The Role of Phospholipase C Signaling in Macrophage-Mediated Inflammatory Response by Liqian Zhu, Clinton Jones, Gaiping Zhang

“…Phospholipase C (PLC) is a family of enzymes that hydrolyze phospholipids, the most significant of which is phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]. …”
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OZONE IMPROVES AUTOGENOUS GRAFT HEALING IN EXPERIMENTAL DIABETES MELLITUS: A MORPHOMETRIC AND IMMUNOHISTOCHEMICAL STUDY by Aysan Lektemür Alpan, Hülya Toker, Hatice Özer

“…Ozone have several actions such as antimicrobial ,immunostimulating, antihypoxic effects, and activates antioxidant enzymes and angiogenesisAim: The aim of this study is to investigate the effect of gaseous ozone on bone healing in diabetic rat calvarial defects treated with autogenous bone graft, morphometrically and immunohistochemically.Material and Methods: Diabetes was induced and critical size defects were created on rats. …”
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The conserved wobble uridine tRNA thiolase Ctu1 is required for angiogenesis and embryonic development. by Yangziwei Yu, Chuqiao Wang, Yan Wang, Heng Shi, Huiyuan Hu, Yibin Du, Zhaoli Zhou

“…CTU2 serves as a scaffold protein, while CTU1 catalyzes the 2-thiolation at the 34th wobble uridine of the anticodon loop. tRNAGlnUUG, tRNAGluUUC, and tRNALysUUU are the tRNA substrates that are modified with a thiol group at the C2 positions (s2) by CTU1, and also with a methoxycarbonylmethyl group at the C5 positions (mcm5) by Elongator and ALKBH8. mcm5s2U34 modification of the three tRNAs, and their modifying enzymes are involved in human disease and development. …”
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Efficacy and Safety of Tracnil™ Administration in Patients with Dermatological Manifestations of PCOS: An Open-Label Single-Arm Study by Ezhil Arasan Ramanan, Sailatha Ravi, K. R. Radha Anbu, Margaret Michael

“…Inositol and associated molecules display inhibitory properties against 5-α reductase, COX-2, and lipase enzymes in addition to their antimicrobial and anti-inflammatory properties. …”
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Geranylgeraniol (GGOH) as a Mevalonate Pathway Activator in the Rescue of Bone Cells Treated with Zoledronic Acid: An In Vitro Study by Riham M. Fliefel, Saleh A. Entekhabi, Michael Ehrenfeld, Sven Otto

“…Nitrogen-containing BPs (N-BPs) as zoledronate (ZA) act by the inhibition of specific enzymes of the mevalonate pathway resulting in altering protein prenylation which is required for the posttranslational maturation of the small GTP-binding proteins. …”
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Acute Liver Failure among Patients on Efavirenz-Based Antiretroviral Therapy by Innocent Lule Segamwenge, Miriam Kaunanele Bernard

“…The key message to note is that frequent monitoring of liver enzymes should be done at initiation of antiretroviral therapy and should continue throughout the treatment period.…”
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Dietary Effects of Probiotic Bacteria, Bacillus amyloliquefaciens AV5 on Growth, Serum and Mucus Immune Response, Metabolomics, and Lipid Metabolism in Nile Tilapia (Oreochromis ni... by Vicent Michael Shija, Glory Emanuel Zakaria, Kwaku Amoah, Li Yi, Junwei Huang, Fortunatus Masanja, Zhong Yong, Jia Cai

“…In addition, in the G1 and G2 groups, higher levels of enzymes involved in lipid metabolism, such as pyruvate kinase, 2-hydroxyethyl-ThPP, and dihydrolipoamide dehydrogenase, were increased. …”
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CUL4-Based Ubiquitin Ligases in Chromatin Regulation: An Evolutionary Perspective by Makiko Nakagawa, Tadashi Nakagawa

“…It is orchestrated by the concerted action of three types of enzymes, with substrate specificity governed by ubiquitin ligases (E3s), which may exist as single proteins or as part of multi-protein complexes. …”
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Molecular Characterization of Methicillin Resistant and Extended Spectrum ?-Lactamase Staphylococcus aureus Isolated from Burn Patients by Shawnm Ahmed Aziz

“…PCR based molecular technique was done for the bla genes related to ?- lactamase enzymes by the specific primers, as well as genes which related to reduced sensitivity to Vancomycin were detected. …”
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Casein Kinases 2-dependent phosphorylation of the placental ligand VAR2CSA regulates Plasmodium falciparum-infected erythrocytes cytoadhesion. by Dominique Dorin-Semblat, Jean-Philippe Semblat, Romain Hamelin, Anand Srivastava, Marilou Tetard, Graziella Matesic, Christian Doerig, Benoit Gamain

“…Mass spectrometry analysis of recombinant VAR2CSA phosphorylated by recombinant Human and P. falciparum CK2α combined with site-directed mutagenesis led to the identification of residue S1068 in VAR2CSA, which is phosphorylated by both enzymes and is associated with CSA binding. Furthermore, using CRISPR/Cas9 we generated a parasite line in which phosphoresidue S1068 was changed to alanine. …”
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Harnessing marine bacteria for next-gen antibiotics: potent inhibition of S. aureus and Riemerella anatipestifer through in vitro, omics, and chemoinformatics approach with enhance... by Syed Shams ul Hassan, Huizi Jin

