Tenidap sodium inhibits secretory non-pancreatic phospholipase A2 synthesis by foetal rat calvarial osteoblasts by W. Pruzanski, B. P. Kennedy, H. van den Bosch, E. Stefanski, M. Wloch, P. Vadas

“…Northern blot analysis showed that TD did not affect the sPLA2 mRNA levels; however, immunoblotting showed a dose-dependent reduction in sPLA2 enzyme. These results, together with a marked reduction in sPLA2 enzymatic activity, suggest that TD inhibits sPLA2 synthesis at the post-transcriptional level. …”
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Vegetation types shape the soil micro-food web compositions and soil multifunctionality in Loess Plateau by Zhiming Chen, Wenjuan Kang, Renyuan He, Guang Li, Zhuzhu Luo, Zhuzhu Luo

“…., and the control vegetation Stipa bungeana on soil micro-food webs and soil multifunctionality, as well as their response mechanisms to soil environmental drivers, were investigated using High-throughput sequencing technology.ResultsC. korshinskii significantly enhanced soil physicochemical properties and soil enzyme activities by facilitating the stability of the soil micro-food web structure driven by soil bacteria and fungi and increasing the soil multifunctionality in contrast to S. bungeana. …”
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Stocking Density Induced Stress on Plasma Cortisol and Whole Blood Glucose Concentration in Nile Tilapia Fish (Oreochromis niloticus) of Lake Victoria, Kenya by Elija Odhiambo, Paul O. Angienda, Patrick Okoth, David Onyango

“…Plasma cortisol levels (ng/ml) were assayed by Enzyme-Linked Immunosorbent Assay (ELISA). Whole blood glucose levels were determined using a hand-held one touch ultraglucose meter (MD-300) and test strips. …”
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High-efficiency biodegradation of crude oil and p-hydroxybenzoic acid by Acinetobacter haemolyticus JS-1: Integrated characterization and genomic analysis by Weiyi Tao, Jijie Lu, Junzhang Lin, Mingshan Ding, Weidong Wang, Shuang Li

“…These genes are likely contributed to its high degradation efficiency. Notably, the CYP153 enzyme is crucial for metabolizing hexadecane and octadecane. …”
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Association of CYP2C9∗3 and CYP2C8∗3 Non-Functional Alleles with Ibuprofen-Induced Upper Gastrointestinal Toxicity in a Saudi Patient by Amina M. Bagher

“…Ibuprofen is predominantly metabolized by the cytochrome P450 (CYP) enzymes CYP2C9 and CYP2C8. Individuals carrying the CYP2C9∗3 or CYP2C8∗3 non-functional alleles have reduced enzyme activities resulting in elevated ibuprofen plasma concentrations and half-life. …”
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Seroprevalence and Risk Factors Associated with Hepatitis E Virus Infection in Three Species of Pet Birds in Northwest China by Wei Cong, Qing-Feng Meng, Xiao-Feng Shan, Wu-Wen Sun, Si-Yuan Qin, Xiao-Xuan Zhang, Si-Yang Huang, Ai-Dong Qian

“…A total of 59 (8.31%) pet birds were tested positive for HEV antibodies by the commercially available enzyme immunoassay kits. Of these, the seroprevalence was diverse in different species pet birds; the most frequent level was 10.83% (39/360) in Eurasian siskin, followed by 6.57% (19/289) in Oriental skylark, and 2.29% (1/36) in black-tailed grosbeak. …”
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Synthesis of antifungal imines as inhibitors of ergosterol biosynthesis by Joydeep Karan, Aditi Kundu, Robin Gogoi, Kanchikeri Math Manjaiah, Ashutosh Kumar Singh, Koyel Mondal, Rajesh Kumar, Parshant Kaushik, Priya Saini, Virendra Singh Rana, Najam Akhtar Shakil

“…The most effective antifungal compounds displayed >80% inhibition of the lanosterol-14α-demethylase enzyme.…”
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Glucose-6-phosphate dehydrogenase deficiency with coinherited Gaucher disease: A rare association by Nupur Parakh, Kusha Sharma, Sunita Sharma, Priti Chatterjee, Varinder Singh

“…Genetic testing revealed pathogenic variations in the GBA gene. Beta glucosidase enzyme levels were low while chitotriosidase was raised (1109.19 nmol/hr/mL). …”
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Crystallographic and computational characterization and in silico target fishing of six aromatic and aliphatic sulfonamide derivatives by Anh Van Nguyen, Anh Thi Ngoc Vu, Andrey N. Utenyshev, Valeriy Tkachev, Nadezhda Polyanskaya, Dmitriy Shchevnikov, Magrarita Vasil’eva, Hieu Tran-Trung, Xuan Ha Nguyen, Olga V. Kovalchukova

“…In silico analyses predicted low toxicity and potential enzyme inhibition, along with antiprotozoal properties, suggesting these compounds as candidates against protozoan pathogens. …”
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Assessing the influence of matcha green tea extract on NF-κB/MAPK signaling pathway activation in rats: A study on irradiation-induced acute hepatic inflammatory response by Noha Sayed Hamed, Eithar K. El Adham, Amal I. Hassan

