Characterization of demethylating DNA glycosylase ROS1 from Nicotiana tabacum L. by D. V. Petrova, N. V. Permyakova, I. R. Grin, D. O. Zharkov

“…The enzyme removed 5-hydroxymethylcytosine (hmC) from DNA with a lower efficiency, showing minimal activity in the presence of mC in the opposite strand. …”
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Computational studies and structural insights for discovery of potential natural aromatase modulators for hormone-dependent breast cancer by Snehal Aditya Arvindekar, Sanket Rathod, Prafulla Balkrishna Choudhari, Pradnya Kiran Mane, Aditya Umesh Arvindekar, Suraj Narayan Mali, Bapu Thorat

“…Introduction: The aromatase enzyme plays an important role in the progress of hormone-dependent breast cancer, especially in estrogen receptor-positive (ER+) breast cancers. …”
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Immunogenicity of HIV-1 <i>Env</i> mRNA and <i>Env-Gag</i> VLP mRNA Vaccines in Mice by Qi Ma, Jing Yang, Xiaoguang Zhang, Hongxia Li, Yanzhe Hao, Xia Feng

“…Env-specific cellular immune responses in mouse splenocytes were evaluated using an Enzyme-linked immunosorbent assay (ELISpot) and in vivo cytotoxic T cell-killing assays. …”
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Non-steroidal anti-inflammatory drugs and oxidative stress biomarkers in fish: a meta-analytic review by Luiz Henrique Zaniolo Justi, Juliana Ferreira Silva, Manuela Santos Santana, Henrique Aparecido Laureano, Meire Ellen Pereira, Cláudia Sirlene Oliveira, Izonete Cristina Guiloski

“…In conclusion, our results demonstrated that fish are sensitive to NSAIDs exposure presenting significant alterations in oxidative stress biomarkers, especially in the GPx enzyme. This enzyme exhibits strong potential as a biomarker of NSAIDs exposure in fish. …”
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Successful Erlotinib Treatment for a Patient with Gefitinib-Related Hepatotoxicity and Lung Adenocarcinoma Refractory to Intermittently Administered Gefitinib by Tatsuya Nagano, Yoshikazu Kotani, Kazuyuki Kobayashi, Masahiro Katsurada, Yukihisa Hatakeyama, Suya Hori, Daisuke Tamura, Daisuke Kasai, Yasuhiro Funada, Yoshihiro Nishimura

“…The patient was treated with gefitinib for 6 weeks until he developed substantially elevated hepatic enzyme levels that resulted in the discontinuation of gefitinib. …”
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Cytokinin Oxidase (CKX) Family Members in ‘duli’ (<i>Pyrus betulifolia Bunge</i>): Genome-Wide Identification and Tissue Expression Profile Under Abiotic Stress by Weimin Wang, Ting Xie, Jiaojiao He, Kuozhen Nie, Zijuan He, Yuxing Zhang, Yingli Li

“…Notably, treatments with Abscisic acid and NaCl significantly enhanced CKX enzyme activity in ‘duli’ over 20 days, reducing levels of zeatin and isopentenyladenine. …”
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A Study on L-Asparaginase of Nocardia levis MK-VL_113 by Alapati Kavitha, Muvva Vijayalakshmi

“…An enzyme-based drug, L-asparaginase, was produced by Nocardia levis MK-VL_113 isolated from laterite soils of Guntur region. …”
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Primary Biliary Cirrhosis and Type II Autoimmune Polyglandular Syndrome by Mark Ram Borgaonkar, David Geoffrey Morgan

“…In 1996, she became jaundiced with a cholestatic enzyme pattern. AMA was positive at a titre of 1:256. …”
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How a gene fuels ear infections by Sedigheh Delmaghani, Aziz El-Amraoui

“…The DYRK1A enzyme is a pivotal contributor to frequent and severe episodes of otitis media in Down syndrome, positioning it as a promising target for therapeutic interventions.…”
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N-acetyltransferase 2 Slow Acetylator Genotype Associated with Adverse Effects of Sulfasalazine in the Treatment of Inflammatory Bowel Disease by Min Chen, Bing Xia, Bixiao Chen, Qiusha Guo, Jin Li, Mei Ye, Zhengguo Hu

