The Role of Phosphatidylethanolamine-N-methyltransferase (PEMT) Gene rs12449964 Polymorphism in the Development of Acute Pancreatitis and its Complications by T. A. Samgina, Yu. E. Azarova, Yu. V. Kanishchev, V. A. Lazarenko, P. M. Nazarenko, A. V. Polonikov

“…The phosphatidylethanolamine-N-methyltransferase enzyme plays a significant role in the regulation of lipid metabolism by catalyzing the process of methylation of phosphatidylethanolamine to phosphatidylcholine. …”
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Biochemical Aspects of a Serine Protease from Caesalpinia echinata Lam. (Brazilwood) Seeds: A Potential Tool to Access the Mobilization of Seed Storage Proteins by Priscila Praxedes-Garcia, Ilana Cruz-Silva, Andrezza Justino Gozzo, Viviane Abreu Nunes, Ricardo José Torquato, Aparecida Sadae Tanaka, Rita de Cássia Figueiredo-Ribeiro, Yamile Gonzalez Gonzalez, Mariana da Silva Araújo

“…The characteristics of the purified enzyme allowed us to classify it as a serine protease. …”
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Copious Podocyturia without Proteinuria and with Normal Renal Function in a Young Adult with Fabry Disease by H. Trimarchi, R. Canzonieri, A. Muryan, A. Schiel, A. Araoz, M. Forrester, A. Karl, F. Lombi, J. Andrews, V. Pomeranz, T. Rengel, E. Zotta

“…The time for starting a patient with Fabry disease on enzyme replacement therapy is still a matter of debate, particularly when no overt classical clinical signs or symptoms are present. …”
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Regulatory mechanism of carbohydrate metabolism pathways on oil biosynthesis of oil plant Symplocos paniculata by Wenbin Zeng, Beilei Xie, Yunzhu Chen, Jingzhen Chen, Peiwang Li, Lijuan Jiang, Changzhu Li, Qiang Liu, Yan Yang

“…Remarkably, during the initial phase of fruit development from 10 to 90 days after flowering (DAF), pivotal genes involved in starch biosynthesis, such as ADP-glucose pyrophosphorylase (AGP), starch synthase (SS), and starch branching enzyme (SBE), facilitated an earlier accumulation of starch within the fruit. …”
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Deranged Bioenergetics and Defective Redox Capacity in T Lymphocytes and Neutrophils Are Related to Cellular Dysfunction and Increased Oxidative Stress in Patients with Active Syst... by Ko-Jen Li, Cheng-Han Wu, Song-Chou Hsieh, Ming-Chi Lu, Chang-Youh Tsai, Chia-Li Yu

“…In addition, the redox capacity, including intracellular GSH levels and the enzyme activity of glutathione peroxidase (GSH-Px) and γ-glutamyl-transpeptidase (GGT), was decreased in SLE-T. …”
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X-Linked Autism Type 9 Caused by a Hemizygote Pathogenic Variant in the TMLHE Gene: Etiological Diagnosis in an Adult Male with Moderate Intellectual Disability by Verhoeven WM, Pfundt R, Engelke UF, Kluijtmans LA, Egger JI

“…The Epsilon-Trimethyllysine Hydroxylase (TMLHE) gene encodes the enzyme N-Trimethyllysine hydroxylase (TMLH) which catalyses the first step in the biosynthesis of carnitine. …”
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Mitochondrial Thioredoxin-Glutathione Reductase from Larval Taenia crassiceps (Cysticerci) by Alberto Guevara-Flores, Irene P. del Arenal, Guillermo Mendoza-Hernández, Juan Pablo Pardo, Oscar Flores-Herrera, Juan L. Rendón

“…Thioredoxin from eukaryotic sources was accepted as substrate. The enzyme reduced H2O2 in a NADPH-dependent manner, although with low catalytic efficiency. …”
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Analysis of bacterial genetic diversity in biofloc by using ARDRA 16S-rRNA gene by , Widanarni, Dewi Nurhayati, Dinamella Wahjuningrum

“…The result with HaeIII cut restriction enzyme from biofloc-associated bacteria gave 11 ARDRA patterns, while with the restriction enzyme HhaI gave eight ARDRA patterns. …”
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Microbial-based natural products as potential inhibitors targeting DNA gyrase B of Mycobacterium tuberculosis: an in silico study by Tilal Elsaman, Magdi Awadalla Mohamed, Malik Suliman Mohamed, Eyman Mohamed Eltayib, Abualgasim Elgaili Abdalla

“…Mycobacterial DNA gyrase is an enzyme that plays a crucial role in the replication and transcription of DNA in MBT. …”
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Regulation of Chemokine Production via Oxidative Pathway in HeLa Cells by Shinichiro Kina, Toshiyuki Nakasone, Hiroyuki Takemoto, Akira Matayoshi, Shoko Makishi, Nao Sunagawa, Feixin Liang, Thongsavanh Phonaphonh, Hajime Sunakawa

