Research Progress on Sugar Signaling during Fruit Development and Ripening by Libin WANG, Junpeng NIU, Guodong WANG, Yuhua XIE, Chen ZHANG, Zhifang YU, Bing XIE, Qiuqin ZHANG, Heyun ZHENG, Ruihong YUAN, Xinli GENG, Shaoling ZHANG

“…The changes of sugar synthesis, transport, metabolism and content during fruit development and ripening are affected by enzymes, genes, transcription factors, transporters, phytohormones and environmental conditions. …”
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Here and there: the double-side transgene localization by P. A. Salnikov, A. A. Khabarova, G. S. Koksharova, R. V. Mungalov, P. S. Belokopytova, I. E. Pristyazhnuk, A. R. Nurislamov, P. Somatich, M. M. Gridina, V. S. Fishman

“…The developed assay requires using intentionally designed vectors that lack recognition sites of one or a set of restriction enzymes used for DNA fragmentation. By looping and sequencing these DNA fragments, we obtain special data that allows us to link the two flanking regions of the transposon. …”
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Compost as an eco-friendly alternative to mitigate salt-induced effects on growth, nutritional, physiological and biochemical responses of date palm by Mohamed Ait-El-Mokhtar, Abdessamad Fakhech, Raja Ben-Laouane, Mohamed Anli, Abderrahim Boutasknit, Youssef Ait-Rahou, Said Wahbi, Abdelilah Meddich

“…NaCl stress induced high lipid peroxidation and H2O2 accumulation; however, the application of compost lowered these two parameters in stressed plants through stimulation of the antioxidant enzymes activity and increasing soluble sugars and proline accumulation.Conclusion Results suggest that the green waste-based compost can boost date palm seedlings tolerance in salt-affected soils by mitigating the different adverse effects of salinity stress.…”
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Influence of a lignification and mineralization of leaf tissues on resistance to a brown rust in common wheat plants by A. A. Konovalov, I. K. Shundrina, E. V. Karpova, I. V. Eltsov, E. A. Orlova, N. P. Goncharov

“…Aromatic substances in plant tissues can have protective effect against fungal diseases. One of the key enzymes in aromatic metabolism of plants, CAD (cinnamyl-alcohol dehydrogenase, dehydrogenase of cinnamyl alcohol; EC 1.1.1.195), at a number of species of plants exerts impact on the content of aromatic substances and on protective properties of tissues from fungal infections. …”
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Comparative transcriptome analysis on candidate genes involved in lipid biosynthesis of developing kernels for three walnut cultivars in Xinjiang by Wenqiang Wang, Hao Wen, Qiang Jin, Wenjun Yu, Gen Li, Minyu Wu, Hongjin Bai, Lirong Shen, Cuiyun Wu

“…We identified 126 candidate genes including 64 genes for FA de novo synthesis, 45 genes for triacylglycerol assembly, and 17 genes for oil bodies involved in lipid biosynthesis by RNA-sequencing. Ten key enzymes including ACCase, LACS6, LACS8, SAD, FAD2, FAD3, LPAAT1, DGAT2, PDAT2, and PLC encoded by 19 genes were highly associated with lipid biosynthesis. …”
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Application and development of CRISPR technology in the secondary metabolic pathway of the active ingredients of phytopharmaceuticals by Haixin Gao, Xinyi Pei, Xianshui Song, Shiying Wang, Zisong Yang, Jianjun Zhu, Qiupeng Lin, Qinlong Zhu, Xiangna Yang

“…By precisely regulating the expression of key enzymes and transcription factors, CRISPR technology not only deepens our understanding of secondary metabolic pathways in medicinal plants but also opens new avenues for drug development and the modernization of traditional Chinese medicine. …”
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Non-classical pulmonary exacerbation in cystic fibrosis revealing ALK-Translocated lung cancer: A case report by Mohamad Hadhud, Johnathan Arnon, Anat Hershko-Moshe, Adi Hollander, Noa Hurvitz-Lehmann, Assaf Potruch, Henny Azmanov, Rottem Kuint, Nurith Hiller, Elie Picard, Naama Sebbag-Sznajder, Shira Leebhoff, Michael Wilschanski, Myriam Grunewald, Liron Birimberg-Schwartz, Malena Cohen-Cymberknoh

