Global Gene Expression Profiling in PPAR-γ Agonist-Treated Kidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney Disease by Daisuke Yoshihara, Masanori Kugita, Tamio Yamaguchi, Harold M. Aukema, Hiroki Kurahashi, Miwa Morita, Yoshiyuki Hiki, James P. Calvet, Darren P. Wallace, Takafumi Toyohara, Takaaki Abe, Shizuko Nagao

“…Stearoyl-coenzyme A desaturase 1 is a key enzyme in fatty acid metabolism found in the top 5 genes downregulated by PIO treatment. …”
Get full text

Small molecule metabolites drive plant rhizosphere microbial community assembly patterns by Yanwei Ma, Heqi Wang, Yalong Kang, Tao Wen

“…In this study, we analyzed 108 plant samples and evaluated root traits, plant growth characteristics, soil enzyme activities, rhizosphere metabolites, and soil chemical properties to identify the primary determinants of rhizosphere community assembly. …”
Get full text

Discovery of the bacterial HslV protease activators as lead molecules with novel mode of action by Aurangzeb Sana, Aurongzeb Muhammad, Shamim Shahbaz, Rashid Yasmeen, Khan Khalid Mohammed, Aziz Tariq, Alharbi Metab, Alasmari Abdullah F.

“…The HslVU enzyme complex, a proteasomal analog found in bacteria, consists of two components, i.e., the HslV protease and the HslU ATPase. …”
Get full text

THE EFFECT OF ADDING 25-HYDROXYCHOLECALCIFEROL TO THE DIET ON SOME BIOCHEMICAL CHARACTERISTICS OF JAPANESE QUAIL by M. S. Dawod, M. A. Al-Bayar

“…The results also indicate that there was a significant increase during the second period (0.05 ≥ P) for the enzyme ALT for treatment T4 when adding 150 mg/kg feed of vitamin D3 and a significant increase (0.05 ≥ P) for the enzyme AST for treatment T4 when adding 150 mg/kg feed of vitamin D3 compared to with the control group. …”
Get full text

Low Citrate Synthase Activity Is Associated with Glucose Intolerance and Lipotoxicity by Yosra Alhindi, Lobke M. Vaanholt, Mustafah Al-Tarrah, Stuart R. Gray, John R. Speakman, Catherine Hambly, Bader S. Alanazi, Brendan M. Gabriel, Arimantas Lionikas, Aivaras Ratkevicius

“…Citrate synthase (CS) is a key mitochondrial enzyme. The aim of this study was to test the hypothesis that low CS activity impairs the metabolic health of mice fed a high fat diet (HFD) and promotes palmitate-induced lipotoxicity in muscle cells. …”
Get full text

Molecular biological research and molecular homologous modeling of Bw.03 subgroup by WANG Li, KONG Yongkui, JIN Huifang, LIU Xin, XIE Ying, LIU Xue, CHANG Yanli, WANG Yafang, YANG Shumiao, ZHU Di, YANG Qiankun

“…The intermolecular force analysis can explain the root cause of enzyme activity weakening.…”
Get full text

The Optimum Lipid Level for the Juvenile Redclaw Crayfish Cherax quadricarinatus: Practical Diets with Soybean Oil as the Lipid Source by Chengzhuang Chen, Chang Xu, Xiaolong Yang, Yongyi Jia, Zhimin Gu, Erchao Li

“…As the level of dietary lipids increased, the total antioxidant capacity and glutathione peroxidase activity in serum showed a tendency to rise and then fall and the enzyme activity was highest in crayfish fed the L6 diet. …”
Get full text

Effect of melatonin on the contents of fatty acids and antioxidants of saffron by Mohammad Mehdi Samim, Ali Sorooshzadeh, Ali Mokhtassi-Bidgoli, Mohammad Sadegh Sabet

“…Also, the highest activities of ascorbate peroxidase and catalase enzymes were observed with 100 μM melatonin applied 124 days after germination. …”
Get full text

Characterization of demethylating DNA glycosylase ROS1 from Nicotiana tabacum L. by D. V. Petrova, N. V. Permyakova, I. R. Grin, D. O. Zharkov

“…The enzyme removed 5-hydroxymethylcytosine (hmC) from DNA with a lower efficiency, showing minimal activity in the presence of mC in the opposite strand. …”
Get full text

Construction of novel pJRD215-derived plasmids using chloramphenicol acetyltransferase (cat) gene as a selection marker for Acidithiobacillus caldus. by Rui Wang, Chunmao Lin, Jianqiang Lin, Xin Pang, Xiangmei Liu, Chengjia Zhang, Jianqun Lin, Linxu Chen

