International Normalized Ratio (INR) Increases amongst Two Patients Living with HIV on Warfarin after Being Switched from a Nevirapine to a Dolutegravir-Based Antiretroviral Regime... by Natalie Sang, Sonak Pastakia, Samuel Nyanje

“…The increased use of dolutegravir-based regimens in the treatment of HIV is unmasking drug interactions, particularly in patients who were previously on nevirapine. Nevirapine is an enzyme inducer and increases the dosing requirements for cytochrome P450 enzyme substrates including warfarin. …”
Get full text

Fabrication of AChE/SnO2-cMWCNTs/Cu Nanocomposite-Based Sensor Electrode for Detection of Methyl Parathion in Water by Vikas Dhull

“…The synergistic and facilitated electron transferring properties of SnO2-cMWCNTs/Cu made it an excellent support for immobilization of enzyme in sensing technology. The enzyme AChE was covalently immobilized with cMWCNTs using glutaraldehyde as crosslinking agent which has enhanced the storage stability and reusability of the method. …”
Get full text

Anderson–Fabry Disease: From Endothelial Dysfunction to Emerging Therapies by Cosimo A. Stamerra, Rita Del Pinto, Paolo di Giosia, Claudio Ferri, Amirhossein Sahebkar

“…In contrast, enzyme replacement and chaperone therapies are already fully available to patients and allow substantial amelioration of quality and quantity of life. …”
Get full text

In Vitro and In Silico Analysis of Bergenia ciliata and Mimosa pudica for Inhibition of α-Amylase by Mahesh Bohara, Sajani Ghaju, Kabita Sharma, Surya Kant Kalauni, Karan Khadayat

“…Furthermore, the active phytochemicals from these plants were docked with human pancreatic α-amylase to study their inhibitory activities to this enzyme. The docking analysis revealed that catechin has lower binding energy (−8.6 kcal/mol) as compared to the commercial drug acarbose (−7.3 kcal/mol) indicating higher affinity towards the enzyme. …”
Get full text

NEDD4 family E3 ligases in osteoporosis: mechanisms and emerging potential therapeutic targets by Heng Wu, Junhui Zuo, Yu Dai, Hairui Li, Song Wang

“…A central player in these processes is ubiquitin-mediated proteasomal degradation, a crucial post-translational modification system that involves ubiquitin, the ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2), ubiquitin ligase (E3), deubiquitinating enzymes, and the proteasome. …”
Get full text

Enhanced Antibacterial Activity of Hydrophobic Modified Lysozyme Against Gram-Negative Bacteria Without Accumulated Resistance by Zhenhui Li, Song Lin, Mei Zhu, Xiaoman Liu, Xin Huang

“…Lysozyme, a kind of wide-spread natural enzyme easily extracted from nature, has become attractive for agriculture and medicine use. …”
Get full text

Impact of No-Tillage and Conventional Tillage Systems on Soil Microbial Communities by Reji P. Mathew, Yucheng Feng, Leonard Githinji, Ramble Ankumah, Kipling S. Balkcom

“…Results of principal components analysis based on soil physicochemical and enzyme variables were in agreement with those based on PLFA and ARISA profiles. …”
Get full text

Screening of Aqueous Extract of Persea americana Seeds for Alpha-Glucosidase Inhibitors by Tajudeen Afolayan Lawal

“…Activity of α-glucosidase enzyme in the gastrointestinal tract has been implicated in postprandial hyperglycaemia. …”
Get full text

Effects of Xylanase Pretreatment on the Quality of Refiner Mechanical Mulberry Branch Fibers by Wenjuan Tao, Lifang Guo, Aojie Meng, Lizhen Wang, Hao Ren, Huamin Zhai

“…To determine the effects of the enzyme action, we analyzed the energy required for refining, related yield, and the dimension, deformation, and morphology of the fibers. …”
Get full text

Modification Effect of Cellulase on the Physicochemical Characteristic of Polysaccharides Edible Films by Anna Zimoch-Korzycka, Jagoda Ambrozik-Haba, Dominika Kulig, Andrzej Jarmoluk

“…The enzyme treatment improved elasticity but decreased tensile strength of films. …”
Get full text

Antioxidant, Anti-Inflammatory, and Cytotoxic Activities of Garcinia nervosa (Clusiaceae) by N. M. U. Seruji, H. Y. Khong, C. J. Kutoi

