Human parathyroid hormone fragment stimulates the de novo synthesis of prostaglandin endoperoxide synthase in chick calvaria by Chin-Yuh Yang, Ching-Liang Meng, Patrick Y- K. Wong

“…The human parathyroid hormone N-terminal fragment [hPTH-(1–34)] increases the conversion of exogenous unsaturated fatty acids to prostaglandins (PGs) in calvarial homogenates. Enzyme activities were completely blocked by indomethacin (5 × 10−7 M), a PG synthase inhibitor, and actinomycin D (5 μM), an inhibitor of transcription, by binding to DNA. …”
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Investigation of the efficacy of tyrosol on doxorubicin-induced acute cardiotoxicity in rats by Mustafa Cellat, Muhammed Etyemez

“…In terms of cardiac tissue catalase enzyme activity, no differences were found between the groups. …”
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International Normalized Ratio (INR) Increases amongst Two Patients Living with HIV on Warfarin after Being Switched from a Nevirapine to a Dolutegravir-Based Antiretroviral Regime... by Natalie Sang, Sonak Pastakia, Samuel Nyanje

“…The increased use of dolutegravir-based regimens in the treatment of HIV is unmasking drug interactions, particularly in patients who were previously on nevirapine. Nevirapine is an enzyme inducer and increases the dosing requirements for cytochrome P450 enzyme substrates including warfarin. …”
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Fabrication of AChE/SnO2-cMWCNTs/Cu Nanocomposite-Based Sensor Electrode for Detection of Methyl Parathion in Water by Vikas Dhull

“…The synergistic and facilitated electron transferring properties of SnO2-cMWCNTs/Cu made it an excellent support for immobilization of enzyme in sensing technology. The enzyme AChE was covalently immobilized with cMWCNTs using glutaraldehyde as crosslinking agent which has enhanced the storage stability and reusability of the method. …”
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In Vitro and In Silico Analysis of Bergenia ciliata and Mimosa pudica for Inhibition of α-Amylase by Mahesh Bohara, Sajani Ghaju, Kabita Sharma, Surya Kant Kalauni, Karan Khadayat

“…Furthermore, the active phytochemicals from these plants were docked with human pancreatic α-amylase to study their inhibitory activities to this enzyme. The docking analysis revealed that catechin has lower binding energy (−8.6 kcal/mol) as compared to the commercial drug acarbose (−7.3 kcal/mol) indicating higher affinity towards the enzyme. …”
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Impact of No-Tillage and Conventional Tillage Systems on Soil Microbial Communities by Reji P. Mathew, Yucheng Feng, Leonard Githinji, Ramble Ankumah, Kipling S. Balkcom

“…Results of principal components analysis based on soil physicochemical and enzyme variables were in agreement with those based on PLFA and ARISA profiles. …”
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Screening of Aqueous Extract of Persea americana Seeds for Alpha-Glucosidase Inhibitors by Tajudeen Afolayan Lawal

“…Activity of α-glucosidase enzyme in the gastrointestinal tract has been implicated in postprandial hyperglycaemia. …”
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Total Phenolic Content and Antioxidant Activity of Different Types of Chocolate, Milk, Semisweet, Dark, and Soy, in Cerebral Cortex, Hippocampus, and Cerebellum of Wistar Rats by Niara da Silva Medeiros, Roberta Koslowsky Marder, Mariane Farias Wohlenberg, Cláudia Funchal, Caroline Dani

“…In the sulfhydryl assay, we observed that the levels of nonenzymatic defenses only increased with the chocolate treatments The SOD enzyme activity was modulated in the tissues treated with the chocolates. …”
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Deranged Bioenergetics and Defective Redox Capacity in T Lymphocytes and Neutrophils Are Related to Cellular Dysfunction and Increased Oxidative Stress in Patients with Active Syst... by Ko-Jen Li, Cheng-Han Wu, Song-Chou Hsieh, Ming-Chi Lu, Chang-Youh Tsai, Chia-Li Yu

“…In addition, the redox capacity, including intracellular GSH levels and the enzyme activity of glutathione peroxidase (GSH-Px) and γ-glutamyl-transpeptidase (GGT), was decreased in SLE-T. …”
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Global Gene Expression Profiling in PPAR-γ Agonist-Treated Kidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney Disease by Daisuke Yoshihara, Masanori Kugita, Tamio Yamaguchi, Harold M. Aukema, Hiroki Kurahashi, Miwa Morita, Yoshiyuki Hiki, James P. Calvet, Darren P. Wallace, Takafumi Toyohara, Takaaki Abe, Shizuko Nagao