“…The P2-cat gene cassette, including a chloramphenicol acetyltransferase gene (cat) from plasmid pACBSR and a promoter (P2) upstream of the tetracycline resistance gene on pBR322, was designed, chloramphenicol acetyltransferase was expressed in A. caldus, and the enzyme activity was assessed. A new vector pSDU1 carrying the replication and mobilization regions derived from pJRD215, the P2-cat gene cassette and a multiple cloning site from pUC19 was successfully constructed. …”
Get full text

Computational studies and structural insights for discovery of potential natural aromatase modulators for hormone-dependent breast cancer by Snehal Aditya Arvindekar, Sanket Rathod, Prafulla Balkrishna Choudhari, Pradnya Kiran Mane, Aditya Umesh Arvindekar, Suraj Narayan Mali, Bapu Thorat

“…Introduction: The aromatase enzyme plays an important role in the progress of hormone-dependent breast cancer, especially in estrogen receptor-positive (ER+) breast cancers. …”
Get full text

Immunogenicity of HIV-1 <i>Env</i> mRNA and <i>Env-Gag</i> VLP mRNA Vaccines in Mice by Qi Ma, Jing Yang, Xiaoguang Zhang, Hongxia Li, Yanzhe Hao, Xia Feng

“…Env-specific cellular immune responses in mouse splenocytes were evaluated using an Enzyme-linked immunosorbent assay (ELISpot) and in vivo cytotoxic T cell-killing assays. …”
Get full text

Non-steroidal anti-inflammatory drugs and oxidative stress biomarkers in fish: a meta-analytic review by Luiz Henrique Zaniolo Justi, Juliana Ferreira Silva, Manuela Santos Santana, Henrique Aparecido Laureano, Meire Ellen Pereira, Cláudia Sirlene Oliveira, Izonete Cristina Guiloski

“…In conclusion, our results demonstrated that fish are sensitive to NSAIDs exposure presenting significant alterations in oxidative stress biomarkers, especially in the GPx enzyme. This enzyme exhibits strong potential as a biomarker of NSAIDs exposure in fish. …”
Get full text

Successful Erlotinib Treatment for a Patient with Gefitinib-Related Hepatotoxicity and Lung Adenocarcinoma Refractory to Intermittently Administered Gefitinib by Tatsuya Nagano, Yoshikazu Kotani, Kazuyuki Kobayashi, Masahiro Katsurada, Yukihisa Hatakeyama, Suya Hori, Daisuke Tamura, Daisuke Kasai, Yasuhiro Funada, Yoshihiro Nishimura

“…The patient was treated with gefitinib for 6 weeks until he developed substantially elevated hepatic enzyme levels that resulted in the discontinuation of gefitinib. …”
Get full text

Highly Active Carbonic Anhydrase of the Thylakoid Lumen of <i>Chlamydomonas reinhardtii</i> by Vasily V. Terentyev, Liubov I. Trubitsina, Anna K. Shukshina, Ivan V. Trubitsin, Natalia N. Rudenko

“…Long-term sustainability of the enzyme was observed at alkaline pH (>8), with maintenance of half of its activity at 4 °C for up to 50 days. …”
Get full text

Cytokinin Oxidase (CKX) Family Members in ‘duli’ (<i>Pyrus betulifolia Bunge</i>): Genome-Wide Identification and Tissue Expression Profile Under Abiotic Stress by Weimin Wang, Ting Xie, Jiaojiao He, Kuozhen Nie, Zijuan He, Yuxing Zhang, Yingli Li

“…Notably, treatments with Abscisic acid and NaCl significantly enhanced CKX enzyme activity in ‘duli’ over 20 days, reducing levels of zeatin and isopentenyladenine. …”
Get full text

A Study on L-Asparaginase of Nocardia levis MK-VL_113 by Alapati Kavitha, Muvva Vijayalakshmi

“…An enzyme-based drug, L-asparaginase, was produced by Nocardia levis MK-VL_113 isolated from laterite soils of Guntur region. …”
Get full text

Primary Biliary Cirrhosis and Type II Autoimmune Polyglandular Syndrome by Mark Ram Borgaonkar, David Geoffrey Morgan

“…In 1996, she became jaundiced with a cholestatic enzyme pattern. AMA was positive at a titre of 1:256. …”
Get full text

How a gene fuels ear infections by Sedigheh Delmaghani, Aziz El-Amraoui

“…The DYRK1A enzyme is a pivotal contributor to frequent and severe episodes of otitis media in Down syndrome, positioning it as a promising target for therapeutic interventions.…”
Get full text

N-acetyltransferase 2 Slow Acetylator Genotype Associated with Adverse Effects of Sulfasalazine in the Treatment of Inflammatory Bowel Disease by Min Chen, Bing Xia, Bixiao Chen, Qiusha Guo, Jin Li, Mei Ye, Zhengguo Hu

“…AIM: N-acetyltransferase 2 (NAT2) is an important enzyme catalyzing N-acetylation of sulfasalazine (SASP). …”
Get full text