“…The lipoxygenase assay showed a high inhibition of enzyme activity for the barks extracts and a moderate enzyme activity for the leaves extracts. …”
Get full text

Role of RING-Type E3 Ubiquitin Ligases in Inflammatory Signalling and Inflammatory Bowel Disease by Liguo Zhu, Ying Li, Longyuan Zhou, Guang Yang, Ying Wang, Jing Han, Li Li, Shenghong Zhang

“…It includes the ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2), and ubiquitin ligase (E3). …”
Get full text

The GbbZIP41 transcription factor participates in terpene trilactones biosynthesis in Ginkgo biloba L. by Nuo Wang, Yi Tu, Sirui Zeng, Jiabao Ye, Weiwei Zhang, Feng Xu, Yongling Liao

“…In addition, the overexpression of GbbZIP41 gene in tobacco reduced the content of terpenoids and down-regulated the enzyme genes of MVA pathway and MEP pathway. Therefore, these results suggested that GbbZIP41 negatively regulates the biosynthesis of TTLs by inhibiting key enzyme genes in the TTLs synthesis pathway.…”
Get full text

Obstacles to Early Diagnosis of Gaucher Disease by Nishimura S, Ma C, Sidransky E, Ryan E

“…While there is no treatment for neuronopathic GD, non-neuronopathic manifestations can be efficiently managed with enzyme replacement therapy or substrate reduction therapy. …”
Get full text

Protective Effect of Commercial Grade Vitamin C against Alcohol-induced Testicular Damage in Male Wistar Rats by Taiwo Emmanuel George, Peter Okhemukhokho Okhiai, Ifabunmi Oduyemi Osonuga, Olusoji Adebusoye Oyesola

“…Sperm motility, morphology, viability and antioxidant enzyme activity, but increase in the level of lipid peroxidation. …”
Get full text

The domestication and the brain: forty years after by N. K. Popova

“…Higher concentration of 5-HT and its metabolite, 5-hydroxyindoleacetic acid, increased activity of the principle enzyme in 5-HT synthesis (tryptophan hydroxylase-2) and decreased activity of the principle enzyme in 5-HT degradation (monoamine oxidase A) was shown in the midbrain of domesticated silver foxes and rats. …”
Get full text

Clinically Relevant Drug Interactions with Monoamine Oxidase Inhibitors by Amber N. Edinoff, Connor R. Swinford, Amira S. Odisho, Caroline R. Burroughs, Cain W. Stark, Walid A. Raslan, Elyse M. Cornett, Adam M. Kaye, Alan D. Kaye

“…Under normal conditions, NE is unable to accumulate to toxic levels due to the presence of MAO-A, an enzyme that degrades neurotransmitters, including NE. …”
Get full text

Effect of Nano silicon particles spraying on carnation (Dianthus caryophyllus L.) plants grown in soilless culture and irrigated with saline water by Ramy G. El-Kinany, Mohamed A. A. Ahmed, Qinli Shan, Dan Sun, Ahmed M. Alzoheiry, Eman A. Swedan

“…Elevated salinity resulted in decreased growth, root development, and flowering traits while accelerating flowering time and increasing Na+ and Cl− content and superoxide dismutase (SOD) enzyme activity. Conversely, SiO2-NPs application improved growth parameters, root development, and flowering traits, enhanced leaf chemical composition and catalase (CAT) enzyme activity, and mitigated negative effects compared to the control. …”
Get full text

Conformational Dynamics of Mitochondrial Inorganic Pyrophosphatase hPPA2 and Its Changes Caused by Pathogenic Mutations by Ekaterina Bezpalaya, Svetlana Kurilova, Nataliya Vorobyeva, Elena Rodina

“…Inorganic pyrophosphatases, or PPases, are ubiquitous enzymes whose activity is necessary for a large number of biosynthetic reactions. …”
Get full text

Thiamine and Thiamine Pyrophosphate as Non-Competitive Inhibitors of Acetylcholinesterase—Experimental and Theoretical Investigations by Łukasz Szeleszczuk, Dariusz Maciej Pisklak, Błażej Grodner

“…The results of the current study indicate a non-competitive type of enzyme inhibition, in contrast to the previously published works suggesting a competitive one.…”
Get full text