Mucopolysaccharidosis: A rare case from ophthalmology perspective by Santosh Singh Patel, Rajesh Kumar Sahu, Reshu Malhotra, Anju Bhaskar, A. K. Chandrakar

“…Newer treatment modalities such as hematopoietic stem cell transplantation and enzyme-replacement therapy have increased the life span of many MPS patients and created the need to improve the management of ocular symptoms.…”
Get full text

A Novel Method to Prepare PolyGMA and its Application to Immobilization of β-Galactosidase by Sun Sufang, Dong Lingyun

“…The conclusion obtained indicated that the ployGMA prepared concurrently with liquid and solid porogen was more suitable to immobilize enzyme because of the much more porous surface structure obtained.…”
Get full text

Bio-active composition, antibacterial activity and molecular docking studies of Salicia nitida (Benth.) root extracts by Wisdom U. Ike, Okereke C. Stanley, Nosiri Ijeoma, Okamgba C. Okezie, Nwokocha W. Osita, Aguwanba Chinedu, Aaron C. Friday

“…Molecular docking simulations revealed valuable insights into the potential interactions between Class A beta-lactamase enzyme (PDB: 3BLM) with Butylated hydroxytoluene (CID: 31404) and 5-Eicosene (CID: 5364600). …”
Get full text

Statistical optimization of pectinases from thermophilic Aspergillus fumigatus BT-4 employing response surface methodology through submerged fermentation using agricultural wastes by Imran Ali, Roheena Abdullah, Sana Saqib, Kinza Nisar, Afshan Kaleem, Mehwish Iqtedar, Irfana Iqbal, Xiaoming Chen

“…Pectinases are crucial enzymes with significant industrial applications, particularly in the food and textile industries. …”
Get full text

Calpain 2 promotes Lenvatinib resistance and cancer stem cell traits via both proteolysis-dependent and independent approach in hepatocellular carcinoma by Xiaolu Ma, Kaixia Zhou, Tianqing Yan, Ling Hu, Suhong Xie, Hui Zheng, Ying Tong, Heng Zhang, Yanchun Wang, Zhiyun Gong, Cuncun Chen, Yanan Tian, Lin Guo, Renquan Lu

“…Mechanistically, we strikingly discovered that CAPN2 exerted its function by both enzyme-dependent and enzyme-independent manner simultaneously: activating β-Catenin signaling through its enzyme activity, and preventing GLI1/GLI2 degradation through direct binding to YWHAE in an enzyme-independent manner, which disrupting the association between YWHAE and GLI1/GLI2 to inhibit YWHAE-induced degradation of GLIs. …”
Get full text

Ultrasonication-assisted lipase-catalyzed esterification of chlorogenic acid: A comparative study using fatty alcohol and acids in solvent and solvent-free conditions by Chia-Hung Kuo, Parushi Nargotra, Tsung-Han Lin, Chwen-Jen Shieh, Yung-Chuan Liu

“…Despite optimization of factors including molar ratio, enzyme dosage, and reaction time, the highest conversion rate achieved was of only 36.8 %. …”
Get full text

Enzymatic Liquefaction and Characterization of Mangifera laurina Blume by Lejaniya Abdul Kalam Saleena, Kelly Yie Lin Tan, Lee Sin Chang, Liew Phing Pui

“…Homogenized pulp of M. laurina was treated with different enzymes (Pectinex Ultra SPL, Celluclast, Fungamyl, and Termamyl). …”
Get full text

Effects of exogenous spraying of melatonin on the growth of Platycrater arguta under drought stress by Xule Zhang, Xiaohua Ma, Yaping Hu, Qingdi Hu, Junxiu Wen, Yizeng Chen, Renjuan Qian, Jian Zheng

“…Key parameters measured included leaf relative water content, net photosynthetic rate (Pn), antioxidant enzyme activity, and soluble sugar content. Drought stress significantly inhibited the growth of P. arguta. …”
Get full text

Сhanges in subcellular distribution of lysosomal cysteine proteinases activity in parenchymatous organs of rats under the action of nitric oxide synthesis modulators by M. A. Fomina, A. A. Terent'ev

“…The revealed changes are associated with the signs of changes in the ratio of pro-enzyme and active forms of cathepsins.Conclusion. …”
Get full text

Characterization of Lactobacillus spp. as Probiotic and Antidiabetic Potential Isolated from Boza, Traditional Fermented Beverage in Turkey by Chandana Kumari V. B., Sujay Huligere, Jayanthi M. K., Khang Wen Goh, Sudhanva M. Desai, Kalabharthi H. L., Ramith Ramu

