Valerenic acid attenuates pathological myocardial hypertrophy by promoting the utilization of multiple substrates in the mitochondrial energy metabolism by Tiantian Liu, Xu Chen, Qianbin Sun, Junjun Li, Qiyan Wang, Peng Wei, Wei Wang, Chun Li, Yong Wang

“…VA reduced the expression of ENO1 and PDK4, the key enzymes in glycolysis. Meanwhile, VA improved the pyruvate-lactate axis and promoted the aerobic oxidation of pyruvate by inhibiting LDAH and MCT4. …”
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Endometrial factors in the implantation failure spectrum: protocol of a MUltidisciplinary observational cohort study in women with Repeated Implantation failure and recurrent Misca... by Servaas Morré, Ron van Golde, Andrea Romano, Linda Stevens Brentjens, Denise Habets, Janneke Den Hartog, Salwan Al-Nasiry, Lotte Wieten, Aafke Van Montfoort

“…The study parameters are the steroid profile (steroid levels and mRNA levels, protein expression and activity of steroid enzymes) in endometrial tissue and peripheral blood, as well as the activating or inhibitory phenotype of uNK cells based on receptor expression in menstrual blood and endometrial tissue and determination of the vaginal and endometrial microbiome using the inter spacer bacterial profiling technique.Ethics and dissemination The protocol is approved by the local medical ethical review committee at the Maastricht University Medical Centre. …”
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Generation of Chicken IgY against SARS-COV-2 Spike Protein and Epitope Mapping by Yan Lu, Yajun Wang, Zhen Zhang, Jingliang Huang, Meicun Yao, Guobin Huang, Yuanyuan Ge, Peichun Zhang, Huaxin Huang, Yong Wang, Huiliang Li, Wen Wang

“…Thus, antibody binding at this location could physically block the access of proteolytic enzymes to S1/S2 cleavage site and thereby impede S1/S2 proteolytic cleavage, which is crucial to subsequent virus-cell membrane fusion and viral cell entry. …”
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The p85 Regulatory Subunit of PI3K Mediates cAMP-PKA and Insulin Biological Effects on MCF-7 Cell Growth and Motility by E. Di Zazzo, A. Feola, C. Zuchegna, A. Romano, C. F. Donini, S. Bartollino, C. Costagliola, R. Frunzio, P. Laccetti, M. Di Domenico, A. Porcellini

“…In epithelial cells, which do not express GLUT4 and gluconeogenic enzymes, insulin-mediated PI3K activation regulates cell survival, growth, and motility. …”
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Endocrine disruptors and cancers. [Perturbateurs endocriniens et cancers] by Souhila AOUICHAT BOUGUERRA, Saliha BOUMAZA, Khouloud HEMILA, Samia NEGGAZI, Nadjiba HAMLAT, Sihem BERDJA, Leïla SMAIL, Besma MOHAMMEDI, Kenza REGUOUAT, Amina BOUDJLIDA, Sofiane KACI, Fatima BOUACHRIA-BOUSMAHA

“…They act by binding to receptors or enzymes and modulate, through their agonist or antagonist activity, the effectiveness or metabolism of natural hormones. …”
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Lactobacillus acidophilus alleviate Salmonella enterica Serovar Typhimurium-induced murine inflammatory/oxidative responses via the p62-Keap1-Nrf2 signaling pathway and cecal micro... by Haihua Li, Xinyi Ma, Zhiyuan Shang, Xuejiao Liu, Jiayun Qiao

“…Typhimurium group, LA early intervention increased the expression of antioxidant enzymes, but decreased the levels of serum malondialdehyde (MDA), interleukin-8 and tumor necrosis factor-α (TNF-α). …”
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Bacterial pathogens dynamic during multi-species infections by Barny, Marie-Anne, Thieffry, Sylvia, Gomes de Faria, Christelle, Thebault, Elisa, Pédron, Jacques

