets the RNA duplex for cleavage by the RNA digestive enzyme, ribonuclease H, resulting in greatly reduced expression of the coded protein. …”
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Aloe vera leaves potential as a new source of transglutaminase by Cahyo Indarto, Supriyanto Supriyanto, Wahyu Prihanta, Dang Ngoc Hung

“…Transglutaminase is an enzyme that catalyzes cross-linking reactions between primary protein chains. …”
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Identification and characterization of a novel tetrapeptide from enzymatic hydrolysates of Baijiu byproduct by Qiang Wu, Changqing Zhong, Guirong Zeng, Xu Zhang, Liping Xiang, Chang Wan, Yougui Yu

“…In order to prepare angiotensin I-converting enzyme (ACE) inhibitory peptides, distilled spent grains of Chinese strong-flavor Baijiu were hydrolyzed by alcalase followed by papain under optimized conditions. …”
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Protein Disulfide Isomerase and Host-Pathogen Interaction by Beatriz S. Stolf, Ioannis Smyrnias, Lucia R. Lopes, Alcione Vendramin, Hiro Goto, Francisco R. M. Laurindo, Ajay M. Shah, Celio X. C. Santos

“…., intra- and interdisulfide and cysteine oxidation) and (ii) phagocytic ROS production via Nox family NADPH oxidase enzyme and the control of phagolysosome function with key implications for antigen processing. …”
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Changes in Serum Cytokines May Predict Therapeutic Efficacy of Tofacitinib in Rheumatoid Arthritis by Yuxuan Li, Lin Yuan, Jie Yang, Yue Lei, Hui Zhang, Liping Xia, Hui Shen, Jing Lu

“…Serum cytokines levels of Th1 (IFN-γ), Th2 (IL-6), Th17 (IL-17), Tregs (IL-35), and TNF-α were detected by enzyme-linked immunosorbent assays. Results. Disease activity was significantly decreased as early as week 4 after tofacitinib treatment. …”
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The Effect of Age and Occupation on the Seroprevalence of Helicobacter pylori Infection by GI Perez-Perez, T Marrie, H Inouye, T Shimoyama, G Marshall, G Meiklejohn, MJ Blaser

“…Serological studies in developed and developing countries using enzyme-linked immunosorbent assays have validated this technique as a rapid, noninvasive method for the diagnosis of Helicobacter pylori infections. …”
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Effect of Trandolapril on Regression of Retinopathy in Hypertensive Patients with Type 2 Diabetes: A Prespecified Analysis of the Benedict Trial by Piero Ruggenenti, Ilian Iliev, Marco Filipponi, Stefano Tadini, Annalisa Perna, Maria Ganeva, Bogdan Ene-Iordache, Paolo Cravedi, Roberto Trevisan, Antonio Bossi, Giuseppe Remuzzi

“…The effect of angiotensin converting enzyme inhibitors (ACEi) on regression of retinopathy in type 2 diabetics is still ill defined. …”
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Improved 11α-hydroxycanrenone production by modification of cytochrome P450 monooxygenase gene in Aspergillus ochraceus by Li Qianqian, Shi Li, Liu Yingying, Guan Shimin, Zhang Shuo, Cai Baoguo, Rong Shaofeng

“…We found that although the cytochrome P450 (CYP) enzyme system in Aspergillus ochraceus strain MF018 could catalyse the conversion of canrenone to 11α-hydroxycanrenone, its biocatalytic efficiency is low. …”
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Amphetamine Positive Urine Toxicology Screen Secondary to Atomoxetine by Joshua L. Fenderson, Amy N. Stratton, Jennifer S. Domingo, Gerald O. Matthews, Christopher D. Tan

“…On arrival to the hospital, a urine toxicological drug screen with immunochemical cloned enzyme donor immunoassay (CEDIA) was performed. Results were positive for amphetamines; however, the presence of these substances could not be confirmed with urine gas chromatography-mass spectrometry (GC-MS). …”
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Positive feedback loop involving AMPK and CLYBL acetylation links metabolic rewiring and inflammatory responses by Wenke Wang, Boquan Wu, Mingjun Hao, Sichong Chen, Ruiting Cong, Wenjie Wu, Pengbo Wang, Qiaoyi Zhang, Pengyu Jia, Yuequn Song, Bo Liu, Siyao Qu, Jian-Fei Pei, Da Li, Naijin Zhang

“…Mechanistically, we found a crucial AMPK-CLYBL acetylation positive feedback loop, triggered by toll-like receptors (TLRs), involving AMPK hypophosphorylation and CLYBL hyperacetylation. The deacetylase enzyme SIRT2 acted as the bridge between AMPK phosphorylation and CLYBL acetylation, thereby regulating macrophage polarization and the release of pro-inflammatory cytokines. …”
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Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity by Mingjiong Zhang, Jiahua Cui, Haoyan Chen, Yifan Cheng, Qiaoyu Chen, Feng Zong, Xiao Lu, Lang Qin, Yu Han, Xingwang Kuai, Yuxing Zhang, Minjie Chu, Shuangshuang Wu, Jianqing Wu

