LIVER DISEASE & SICKLE CELL DISEASE: AUTOIMMUNE HEPATITIS MORE THAN A COINCIDENCE; A SYSTEMATIC LITERATURE REVIEW. by Kelvin Lynch, Andrea Mega, Andrea Piccin, Massimo Daves, Helen Fogarty

“…More than 50% of SCD patients have elevated liver enzymes. Common underlying aetiologies include sickle cell hepatic crisis, viral hepatitis, sickle cell intrahepatic cholestasis and hepatic sequestration in the acute setting, and cholelithiasis and iron overload in the chronic setting. …”
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Topological transformation of microbial proteins into iron single-atom sites for selective hydrogen peroxide electrosynthesis by Xiaofeng Xiao, Zechao Zhuang, Shuhu Yin, Jiexin Zhu, Tao Gan, Ruohan Yu, Jinsong Wu, Xiaochun Tian, Yanxia Jiang, Dingsheng Wang, Feng Zhao

“…These moieties resemble the structural features of nonheme Fe-dependent enzymes while being effectively confined on a microbe-derived, electrically conductive carbon support, enabling high-current density electrolysis. …”
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How Antiretroviral Drug Concentrations Could Be Affected by Oxidative Stress, Physical Capacities and Genetics: A Focus on Dolutegravir Treated Male PLWH by Jessica Cusato, Anna Mulasso, Micol Ferrara, Alessandra Manca, Guido Accardo, Alice Palermiti, Miriam Antonucci, Gianluca Bianco, Francesco Chiara, Jacopo Mula, Maria Cristina Tettoni, Simone Cuomo, Giulia Trevisan, Stefano Bonora, Giovanni Di Perri, Corrado Lupo, Alberto Rainoldi, Antonio D’Avolio

“…ROS influence the expression of gene-encoding enzymes and transporters involved in drug biotransformation. …”
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Cardiometabolic Risk in Hyperlipidemic Men and Women by Michael Leutner, Christian Göbl, Alice Wielandner, Eleonora Howorka, Marlies Prünner, Latife Bozkurt, Jürgen Harreiter, Helmut Prosch, Oliver Schlager, Silvia Charwat-Resl, Alexandra Kautzky-Willer

“…HL-women were older and had overall more favourable concentrations of lipid parameters and liver enzymes but did not differ regarding vascular morphology and insulin sensitivity compared to HL-men of comparable body mass index (BMI).…”
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Impact of a Carvacrol Treatment on Post-Harvest Ripening Quality and Cell Wall Metabolism in the Kiwifruit by Donglan Luo, Xiaogang Wang, Tingting Mi, Jianye Chen, Liangjie Ba, Sen Cao

“…A correlation analysis shows that firmness is highly and negatively correlated with the cell wall degrading enzymes PG, PME, β-Gal, Cx, and α-L-Af, with R values of −0.88, −0.83, −0.98, −0.94, and −0.93, respectively. …”
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Protein hydrolysates of niosome-encapsulated skipjack (Katsuwonus pelamis) viscera: Antioxidant, anticancer, and release properties by Shima Kaveh, Alireza Sadeghi Mahoonak, Vahid Erfani-Moghadam, Mohammad Ghorbani, Aliakbar Gholamhosseinpour, Mojtaba Raeisi

“…So, this study aimed to produce skipjack viscera protein hydrolysates (FPH) using different enzymes (pancreatin, alcalase, trypsin, and pepsin) at different hydrolysis times. …”
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Eco-Friendly Extraction of Phlorotannins from <i>Padina pavonica</i>: Identification Related to Purification Methods Towards Innovative Cosmetic Applications by Moustapha Nour, Valérie Stiger-Pouvreau, Alain Guenneguez, Laurence Meslet-Cladière, Stéphane Cérantola, Ahmed Ali, Gaelle Simon, Abdourahman Daher, Sylvain Petek

“…All fractions were also evaluated for their anti-ageing potential by assessing their ability to inhibit two vital skin-ageing enzymes, tyrosinase and elastase. Structural analysis by ¹H-¹³C HMBC NMR and LC-MS revealed a selectivity of phlorotannins depending on the purification methods. …”
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Abnormalities in mitochondrial energy metabolism induced by cryopreservation negatively affect goat sperm motility by Shengqin Zang, Shuqi Zou, Xiangyi Chen, Bo Pan, Ao Ning, Jianpeng Qin, Yaozong Wei, Kunlin Du, Jiangfeng Ye, Qiuxia Liang, Yi Fang, Qiongla, Cirenlamu, Tianzeng Song, Tianzeng Song, Guangbin Zhou

“…In addition, the activity of key rate-limiting enzymes involved in very long-chain fatty acid biosynthesis and β-oxidation—specifically acetyl-CoA carboxylase, fatty acid synthase, and carnitine palmitoyltransferase I related to capric acid metabolism—was considerably reduced. …”
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Native Microbiota of Rapeseed Cake as Potential Source of Industrial Producers by Olga P. Sverdlova, Elizaveta V. Podshivalova, Natalya Yu. Sharova, Daria D. Belova

“…The obtained isolates could be of interest as industrial producers of useful metabolites, e.g., enzymes, pigments, organic acids, etc. Further research will identify the microbial species, their useful properties, and optimal cultivation conditions.…”
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A Structural Effect of the Antioxidant Curcuminoids on the Aβ(1–42) Amyloid Peptide by Angelo Santoro, Antonio Ricci, Manuela Rodriquez, Michela Buonocore, Anna Maria D’Ursi

