Structure-function analysis of carrier protein-dependent 2-sulfamoylacetyl transferase in the biosynthesis of altemicidin by Yuhao Zhu, Takahiro Mori, Masayuki Karasawa, Kohei Shirai, Wenjiao Cheng, Tohru Terada, Takayoshi Awakawa, Ikuro Abe

“…Moreover, SbzI is the only naturally occurring enzyme that catalyzes the direct incorporation of sulfonamide, a valuable pharmacophore in medicinal chemistry. …”
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Phytochemical constituent, α-amylase and α-glucosidase inhibitory activities of Black Soybean (Glycine soja (L.) Merr.) ethanol extract by Afifah Bambang Sutjiatmo, Suci Narvikasari, Ananda Khairunisa Solihat, Wahyu Widowati, Hanna Sari Widya Kusuma, Fadhilah Haifa Zahiroh

“…Inhibitory activity of α-amylase and α-glucosidase enzymes was tested in vitro with acarbose as a control. …”
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Intracerebroventricular administration of a modified hexosaminidase ameliorates late-stage neurodegeneration in a GM2 mouse model. by Manuel E Lopez, Daniel Wendt, Roger Lawrence, Kerui Gong, Hoonsan Ong, Bryan Yip, Joseph Chen, Linley Mangini, Britta Handyside, Alexander Giaramita, Aashish Lamichhane, Melanie Lo, Vishal Agrawal, Jeremy Van Vleet, Amanda Abolhesn, Jessica B Felix, Isaac Villalpando, Vikas Bhat, Rolando De Angelis, Yuanbin Ru, Ayesha Khan, Sylvia Fong, Terri Christianson, Sherry Bullens, Brett E Crawford, Stuart Bunting, Mika Aoyagi-Scharber

“…Additionally, HexD3 had advantages over HexA in enzyme stability, distribution potential, and homodimer activity. …”
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A novel UBA1 gene mutation in a patient with infantile respiratory distress syndrome by Masafumi Miyata, Arisa Kojima, Yuri Kawai, Hidetoshi Uchida, Hiroko Boda, Naoko Ishihara, Hidehito Inagaki, Tetsushi Yoshikawa, Hiroki Kurahashi

“…Abstract UBA1 is an E1 ubiquitin-activating enzyme that initiates the ubiquitylation of target proteins and is thus a key component of the ubiquitin signaling pathway. …”
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Role of RING-Type E3 Ubiquitin Ligases in Inflammatory Signalling and Inflammatory Bowel Disease by Liguo Zhu, Ying Li, Longyuan Zhou, Guang Yang, Ying Wang, Jing Han, Li Li, Shenghong Zhang

“…It includes the ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2), and ubiquitin ligase (E3). …”
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The GbbZIP41 transcription factor participates in terpene trilactones biosynthesis in Ginkgo biloba L. by Nuo Wang, Yi Tu, Sirui Zeng, Jiabao Ye, Weiwei Zhang, Feng Xu, Yongling Liao

“…In addition, the overexpression of GbbZIP41 gene in tobacco reduced the content of terpenoids and down-regulated the enzyme genes of MVA pathway and MEP pathway. Therefore, these results suggested that GbbZIP41 negatively regulates the biosynthesis of TTLs by inhibiting key enzyme genes in the TTLs synthesis pathway.…”
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Obstacles to Early Diagnosis of Gaucher Disease by Nishimura S, Ma C, Sidransky E, Ryan E

“…While there is no treatment for neuronopathic GD, non-neuronopathic manifestations can be efficiently managed with enzyme replacement therapy or substrate reduction therapy. …”
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Protective Effect of Commercial Grade Vitamin C against Alcohol-induced Testicular Damage in Male Wistar Rats by Taiwo Emmanuel George, Peter Okhemukhokho Okhiai, Ifabunmi Oduyemi Osonuga, Olusoji Adebusoye Oyesola

“…Sperm motility, morphology, viability and antioxidant enzyme activity, but increase in the level of lipid peroxidation. …”
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The domestication and the brain: forty years after by N. K. Popova

“…Higher concentration of 5-HT and its metabolite, 5-hydroxyindoleacetic acid, increased activity of the principle enzyme in 5-HT synthesis (tryptophan hydroxylase-2) and decreased activity of the principle enzyme in 5-HT degradation (monoamine oxidase A) was shown in the midbrain of domesticated silver foxes and rats. …”
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Optimization of Protease Activity of Endophytic Bacteria EUA-136 and EUA-139 from Bruguiera gymnorrhiza Using Response Surface Methodology by Anthoni Agustien, Miftahul Zovia, Rima Dwitaviani, Yetti Marlida

