N-3 Polyunsaturated Fatty Acids Stimulate Bile Acid Detoxification in Human Cell Models by Anna Cieślak, Jocelyn Trottier, Mélanie Verreault, Piotr Milkiewicz, Marie-Claude Vohl, Olivier Barbier

“…Gene expression analyses of HepG2 cells reveal that n-3 PUFAs reduce the expression of genes involved in BA synthesis (CYP7A1, CYP27A1) and uptake (NTCP), while activating genes encoding metabolic enzymes (SULT2A1) and excretion transporters (MRP2, MRP3). …”
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Plant Colonization by Biocontrol Bacteria and Improved Plant Health: A Review by Roohallah Saberi Riseh, Fariba Fathi, Mozhgan Gholizadeh Vazvani, Mika Tapio Tarkka

“…Also, the present review attempts to explore the mechanisms facilitating bacterial movement within the plant such as migrating through interconnected spaces such as vessels or in the apoplast, and applying quorum sensing or extracellular enzymes during colonization and what is needed to establish a long-term association within a plant. …”
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Molecular identification of chitinase and its function in growth of Odontobutis potamophila by Siyu Lu, Lin Du, Ting Zhang, Dan Wang, Jinjuan Wan, Guoxing Liu, Yuning Hu, Yu Xu, Zhiqiang Xu, Xuguang Li

“…Chitinases are pivotal enzymes for the degradation of chitin, which play a role in food digestion. …”
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Megoura crassicauda promote the ability of Vicia faba L. to remediate cadmium pollution of water and soil by Sijing Wan, Shasha Wang, Yan Li, Yexin Xie, Qimei Li, Yinjie Fang, Zhenjuan Yin, Shigui Wang, Yifan Zhai, Bin Tang

“…We also found that prolonged Cd treatment increased the activities of stress-related antioxidant enzymes in fava beans, including superoxide dismutase, peroxidase, and malondialdehyde. …”
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Lipid-lowering Efficacy of Plant Proteins and Their Application Potential by Yue WANG, Chunhua GUAN, Hong BI, Fengyating WU, Yanqin SHEN, Liang TAO, Yang TIAN

“…To consolidate the evidence on the lipid-lowering impacts of dietary plant proteins both in vivo and in vitro, summarizes the effects of amino acid composition of glycine, arginine, leucine and other amino acids in proteins on the lipid-lowering effects, discusses their lipid-lowering mechanisms by several pathways, such as adsorption of bile acid and cholesterol in the gut tract, enhancement/inhibition of rate-limiting enzymes in the processes of cholesterol synthesis, fatty acid oxidation, and the conversion of cholesterol to bile acids, modulation of the pathways related to PPAR signaling, cholesterol absorption and lipid synthesis gene expression, and improves the composition of gut microorganisms and metabolites to explore its lipid-lowering mechanism. …”
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<i>Garcinia brasiliensis</i> Leaves Extracts Inhibit the Development of Ascitic and Solid Ehrlich Tumors by Lucas Sylvestre Silva, Eduardo Cavallini, Rafael André da Silva, Monielle Sant’Ana, Ariane Harumi Yoshikawa, Thiago Salomão, Bianca Huang, Paula Craice, Luiz Philipe de Souza Ferreira, Heitor Pedro Della Matta, Cristiane Damas Gil, Maria de Lourdes Gomes Pereira, Ana Paula Girol

“…In relation to tumor-induced animals, morphological changes, plasma enzymes, inflammatory mediators and the induction of apoptosis were analyzed, in addition to histopathological studies, to evaluate the inhibition of tumor growth. …”
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Structural Characteristics and Inhibiting Oxidative Stress of Nine-steaming-nine-processing Polygonatum Kingianum Coll.et Hemsl Polysaccharides by LIU Yu-bin, CHEN Chang-an, SU Yi-lin, LUO Zhen, YAN Jin, LI Pan, DU Bing

“…It also upregulated antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH), alleviating oxidative stress induced by free fatty acids. …”
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Antidiabetic Activity of Benzopyrone Analogues in Nicotinamide-Streptozotocin Induced Type 2 Diabetes in Rats by Yogendra Nayak, Venkatachalam Hillemane, Vijay Kumar Daroji, B. S. Jayashree, M. K. Unnikrishnan

“…There was significant normalisation of liver antioxidant enzymes compared to diabetic rats indicating that all the synthesised benzopyrone analogues are beneficial in reducing oxidative stress and are on par with the standard quercetin and glibenclamide in experimental T2D.…”
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Thiopurines Induce Oxidative Stress in T-Lymphocytes: A Proteomic Approach by Misbah Misdaq, Sonia Ziegler, Nicolas von Ahsen, Michael Oellerich, Abdul R. Asif

“…Immunoblot analyses showed treatment altered expression of key antioxidant enzymes (i.e., SOD2 and catalase) in both wt and kd groups, while SOD1 was downregulated by 6-TG treatment and TPMT knockdown. …”
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Transcriptome Analysis of <i>Stephania yunnanensis</i> and Functional Validation of CYP80s Involved in Benzylisoquinoline Alkaloid Biosynthesis by Wenlong Shi, Qishuang Li, Xinyi Li, Linglong Luo, Jingyi Gan, Ying Ma, Jian Wang, Tong Chen, Yifeng Zhang, Ping Su, Xiaohui Ma, Juan Guo, Luqi Huang

