Lessons Learned and Questions Raised by an Atypical Case of Clozapine-Induced Myocarditis by Charles H. Earnshaw, Lucy Powell, Owen Haeney

“…A diagnosis of myocarditis was confirmed as a result of elevated cardiac enzyme levels and an echocardiogram. Following withdrawal of clozapine, supportive management, and initiation of cardiac medication, the patient made a successful recovery. …”
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Stimulation of neutrophil functions by C5adesArg: an in vitro model of haemodialysis by I. Eckle, G. Kolb, E. Martinez Martin, K. Havemann

“…C5adesArg generated in vitro by yeast incubation of autologous plasma stimulates PMN chemotaxis and oxidative metabolism but has no effect on enzyme release. Preincubation of whole blood with C5adesArg causes aggregation and changed oxidative burst activity of the isolated PMN. …”
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Discovery of New Ligand with Quinoline Scaffold as Potent Allosteric Inhibitor of HIV-1 and Its Copper Complexes as a Powerful Catalyst for the Synthesis of Chiral Benzimidazole De... by Sabikeh G. Azimi, Ghodsieh Bagherzade, Mohammad Reza Saberi, Zeinab Amiri Tehranizadeh

“…The potency of these compounds as anti-HIV-1 agents was investigated using molecular docking into integrase (IN) enzyme with code 1QS4 and the GROMACS software for molecular dynamics simulation. …”
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Detection of IgM antibrucella antibody in the absence of IgGs: a challenge for the clinical interpretation of brucella serology. by Julián Solís García Del Pozo, Santiago Lorente Ortuño, Elena Navarro, Javier Solera

“…The use of enzyme-linked immunosorbent assay (ELISA) for the detection of IgG and IgM antibodies antibrucella has become widespread in the diagnosis of human brucellosis. …”
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Chronic cholecystitis at patients with the various trophological status: mechanisms and feature of clinical course by Ye. V. Anisimova, I. V. Kozlova, S. V. Volkov

“…Food behavior analysis was carried out, clinical features, anthopometry were determined, bile lipid spectrum, serum content of leptin and insulin were studied by enzyme-linked immunoassay.Results. Investigation of gallbladder diseases has objectively demonstrated, that trophological status affects development and course of chronic cholecystitis, but is not the only determining factor.Conclusions. …”
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Noncirrhotic Extrahepatic Portosystemic Shunt Causing Adult-Onset Encephalopathy Treated with Endovascular Closure by Eldad Elnekave, Eugenia Belenky, Lindsley Van der Veer

“…Hepatitis panel, relevant serological tests, tumor markers (CA-19-9, CEA), and urea cycle enzyme studies were unrevealing. Lactulose and rifaximin therapy failed to normalize serum ammonia levels. …”
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Prognostic value of serum cystatin C in patients with sepsis by Chunfang Hu, Zhiyuan Zhang, Bin Hou, Han Xue, Xuehua Pu, Jilu Ye

“…Materials and Methods: The levels of serum cystatin C, C-reactive protein (CRP), and procalcitonin (PCT) were measured via enzyme-linked immunosorbent assay (ELISA). The patients with sepsis were followed up for 30 days to record their survival conditions. …”
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Effect of Tongqiao Huoxue Decoction on cAMP-PKA Signaling Pathway in Rats with Vascular Dementia by Yufen WU, Changjun LU, Linglu DUN, Xiaocui LEI, Yuqiao QIN, Guocheng LIU, Bingxin WEI

“…After that rats were perfused with Tongqiao Huoxue decoction, and the changes of cAMP and PKA were detected by Enzyme-linked immunosorbent assay (ELISA).Results:The content of cAMP and PKA in VD rats were lower than those in sham operated rats (<italic>P</italic>&lt;0.01). …”
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Adaptive Genetic Traits in Human Populations: Evolutionary Responses to Malaria by Arun Ghosh, Aparna Ajith S, Abhijith Pradeep

“…Notable adaptations include hemoglobinopathies (sickle cell trait, thalassemias, hemoglobin C), enzyme disorders (G6PD deficiency, pyruvate kinase deficiency), and membrane protein variations (Duffy antigen negativity, hereditary ovalocytosis). …”
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Involvement of different protein kinases and phospholipases A2 in phorbol ester (TPA)-induced arachidonic acid liberation in bovine platelets by M. Lehr, K. Griessbach