“…The study primarily aimed to evaluate the inhibitory effects of the extract on enzymes AG and AA. Bacterial isolates demonstrated a significant inhibitory activity against both enzyme AG (32%–67% inhibition) and enzyme AA (18%–46% inhibition) in different forms, including supernatant (CS), lysed extract (CE), and intact cell (IC). …”
Get full text

Phytoremediation of Oil-Contaminated Soil by <i>Tagetes erecta</i> L. Combined with Biochar and Microbial Agent by Xin Fang, Pufan Zheng, Haomin Wang, Kefan Wang, Cong Shi, Fuchen Shi

“…Compared with the treatments with biochar, the chlorophyll fluorescence parameter NPQ_Lss and plant antioxidant enzyme activities significantly decreased in the treatments applied with the microbial agent, while soil enzyme activities, especially oxidoreductase activities, significantly increased. …”
Get full text

The effects of Fe2O3 nanoparticles on catalytic function of human acetylcholinesterase: size and concentration role by Samaneh Rashtbari, Zahra Hassanpour Aydinlou, Leila Sadeghi

“…Acetylcholinesterase (AChE) is a cholinergic enzyme in central and peripheral nervous systems. …”
Get full text

Design and assessment of lipase-CuO nanoparticle conjugates for enhanced antimicrobial efficacy against clinical pathogens by Eman M. Handak, Dina H. Amin, Mai M. Elhateir

“…Statistical optimization of lipase enzyme was done using a Plackett-Burman design giving two enhancement models for lipase production with increasing in productivity up to 143.43% (2800 U/ml). …”
Get full text

Detection and Structural Characterization of Nucleophiles Trapped Reactive Metabolites of Limonin Using Liquid Chromatography-Mass Spectrometry by Yujie Deng, Yudong Fu, Shumin Xu, Ping Wang, Nailong Yang, Chengqian Li, Qing Yu

“…Recent studies demonstrated that LIM has great potential for inhibiting the activity of drug-metabolizing enzymes. However, the mechanisms of LIM-induced enzyme inactivation processes remain unexplored. …”
Get full text

Oxidative stress and DNA lesions: the role of 8-oxoguanine lesions in Trypanosoma cruzi cell viability. by Pedro H N Aguiar, Carolina Furtado, Bruno M Repolês, Grazielle A Ribeiro, Isabela C Mendes, Eduardo F Peloso, Fernanda R Gadelha, Andrea M Macedo, Glória R Franco, Sérgio D J Pena, Santuza M R Teixeira, Leda Q Vieira, Alessandra A Guarneri, Luciana O Andrade, Carlos R Machado

“…We focused on the MutT enzyme, which is responsible for removing 8-oxoG from the nucleotide pool. …”
Get full text

Design, synthesis, in vitro, and in silico studies of 4-fluorocinnamaldehyde based thiosemicarbazones as urease inhibitors by Muhammad Islam, Saeed Ullah, Ajmal Khan, Zahra Batool, Suraj N. Mali, Shailesh S. Gurav, Kholood A. Dahlous, Saikh Mohammad, Javid Hussain, Ahmed Al-Harrasi, Zahid Shafiq

“…Abstract Clinically significant problems such as kidney stones and stomach ulcers are linked to the activation of the urease enzyme. At low pH, this enzyme gives an ideal environment to Helicobacter pylori in the stomach which is the cause of gastric ulcers and peptic ulcers. …”
Get full text

Protective effects of resveratrol on the expression of catalase, glutathione peroxidase, and superoxide dismutase genes in the ovary and their activity in the serum of rats exposed... by Mohammad Karimian, Mozhdeh Ghadiri, Seyedeh Mahsa Poormoosavi, Hossein Najafzadehvarzi

“…However, Res in all doses decreased only the Cat enzyme activity. Bioinformatics analysis indicates that Res can interact with the promoter regions and cavities of all 3 enzymes.  …”
Get full text

Effects of Copper on Euglena sp. Local Strains and Remediation Capabilities by Witia Ardipeni, Eko Agus Suyono, Nugroho Dewayanto, Na’imatul Mufida, Tia Erfianti, Ria Amelia, Dedy Kurnianto

“…The activity of the SOD enzyme is increased in cultures exposed to copper. …”
Get full text

Estimacão da qualidade industrial da batata (Solanum tuberosum L.) atraves do uso da isoenzima glutamato oxaloacetato transaminase by M.A. Andreu, A. da S. Pereira

“…Results of the comparisons indicated a significant association between the 1.00 band of the evaluated enzyme and the chips color, which allowed an early estimation by this enzyme of the effect of frying. …”
Get full text

Design and Development of Biosensors for the Detection of Heavy Metal Toxicity by Graziella L. Turdean

“…Many compounds (including heavy metals, HMs) used in different fields of industry and/or agriculture act as inhibitors of enzymes, which, as consequence, are unable to bind the substrate. …”
Get full text