Discovery of New Ligand with Quinoline Scaffold as Potent Allosteric Inhibitor of HIV-1 and Its Copper Complexes as a Powerful Catalyst for the Synthesis of Chiral Benzimidazole De... by Sabikeh G. Azimi, Ghodsieh Bagherzade, Mohammad Reza Saberi, Zeinab Amiri Tehranizadeh

“…The potency of these compounds as anti-HIV-1 agents was investigated using molecular docking into integrase (IN) enzyme with code 1QS4 and the GROMACS software for molecular dynamics simulation. …”
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Noncirrhotic Extrahepatic Portosystemic Shunt Causing Adult-Onset Encephalopathy Treated with Endovascular Closure by Eldad Elnekave, Eugenia Belenky, Lindsley Van der Veer

“…Hepatitis panel, relevant serological tests, tumor markers (CA-19-9, CEA), and urea cycle enzyme studies were unrevealing. Lactulose and rifaximin therapy failed to normalize serum ammonia levels. …”
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Prognostic value of serum cystatin C in patients with sepsis by Chunfang Hu, Zhiyuan Zhang, Bin Hou, Han Xue, Xuehua Pu, Jilu Ye

“…Materials and Methods: The levels of serum cystatin C, C-reactive protein (CRP), and procalcitonin (PCT) were measured via enzyme-linked immunosorbent assay (ELISA). The patients with sepsis were followed up for 30 days to record their survival conditions. …”
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Involvement of different protein kinases and phospholipases A2 in phorbol ester (TPA)-induced arachidonic acid liberation in bovine platelets by M. Lehr, K. Griessbach

“…TPA stimulates arachidonic acid release mainly by activating group IV cytosolic PLA2 (cPLA2), since inhibitors of this enzyme markedly inhibited arachidonic acid formation. …”
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Improving breast cancer treatments using pharmacomicrobiomics by Aswin Anand Pai, Aadra Prashant Bhatt

“…The authors present compelling evidence that functional differences in the gut microbiota, specifically the bacterial enzyme β-glucuronidase, leads to inter-individual variability in systemic exposure of tamoxifen, affecting drug efficacy. …”
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Two Mixed-Ligand Cu(II) Polymers: Treatment Activity on Acute Cerebral Infarction Combined with Alteplase by Wen-Ping Liu, Tao Xue, Yangchun Li, Ruoyu Cui

“…Furthermore, the biological activity of compounds was evaluated, and the related mechanism was explored as well. Firstly, the enzyme-linked immunosorbent assay (ELISA) was conducted to measure the content of coagulation factors in the serum after compound treatment. …”
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CYP Gene Expression and In Vivo Biological Effects of Khat Ethanol Extract, Cathinone and Cathine in Caenorhabditis elegans by Sharoen Yu Ming Lim, Mohammed Abdullah Alshawsh, Mustafa Alshagga, Cin Kong, Chee-Mun Fang, Yan Pan

“… The significant influence of khat, cathinone, and cathine on appetite suppression, reproduction impairment, and inhibitory effects on CYPs enzyme activity is widely recognised, but much remains unknown about its mode of action. …”
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Use of Hydrophilic Insoluble Polymers in the Restoration of Metal-Contaminated Soils by Guiwei Qu, Amarilis de Varennes

“…Plant growth and plant nutrients concentrations, extractable levels of metals in soil, and soil enzyme activities were used to monitor the improvement in soil quality following the application of these polymers. …”
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Exploring the Infectious Drug Target Glutathione S-Transferase in Plasmodium falciparum with the Inhibitory Potential of Azadirachta indica Phytocompounds by Esam S. Al-Malki

“…Neem compounds are being studied for their potential as new and effective antimalarial drugs, and there is mounting evidence that they may help treat malaria. The PfGST enzyme is crucial to the malaria parasite’s survival, making it a desirable target for new antimalarial drugs, and the study aims to examine the bark region compounds as PfGST inhibitors. …”
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Ocular neuroinflammatory response secondary to SARS-CoV-2 infection-a review by Yun Zhao, Ying Tang, Qi Yao Wang, Jia Li

“…Because the receptor for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2), can be found in many intraocular tissues, coronavirus disease 2019 (COVID-19) may also contribute to persistent intraocular neuroinflammation, microcirculation dysfunction and ocular symptoms. …”
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Iron-Binding Capacity and Antidiabetic Activity of Baby Clam (<i>Corbiculidae</i> sp.) Meat Protein Hydrolysate by Tam Dinh Le Vo, Thu Huynh, Thuy Thi Le, An Thi Tuong Tran, Bao Chi Vo

