Carbohydrate intolerance by V. O. Kaybysheva, Ye. K. Baranskaya

“…If food intolerance was confirmed, high performance treatment methods should be applied including dietary modification with elimination of intolerable food products, addition of specific enzyme preparations to the treatment mode. Conclusion. …”
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Disruption of BCAA degradation is a critical characteristic of diabetic cardiomyopathy revealed by integrated transcriptome and metabolome analysis by Wu Yanxia, Jiang Wanxiang, Wang Junlong, Xie Guoqing, Sun Yan, Yang Jinliang

“…Furthermore, the study identified the transcription factor Gata3 as a predicted negative regulator of the gene encoding the key enzyme for BCAA degradation. These findings suggest that the disruption of BCAA degradation is a critical characteristic of diabetic myocardial damage and indicate a potential role for Gata3 in the dysregulation of BCAA metabolism in the context of DCM.…”
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Cyclooxygenase-2 inhibitors: promise or peril? by Laurel J. Mengle-Gaw, Benjamin D. Schwartz

“…The discovery of two isoforms of the cyclooxygenase enzyme, COX-1 and COX-2, and the development of COX-2-specific inhibitors as anti-inflammatories and analgesics have offered great promise that the therapeutic benefits of NSAIDs could be optimized through inhibition of COX-2, while minimizing their adverse side effect profile associated with inhibition of COX-1. …”
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Comparison of Two Methods for Assaying Reducing Sugars in the Determination of Carbohydrase Activities by Alexander V. Gusakov, Elena G. Kondratyeva, Arkady P. Sinitsyn

“…Using twelve commercial enzyme preparations, the comparison of the NS and DNS assays in determination of cellulase, β-glucanase, xylanase, and β-mannanase activities was carried out. …”
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Caffeine's Vascular Mechanisms of Action by Darío Echeverri, Félix R. Montes, Mariana Cabrera, Angélica Galán, Angélica Prieto

“…In endothelial cells, it increases intracellular calcium stimulating the production of nitric oxide through the expression of the endothelial nitric oxide synthase enzyme. Nitric oxide is diffused to the vascular smooth muscle cell to produce vasodilation. …”
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Chemokines and Cytokines as Salivary Biomarkers for the Early Diagnosis of Oral Cancer by Gareema Prasad, Michael McCullough

“…Chemokines have been shown to be important in both inflammation and carcinogenesis and are able to be measured in saliva with relatively robust methods including enzyme-linked immunosorbent assays (ELISA). Thus it has been hypothesized that patients with oral cancer and oral potentially malignant lesions will have elevated levels of specific chemokines in oral fluids and that this may be used as a marker of both the early detection of malignant disease and progression to malignancy. …”
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Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation by Shiwen Fan, Kaixin Wang, Tianhao Zhang, Daling Deng, Jiwei Shen, Bowen Zhao, Daan Fu, Xiangdong Chen

“…Oxidative stress is a pivotal factor in the complex pathophysiology of pain, with glutathione peroxidase 4 (GPX4) recognized as a crucial antioxidant enzyme involved in both antioxidant defense mechanisms and ferroptosis pathways. …”
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Identifying a Novel DPYD Polymorphism Associated with Severe Toxicity to 5-FU Chemotherapy in a Saudi Patient by Nedal Bukhari, Faisal Azam, Mohammed Alfawaz, Mohammed Zahrani

“…Dihydropyrimidine dehydrogenase (DPD) is the major enzyme in the catabolism of 5-Fluorouracil (5-FU) and its prodrug capecitabine. …”
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Xanthine Oxidase: Isolation, Assays of Activity, and Inhibition by Danijela A. Kostić, Danica S. Dimitrijević, Gordana S. Stojanović, Ivan R. Palić, Aleksandra S. Đorđević, Jovana D. Ickovski

“…Xanthine oxidase (XO) is an important enzyme catalyzing the hydroxylation of hypoxanthine to xanthine and xanthine to uric acid which is excreted by kidneys. …”
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Suppression of Postprandial Glycaemia by L-Arabinose in Rats is More Associated with Starch than Sucrose Ingestion - Short Report by Jurgoński Adam, Krotkiewski Marcin, Juśkiewicz Jerzy, Billing-Marczak Katarzyna

