Quality Comparison of Hawthorn Wines Fermented by Saccharomyces cerevisiae with and without Pulp Contact and Pectase Treatment by Wenye Zhang, Lei Chi, Yan Wu, Lei Zhang, Chunping Xu

“…The pectase-treated wines had significantly higher concentrations of acetic acid, ethyl octanoate, and isoamyl acetate than the non-enzyme-treated wines. Furthermore, the nonextracted wines had significantly higher concentrations of isoamyl alcohol, phenylethyl alcohol, ethyl lactate, and isoamyl acetate than the extracted wines. …”
Get full text

SHOX Duplication and Tall Stature in a Patient with Xq Deletion and Vascular Disease by J. M. Ramirez, F. A. Rodríguez, M. I. Echeverría, A. L. Vargas, A. E. Calderón, R. M. Miatello, N. F. Renna

“…Also, taking into account the fact that the gene locus of the angiotensin-converting enzyme type 2 (ACE2) is located in Xp, our goal was to investigate the influence of this gene in the development of cardiovascular disease. …”
Get full text

Superoxide Dismutase 3 Limits Collagen-Induced Arthritis in the Absence of Phagocyte Oxidative Burst by Tiina Kelkka, Juha Petteri Laurila, Outi Sareila, Peter Olofsson, Mikko Olavi Laukkanen, Rikard Holmdahl

“…Extracellular superoxide dismutase (SOD3), an enzyme mediating dismutation of superoxide into hydrogen peroxide, has been shown to reduce inflammation by inhibiting macrophage migration into injured tissues. …”
Get full text

Calcium Channel Blocker Lacidipine Promotes Antitumor Immunity by Reprogramming Tryptophan Metabolism by Yuwen Sheng, Chong Qiao, Zhonghui Zhang, Xiaoke Shi, Linhan Yang, Ruiying Xi, Jialing Yu, Wanli Liu, Guolin Zhang, Fei Wang

“…Here, calcium channel blocker lacidipine is identified to potently inhibit the enzymatic activity and expression of indoleamine 2,3‐dioxygenase 1 (IDO1), a rate‐limiting enzyme in tryptophan metabolism. Lacidipine activates effector T cells and incapacitates regulatory T cells (Tregs) to augment the anti‐tumor effect of chemotherapeutic agents in breast cancer by converting immunologically “cold” into “hot” tumors. …”
Get full text

Merging metabolic modeling and imaging for screening therapeutic targets in colorectal cancer by Niki Tavakoli, Emma J. Fong, Abigail Coleman, Yu-Kai Huang, Mathias Bigger, Michael E. Doche, Seungil Kim, Heinz-Josef Lenz, Nicholas A. Graham, Paul Macklin, Stacey D. Finley, Shannon M. Mumenthaler

“…This process involved a novel machine learning-based method to computationally screen, in a high-throughput manner, the effects of enzyme perturbations predicted by a computational model of CRC metabolism. …”
Get full text

IDO1 inhibits ferroptosis by regulating FTO-mediated m6A methylation and SLC7A11 mRNA stability during glioblastoma progression by Qianting Tian, Guixue Dan, Xuyan Wang, Jiamei Zhu, Chaochun Chen, Dekun Tang, Ziming Wang, Dan Chen, Shan Lei, Chao Yang, Houmei Wang, Bing Guo, Bangming Jin, Tengxiang Chen, Lei Tang

“…Abstract Indoleamine 2, 3-dioxygenase 1 (IDO1) has been recognized as an enzyme involved in tryptophan catabolism with immunosuppressive ability. …”
Get full text

Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer’s disease model by Jiqing Xu, Fred de Winter, Catherine Farrokhi, Edward Rockenstein, Michael Mante, Anthony Adame, Jonathan Cook, Xin Jin, Eliezer Masliah, Kuo-Fen Lee

“…Furthermore, we showed that soluble ectodomains of both type I and type III NRG1 significantly increased expression of Aβ-degrading enzyme neprilysin (NEP) in primary neuronal cultures. …”
Get full text

Removal Efficiency of Cr6+ by Indigenous Pichia sp. Isolated from Textile Factory Effluent by Pablo M. Fernández, María M. Martorell, Julia I. Fariña, Lucia I. C. Figueroa

“…The presence of a chromate reductase activity points out a possible role of an enzyme in Cr6+ reduction.…”
Get full text

Synthesis of antifungal imines as inhibitors of ergosterol biosynthesis by Joydeep Karan, Aditi Kundu, Robin Gogoi, Kanchikeri Math Manjaiah, Ashutosh Kumar Singh, Koyel Mondal, Rajesh Kumar, Parshant Kaushik, Priya Saini, Virendra Singh Rana, Najam Akhtar Shakil

“…The most effective antifungal compounds displayed >80% inhibition of the lanosterol-14α-demethylase enzyme.…”
Get full text

Porphyromonas gulae and canine periodontal disease: Current understanding and future directions by Kyu Hwan Kwack, Eun-Young Jang, Cheul Kim, Young-Suk Choi, Jae-Hyung Lee, Ji-Hoi Moon

“…This review examines the initial isolation, phylogenetic analysis, habitat, host range, relationships with host health status and age, and key pathogenic determinants, including fimbriae, proteases, citrullinating enzyme, and lipopolysaccharide. Control strategies discussed include polyphosphate to disrupt haeme/iron utilization, clindamycin with interferon alpha to reduce bacterial load and enhance the immune response, and a protease inhibitor. …”
Get full text