“…Antioxidants like curcumin, a derivative of Curcuma longa, help mitigate ER stress by scavenging ROS and enhancing antioxidant enzymes. Furthermore, evidence in the literature highlights the effect of curcumin on the secondary structure of Aβ(1–42). …”
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Recovery of Prenatal Baicalein Exposure Perturbed Reproduction by Postnatal Exposure of Testosterone in Male Mice by Sridevi Vaadala, Naveen Ponneri, Venkata Shashank Karanam, Sri Bhashyam Sainath, Pamanji Sreenivasuala Reddy, Ramachandra Reddy Pamuru, Arifullah Mohammed

“…A downward trend was observed in testicular steroidogenic marker enzymes (3β- and 17β-steroid dehydrogenases) and serum testosterone, whereas increase in serum titers of FSH and LH along with altered the testicular histology. …”
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CRISPR-based epigenetic editing of Gad1 improves synaptic inhibition and cognitive behavior in a Tauopathy mouse model by Lei Wan, Ping Zhong, Pei Li, Yong Ren, Wei Wang, Mingjun Yu, Henry Y. Feng, Zhen Yan

“…We confirmed that GABA synthesizing enzymes, GAD1 and GAD2, were significantly downregulated in prefrontal cortex (PFC) of AD human postmortem tissues. …”
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Hydrogen Sulfide Increases Nitric Oxide Production and Subsequent S-Nitrosylation in Endothelial Cells by Ping-Ho Chen, Yaw-Syan Fu, Yun-Ming Wang, Kun-Han Yang, Danny Ling Wang, Bin Huang

“…Therefore, NO did not reciprocally increase the expression of H2S-generating enzymes and the H2S level. The present study provides an integrated insight of cellular responses to H2S and NO from protein expression to gaseous molecule generation, which indicates the upstream role of H2S in modulating NO production and protein S-nitrosylation.…”
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Chemoproteomic analysis of the promising candidate molecule of the indole derivative with lab code SV-1010 and other non-steroidal anti-inflammatory drugs by Pavel A. Galenko-Yaroshevsky, Ivan Yu. Torshin, Andrey N. Gromov, Ivan A. Reyer, Olga A. Gromova, Tereza R. Glechyan, Konstantin F. Suzdalev, Andrey V. Zadorozhniy, Anait V. Zelenskaya

“…SV-1010 can activate Cannabinoid CB2 receptors, inhibit enzymes of leukotriene biosynthesis, CC receptors of pro-inflammatory chemokines and leukotrienes. …”
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The Function of SUMOylation and Its Role in the Development of Cancer Cells under Stress Conditions: A Systematic Review by Qi Zhao, Ying Ma, Zugui Li, Kexin Zhang, Minying Zheng, Shiwu Zhang

“…SUMOylation is a dynamic process finely regulated by SUMOylation enzymes and proteases to maintain a balance between SUMOylation and deSUMOylation. …”
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Probiotic Potential of Lactobacillus Strains with Antifungal Activity Isolated from Animal Manure by Soundharrajan Ilavenil, Hyung Soo Park, Mayakrishnan Vijayakumar, Mariadhas Valan Arasu, Da Hye Kim, Sivanesan Ravikumar, Ki Choon Choi

“…Further, the production of extracellular proteolytic and glycolytic enzymes, survival under low pH, bile salts, and gastric juice together with positive bile salt hydrolase (Bsh) activity, cholesterol lowering, cell surface hydrophobicity, and aggregation properties were the strains advantages. …”
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Adaptation of Archaeal Communities to Summer Hypoxia in the Sediment of Bohai Sea by Xiaoxiao Guo, Yanying Li, Guisheng Song, Liang Zhao, Jing Wang

“…The enrichment of specific nitrogen transformation enzymes showed the potential for nitrogen fixation and removal, which might contribute to the balance of N budget and thus facilitate the ecological restoration under eutrophication in Bohai Sea. …”
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A Snake Venom-Secreted Phospholipase A2 Induces Foam Cell Formation Depending on the Activation of Factors Involved in Lipid Homeostasis by Elbio Leiguez, Karina Cristina Giannotti, Mariana do Nascimento Viana, Márcio Hideki Matsubara, Cristina Maria Fernandes, José Maria Gutiérrez, Bruno Lomonte, Catarina Teixeira

“…Pharmacological interventions evidenced that PPAR-γ, PPAR-β/δ, and CD36 as well as the endoplasmic reticulum enzymes ACAT and DGAT are essential for LD formation. …”
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Discovery of two novel Flavobacterium species with potential for complex polysaccharide degradation by Xu-Dong Lian, Yong Guan, Yue Jiang, Dong-Heui Kwak, Mi-Kyung Lee, Zhun Li

“…Additional investigations using the dbCAN and dbCAN-PUL databases identified the presence of carbohydrate-hydrolyzing enzymes (CAZymes) and polysaccharide utilization loci (PULs) within these strains, suggesting their potential to degrade various polysaccharides. …”
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Ester derivatives of Dictyostelium differentiation-inducing factors exhibit antibacterial activity, possibly via a prodrug-like function by Katsunori Takahashi, Haruhisa Kikuchi, Takehiro Nishimura, Hirotaka Ishigaki, Yusuke Miura, Ayuko Takahashi, Yuzuru Kubohara

“…The results suggest that suitable ester modifications could enhance the in vivo antibacterial potential of DIF compounds, particularly if they can bypass HSA binding and be activated by bacterial enzymes.…”
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