Machine learning based QSAR and Molecular Dynamics simulations in the structural design and mechanism of action of imidazole derivatives with anti-melanoma activity by Rosalvo Ferreira de Oliveira Neto, Sérgio Ruschi Bergamachi Silva, Cintia Emi Yanaguibashi Leal, Edilson Beserra de Alencar Filho

“…Additionally, the imidazopyrazine nucleus was compared to a known inhibitor of the Aurora Kinase enzyme, an important target in cancer therapy. Thus, strategic imidazopyrazines were subjected to comparative molecular dynamics calculations, providing inferences about their possible mechanisms of action. …”
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Current Concepts of Hyperinflammation in Chronic Granulomatous Disease by Nikolaus Rieber, Andreas Hector, Taco Kuijpers, Dirk Roos, Dominik Hartl

“…The underlying pathomechanisms driving hyperinflammatory reactions in CGD are poorly understood, but recent studies implicate reduced neutrophil apoptosis and efferocytosis, dysbalanced innate immune receptors, altered T-cell surface redox levels, induction of Th17 cells, the enzyme indolamine-2,3-dioxygenase (IDO), impaired Nrf2 activity, and inflammasome activation. …”
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The Loss of HIF1α Leads to Increased Susceptibility to Cadmium-Chloride-Induced Toxicity in Mouse Embryonic Fibroblasts by Ajith Vengellur, Elizabeth Grier, John J. LaPres

“…Increased cell death in the HIF1α −/− cells was correlated with lower metallothionein protein, elevated levels of reactive oxygen species, and decreased superoxide dismutase enzyme activity. The total and oxidized glutathione levels, and, correspondingly, lipid peroxidation levels were elevated in the null cells compared to wild-type cells, indicating increased antioxidant demand and greater oxidative stress. …”
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Effects of Tannin Extract from Gongronema latifolium Leaves on Lipoxygenase Cucumeropsis manii Seeds by Sabinus O. O. Eze, Bennett C. Nwanguma

“…This tannin extract could be included during food processing as preservative against food deterioration that might be caused by oxidative enzymes such as lipoxygenase.…”
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Effects of Glucomannan on the Sacculus Rotundus and Peripheral Blood Lymphocytes in New Zealand Rabbits during Aflatoxicosis by Emrah Sur, Hasan Hüseyin Dönmez, Murat Boydak, Mehmet Bozkurt Ataman

“…This study was aimed to determine the effects of the glucomannan added to aflatoxin- (AF-) contaminated diet on the sacculus rotundus and peripheral blood lymphocytes of New Zealand rabbits by histological and enzyme histochemical methods. Twenty-four adult rabbits of both sexes were divided into four equal groups, namely, as control, glucomannan 0.2 g/day, AF 125 μg/kg/day, and glucomannan combined with AF. …”
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Tinctoride A, a New Hopan-Type Triterpenoic Peracid from the Thallus of Lichen Parmotrema Tinctorum (Despr. ex Nyl.) Hale by Le-Thuy-Thuy-Trang Hoang, Thanh-Nha Tran, Thi-Phi-Giao Vo, Hoang-Vinh-Truong Phan, Phan-Si-Nguyen Dong, Dinh-Tri Mai, Ngoc-An Nguyen, Thi-Minh-Suong Huynh, Hong Truong Luu, Tien-Dung Le, Minh-Trung Dao, Van-Kieu Nguyen

“…Their chemical structures were identified by extensive 1D and 2D NMR analysis and high-resolution mass spectroscopy and compared with those reported in the literature. The enzyme inhibitory potential of compounds 1–3 against α-glucosidase was investigated, exhibiting nil to weak inhibitory activity.…”
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Detection of Antibody against Helicobacter pylori in the Saliva of Patients with Dyspepsia by Robert L Clancy, Allan W Cripps, Diana C Taylor, Lois A McShane, Victor J Webster

“…This study examined the clinical value of a saliva enzyme-linked immunoadsorbent assay (ELISA) for anti-H pylori antibody, compared with the serum ELISA assay, and found the sensitivity of the saliva assay was 89%, specificity 94%, accuracy 93%, positive predictive value 89% and negative predictive value 94%. …”
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The Protective Potential Role of ACE2 against COVID-19 by Fereshteh Golab, Gelareh Vahabzadeh, Leila SadeghRoudbari, Arefeh Shirazi, Robabeh Shabani, Sara Tanbakooei, Lida Kooshesh

“…The angiotensin-converting enzyme 2 (ACE2) has been shown as a necessary receptor to cell fusion, which is involved in infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). …”
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Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced α-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reacti... by Nikolaus Berndt, Sascha Bulik, Hermann-Georg Holzhütter

“…By contrast, progressive inhibition of the enzyme aconitase had only little impact on these mitochondrial parameters. …”
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Variation in Macro and Trace Elements in Progression of Type 2 Diabetes by Khalid Siddiqui, Nahla Bawazeer, Salini Scaria Joy