“… Protease is a vital enzyme used in industries such as detergents, pharmaceuticals, and animal feed, with a growing demand in the enzyme market. …”
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Clinically Relevant Drug Interactions with Monoamine Oxidase Inhibitors by Amber N. Edinoff, Connor R. Swinford, Amira S. Odisho, Caroline R. Burroughs, Cain W. Stark, Walid A. Raslan, Elyse M. Cornett, Adam M. Kaye, Alan D. Kaye

“…Under normal conditions, NE is unable to accumulate to toxic levels due to the presence of MAO-A, an enzyme that degrades neurotransmitters, including NE. …”
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Effect of Nano silicon particles spraying on carnation (Dianthus caryophyllus L.) plants grown in soilless culture and irrigated with saline water by Ramy G. El-Kinany, Mohamed A. A. Ahmed, Qinli Shan, Dan Sun, Ahmed M. Alzoheiry, Eman A. Swedan

“…Elevated salinity resulted in decreased growth, root development, and flowering traits while accelerating flowering time and increasing Na+ and Cl− content and superoxide dismutase (SOD) enzyme activity. Conversely, SiO2-NPs application improved growth parameters, root development, and flowering traits, enhanced leaf chemical composition and catalase (CAT) enzyme activity, and mitigated negative effects compared to the control. …”
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Conformational Dynamics of Mitochondrial Inorganic Pyrophosphatase hPPA2 and Its Changes Caused by Pathogenic Mutations by Ekaterina Bezpalaya, Svetlana Kurilova, Nataliya Vorobyeva, Elena Rodina

“…Inorganic pyrophosphatases, or PPases, are ubiquitous enzymes whose activity is necessary for a large number of biosynthetic reactions. …”
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Thiamine and Thiamine Pyrophosphate as Non-Competitive Inhibitors of Acetylcholinesterase—Experimental and Theoretical Investigations by Łukasz Szeleszczuk, Dariusz Maciej Pisklak, Błażej Grodner

“…The results of the current study indicate a non-competitive type of enzyme inhibition, in contrast to the previously published works suggesting a competitive one.…”
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Antidiabetic Potential of Marine Brown Algae—a Mini Review by Thilina L. Gunathilaka, Kalpa Samarakoon, Pathmasiri Ranasinghe, L. Dinithi C. Peiris

“…Phlorotannins present in marine brown algae exhibited antidiabetic activities through different mechanisms such as the inhibitory effect of enzyme targets mainly by inhibiting the enzymes such as α-amylase, α-glucosidase, angiotensin-converting enzymes (ACE), aldose reductase, dipeptidyl peptidase-4, and protein tyrosine phosphatase 1B (PTP 1B) enzyme. …”
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In Silico Analysis on the Interaction of Haloacid Dehalogenase from Bacillus cereus IndB1 with 2-Chloroalkanoic Acid Substrates by Enny Ratnaningsih, Saepulloh Saepulloh

“…The haloacid dehalogenase gene from Bacillus cereus IndB1 (bcfd1) has been isolated, expressed, and Bcfd1 enzyme activity towards monochloroacetic acid has been successfully studied. …”
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Estimation of Alpha-Amylase in Smokers with and without Leukoplakia and Oral Cancer—A Comparative Study by Amit A. Basannavar, Ankita Bhargava, Alkananda Sahoo, Nidhi Dhakar, Rahul R. Shetty, Debanti Giri

“…Background: Alpha-amylase is an enzyme found in saliva that plays a crucial role in the initial stages of digestion. …”
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Structure and identification of the native PLP synthase complex from Methanosarcina acetivorans lysate by Angela Agnew, Ethan Humm, Kang Zhou, Robert P. Gunsalus, Z. Hong Zhou

“…In addition to being the first reconstruction of the PdxS enzyme from a heterogeneous cellular sample, our results reveal a departure from previously published archaeal PdxS crystal structures, lacking the 37-amino-acid insertion present in these prior cases. …”
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O2-self-supplying and glutathione-depleting scaffold for synergistic cancer therapy by Jiajia Zeng, Chongxian He, Xinna Bai, Cijun Shuai, Hao Pan

“…Specifically, CeO2 alleviates hypoxia through its catalase enzyme activity, which promotes the continuous photodynamic process. …”
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Persistently high concentrations of β-hydroxybutyrate affect hepatic SOD2 expression and blood SOD activity in high-yielding dairy cows by Dominika Grzybowska, Katarzyna Żarczyńska, Przemysław Sobiech, Paweł Brym, Dawid Tobolski

“…Abstract Background Elevated BHB levels are hypothesized to influence hepatic antioxidant enzyme expression and activity, contributing to oxidative response. …”
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