“…To investigate the anti-bacterial mechanism, all compounds were docked with two enzymes and TLR4 protein for predicting the vaccine construct, and the best docking score was achieved against RMFP with the highest score of -12.9 for compound 4. …”
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Pathogenic Process-Associated Transcriptome Analysis of Stemphylium lycopersici from Tomato by Dezhen Zhang, Wenjuan Chi, Cuicui Wang, Huijie Dai, Jintang Li, Chunlei Li, Fajun Li

“…Additionally, some genes involved in signal regulation or encoding hemicellulose- and cellulose-degrading enzymes and extracellular proteases were commonly upregulated during pathogenesis. …”
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A Study of the Different Strains of the Genus <i>Azospirillum</i> spp. on Increasing Productivity and Stress Resilience in Plants by Wenli Sun, Mohamad Hesam Shahrajabian, Na Wang

“…The most important modes of action of bacterial plant biostimulants on different plants are increasing disease resistance; activation of genes; production of chelating agents and organic acids; boosting quality through metabolome modulation; affecting the biosynthesis of phytochemicals; coordinating the activity of antioxidants and antioxidant enzymes; synthesis and accumulation of anthocyanins, vitamin C, and polyphenols; enhancing abiotic stress through cytokinin and abscisic acid (ABA) production; upregulation of stress-related genes; and the production of exopolysaccharides, secondary metabolites, and ACC deaminase. …”
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USING THE METHODS OF SYSTEMS BIOLOGY FOR PREDICTING PERSPECTIVE TARGET GENES TO SELECT C3 AND C4 CEREALS FOR OXIDATIVE STRESS RESISTANCE by A. V. Doroshkov, A. V. Bobrovskikh

“…However, the biochemical components of the system are redundant, for each reaction is catalyzed by a series of enzymes encoded by different genes. Choosing the most perspective components of this system will help speed up evaluating the optimal breeding strategy for improving abiotic stress tolerance in economically valuable plants. …”
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Protective Effects of Garlic and Cinnamon Oils on Hepatocellular Carcinoma in Albino Rats by Salah M. Aly, Hamdy A. Fetaih, Abeer A. I. Hassanin, Mosleh M. Abomughaid, Aliaa A. Ismail

“…The HCC-induced group showed a significant decrease in the body mass and a significant elevation in the liver weight, alpha-fetoprotein (AFP), liver enzymes, hepatic malondialdehyde (MDA), and p53 protein expression levels as well as genetic mutations in intron 5 of p53 gene in the form of Single-Nucleotide Polymorphisms (SNPs) and insertions. …”
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Selective cultivation of bacterial strains with lipolytic and hydrocarbon-oxidizing activity from bottom sediments of the Ob River, Western Siberia by A. I. Gerasimchuk, D. A. Ivasenko, A. A. Kasymova, Yu. A. Frank

“…The aim of this work was to isolate and study pure cultures of microorganisms – producers of industrially important enzymes and decomposers of organic matter – from bottom sediments of the Ob River. …”
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Research progress on the therapeutic roles and mechanisms of hydrogen-rich water in periodontitis by LIU Fushuang, WEI Xiaoxuan, ZHOU Jianpeng, WANG Jun

“…Additionally, HRW can alleviate periodontal tissue damage by inhibiting oxidative stress and up-regulating the expression of antioxidant enzymes, such as glutathione peroxidase and superoxide dismutase. …”
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Asymptomatic Hyperuricemia Is Associated with Achilles Tendon Rupture through Disrupting the Normal Functions of Tendon Stem/Progenitor Cells by Jingjing Liang, Biao Chen, Yanmei Li, Daibang Nie, Changbin Lei, Qing Yang, Yiqin Zhou, Shenglong Li, Shuaizhi Chen, Bin Li, Lin Shu, Liaobin Chen, Wang Wang

“…In vitro study demonstrated that uric acid (UA) dose dependently reduced rat Achilles TSPC viability, decreased the expressions of tendon collagens, and deformed their structural organization while significantly increased the transcript levels of matrix degradative enzymes and proinflammatory factors. Consistently, marked disruptions in Achilles tendon tissue structural and functional integrity were found in a rat model of hyperuricemia, together with enhanced immune cell infiltration. …”
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Is polymyositis a rare or over-diagnosed entity? A descriptive follow-up study of patients initially admitted in a tertiary center with the diagnosis of polymyositis by Pablo Arturo Olivo Pallo, Matheus Santos Rodrigues Silva, Fernando Henrique Carlos de Souza, Samuel Katsuyuki Shinjo

“…Twenty-two of 30 patients with PM continued follow-up in our service, all with clinical remission or complete clinical response, full recovery of muscle strength, and normalization of the serum levels for muscle enzymes. Conclusions: Patients with PM should be reevaluated constantly, as PM can mimic other muscle diseases. …”
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Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome in a Child with Cystic Fibrosis by Ahmed Abushahin, Haneen Toma, Sara G. Hamad, Mutasim Abu-Hasan

“…Blood tests showed high eosinophilia, high C-reactive protein (CRP), and high liver enzymes levels. The clinical features and the laboratory findings were consistent with the DRESS syndrome. …”
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