“…Trace elements participate in tissue and cellular and subcellular functions; these include immune regulation by humoral and cellular mechanisms, nerve conduction, muscle contractions, membrane potential regulations, and mitochondrial activity and enzyme reactions. The status of micronutrients such as iron and vanadium is higher in type 2 diabetes. …”
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Reduction of Phosphorus Pollution from Broilers Waste through Supplementation of Wheat Based Broilers Feed with Phytase by Ahmed Abdel-Megeed, Arifa Tahir

“…The present study was conducted to reduce phosphorus pollution from broilers waste by supplementing phytase enzyme in broilers fee. Two hundred two-week-old broilers (Hubbard) were selected and randomly allocated to three dietary treatment groups, one control group (without phytase) and two trial groups (group A with 300 U/kg phytase and group B with 600 U/kg phytase). …”
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Identification and Mechanism of Echinochloa crus-galli Resistance to Fenoxaprop-p-ethyl with respect to Physiological and Anatomical Differences by Amany Hamza, Aly Derbalah, Mohamed El-Nady

“…The resistance of E. crus-galli to fenoxaprop-p-ethyl may be due to the faster metabolism of fenoxaprop-p-ethyl below the physiologically active concentration or the insensitivity of its target enzyme (Acetyl-CoA carboxylase).…”
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Identification of pathogenic bacteria by biosensors in water and wastewater by Sakineh Hargolzadeh, Soheila Kashanian, Maryam Nazari

“…Therefore, timely diagnosis of these pathogens is very important. the use of specialized personnel, machines, and tools in molecular methods such as enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) are expensive, and traditional methods such as plate culture are time-consuming. …”
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Biotechnology in direct air capture, enhanced weathering, and methane removal: emerging opportunities and gaps by Paul L. Reginato

“…The GHGR technologies of focus are (1) the potential for the enzyme carbonic anhydrase to catalyze CO2 exchange in direct air capture; (2) the potential utility of microbes for accelerating soil-based or reactor-based enhanced rock weathering; and (3) the potential for methanotrophic bacteria or methane monooxygenase enzymes to oxidize methane for atmospheric methane removal via enhanced methanotrophy or bioreactors. …”
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Comparison of the Biological Activity of Crude Polysaccharide Fractions Obtained from Cedrela sinensis Using Different Extraction Methods by Oh Min Hui, Yoon Kyung Young

“…Hot-water and processes assisted by ultrasound and enzymes (Shearzyme or Viscozyme) were carried out. …”
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In Vitro Effect of Aqueous Extract and Fraction IV Portion of Ximenia americana Stem Bark on Trypanosoma congolense DNA by Victor Ambrose Maikai, Beatty Viv Maikai, Patricia Ishyaku Kobo

“…The DNA of the trypanosomes was isolated and digested using ECOR1 enzyme and subsequently PCR was carried out. Results showed that aqueous extract and fraction IV portion immobilized 55% and 90% of the trypanosomes after 30-minute incubation. …”
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Immobilization of Dextranase Using Anionic Natural Polymer Alginate as a Matrix for the Degradation of a Long-Chain Biopolymer (Dextran) by Faiza Shahid, Afsheen Aman, Shah Ali Ul Qader

“…After comparing the characteristics of the entrapped enzyme with those of the soluble one, it was observed that the characteristics were more or less the same except for the change in reaction time which was noticed to be prolonged in the case of entrapped dextranase while the change in temperature and pH optima was not observed. …”
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Upregulation of p53 by tannic acid treatment suppresses the proliferation of human colorectal carcinoma by Karakurt Serdar, Kandir Sinan, Gökçek-Saraç Çiğdem

“…Tannic acid has been found to modulate enzyme, protein, and gene expressions of NQO1 in different levels and the upregulation of protein/gene expressions of p53 (p < 0.001), which leads the cells to trigger apoptosis. …”
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Early Renal Involvement in a Girl with Classic Fabry Disease by Fernando Perretta, Norberto Antongiovanni, Sebastián Jaurretche

“…Fabry disease is an X-linked lysosomal storage disorder resulting from the deficiency or absence of the enzyme alpha galactosidase A; this defect leads to the systemic accumulation of globotriaosylceramide and its metabolites. …”
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The DNA Polymerase _-Primase Complex: Multiple Functions and Interactions by Marco Muzi-Falconi, Michele Giannattasio, Marco Foiani, Paolo Plevani

“…In fact, pol _ is associated with DNA primase to form a four subunit complex and, as a consequence, is the only enzyme able to start DNA synthesis de novo. Because of this peculiarity the major role of the DNA polymerase _-primase complex (pol-prim) is in the initiation of DNA replication at chromosomal origins and in the discontinuous synthesis of Okazaki fragments on the lagging strand of the replication fork. …”
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