“…We describe the case of a 35-year-old man with mild, stable CF disease who presented with severe respiratory distress, systemic symptoms, elevated liver enzymes and hypereosinophilia along with a lung mass and pleural effusion. …”
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Physiological Properties of Dietary Ellagitannin-Rich Preparations Obtained from Strawberry Pomace Using Different Extraction Methods by Juśkiewicz Jerzy, Król Bogusław, Kosmala Monika, Milala Joanna, Zduńczyk Zenon, Żary-Sikorska Ewa

“…To measure animals response, parameters describing the caecal fermentation (ammonia and short-chain fatty acid concentrations, bacterial enzymes activity), blood serum lipoprotein profile, and TBARS content in selected tissues (heart, liver, kidney) were assessed. …”
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Branched-chain fatty acids from goat milk alleviate ulcerative colitis via the TLR4/NF-κB/NLRP3 pathway by Jiaxin Zhang, Jinjing Zhong, Zhengying Cui, Yu Shen, Yaping Zheng, Yu Zhang, Chaoxin Man, Yanmei Hou, Qianyu Zhao, Yujun Jiang

“…These results show that BCFAs extracted from goat milk can significantly alleviate weight loss in mice, and reduce the disease activity index and the activity of myeloperoxidase while increasing the content of antioxidant enzymes in colon tissue and reducing the oxidation stress response. …”
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Novel Antibacterial 4-Piperazinylquinoline Hybrid Derivatives Against <i>Staphylococcus aureus</i>: Design, Synthesis, and In Vitro and In Silico Insights by Gabriele La Monica, Annamaria Gallo, Alessia Bono, Federica Alamia, Antonino Lauria, Rosa Alduina, Annamaria Martorana

“…Further in silico docking and molecular dynamics studies highlighted strong interactions of <b>5k</b> with bacterial enzymes, such as tyrosyl-tRNA synthetase, pyruvate kinase, and DNA gyrase B, suggesting potential modes of action. …”
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Utility of Integrated Analysis of Pharmacogenomics and Pharmacometabolomics in Early Phase Clinical Trial: A Case Study of a New Molecular Entity by Jaeseong Oh, Sojeong Yi, Namyi Gu, Dongseong Shin, Kyung-Sang Yu, Seo Hyun Yoon, Joo-Youn Cho, In-Jin Jang

“…The pharmacogenomics screening was performed from whole blood samples using the Affymetrix DMET (Drug-Metabolizing Enzymes and Transporters) Plus microarray, and confirmation of genetic variants was performed using real-time polymerase chain reaction. …”
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Genomic insights and comparative analysis of Colletotrichum species associated with anthracnose fruit rot and crown rot of strawberry in North Carolina by Tika B. Adhikari, Norman Muzhinji, Ashley N. Philbrick, Frank J. Louws, Frank J. Louws

“…The predicted gene models included effectors (339 to 480), secondary metabolic gene clusters (67 to 90), and carbohydrate-active enzymes (800 to 1,060), with C. siamense isolates exhibiting the highest numbers in these categories. …”
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Physiological and molecular mechanisms of exogenous salicylic acid in enhancing salt tolerance in tobacco seedlings by regulating antioxidant defence system and gene expression by Xiliang Song, Jian Chen, Can Xu, Xianjie Cai, Wenjing Song, Aixia Chang, Yu Zhang, Chenggang Luo

“…Under salt stressed conditions, the activities of antioxidant enzymes, including superoxide dismutase, ascorbate peroxidase, catalase, and peroxidase increased by 4.2%~14.4% in SA sprayed tobacco seedlings. …”
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Co-inoculation of Trichoderma viride with Azospirillum brasilense could suppress the development of Harpophora maydis-infected maize in Egypt by Rasha M. Elmeihy, Omar A. Hewedy, Maryam S. Alhumaidi, Khadijah A. Altammar, Eman O. Hassan, Samah A. El-Debaiky