“…Soft rot Pectobacteriacea (SRP) gathers more than 30 bacterial species that collectively rot a wide range of plants by producing and secreting a large set of plant cell wall degrading enzymes (PCWDEs). Worldwide potato field surveys identified 15 different SRP species on symptomatic plants and tubers. …”
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Investigating the role of cathepsins in breast cancer progression: a Mendelian randomization study by Shengyi Zhou, Shengyi Zhou, Shengyi Zhou, Yizhou Sun, Yizhou Sun, Wenzhang Zha, Wenzhang Zha, Guangjun Zhou, Guangjun Zhou

“…Within the human lysosomal system, a class of enzymes known as cathepsins exhibit elevated expression levels in various malignant tumors, suggesting that they may play key roles in cancer progression.MethodsThis study employed the two-sample Mendelian randomization (MR) approach to investigate the potential causal relationship between cathepsin levels and the risk of developing breast cancer. …”
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Influence of ABCB1 polymorphisms on aripiprazole and dehydroaripiprazole plasma concentrations by Francisco José Toja-Camba, María Vidal-Millares, María José Durán-Maseda, Gonzalo Hermelo-Vidal, Ángel Carracedo, Olalla Maroñas, Luis Ramudo-Cela, Irene Zarra-Ferro, Anxo Fernández-Ferreiro, Cristina Mondelo-García

“…The metabolizing state of the two main aripiprazole metabolizing enzymes (CYP2D6 and CYP3A4) were considered to specifically study the effect of P-gp on plasma concentrations of the parent compound and its active metabolite. …”
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Chemical Composition, In Vivo, and In Silico Molecular Docking Studies of the Effect of <i>Syzygium aromaticum</i> (Clove) Essential Oil on Ochratoxin A-Induced Acute Neurotoxicity by Mostapha Brahmi, Djallal Eddine H. Adli, Imane Kaoudj, Faisal K. Alkholifi, Wafaa Arabi, Soumia Sohbi, Kaddour Ziani, Khaled Kahloula, Miloud Slimani, Sherouk Hussein Sweilam

“…The in silico analysis revealed significant affinities between clove oils and two tested esterase enzymes (ACh and BuChE) that were more than or similar to the four neurotransmitters “dopamine, serotonin, norepinephrine, and glutamic acid” and the co-crystallized ligands NAG, MES, and GZ5. …”
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Screening of N-Acyl Homoserine Lactone-degrading Bacteria and Evaluation of Their Quorum Quenching Activities by Xiqian TAN, Xiaoqing WANG, Fangchao CUI, Dangfeng WANG, Xinran LÜ, Xuepeng LI, Jianrong LI

“…To study the types of quorum quenching bacteria in soil and their quorum quenching characteristics, the study screened, isolated, and identified quorum quenching strains from soil and assessed their quorum quenching properties, the inhibitory and dispersion abilities on the biofilm of Hafnia alvei (H. alvei), and the potential types of quorum quenching enzymes by specific primer amplification. Four bacteria that showed significant degrading activity against the quorum sensing signals produced by H. alvei were isolated and identified as Enterobacter hormaechei (GS31), Bacillus cereus (GS44), Bacillus thuringiensis (GS48), and Serratia sp. …”
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Comparative genomics reveals low levels of inter- and intraspecies diversity in the causal agents of dwarf and common bunt of wheat and hint at conspecificity of Tilletia caries an... by Somayyeh Sedaghatjoo, Bagdevi Mishra, Monika K. Forster, Yvonne Becker, Jens Keilwagen, Berta Killermann, Marco Thines, Petr Karlovsky, Wolfgang Maier

“…Overall, 75% of the identified protein-coding genes comprising 84% of the total predicted carbohydrate utilizing enzymes, 72.5% putatively secreted proteins, and 47.4% of effector-like proteins were conserved and shared across all 16 isolates. …”
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Effects of Soil Disinfection Using Chlorine Dioxide on Soil Fungal Communities in Apple Replant Fields and the Growth of <i>Malus hupehensis</i> Rehd. Seedlings by Gongshuai Wang, Yuxin Xie, Jinhui Lv, Susu Zhang, Chengmiao Yin, Yusong Liu, Zhiquan Mao

