A Possible Novel Anti-Inflammatory Mechanism for the Pharmacological Prolyl Hydroxylase Inhibitor 3,4-Dihydroxybenzoate: Implications for Use as a Therapeutic for Parkinson’s Disea... by Shankar J. Chinta, Subramanian Rajagopalan, Abirami Ganesan, Julie K. Andersen

“…Previously we demonstrated that pharmacological inhibition of a class of enzymes known as prolyl hydroxylases via 3,4-dihydroxybenzoate administration protected against MPTP-induced neurotoxicity, however the exact mechanisms involved were not elucidated. …”
Get full text

Dyslipidemia and Fatty Liver Disease in Overweight and Obese Children by Asma Deeb, Salima Attia, Samia Mahmoud, Ghada Elhaj, Abubaker Elfatih

“…Fasting lipid, liver transaminases, and ultrasound scans (US) for those with elevated enzymes were performed. Descriptive statistics were used for quantitative parameters. …”
Get full text

CAPS markers in plant biology by Y. N. Shavrukov

“…CAPS markers are based on PCR amplification of DNA fragments with specific primers followed by digestion with restriction enzymes and separation of the products in agarose gel. …”
Get full text

Dysmorphic Facial Features and Other Clinical Characteristics in Two Patients with PEX1 Gene Mutations by Mehmet Gunduz, Ozlem Unal

“…Case II was 2.5-year-old girl referred for investigation of global developmental delay and elevated liver enzymes. Ophthalmologic examination findings were consistent with bilateral nystagmus and retinitis pigmentosa. …”
Get full text

Triterpene esters from Uncaria rhynchophylla hooks as potent HIV-1 protease inhibitors and their molecular docking study by JiSuk Lee

“…These compounds exhibited potent inhibition of HIV-1 protease (PR), one of the essential enzymes in the virus’s life cycle, with 3β-hydroxy-27-p-Z-coumaroyloxyurs-12-en-28-oic acid (8) showing the most potent inhibitory activity. …”
Get full text

Regulation of modular Cyclin and CDK feedback loops by an E2F transcriptionoscillator in the mammalian cell cycle by Orit Lavi, Doron Ginsberg, Yoram Louzoun

“…The cell cycle is regulated by a large number of enzymes and transcription factors. We have developed a modular description of the cell cycle, based on a set of interleaved modular feedback loops, each leading to a cyclic behavior. …”
Get full text

Surgical Removal of a Canine Aortic Thromboembolism Secondary to Pancreatitis by Jill Narak, Emily C. Graff, Katrin Saile, D. Michael Tillson

“…Clinicopathologic analysis revealed increased muscle enzymes and proteinuria. Abdominal ultrasonography confirmed aortic thromboembolism (ATE), and surgical histopathology diagnosed necrotizing pancreatitis. …”
Get full text

Silver Nanoparticles in Antifungal Applications: A Comparison of Biosynthesized and Physical Synthesized Nanoparticles on Paper-Biodegrading Fungi by Akram Kheiri, Parisa Mohammadi, Parinaz Ghadam

“…Background: Paper substrates are highly susceptible to fungal degradation, as fungi produce enzymes that decompose paper materials. This study investigates and compares the antifungal efficacy of silver nanoparticles (AgNPs) synthesized through various physical and biological methods. …”
Get full text

Molecular Circuits of Resolution in the Eye by Elvira L. Liclican, Karsten Gronert

“…A rapidly emerging field has identified key biosynthetic enzymes, receptors, and temporally defined endogenous formation of ω-3– and ω-6–derived protective lipid circuits in the eye. …”
Get full text

The effects of the gut bacterial product, gassericin A, on obesity in mice by Valeh Mahdavi, Hamid Reza Kazerani, Fereidoun Taghizad, Hedyeh Balaei

“…Results A high-calorie diet negatively impacted abdominal fat, serum cholesterol, LDL, and hepatic enzymes. However, gassericin A significantly improved these effects, despite increasing weight gain and abdominal fat. …”
Get full text

Pengaruh Stres Terhadap Pertumbuhan Janin dan Kadar Kortisol Plasma Serum Tikus (Rattus Norvegicus) Bunting yang Terpapar Stressor Renjatan Listrik by Zilfi Yola Pitri, Hirowati Ali, Desmiwarti Desmiwarti

“…Pengumpulan data menggunakan metode Enzym-Linked Immunosorbent Assay (ELISA) dengan mengalirkan arus listrik 25 V, frekuensi 60 Hz selama 14 hari di laboratorium Biomedik Fakultas Kedokteran Universitas Andalas pada bulan Februari – Maret 2019 dengan teknik total sampling menggunakan Uji Independent sample test. …”
Get full text

Structural basis for c-di-GMP-mediated inside-out signaling controlling periplasmic proteolysis. by Marcos V A S Navarro, Peter D Newell, Petya V Krasteva, Debashree Chatterjee, Dean R Madden, George A O'Toole, Holger Sondermann

“…Binding of c-di-GMP to the phosphodiesterase domain disrupts the inactive state, permitting the formation of a trans-subunit dimer interface between adjacent phosphodiesterase domains via interactions conserved in c-di-GMP-degrading enzymes. Efficient mechanical coupling of the conformational changes across the membrane is realized through an extensively domain-swapped, unique periplasmic fold. …”
Get full text

Therapy with Interleukin-22 Alleviates Hepatic Injury and Hemostasis Dysregulation in Rat Model of Acute Liver Failure by Tariq Helal Ashour

“…The following parameters were investigated: (1) survival rate, (2) serum levels of liver function enzymes (aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP)), total bilirubin (TBILI), and total albumen (ALB), (3) blood clotting tests (prothrombin time (PT), activated partial thromboplastin time (aPTT), and fibrinogen level (FIB)) and white blood cells (WBCs), red blood cells (RBCs), and platelet counts, (4) hepatic levels of tumor necrosis factor-α (TNF-α) and cyclooxygenase-2 (COX-2), and (5) liver histopathology. …”
Get full text

Mycosynthesis of zinc sulfide/zinc oxide nanocomposite using Fusarium oxysporum for catalytic degradation of methylene blue dye, antimicrobial, and anticancer activities by Hosam Salaheldin, Aya Aboelnga, Ashraf Elsayed

“…Several analytical techniques, such as XRD, TEM, UV-Vis, FTIR, DLS, and zeta potential studies, have confirmed the synthesis of NPs. Fungal CFF enzymes and metabolites stabilized produced NPs, according to FTIR. …”
Get full text

Exploring the Effects of Imidacloprid on Liver Health and the Microbiome in Rats: A Comprehensive Study by Alaa T. Qumsani

“…Morphological changes were related to disturbances in the activity of liver enzymes, reflecting deteriorating liver function with increased imidacloprid exposure. …”
Get full text

Transgenic plants as a model for studying еpigenetic regulation of gene expression by T. V. Marenkova, E. V. Deineko

“…RNA polymerase V also transcribes the noncoding transcript of the target gene, but it serves as a scaf¬fold that interacts with siRNAs and that recruits proteins and enzymes responsible for DNA and histone methylation. …”
Get full text

Antioxidant peptides encrypted in flaxseed proteome: An in silico assessment by Dawei Ji, Chibuike C. Udenigwe, