High-throughput Identification of Phage-derived Imaging Agents by Kimberly A. Kelly, Paul A. Clemons, Amy M. Yu, Ralph Weissleder

“…Here, we describe the development and testing of a new analysis method to identify and display hits from phage-display experiments and high-throughput enzyme-linked immunosorbent assay screens. We test the method using a phage screen against activated macrophages to develop imaging agents with higher specificity for active disease processes. …”
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Chest Pain in Adolescent Japanese Male Mimicking Acute Coronary Syndrome by Sachin K. Gupta, Zahra Naheed

“…Most common etiology for chest pain with cardiac enzyme elevation in adolescent population is usually viral myopericarditis. …”
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Osteogenesis Imperfecta, Pseudoachalasia, and Gastric Cancer by Dilsa Mizrak, Ali Alkan, Batuhan Erdogdu, Gungor Utkan

“…Chemotherapy was given after assessing dihydropyrimidine dehydrogenase (DPD) enzyme activity, which can be deficient in OI patients. …”
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Curdlan sulphate modulates protein synthesis and enhances NF-κB and C/EBP binding activity in HepG2 cells by A. Guzdek, H. Rokita

“…Curdlan sulphate may, at least in part, affect protein synthesis at a pretranslational level, as the expression of ACT mRNA was found to be increased, whereas intracellular enzyme, manganese superoxide dismutase mRNA level was decreased in the cell culture treated with curdlan sulphate. …”
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Alterations of the Biochemical Pathways of Plants by the Air Pollutant Ozone: Which are the True Gauges of Injury? by Robert L. Heath

“…Currently there are several hypotheses regarding a response of plants to ozone fumigation: [1] membrane dysfunction and alteration of purpose; [2] stress ethylene interactions; [3] impairment of photosynthesis via changes in Rubisco levels and the guard cells so that the stomata do not track correctly the environment; [4] antioxidant protection through metabolites and enzyme systems to reduce the oxidant load; and [5] general impairment or disruption of metabolic pathways.…”
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Premature Moustache As Presenting Symptom of Nonclassic Congenital Adrenal Hyperplasia due to 2 Uncommon Mutations of the CYP21A2 Gene by Guy Massa, Philippe Gillis, Marianne Schwartz

“…Genetic analysis revealed 2 rare mutations of the CYP21A2 gene, the gene encoding for the 21-hydroxylase enzyme: a recently reported R132C mutation in exon 3 and a R339H mutation in exon 8, both reported in the nonclassic CAH. …”
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Design and synthesis of phenylthiophosphoryl dichloride derivatives and evaluation of their antitumour and anti-inflammatory activities by Chunyun Xu, Na Yang, Haichun Yu, Xiaojing Wang

“…We predicted its potential anticancer targets based on network pharmacology and then verified the inhibitory effect of the active compound S11 on the pathway PI3K/AKT by enzyme inhibition and molecular docking assay. In addition, compound S11 exhibited a potent anti-inflammatory effect on macrophages, effectively reducing the levels of inflammatory mediators TNF-α, IL-10 and HO-1. …”
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Serum PM20D1 levels are associated with nutritional status and inflammatory factors in gastric cancer patients undergoing early enteral nutrition by Jin Zhengyu, Chen Yuning

“…Peptidase M20 domain containing 1 (PM20D1) is a secretory enzyme associated with glucose and lipid metabolism. …”
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Mitochondrial DNA Damage and Animal Longevity: Insights from Comparative Studies by Reinald Pamplona

“…Chemical reactions in living cells are under strict enzyme control and conform to a tightly regulated metabolic program. …”
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Isothermal amplification of long DNA fragments at low temperature by improved strand displacement amplification by Yinhua Zhang, Ashley N Luck, Nathan A Tanner

“…Strand displacement amplification (SDA) is an isothermal amplification technique wherein amplification of a nucleic acid is initiated by nicking enzyme activity at sites flanking the target. Diagnostic SDA is very fast but requires precise optimization and is limited to very short amplicons. …”
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Cyclooxygenase-2 inhibitors: promise or peril? by Laurel J. Mengle-Gaw, Benjamin D. Schwartz