“…In the starch tolerance test, the glycaemia after L-arabinose ingestion was significantly decreased both at time intervals and in total. Inhibition of enzyme activity involved in starch digestion (amylase, maltase) may be suggested as the most probable mechanism responsible for the observed effects…”
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The effect of silymarin on ischemia-reperfusion injury in skeletal muscles of rats by Abdullah Ozer, Basak Kocak, Mustafa Arslan, Baris Mardin, Aysegul Kucuk, Saban Cem Sezen, Mustafa Hakan Zor, Mustafa Kavutcu

“…The activity of the CAT enzyme was much higher in Group I/R compared to Group C. …”
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The first experience of two-stage treatment of transsphincteric fistulas of rectum by means of fibrin sealant by S. A. Frolov, A. M. Kuzminov, V. Yu. Korolik, I. S. Bogormistrov, M. O. Chernozhukova, Sh. T. Minbayev

“…To improve the short­term and long­term results of transsphincteric rectal fistulas treatment by patented two­stage method that includes elimination of fistulous tract with the subsequent enzyme treatment of the wound channel and delayed sealing by two­component biological glue. …”
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Synergistic effects of Vachellia nilotica-derived zinc oxide nanoparticles and melatonin on drought tolerance in Fragaria × ananassa by Tauseef Anwar, Alia Safdar, Huma Qureshi, Ejaz Hussain Siddiqi, Naimat Ullah, Muhammad Tahir Naseem, Walid Soufan

“…Growth and stress parameters included shoot/root length, fruit biomass, bud number, chlorophyll content, oxidative stress markers (H₂O₂, MDA), and antioxidant enzyme activities in the leaves of Fragaria × ananassa. …”
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Metabolome and transcriptome analysis reveal the pigments biosynthesis pathways in different color fruit peels of Clausena lansium L. Skeels by Zhichang Zhao, Mark Owusu Adjei, Ruixiong Luo, Huaping Yu, Yali Pang, Jian Wang, Yu Zhang, Jun Ma, Aiping Gao

“…Zeaxanthin was absent from both peels, suggesting that the b-carotene hydroxylase enzyme is not active. Both peels contain delphinidin-based (Dp) and cyanidin-based (Cy) anthocyanins, but not pelargonidin-based (Pg). …”
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McArdle's Disease Presenting as Unexplained Dyspnea in a Young Woman by Nha Voduc, Katherine A Webb, Christine D'Arsigny, Ian McBride, Denis E O'Donnell

“…McArdle's disease is a rare, inherited deficiency of myophosphorylase, an enzyme required for the utilization of glycogen. Patients with myophosphorylase deficiency classically present with exercise intolerance, leg pain and muscle fatigue. …”
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Possible Link between Metabolic Syndrome and Chronic Kidney Disease in the Development of Cardiovascular Disease by Kosaku Nitta

“…Initial antihypertensive therapy should consist of an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker. …”
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Mitochondrial DNA Damage and Animal Longevity: Insights from Comparative Studies by Reinald Pamplona

“…Chemical reactions in living cells are under strict enzyme control and conform to a tightly regulated metabolic program. …”
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Cardiovascular Activities of of the bradykinin system by Jagdish N. Sharma

“…The cardioprotective property of theangiotensin-converting enzyme inhibitors is primarily mediated via a kinin-releasingpathway, which may cause regression of the left ventricular hypertrophy in hypertensivesituations. …”
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The Role of the Aceullular Pertussis Vaccine and the Comeback of 'Pertussis Pete'? by John M Conly, B Lynn Johnston

“…Until two decades ago, pertussis in adults was a medical curiosity (2-4), but with the purification of specific Bordetella species antigens, the development of reliable enzyme immunoassays allowing accurate serological diagnosis and better understanding of the duration of immunity from vaccination, it has been clearly demonstrated that B pertussis is a common cause of prolonged cough in adults. …”
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Remarkable Role of Indoleamine 2,3-Dioxygenase and Tryptophan Metabolites in Infectious Diseases: Potential Role in Macrophage-Mediated Inflammatory Diseases by Yuki Murakami, Masato Hoshi, Yukio Imamura, Yuko Arioka, Yasuko Yamamoto, Kuniaki Saito

“…Indoleamine 2,3-dioxygenase 1 (IDO1), the L-tryptophan-degrading enzyme, plays a key role in the immunomodulatory effects on several types of immune cells. …”
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