“…Next, a series of biochemical experiments were conducted to examine the impact of M on lipid peroxidation levels, antioxidant enzyme activities, and pro-inflammatory cytokines (IL-6, IL-10, and TNF-α) in liver tissue. …”
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Institutional Incidence of Severe tPA-Induced Angioedema in Ischemic Cerebral Vascular Accidents by Matthew Sczepanski, Paul Bozyk

“…Angiotensin-converting enzyme (ACE) inhibitors and middle cerebral artery distribution have been associated with a higher risk of developing angioedema. …”
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Tailoring microbial redox with alternating current for efficient mineralization of refractory organic nitrogen compounds in wastewater by Ye Yuan, Xucui Qian, Lulu Zhang, Wanxin Yin, Tianming Chen, Zhaoxia Li, Cheng Ding, Bo Wang, Bin Liang, Aijie Wang, Yang Liu, Fan Chen

“…Multi-omics analysis shows enrichment of functional microbial consortia involved in NB reduction, aromatic compound oxidation, ammonia oxidation, nitrate/nitrite reduction, and electron transfer, with upregulated enzyme gene expression. Carbon metabolites from catechol meta-cleavage support nitro-reduction, denitrification, and cell viability without external carbon sources. …”
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Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency by Nadia Charfi, Mahdi Kamoun, Mouna Feki Mnif, Neila Mseddi, Fatma Mnif, Nozha Kallel, Basma Ben Naceur, Nabila Rekik, Hela Fourati, Emna Daoud, Zainab Mnif, Mourad Hadj Sliman, Tahia Sellami-Boudawara, Mohamed Abid

“…Congenital adrenal hyperplasia (CAH) describes a group of inherited autosomal recessive disorders characterized by enzyme defects in the steroidogenic pathways that lead to the biosynthesis of cortisol, aldosterone, and androgens. …”
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The Modification Effect of Influenza Vaccine on Prognostic Indicators for Cardiovascular Events after Acute Coronary Syndrome: Observations from an Influenza Vaccination Trial by Apirak Sribhutorn, Arintaya Phrommintikul, Wanwarang Wongcharoen, Usa Chaikledkaew, Suntara Eakanunkul, Apichard Sukonthasarn

“…The prognosis of acute coronary syndrome (ACS) patients has been improved with several treatments such as antithrombotics, beta-blockers, and angiotensin-converting enzyme inhibitors (ACEI) as well as coronary revascularization. …”
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Physiological and transcriptome analysis of sex-specific responses to cadmium stress in poplars by Meihua Liu, Sumei Wu, Yigang Song, Mengjiao Shi, Lita Yi

“…Under Cd stress, the genes related to oxidation-reduction processes, antioxidant enzyme activity and defense mechanisms, cell wall synthesis, and glutathione metabolism were mainly enriched and upregulated in females, whereas in males, genes related to photosynthesis and photosynthetic pigment biosynthesis were mainly enriched and downregulated, indicating greater damage to the photosynthetic system than in females. …”
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Preparation of Cod Gelatin Antifreeze Peptides and Its Application of Frozen-Thawed Surimi by Jin ZHANG, Tao YUAN, Xiaomei SHA, Yuelun XU, Yating KUANG, Zizi HU

“…The results showed that the optimal preparation process for DcAFPs involved using compound protease, with a substrate concentration of 3.5% (w/v), an enzyme-to-substrate ratio of 5% (w/w), a hydrolysis pH of 8, a hydrolysis temperature of 55 ℃, and a hydrolysis time of 2 hours. …”
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Tumor Necrosis Factor-α Promotes the Tumorigenesis, Lymphangiogenesis, and Lymphatic Metastasis in Cervical Cancer via Activating VEGFC-Mediated AKT and ERK Pathways by Xiao Chen, Luping Lin, Qiaoling Wu, Sang Li, Huihui Wang, Yang Sun

“…The level of vascular endothelial growth factor (VEGFC) in the corresponding CM was then detected using an enzyme-linked immunosorbent assay (ELISA). Next, human lymphatic endothelial cells (HLECs) were cultured in CM-TNF-α or CM for 48 h. …”
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Phenolic compounds and biological activities of grape (Vitis vinifera L.) seeds at different ripening stages: insights from Algerian varieties by F. Kamah, A. Basli, R. Erenler, A. Bouzana, C. Bensouici, T. Richard, F.A. Al-Mekhlafi, M.A. Wadaan, M.S. Al-Khalifa, F. Boulkenafet

“…Antioxidant activities were consistent with phenolic content trends, with significant tyrosinase enzyme suppression and high SPF factor observed. Principal Component Analysis highlighted strong correlations between phenolic profiles and antioxidant activities. …”
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A Case Report of Acute-on-Chronic Methemoglobinemia by Gabriel Lathrop, Rodney Fullmer

“…A rare cause results from congenital deficiency of cytochrome b5 reductase, a nicotinamide adenine dinucleotide dependent enzyme within red blood cells that donates electrons to reduce ferric to ferrous iron. …”
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Investigation on the effectiveness of progranulin as a novel predictive biomarker for allergic disorders by Nisreen Waleed Mustafa, Zaid Nabeel Elia, Abeer Mansour Abdel Rasool, Sanaria Fawzi Jarjes, Salam Farid Nawara, Shakhawan Hamid

“…Serum PGRN level was estimated by the enzyme-linked immunosorbent assay (ELISA) technique, while interleukin-6 (IL-6) concentration was determined by the fluorescent immunoassay technique. …”
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