“…Stearoyl-coenzyme A desaturase 1 is a key enzyme in fatty acid metabolism found in the top 5 genes downregulated by PIO treatment. …”
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Analysis of five cases showing false-high Hemoglobin A1c due to reduced catalase activity by Kenji Hara, Atsushi Ujiie, Shiori Suzuki, Takenori Okumura, Mio Kubo, Hiroyuki Shinozaki, Mototaka Yamauchi, Takafumi Tsuchiya, Kohzo Takebayashi, Nobuyuki Shimozawa, Masafumi Koga, Koshi Hashimoto

“…We encountered five cases that exhibited false-high Hemoglobin A1c (HbA1c) levels when samples were examined using the enzyme-based NORUDIA N HbA1c kit. HbA1c levels were higher than those obtained using other methods, such as HPLC, immune-based methods, and other enzyme-based kits. …”
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The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids by Drahomira Holmannova, Lenka Borska, Ctirad Andrys, Pavel Borsky, Jan Kremlacek, Kvetoslava Hamakova, Vit Rehacek, Andrea Malkova, Tereza Svadlakova, Vladimir Palicka, Jan Krejsek, Zdenek Fiala

“…Clinical examination (PASI score, MetS), enzyme-linked immunosorbent assay (ELISA), and Enzyme Immunoassay (EIA). …”
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Antioxidant, Anti-Inflammatory, and Cytotoxic Activities of Garcinia nervosa (Clusiaceae) by N. M. U. Seruji, H. Y. Khong, C. J. Kutoi

“…The lipoxygenase assay showed a high inhibition of enzyme activity for the barks extracts and a moderate enzyme activity for the leaves extracts. …”
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Obstacles to Early Diagnosis of Gaucher Disease by Nishimura S, Ma C, Sidransky E, Ryan E

“…While there is no treatment for neuronopathic GD, non-neuronopathic manifestations can be efficiently managed with enzyme replacement therapy or substrate reduction therapy. …”
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Clinically Relevant Drug Interactions with Monoamine Oxidase Inhibitors by Amber N. Edinoff, Connor R. Swinford, Amira S. Odisho, Caroline R. Burroughs, Cain W. Stark, Walid A. Raslan, Elyse M. Cornett, Adam M. Kaye, Alan D. Kaye

“…Under normal conditions, NE is unable to accumulate to toxic levels due to the presence of MAO-A, an enzyme that degrades neurotransmitters, including NE. …”
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Thiamine and Thiamine Pyrophosphate as Non-Competitive Inhibitors of Acetylcholinesterase—Experimental and Theoretical Investigations by Łukasz Szeleszczuk, Dariusz Maciej Pisklak, Błażej Grodner

“…The results of the current study indicate a non-competitive type of enzyme inhibition, in contrast to the previously published works suggesting a competitive one.…”
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In Silico Analysis on the Interaction of Haloacid Dehalogenase from Bacillus cereus IndB1 with 2-Chloroalkanoic Acid Substrates by Enny Ratnaningsih, Saepulloh Saepulloh

“…The haloacid dehalogenase gene from Bacillus cereus IndB1 (bcfd1) has been isolated, expressed, and Bcfd1 enzyme activity towards monochloroacetic acid has been successfully studied. …”
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Substituted piperazine conjugated to quinoline-thiosemicarbazide as potent α-glucosidase inhibitors to target hyperglycemia by Mehran Ghasemi, Mohammad Mahdavi, Maryam Dehghan, Mohammadreza Eftekharian, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Aida Iraji, Ahmed Al-Harrasi

“…One therapeutic approach to managing this condition is the inhibition of α-glucosidase, an enzyme involved in carbohydrate digestion, to reduce postprandial blood glucose levels. …”
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Synthesis of Anti-Inflammatory Drugs’ Chalcone Derivatives and a Study of Their Conformational Properties Through a Combination of Nuclear Magnetic Resonance Spectroscopy and Molec... by Nikitas Georgiou, Andromachi Tzani, Kyriaki Vavougyiou, Christos Papadopoulos, Nikolaos Eleftheriadis, Primož Šket, Demeter Tzeli, Tuomas Niemi-Aro, Anastasia Detsi, Thomas Mavromoustakos

“…Background: In this study, two chalcone analogs were synthesized through in silico and experimental methods, and their potential to inhibit the lipoxygenase enzyme, which plays a role in the inflammation pathway, was assessed. …”
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Application of Box-Behnken Design in Optimization of Glucose Production from Oil Palm Empty Fruit Bunch Cellulose by Satriani Aga Pasma, Rusli Daik, Mohamad Yusof Maskat, Osman Hassan

“…Hydrolysis parameters including amount of enzyme, amount of cellulose, and reaction time were investigated. …”
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