“…T. viride showed high mycoparasitic potential against H. maydis via various antagonistic activities, including the production of lytic enzymes, secondary metabolites, volatile compounds, and siderophores. …”
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Synthesis, Antimalarial Activity and Molecular Dynamics Studies of Pipecolisporin: A Novel Cyclic Hexapeptide with Potent Therapeutic Potential by Nety Kurniaty, Taufik Muhammad Fakih, Rani Maharani, Unang Supratman, Ace Tatang Hidayat, Nurhidanatasha Abu Bakar, Xiaoshuang Wei

“…In addition to the experimental synthesis, computational studies were conducted to analyze the interaction of pipecolisporin with key malaria-related enzymes, such as dihydrofolate reductase, plasmepsin V, and lactate dehydrogenase. …”
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Impact of copper stress in the intestinal barriers and gut microbiota of Chinese stripe-necked turtle (Mauremys sinensis) by Zeeshan Ali, Ijaz Khan, Muhammad Shahid Iqbal, Haitao Shi, Li Ding, Meiling Hong

“…The mRNA expression level of bacteriostatic enzymes significantly reduced. Furthermore, This study found that copper exposure increases gut permeability by suppressing tight junction genes and triggers an inflammatory response in the gut, as indicated by elevated inflammatory cytokines. …”
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In silico comparative genomic analysis unravels a new candidate protein arsenal specifically associated with Fusarium oxysporum f. sp. albedinis pathogenesis by Hafida Ayada, Boutayna Dhioui, Hamid Mazouz, Abdelhay El harrak, Fatima Jaiti, Bouchra Ouhmidou, Mohammed Diouri, Mohieddine Moumni

“…Further analysis of secreted CAZymes revealed an arsenal of enzymes involved in plant cell wall degradation. This arsenal includes an exclusively Foa-specific CAZyme (GH5-7). …”
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Ugochukwu, Oliver Ukachi by Maduabuchi , Patrick Aja, Chukwu, Chinecherem Adanna, Okechukwu, Ugwu Paul Chima, Anthony, Boniface Ale, Chinedu , Peter Agu, Deusdedi, Tusubira, Chukwu, Darlington C, Onyedika, Gabriel Ani, Ugbala, Ezebuilo Ekpono, Akobi , Hilary Ogwoni, Awoke , Joshua Nonso, Ogbu, Patience N, Aja, Lucy, Orji, Obasi Uche, Nweke, Chinoso Peter, Egwu, Chinedu, Ekpono, Ejike Ugbala, Ewa, Gift Onyinyechi, Igwenyi, Ikechuku Okorie, Esther, Alum Ugo, Uti, Daniel Ejim, Offor, Christian Emeka, Ifie, Josiah E., Njoku, Amaobichukwu, Kenneth, Ekenechukwu, Ejike, Daniel Eze

“…Malondialdehyde, liver enzymes, reactive oxygen species, total bilirubin, and direct bilirubin levels were all significantly elevated by BPA (p 0.05). …”
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Elevated Liver Function Tests as Predictors of Severe Maternal Outcomes in Women with Preeclampsia by Sadia Chaudhary, Hafiza Ateeqa Mubarak, Anila Sabir, Hina Sadaf, Anas Khalil, Zahid Mahmood, Marium Shoukat, Farah Naz Tahir

“… Background: Preeclampsia is a hypertensive disorder of pregnancy that ultimately led to high mortality and morbidity due to its complication HELP (Hemolysis, Elevated Liver Enzymes, and Low Platelet count), syndrome, and its association with elevated liver function tests. …”
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Immediate management of a cirrhosis-induced severe pericardial effusion: a case report and review of the literature by Maryam Taheri, Arash Hassanpour Dargah, Pedram Ramezani, Mohsen Anafje, Amir Nasrollahizadeh, Pouya Ebrahimi, Mohammad Hossein Mandegar

“…Laboratory tests indicated severe hepatic and renal dysfunction, with elevated liver enzymes, bilirubin, and blood urea nitrogen. Imaging studies, including electrocardiogram, computed tomography angiography, and transthoracic echocardiogram, confirmed large pericardial effusion with signs of cardiac tamponade. …”
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