“…TPA stimulates arachidonic acid release mainly by activating group IV cytosolic PLA2 (cPLA2), since inhibitors of this enzyme markedly inhibited arachidonic acid formation. …”
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Engineering a bacterial toxin deaminase from the DYW-family into a novel cytosine base editor for plants and mammalian cells by Dingbo Zhang, Fiona Parth, Laura Matos da Silva, Teng-Cheong Ha, Axel Schambach, Jens Boch

“…Truncations result in an extraordinarily small enzyme. The SsdA-base editor efficiently converts C-to-T in rice and barley protoplasts and induces mutations in rice plants and mammalian cells. …”
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Graph-theoretic conditions for zero-eigenvalue Turing instability in general chemical reaction networks by Maya Mincheva, Gheorghe Craciun

“…The technique is illustrated with a model of a bifunctional enzyme.…”
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Assessment of Serum Adiponectin and Leptin in Chronic Periodontitis Over Healthy Individuals by Reghunathan S. Preethanath, Swaroop Chandy, Nubesh Khan Syed, Bugude Shiva Shankar, Pavithra Rangarajan Seshadri, R Narayane, P. K. Saraswathi Bai

“…Assessments were conducted on periodontal markers, including bleeding on probing (POP), gingival index (GI), plaque index (PI), probing pocket depth (PPD), and clinical attachment level (CAL). An enzyme-linked immunosorbent assay (ELISA) test was used to assess the levels of adiponectin and leptin in serum samples. …”
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Preference for and resistance to a toxic sulfur volatile opens up a unique niche in Drosophila busckii by Venkatesh Pal Mahadevan, Diego Galagovsky, Markus Knaden, Bill S. Hansson

“…This adaptability is likely linked to insensitivity of the enzyme complex cytochrome c oxidase (COX), which is a DMDS target in other insects. …”
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Improving breast cancer treatments using pharmacomicrobiomics by Aswin Anand Pai, Aadra Prashant Bhatt

“…The authors present compelling evidence that functional differences in the gut microbiota, specifically the bacterial enzyme β-glucuronidase, leads to inter-individual variability in systemic exposure of tamoxifen, affecting drug efficacy. …”
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Two Mixed-Ligand Cu(II) Polymers: Treatment Activity on Acute Cerebral Infarction Combined with Alteplase by Wen-Ping Liu, Tao Xue, Yangchun Li, Ruoyu Cui

“…Furthermore, the biological activity of compounds was evaluated, and the related mechanism was explored as well. Firstly, the enzyme-linked immunosorbent assay (ELISA) was conducted to measure the content of coagulation factors in the serum after compound treatment. …”
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Comparison of Two Methods for Assaying Reducing Sugars in the Determination of Carbohydrase Activities by Alexander V. Gusakov, Elena G. Kondratyeva, Arkady P. Sinitsyn

“…Using twelve commercial enzyme preparations, the comparison of the NS and DNS assays in determination of cellulase, β-glucanase, xylanase, and β-mannanase activities was carried out. …”
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CYP Gene Expression and In Vivo Biological Effects of Khat Ethanol Extract, Cathinone and Cathine in Caenorhabditis elegans by Sharoen Yu Ming Lim, Mohammed Abdullah Alshawsh, Mustafa Alshagga, Cin Kong, Chee-Mun Fang, Yan Pan

“… The significant influence of khat, cathinone, and cathine on appetite suppression, reproduction impairment, and inhibitory effects on CYPs enzyme activity is widely recognised, but much remains unknown about its mode of action. …”
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Use of Hydrophilic Insoluble Polymers in the Restoration of Metal-Contaminated Soils by Guiwei Qu, Amarilis de Varennes

“…Plant growth and plant nutrients concentrations, extractable levels of metals in soil, and soil enzyme activities were used to monitor the improvement in soil quality following the application of these polymers. …”
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Effects of Pregnancy and Bacterial Vaginosis on Proinflammatory Cytokine and Secretory Leukocyte Protease Inhibitor Concentrations in Vaginal Secretions by Jennifer Balkus, Kathy Agnew, Richard Lawler, Caroline Mitchell, Jane Hitti

“…One-hundred and twenty-two women at 12–20 weeks' gestation and 133 nonpregnant controls had vaginal concentrations of interleukin (IL)-1β, IL-6, IL-8, and SLPI measured by enzyme immunoassay. Multivariable linear regression was used to evaluate factors independently associated with vaginal cytokine and SLPI response. …”
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