“…The discovery of two isoforms of the cyclooxygenase enzyme, COX-1 and COX-2, and the development of COX-2-specific inhibitors as anti-inflammatories and analgesics have offered great promise that the therapeutic benefits of NSAIDs could be optimized through inhibition of COX-2, while minimizing their adverse side effect profile associated with inhibition of COX-1. …”
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Cardiovascular Activities of of the bradykinin system by Jagdish N. Sharma

“…The cardioprotective property of theangiotensin-converting enzyme inhibitors is primarily mediated via a kinin-releasingpathway, which may cause regression of the left ventricular hypertrophy in hypertensivesituations. …”
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Chemokines and Cytokines as Salivary Biomarkers for the Early Diagnosis of Oral Cancer by Gareema Prasad, Michael McCullough

“…Chemokines have been shown to be important in both inflammation and carcinogenesis and are able to be measured in saliva with relatively robust methods including enzyme-linked immunosorbent assays (ELISA). Thus it has been hypothesized that patients with oral cancer and oral potentially malignant lesions will have elevated levels of specific chemokines in oral fluids and that this may be used as a marker of both the early detection of malignant disease and progression to malignancy. …”
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Food Processing and Maillard Reaction Products: Effect on Human Health and Nutrition by Nahid Tamanna, Niaz Mahmood

“…It is often called nonenzymatic browning reaction since it takes place in the absence of enzyme. When foods are being processed or cooked at high temperature, chemical reaction between amino acids and reducing sugars leads to the formation of Maillard reaction products (MRPs). …”
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The Role of the Aceullular Pertussis Vaccine and the Comeback of 'Pertussis Pete'? by John M Conly, B Lynn Johnston

“…Until two decades ago, pertussis in adults was a medical curiosity (2-4), but with the purification of specific Bordetella species antigens, the development of reliable enzyme immunoassays allowing accurate serological diagnosis and better understanding of the duration of immunity from vaccination, it has been clearly demonstrated that B pertussis is a common cause of prolonged cough in adults. …”
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Hepatocyte growth factor stimulates neutrophil degranulation but not respiratory burst by I. C. Kowanko, A. Ferrante, T. Nakamura

“…The data show that HGF at 1–10 ng/ml increased lysosomal enzyme release from both specific and azurophilic granules of cytochalasin-B treated neutrophils. …”
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Beyond the Swell: Decoding the Enigma of Bilateral Hand Angioedema in Response to Sacubitril–valsartan Therapy by Samantha Aster Pinto, Joel Quadros Piedade, Venkatesh Malali, Amar Prabhudesai

“…With angiotensin receptor neprilysin inhibitor replacing angiotensin converting enzyme inhibitors as the preferred treatment for heart failure with reduced ejection fraction, it is crucial for clinicians to recognize the risk of angioedema associated with this therapy. …”
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Noninvasive in Vivo Imaging of Protein Kinase a Activity by Jan Øivind Moskaug, Harald Carlsen, Rune Blomhoff

“…The model uses luciferase, which has been mutated to contain a target sequence of PKA, thus making luminescence from the enzyme dependent on its state of phosphorylation. …”
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Substitute for polyethylene (PE) films: A novel attapulgite super absorbent polymer applied in a semi-humid drought-prone region of the Loess Plateau by Xiaofan Pan, Hengjia Zhang, Shouchao Yu, Haoliang Deng, Xietian Chen, Chenli Zhou, Fuqiang Li, Haiyan Li

“…Taking into account indicators such as soil hydrothermal, soil microbial quantity, soil enzyme activity, spring maize growth, yield, water productivity and economic benefit, the application of 45 kg ha−1 attapulgite super absorbent polymer had the best overall effect. …”
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Ascorbate-glutathione cycle in wheat and rice seedlings under anoxia and subsequent reaeration by V. V. Yemelyanov, E. G. Prikaziuk, V. V. Lastochkin, O. M. Aresheva, T. V. Chirkova

“…The operation of the AGC (enzymes and low-molecular components) in wheat (Triticum aestivum, cv. …”
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