“…Here we find that an ER transmembrane enzyme, sterol O-acyltransferase 2 (SOAT2), is overexpressed in regulatory T (Treg) cells from elderly patients with lung squamous cell carcinoma (LSCC), while radiomics analysis of LSCC patients associates increased SOAT2 expression with reduced immune infiltration and poor prognosis. …”
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Tailoring microbial redox with alternating current for efficient mineralization of refractory organic nitrogen compounds in wastewater by Ye Yuan, Xucui Qian, Lulu Zhang, Wanxin Yin, Tianming Chen, Zhaoxia Li, Cheng Ding, Bo Wang, Bin Liang, Aijie Wang, Yang Liu, Fan Chen

“…Multi-omics analysis shows enrichment of functional microbial consortia involved in NB reduction, aromatic compound oxidation, ammonia oxidation, nitrate/nitrite reduction, and electron transfer, with upregulated enzyme gene expression. Carbon metabolites from catechol meta-cleavage support nitro-reduction, denitrification, and cell viability without external carbon sources. …”
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Leptin decreases Th17/Treg ratio to facilitate neuroblastoma via inhibiting long-chain fatty acid catabolism in tumor cells by Meng Li, Di Li, Hai-Yun Wang, Weixin Zhang, Zhenjian Zhuo, Huiqin Guo, Jiabin Liu, Yue Zhuo, Jue Tang, Jing He, Lei Miao

“…Mechanically, leptin in NB cells blunted the activity of carnitine palmitoyltransferase 2 (CPT2), the key enzyme for LCAC catabolism, by inhibiting sirtuin 3-mediated CPT2 deacetylation, which depresses oxidative phosphorylation (OXPHOS) for energy supply and increases lactic acid (LA) production from glycolysis to modulate CD4+ T cell differentiation. …”
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Genotypic and Phenotypic Assessment of Hyaluronidase among Type Strains of a Select Group of Staphylococcal Species by Mark E. Hart, Morgan J. Hart, Anna J. Roop

“…These data support the hypothesis that among members of the Staphylococcus genus only strains of S. aureus possess the enzyme hyaluronidase. This would suggest that hyaluronidase represents yet another potential virulence factor employed by S. aureus to cause disease and may represent a diagnostically important characteristic for distinguishing S. aureus from other members of this genus.…”
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Validation of a triiodothyronine (T3) ELISA for mouse fecal samples by Lucia M. Thompson, Brailey M. Coulter, Cinnamon L. VanPutte

“…We demonstrated that using a methanol extraction protocol produced the most reliable fecal T3 measurement in an enzyme‐linked immunosorbent assay (ELISA). We found that during a thyroid hormone‐treated state, fecal and plasma T3 measurements from mice are directly related, while during a methimazole‐treated state, fecal and plasma T3 measurements from mice are inversely related. …”
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Transglutaminase 2 Induces Deficits in Social Behavior in Mice by Amanda Crider, Talisha Davis, Anthony O. Ahmed, Lin Mei, Anilkumar Pillai

“…In the present study, we examined the role of transglutaminase 2 (TG2), a calcium-dependent enzyme known to be induced following ER stress, in social behavior in mice. …”
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IL-6 Promotes Islet β-Cell Dysfunction in Rat Collagen-Induced Arthritis by Huan Jin, Yaogui Ning, Haotong Zhou, Youlian Wang

“…Furthermore, in line with the upregulated IL-6 expression, the apoptosis related enzyme caspase-3 was also markedly increased. These data showed that the elevated FBG in CIA may be associated with the reduced FIns level secondary to the overapoptosis of pancreas islet cells induced by IL-6.…”
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WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis by Enrico Briguglio, Rosanna Di Paola, Irene Paterniti, Emanuela Mazzon, Giacomo Oteri, Giancarlo Cordasco, Salvatore Cuzzocrea

“…Eighths days after placement of the ligature, we evaluated several markers of inflammation such us (1) myeloperoxidase activity, (2) a cytokines and adhesion molecules expression, (3) NF-κB expression, (4) iNOS expression, (5) the nitration of tyrosine residues, (6) activation of the nuclear enzyme poly(ADP-ribose) polymerase, (7) apoptosis, and (8) the degree of gingivomucosal tissues injury. …”
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CHD7 Regulates Osteogenic Differentiation of Human Dental Follicle Cells via PTH1R Signaling by Caojie Liu, Qiwen Li, Qingyue Xiao, Ping Gong, Ning Kang

“…Chromodomain helicase DNA-binding protein 7 (CHD7) is an ATP-dependent chromatin remodeling enzyme, functioning as chromatin reader to conduct epigenetic modification. …”
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