“…The highest IBC and α-amylase inhibition activity were targets for obtaining the best hydrolysis condition, including the clam meat-to-water ratio, enzyme-to-substrate (E:S) ratio, and time. Under the best condition, the hydrolysates demonstrated the IBC of 1246.20 ± 44.00 µg Fe2+/g protein and α-amylase inhibition activity of 48.33 ± 1.44%, approaching three-quarters of the activity of ethylenediaminetetraacetic acid (EDTA) sodium salt and acarbose, respectively. …”
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De novo biosynthesis of quercetin in Yarrowia Lipolytica through systematic metabolic engineering for enhanced yield by Yuxing Dong, Wenping Wei, Mengfan Li, Tao Qian, Jiayun Xu, Xiaohe Chu, Bang-Ce Ye

“…We designed a kaempferol biosynthetic pathway by integrating multiple-copy fusion enzyme expression modules, F3H-(GGGGS)2-FLS, into the genome with an optimized linker (GGGGS)2 to enhance kaempferol production from naringenin. …”
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The impact of cardiac complications on COVID-19 outcomes by Yu. V. Rudenko, V. I. Mazur

“…Possible mechanisms of cardiac damage are the high affinity of the SARS-CoV-2 adhesion protein to angiotensin-converting enzyme 2 receptors, cytokine storm, ischemia, inflammation, and acute respiratory distress syndrome. …”
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SOD1 Transcriptional and Posttranscriptional Regulation and Its Potential Implications in ALS by Pamela Milani, Stella Gagliardi, Emanuela Cova, Cristina Cereda

“…Copper-zinc superoxide dismutase (SOD1) is a detoxifying enzyme localized in the cytosol, nucleus, peroxisomes, and mitochondria. …”
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Intracellular Shuttle: The Lactate Aerobic Metabolism by Rogério Santos de Oliveira Cruz, Rafael Alves de Aguiar, Tiago Turnes, Rafael Penteado Dos Santos, Mariana Fernandes Mendes de Oliveira, Fabrizio Caputo

“…A new hypothesis has been presented based on the fact that lactate-to-pyruvate conversion cannot occur in cytosol, because the LDH enzyme characteristics and cytosolic environment do not allow the reaction in this way. …”
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Comparison of Protein Acetyltransferase Action of CRTAase with the Prototypes of HAT by Prija Ponnan, Ajit Kumar, Prabhjot Singh, Prachi Gupta, Rini Joshi, Marco Gaspari, Luciano Saso, Ashok K. Prasad, Ramesh C. Rastogi, Virinder S. Parmar, Hanumantharao G. Raj

“…Our laboratory is credited for the discovery of enzymatic acetylation of protein, a phenomenon unknown till we identified an enzyme termed acetoxy drug: protein transacetylase (TAase), catalyzing the transfer of acetyl group from polyphenolic acetates to receptor proteins (RP). …”
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Comparative Study of Serological Tests for Mycoplasma synoviae Diagnosis in Commercial Poultry Breeders by R. L. Luciano, A. L. S. P. Cardoso, G. F. Z. Stoppa, A. M. I. Kanashiro, A. G. M. de Castro, E. N. C. Tessari

“…Serum from commercial poultry breeders (𝑛=2781) was tested for MS by serum plate agglutination (SPA), hemagglutination inhibition (HI), and enzyme-linked immunosorbent assay (ELISA). From 2,781 samples tested, 736 (26.46%) were positive in SPA. …”
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Factors Influencing Oxidative Imbalance in Pulmonary Fibrosis: An Immunohistochemical Study by Simona Inghilleri, Patrizia Morbini, Ilaria Campo, Michele Zorzetto, Tiberio Oggionni, Ernesto Pozzi, Maurizio Luisetti

“…Fibroblast lesions of UIP and of COP share a similar degree of activation of RAGE, while antioxidant enzyme expression markedly reduced in UIP.…”
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Co-targeting of metabolism using dietary and pharmacologic approaches reduces breast cancer metastatic burden by Qianying Zuo, Jin Young Yoo, Erik R. Nelson, Matthew J. Sikora, Rebecca B. Riggins, Zeynep Madak-Erdogan

“…We found that Fulv treatment downregulates the ketogenesis pathway enzyme OXCT1, leading to β-hydroxybutyrate accumulation and decreased tumor cell viability. …”
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Interleukin-10 in the Pathophysiology of Inflammatory Bowel Disease: Increased Serum Concentrations During the Recovery Phase by Keiichi Mitsuyama, Nobuo Tomiyasu, Kosuke Takaki, Junya Masuda, Hiroshi Yamasaki, Kotaro Kuwaki, Teiko Takeda, Shigehiko Kitazaki, Osamu Tsuruta, Michio Sata

“…Using a specific enzyme-linked immunosorbent assay, IL-10 concentrations were measured in serum from 62 patients with ulcerative colitis (UC), 43 with Crohn's disease (CD), 25 with other colitides, and 44 normal control subjects. …”
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