“…Based on this analysis, we identified three CYP80 enzymes (SyCYP80Q5-1, SyCYP80Q5-3, and SyCYP80G6), which exhibited different activities toward (<i>S</i>)- and (<i>R</i>)-configured substrates in <i>S. yunnanensis</i> and demonstrated strict stereoselectivity enroute to aporphine. …”
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Dietary Capsaicin Supplementation Mitigates Calving-Induced Stress and Enhances Antioxidant Capacity, Immune Function, and Gut Microbiota in Periparturient Dairy Cows by Hangfan Li, Zibin Wu, Baisheng Yu, Jinyuan Chen, Chuang Yang, Yongqing Guo, Baoli Sun

“…Results showed that capsaicin significantly reduced milk somatic cell count and pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) while enhancing serum antioxidant enzymes (SOD, GSH-Px, and CAT) and immunoglobulin levels (IgG, IgA, and IgM). …”
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Clinical diagnosis of Q fever by targeted next-generation sequencing for identification of Coxiella burnetii by Shaohua Zhan, Haoyuan Jin, Hanbing Ji, Xin Hou, Jing Li, Ye Zhang, Jiajia Zheng, Liyan Cui

“…Although blood cultures were negative, elevated infection markers (CRP, PCT, and ferritin) and liver enzymes (ALT, AST, GGT, ALP, and LDH) were observed. …”
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X-linked ubiquitin-specific peptidase 11 (USP11) increases susceptibility to Cushing’s disease in women by Tao Zhang, Yanting Liu, Fang Liu, Kaiyu Guo, Runhua Tang, Jingwei Ye, Li Xue, Zhipeng Su, Zhe Bao Wu

“…In this study, we analyzed the expression of deubiquitinating enzymes in functioning ACTH PitNETs from both male and female subjects using RNA sequencing and identified USP11 as a potential susceptibility factor contributing to the higher prevalence of these PitNETs in females. …”
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Anti-Glycemic and Anti-Hepatotoxic Effects of Mangosteen Vinegar Rind from Garcinia mangostana Against HFD/STZ-Induced Type II Diabetes in Mice by Karim Naymul, Jeenduang Nutjaree, Tangpong Jitbanjong

“…After the treatment, lipid profile, glycogen and bilirubin contents, oxidative damage (malondialdehyde, MDA), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities, antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT) were measured in plasma and/or liver tissues. …”
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Effects and Impact of Selenium on Human Health, A Review by Song Bai, Miaohe Zhang, Shouying Tang, Miao Li, Rong Wu, Suran Wan, Lijun Chen, Xian Wei, Shuang Feng

“…As a key component of various enzymes and proteins, selenium primarily exerts its biological functions in the form of selenoproteins within the body. …”
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The Impact of Root Temperature on Photosynthesis and Isoprene Emission in Three Different Plant Species by Mauro Medori, Lucia Michelini, Isabel Nogues, Francesco Loreto, Carlo Calfapietra

“…In the green house experiments where the warming corresponded with high stress conditions, as confirmed by higher activities of the main antioxidant enzymes, we found that isoprene uncoupled from photosynthesis at a certain stage of the warming treatment and that even when photosynthesis approached to zero isoprene emission was still ongoing. …”
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Dietary Fiber with Functional Properties Counteracts the Thwarting Effects of Copper Nanoparticles on the Microbial Enzymatic Activity and Short-Chain Fatty Acid Production in the... by Jerzy Juśkiewicz, Bartosz Fotschki, Anna Stępniowska, Ewelina Cholewińska, Dorota Napiórkowska, Aleksandra Marzec, Łucja Brzuzan, Joanna Fotschki, Ewa Żary-Sikorska, Katarzyna Ognik

“…The activity of bacterial enzymes and short-chain fatty acids (SCFA) production were analyzed in the excreted feces collected on subsequent days of feeding. …”
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Metabolic and Genetic Determinants of Lipid Metabolism Disruption in Non-Alcoholic Fatty Liver Disease by O. Yu. Kytikova, T. P. Novgorodtseva, Yu. K. Denisenko, D. A. Kovalevsky

“…The regulation of fatty acid metabolism involves enzymes desaturase (FADS1, FADS2) and elongase (ELOVL2 and ELOVL5) fatty acids. …”
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Pomegranate Juices: Analytical and Bio-Toxicological Comparison of Pasteurization and High-Pressure Processing in the Development of Healthy Products by Francesco Cairone, Stefania Cesa, Irene Arpante, Simonetta Cristina Di Simone, Alejandro Han Mendez, Claudio Ferrante, Luigi Menghini, Antonello Filippi, Caterina Fraschetti, Gokhan Zengin, Simone Carradori, Marialucia Gallorini, Luisa Mannina, Mattia Spano

“…The potential inhibition of key enzymes of degenerative processes (cholinesterases, tyrosinase) and diabetes (amylase, glucosidase), the allelopathy toward <i>Cichorium intybus</i>, <i>Dicondra repens</i>, and <i>Diplotaxis tenuifolia</i>, and the in vivo toxicity on brine shrimp were also evaluated. …”
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Pretreatment of Small-for-Size Grafts In Vivo by γ-Aminobutyric Acid Receptor Regulation against Oxidative Stress-Induced Injury in Rat Split Orthotopic Liver Transplantation by Tomohide Hori, Shinji Uemoto, Lindsay B. Walden, Feng Chen, Ann-Marie T. Baine, Toshiyuki Hata, Justin H. Nguyen

“…Immunohistological assessment for apoptotic induction and western blotting for 4-hydroxynonenal, ataxia-telangiectasia mutated kinase (ATM), histone H2AX, phosphatidylinositol-3 kinase (PI3K), Akt, and free radical scavenging enzymes were performed. Results. Pretreatment by GABAR showed improvement in survival, histopathological assessment, and biochemical tests. …”
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