Monovalent Lectin Microvirin Utilizes Hydropathic Recognition of HIV-1 Env for Inhibition of Virus Cell Infection by Bibek Parajuli, Kriti Acharya, Harry Charles Bach, Shiyu Zhang, Cameron F. Abrams, Irwin Chaiken

“…MVN binding site amino acid residues were individually replaced by alanine, and the resulting purified recombinant MVN variants were examined for gp120 interaction using competition Enzyme-Linked Immunosorbent Assay (ELISA), biosensor surface plasmon resonance, calorimetry, and virus neutralization assays. …”
Get full text

A climatically significant abiotic mechanism driving carbon loss and nitrogen limitation in peat bogs by Alexandra B. Cory, Rachel M. Wilson, M. Elizabeth Holmes, William J. Riley, Yueh-Fen Li, Malak M. Tfaily, Sarah C. Bagby, Isogenie Field Team, EMERGE Project Coordinators, Patrick M. Crill, Jessica G. Ernakovich, Virginia I. Rich, Jeffrey P. Chanton

“…Numerous sterility assessments rule out biological contamination or extracellular enzyme activity as significant sources of this CO2. …”
Get full text

Chemopreventive Potential of Synergy1 and Soybean in Reducing Azoxymethane-Induced Aberrant Crypt Foci in Fisher 344 Male Rats by V. P. Gourineni, M. Verghese, J. Boateng, L. Shackelford, K. N Bhat

“…Colonic ACF enumeration and hepatic enzyme activities were measured. Reductions (%) in total ACF among treatment groups fed combinations were higher (67–77) compared to groups fed singly (52–64). …”
Get full text

CYP1A1 Relieves Lipopolysaccharide-Induced Inflammatory Responses in Bovine Mammary Epithelial Cells by Wen-Yao Zhang, Hao Wang, Shaopei Qi, Xixi Wang, Xueru Li, Kun Zhou, Yong Zhang, Ming-Qing Gao

“…The expression of cytochrome P4501A1 (CYP1A1) enzyme is changed in various organs during the host response to inflammation or infection, leading to alterations in the metabolism of endogenous and exogenous compounds. …”
Get full text

Helicobacter pylori CagA promotes gastric cancer immune escape by upregulating SQLE by Sifan Liu, Nan Zhang, Xu Ji, Shuyue Yang, Zheng Zhao, Peng Li

“…This study revealed that H. pylori CagA upregulated squalene epoxidase (SQLE) expression, a key enzyme in the cholesterol biosynthesis pathway. Elevated SQLE activity increased cellular palmitoyl-CoA levels, enhancing PD-L1 palmitoylation while decreasing its ubiquitination. …”
Get full text

Characterization of Serum Phospholipase A2 Activity in Three Diverse Species of West African Crocodiles by Mark Merchant, Kate Juneau, Jared Gemillion, Rodolfo Falconi, Aaron Doucet, Matthew H. Shirley

“…Secretory phospholipase A2, an enzyme that exhibits substantial immunological activity, was measured in the serum of three species of diverse West African crocodiles. …”
Get full text

HIV and the Gut Microbiota, Partners in Crime: Breaking the Vicious Cycle to Unearth New Therapeutic Targets by Kishanda Vyboh, Mohammad-Ali Jenabian, Vikram Mehraj, Jean-Pierre Routy

“…Microbial translocation and their downstream effects such as increased indolamine 2,3-dioxygenase (IDO) enzyme expression and activity create a self-sustaining feedback loop which enhances HIV disease progression and constitute a vicious cycle of inflammation and immune activation combining viral and bacterial factors. …”
Get full text

Isolation and In Silico Anti-COVID-19 Main Protease (Mpro) Activities of Flavonoids and a Sesquiterpene Lactone from Artemisia sublessingiana by Roza I. Jalmakhanbetova, Yerlan M. Suleimen, Masayoshi Oyama, Eslam B. Elkaeed, Ibrahim. H. Eissa, Raigul N. Suleimen, Ahmed M. Metwaly, Margarita Yu. Ishmuratova

“…The isolated compounds were in silico examined against the COVID-19 main protease (Mpro) enzyme. Compounds 1–6 exhibited promising binding modes showing free energies ranging from −6.39 to −6.81 (kcal/mol). …”
Get full text

Development of Automatic 3D Blood Vessel Search and Automatic Blood Sampling System by Using Hybrid Stereo-Autofocus Method by Eiji Nakamachi, Yusuke Morita, Yoshifumi Mizuno

“…Additionally, we established an automatic blood sampling system for SMBG and assessed its performance in relation to punctures, blood suction, transport, and discharge on an enzyme sensor. The 3D BVS and automatic blood sampling system are adequate for use in a portable SMBG device.…”
Get full text

Optimization and Validation of Indirect ELISA Using Truncated TssB Protein for the Serodiagnosis of Glanders amongst Equines by Harisankar Singha, Praveen Malik, Sachin K. Goyal, Sandip K. Khurana, Chiranjay Mukhopadhyay, Vandana K. Eshwara, Raj K. Singh

“…In an attempt to develop recombinant protein based enzyme-linked immunosorbent assay (ELISA), N-terminal 200 amino acid sequences of B. mallei TssB protein—a type 6 secretory effector protein—were expressed in prokaryotic expression system. …”
Get full text