“…The activities of root-protective enzymes, including superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD), also increased to varying degrees, whereas the malondialdehyde (MDA) content was significantly reduced compared with the control treatment. …”
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Antioxidant effect of Lactobacillus fermentum HFY02-fermented soy milk on D-galactose-induced aging mouse model by Tiantian Hu, Rui Chen, Yu Qian, Ke Ye, Xingyao Long, Kun-Young Park, Xin Zhao

“…In conclusion, soybean milk fermented by LF-HFY02 can increase the content of antioxidant factors and the activity of antioxidant enzymes by regulating gene and protein expression, and finally inhibit the process of tissue cell peroxidation, and improve the oxidative damage of mouse skin and liver. …”
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Effects of acteoside from Cistanche tubulosa on the plasma metabolome of cancer-related fatigue mice inoculated with colon cancer cells by Shilei Zhang, Fukai Gong, Jiali Liu, Shuping You, Tao Liu, Jianhua Yang, Junping Hu

“…Furthermore, several key enzymes, including CYP3A4, CYP19A1, CYP2E1, TNF, BCL-2, RYR2, and ATP2A1, were identified as potential targets underlying the anti-CRF effects of ACT.ConclusionThis study suggests that ACT derived from C. tubulosa harbors protective properties against cancer-related fatigue mediated by tumor cells.…”
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Silver Ecotoxicity Estimation by the Soil State Biological Indicators by S. I. Kolesnikov, N. I. Tsepina, L.V. Sudina, T. V. Minnikova, K. Sh. Kazeev, Yu. V. Akimenko

“…Silver pollution of soils in most cases leads to deterioration of their biological properties: the total number of bacteria, the abundance of bacteria of the genus Azotobacter, the activity of enzymes (catalase and dehydrogenases), and the phytotoxicity indicators decrease. …”
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The structural characteristics of dietary fibers from Tremella fuciformis and their hypolipidemic effects in mice by Shanshan Zhang, Xinle Xu, Xu Cao, Tingting Liu

“…In this study, Tremella fuciformis residues as raw material, dietary fibers from tremella were prepared by multiple enzymes. The structure of dietary fibers from tremella was studied by Fourier transform infrared (FTIR), X-ray diffraction analysis (XRD) and scanning electron microscopy (SEM). …”
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Adaptability of clams to prolonged heatwaves: Influences on gene expression, antioxidant capacity, and histology of Chinese cyclina Cyclina sinensis by Meimei Liu, Zhichao Wang, Hongwei Ni, Wenqing Zhuo, Gaoyuan Yuan, Zhiguo Dong

“…The transcript levels of chaperones genes and antioxidant enzymes were up-regulated after acute heat stress treatment (35℃). …”
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Preparation, structural property, and antioxidant activities of a novel pectin polysaccharide from the flowers of Hibiscus syriacus Linn. by Jialong Chen, Chaojun Ye, Lu Zhang, Zhiliang Xie, Jianjun Zhu, Zhi Zhang

“…Furthermore, HFPS effectively protected HepG2 cells against H2O2-induced oxidative stress by reducing ROS accumulation, modulating redox-related enzymes (Superoxide dismutase, Catalase, Glutathione peroxidase), and alleviating oxidative damage. …”
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Comprehensive study of Tilapia skin collagen peptide on ileal injury and intestinal flora in rats induced by high altitude hypoxia by Jingyi Wang, Hao Wang, Chunxia Li, Xiaojuan Zhang, Jin Liu, Yanzhou Hu, Ping Qian

“…Furthermore, CP significantly up-regulated the an tioxidant enzymes SOD and GSH-Px and down-regulated MDA in the serum of rats, and improved hypoxia-induced oxidative stress. 16S rDNA sequencing of the intestinal flora revealed that CP significantly reduced the abundance of the pathogenic bacterium Escherichia, increased the abundance of the beneficial bacterium Limosilactobacillu, and significantly increased the levels of acetic acid, isobutyric acid, and isovaleric acid in feces. …”
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