THE IMPORTANCE OF DIET THERAPY IN THE TREATMENT OF PHENYLKETONURIA: A CASE REPORT by Nikolina Gaćina, Jerko Vučak

“…It is caused by the impossibility of converting the essential amino acid phenylalanine into tyrosine, most often due to insufficient production or a complete lack of the enzyme phenylalanine hydroxylase due to a mutation in its gene. …”
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Biodegradation of Eugenol by Bacillus Cereus Strain PN24 by Jagannath C. Kadakol, Chandrappa M. Kamanavalli

“…On the other hand, the intermediate of the eugenol-degrading pathway, such as ferulic acid was not detected in the culture medium as an intermediate, as evidenced by isolation and identification of metabolites and enzyme activities in the cell-free extract. Such a bacterial strain could be used for phenolic environmental clean-up given optimal nutrient conditions.…”
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Case report: A rollercoaster journey of pemphigus vegetans by Xiaoyuan Hou, Jia Chen

“…Histopathological examination revealed epidermal hyperplasia with significant infiltration of neutrophils and eosinophils in the dermis. Enzyme-linked immunosorbent assay showed elevated anti-Dsg3 antibodies (203.2 U/ml), and immunohistochemical staining confirmed positive expression of anti-Dsg3 IgG antibodies in keratinocytes. …”
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The Effects of Addition of Mononucleotides on Sma nuc Endonuclease Activity by Julia Romanova, Maria Filimonova

“…Examination of the effects of mononucleotides on Sma nuc endonuclease originated from Gram negative bacterium Serratia marcescens displayed that any mononucleotide produced by Sma nuc during hydrolysis of DNA or RNA may regulate the enzyme activity affecting the RNase activity without pronounced influence on the activity towards DNA. …”
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Recent insights into the cellular mechanisms of acute pancreatitis by Laura I Cosen-Binker, Herbert Y Gaisano

“…In acute pancreatitis, initiating cellular events causing acinar cell injury includes co-localization of zymogens with lysosomal hydrolases, leading to premature enzyme activation and pathological exocytosis of zymogens into the interstitial space. …”
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Sarcoidosis Treatment with Antifungal Medication: A Follow-Up by Marjeta Terčelj, Barbara Salobir, Mirjana Zupancic, Ragnar Rylander

“…Chitotriosidase and angiotensin converting enzyme were determined. The time in months till remission was observed as well as the number of recurrences.…”
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Efficacy and Safety Concerns with Sn-Mesoporphyrin as an Adjunct Therapy in Neonatal Hyperbilirubinemia: A Literature Review by Prakar Poudel, Sudhir Adhikari

“…The rationale logic of heme oxygenase enzyme inhibition to lower bilirubin levels is intriguing. …”
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Nitric oxide as a mediator of inflammation?—You had better believe it by Mark J. S. Miller, Matthew B. Grisham

“…In order to appreciate the precise contributions of nitric oxide to a pathophysiological process, one must account for enzyme source, coproduction of oxidants and antioxidant defences, time, rate of nitric oxide production, cellular source, peroxynitrite formation and effects on DNA (mutagenesis/apoptosis). …”
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Hunter Syndrome Diagnosed by Otorhinolaryngologist by Ayako Hashimoto, Tadayuki Kumagai, Hiroyuki Mineta

“…Hunter syndrome is a lysosomal disease characterized by deficiency of the lysosomal enzyme iduronate-2-sulfatase (I2S). It has an estimated incidence of approximately 1 in 1,62,000 live male births. …”
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Glyphosate and Microbiota: controversies and truths by Stefania Colantuono, Maria Antonietta Zavarella, Gabriela Leonti, Ilaria Baglivo, Cristiano Caruso, Alfredo Papa

“…Glyphosate-based herbicides (GBHs) are currently the most widely used herbicides in the world, and for many years, they have been considered safe for human health due to the assumption that human cells are presumably not directly affected by glyphosate, given the lack of the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) enzyme. However, the effect of glyphosate on the host-associated microbiota has been recently suggested in several studies. …”
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Role of plasminogen/plasmin system components and matrix metalloproteases in retinal artery occlusion following cardiac surgery by L.V. Natrus, N.Ia. Kovalchuk, I.S. Tanasiichuk, Iu.O. Panchenko

“…MMP levels were determined by enzyme gelatin zymography. Results: The PAI-1 levels were three times higher in HR groups than in controls. …”
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Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the Keap1/Nrf2/HO-1 signaling pathway by Weiwei Tang, Xiaomin Huang, Yun-Di Yi, Fan Cao, Manli Deng, Jiawei Fan, Zheng-Xuan Jiang, Li-Ming Tao, Xianwen Wang, Lei Shi