“…The iron chelator 𝑜-phenanthroline effectively inhibited H2O2-induced ERK2 activation. Enzyme-linked immunosorbent assays showed that IL-8 protein secretion was elevated in ROS-treated HeLa cells. …”
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Generation of a transgene-free Induced pluripotent stem (iPS) cell line (JNCHi002-A) from a female heterozygous carrier of the low density lipoprotein receptor (LDLR) gene mutation... by Rujin Tian, Yixiao Li, Hongmei Xin, Yue Jiang, Haozheng Zhang, Lin Zhong, Zhongtao Gai, Qianqian Deng, Chunhui Wang, Kaihui Zhang

“…This enzyme serves as the rate-limiting step in the biosynthesis of cholesterol. …”
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Computational model for mammalian circadian oscillator: interacting with NAD+/SIRT1 pathway and age-related changes in gene expression of circadian oscillator by N. L. Podkolodnyy, N. N. Tverdokhleb, O. A. Podkolodnaya

“…The deacetylation of circadian oscillator components by this enzyme closes the feedback mediated through this pathway. …”
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Addressing genome scale design tradeoffs in Pseudomonas putida for bioconversion of an aromatic carbon source by Deepanwita Banerjee, Javier Menasalvas, Yan Chen, Jennifer W. Gin, Edward E. K. Baidoo, Christopher J. Petzold, Thomas Eng, Aindrila Mukhopadhyay

“…Through proteomics, promoter-variation, and growth characterization of a fully implemented gene deletion design, we provide evidence that aromatic catabolism in the completed design is rate-limited by fumarase hydratase (FUM) enzyme activity in the citrate cycle and requires careful optimization of another fumarate hydratase protein (PP_0897) expression to achieve growth and production. …”
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Vaginal flora in HPV infection: a cross‑sectional analysis by Peining Dou, Feng Fang, Rongqiu Qin, Jingsong Nie, Xiaoyan Chen, Xiaoyan Yin, Yiding Wang, Shengying Shi

“…Reduced levels of Lactobacillus, increased prevalence of Gardnerella, and abnormal enzyme profiles are closely linked to HPV infection.…”
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Fecal microbiota transplantation alleviates radiation enteritis by modulating gut microbiota and metabolite profiles by Qin Ding, Jing Xue, Nan Li, Zhihui Hu, Jianbo Song

“…The results demonstrated that FMT, particularly in the M-FMT group, effectively alleviated RE by reducing DAI scores, histological damage, and inflammatory markers while enhancing enzyme activity, superoxide dismutase (SOD) levels, and intestinal absorption. …”
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Case report: A novel 11-bp deletion in exon 11 causing a frameshift in the C-terminal of the ALAS2 gene leading to X-linked sideroblastic anemia—a family study by Salam Al kindi, Salam Al kindi, Altaf Al-Mamari, Shoaib Al-Zadjali, Mohamed Al-Rawahi, Ali Al Madhani, Anil V. Pathare

“…It is due to mutations of the erythroid-specific enzyme ALAS2, the first enzyme of the heme biosynthetic pathway. …”
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Efficacy and safety of avacopan in antineutrophil cytoplasmic autoantibody-associated vasculitis: a retrospective cohort study in Japan by Genri Tagami, Makoto Yamaguchi, Hirokazu Sugiyama, Hiroshi Kinashi, Kentaro Imai, Keisuke Kamiya, Takayuki Katsuno, Takahiro Imaizumi, Shogo Banno, Yasuhiko Ito, Takuji Ishimoto

“…Adverse events were reported in 10 patients (47.6%), with elevated liver enzyme levels observed in eight patients (38.1%) as the most frequent complication. …”
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Characterization of novel cold-active chitin deacetylase for green production of bioactive chitosan by Mohamed N. Abd El-Ghany, Salwa A. Hamdi, Ahmed K. Zahran, Mustafa A. Abou-Taleb, Abdallah M. Heikel, Muhammed T. Abou El-Kheir, Mohamed G. Farahat

“…The optimum temperature and pH of SpsCDA were 15 °C and 8.0, respectively, and the enzyme activity was significantly enhanced in the presence of NaCl. …”
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Unveiling the Phytochemical Diversity and Bioactivity of <i>Astragalus melanophrurius</i>: A First Report Integrating Experimental and In Silico Approaches by Gulcan Gencer, Cengiz Sarikurkcu, Bektas Tepe

“…This study aimed to investigate the chemical profile, antioxidant capacity, and enzyme inhibitory activities of methanol extracts from various plant parts of <i>A. melanophrurius</i>. …”
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Effects of abscisic acid and gibberellin on sugar accumulation in 'Fengtang' Plum (Prunus salicina LindI.) by Qianjun Song, Xiaoshuang Nie, Hong Chen

“…The conclusion is that ABA increases fruit sugar content by increasing the expression of the fruit sugar transporter protein genes PsSWEET4 and PsSTP1 as well as the sucrose synthase genes PsSUS4 and PsSPS2, whereas GA3 decreases sugar accumulation and delays fruit ripening by decreasing the accumulation of sugar during ripening by increasing the expression of the neutral transforming enzyme genes PsNINV1/3/4 to break down sucrose into fructose and glucose.…”
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