“…AIM: N-acetyltransferase 2 (NAT2) is an important enzyme catalyzing N-acetylation of sulfasalazine (SASP). …”
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Biodegradation of Eugenol by Bacillus Cereus Strain PN24 by Jagannath C. Kadakol, Chandrappa M. Kamanavalli

“…On the other hand, the intermediate of the eugenol-degrading pathway, such as ferulic acid was not detected in the culture medium as an intermediate, as evidenced by isolation and identification of metabolites and enzyme activities in the cell-free extract. Such a bacterial strain could be used for phenolic environmental clean-up given optimal nutrient conditions.…”
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The Effects of Addition of Mononucleotides on Sma nuc Endonuclease Activity by Julia Romanova, Maria Filimonova

“…Examination of the effects of mononucleotides on Sma nuc endonuclease originated from Gram negative bacterium Serratia marcescens displayed that any mononucleotide produced by Sma nuc during hydrolysis of DNA or RNA may regulate the enzyme activity affecting the RNase activity without pronounced influence on the activity towards DNA. …”
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Recent insights into the cellular mechanisms of acute pancreatitis by Laura I Cosen-Binker, Herbert Y Gaisano

“…In acute pancreatitis, initiating cellular events causing acinar cell injury includes co-localization of zymogens with lysosomal hydrolases, leading to premature enzyme activation and pathological exocytosis of zymogens into the interstitial space. …”
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Sarcoidosis Treatment with Antifungal Medication: A Follow-Up by Marjeta Terčelj, Barbara Salobir, Mirjana Zupancic, Ragnar Rylander

“…Chitotriosidase and angiotensin converting enzyme were determined. The time in months till remission was observed as well as the number of recurrences.…”
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Efficacy and Safety Concerns with Sn-Mesoporphyrin as an Adjunct Therapy in Neonatal Hyperbilirubinemia: A Literature Review by Prakar Poudel, Sudhir Adhikari

“…The rationale logic of heme oxygenase enzyme inhibition to lower bilirubin levels is intriguing. …”
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Nitric oxide as a mediator of inflammation?—You had better believe it by Mark J. S. Miller, Matthew B. Grisham

“…In order to appreciate the precise contributions of nitric oxide to a pathophysiological process, one must account for enzyme source, coproduction of oxidants and antioxidant defences, time, rate of nitric oxide production, cellular source, peroxynitrite formation and effects on DNA (mutagenesis/apoptosis). …”
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Hunter Syndrome Diagnosed by Otorhinolaryngologist by Ayako Hashimoto, Tadayuki Kumagai, Hiroyuki Mineta

“…Hunter syndrome is a lysosomal disease characterized by deficiency of the lysosomal enzyme iduronate-2-sulfatase (I2S). It has an estimated incidence of approximately 1 in 1,62,000 live male births. …”
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Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the Keap1/Nrf2/HO-1 signaling pathway by Weiwei Tang, Xiaomin Huang, Yun-Di Yi, Fan Cao, Manli Deng, Jiawei Fan, Zheng-Xuan Jiang, Li-Ming Tao, Xianwen Wang, Lei Shi

“…In summary, this study revealed that HA-CUR NPs, which are composed of a natural product and biomacromolecules with outstanding artificial antioxidant enzyme activities, may be novel agents for effectively and safely treating uveitis and other ROS-related diseases.…”
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Prolactin Is a Strong Candidate for the Regulation of Luteal Steroidogenesis in Vizcachas (Lagostomus maximus) by S. Proietto, S. A. Cortasa, M. C. Corso, P. I. F. Inserra, S. E. Charif, A. R. Schmidt, N. P. Di Giorgio, V. Lux-Lantos, A. D. Vitullo, V. B. Dorfman, J. Halperin

“…Remarkably, the P4-sinthesizing enzyme 3β-HSD accompanied the expression pattern of PRLR/LHR throughout gestation. …”
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Allium cepa L. as a natural antioxidant: Its efficacy in combating heat stress-induced physiological alterations by Ayobami O. Sobanke, Afusat Aiyeola, Frances I. Okwuonu, Wuraola S. Nnaemeka, Jeremiah C. Ndubuisi, Franklin I. Udeoji, Jane N. Adiele

“…Many of these alterations were reversed by AC supplementation, by increasing RBC counts, HB levels, and antioxidant enzyme activities while decreasing LDL-c, TG and TC, MDA, and TNF-α (tumor necrosis factor-α). …”
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