“…In summary, this study revealed that HA-CUR NPs, which are composed of a natural product and biomacromolecules with outstanding artificial antioxidant enzyme activities, may be novel agents for effectively and safely treating uveitis and other ROS-related diseases.…”
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Prolactin Is a Strong Candidate for the Regulation of Luteal Steroidogenesis in Vizcachas (Lagostomus maximus) by S. Proietto, S. A. Cortasa, M. C. Corso, P. I. F. Inserra, S. E. Charif, A. R. Schmidt, N. P. Di Giorgio, V. Lux-Lantos, A. D. Vitullo, V. B. Dorfman, J. Halperin

“…Remarkably, the P4-sinthesizing enzyme 3β-HSD accompanied the expression pattern of PRLR/LHR throughout gestation. …”
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Allium cepa L. as a natural antioxidant: Its efficacy in combating heat stress-induced physiological alterations by Ayobami O. Sobanke, Afusat Aiyeola, Frances I. Okwuonu, Wuraola S. Nnaemeka, Jeremiah C. Ndubuisi, Franklin I. Udeoji, Jane N. Adiele

“…Many of these alterations were reversed by AC supplementation, by increasing RBC counts, HB levels, and antioxidant enzyme activities while decreasing LDL-c, TG and TC, MDA, and TNF-α (tumor necrosis factor-α). …”
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Pirfenidone regulates seizures through the HMGB1/TLR4 axis to improve cognitive functions and modulate oxidative stress and neurotransmitters in PTZ-induced kindling in mice by Mansi Dahalia, Sparsh Gupta, Haya Majid, Divya Vohora, Nidhi

“…Seizure severity and cognitive function were assessed in the pentylenetetrazol-kindling model, along with biochemical assays that evaluated antioxidant enzymes, inflammatory markers, neurotransmitter levels, and liver enzyme levels. …”
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Nonclassical Axis of the Renin-Angiotensin System and Neprilysin: Key Mediators That Underlie the Cardioprotective Effect of PPAR-Alpha Activation during Myocardial Ischemia in a M... by María Sánchez-Aguilar, Luz Ibarra-Lara, Leonardo del Valle-Mondragón, Elizabeth Soria-Castro, Juan Carlos Torres-Narváez, Elizabeth Carreón-Torres, Alicia Sánchez-Mendoza, María Esther Rubio-Ruíz

“…Ischemia activated the angiotensin-converting enzyme (ACE)/angiotensin II/angiotensin receptor 1 (AT1R) and angiotensin III/angiotensin IV/angiotensin receptor 4 (AT4R)-IRAP axes. …”
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The effect of silymarin on ischemia-reperfusion injury in skeletal muscles of rats by Abdullah Ozer, Basak Kocak, Mustafa Arslan, Baris Mardin, Aysegul Kucuk, Saban Cem Sezen, Mustafa Hakan Zor, Mustafa Kavutcu

“…The activity of the CAT enzyme was much higher in Group I/R compared to Group C. …”
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The first experience of two-stage treatment of transsphincteric fistulas of rectum by means of fibrin sealant by S. A. Frolov, A. M. Kuzminov, V. Yu. Korolik, I. S. Bogormistrov, M. O. Chernozhukova, Sh. T. Minbayev

“…To improve the short­term and long­term results of transsphincteric rectal fistulas treatment by patented two­stage method that includes elimination of fistulous tract with the subsequent enzyme treatment of the wound channel and delayed sealing by two­component biological glue. …”
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Differentiated effects and mechanisms of N-, P-, S-, and Fe-modified biochar materials for remediating Cd- and Pb-contaminated calcareous soil by Amir Bostani, Xingying Meng, Le Jiao, Srđan D. Rončević, Peng Zhang, Hongwen Sun

“…Additionally, PBC promoted the growth, enzyme activity, and tolerance to Cd- and Pb-contaminated soil of Chinese cabbage. …”
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Fusion to Flaviviral Leader Peptide Targets HIV-1 Reverse Transcriptase for Secretion and Reduces Its Enzymatic Activity and Ability to Induce Oxidative Stress but Has No Major Eff... by Anastasia Latanova, Stefan Petkov, Yulia Kuzmenko, Athina Kilpeläinen, Alexander Ivanov, Olga Smirnova, Olga Krotova, Sergey Korolev, Jorma Hinkula, Vadim Karpov, Maria Isaguliants, Elizaveta Starodubova

“…Reverse transcriptase (RT) is a key enzyme in viral replication and susceptibility to ART and a crucial target of immunotherapy against drug-resistant HIV-1. …”
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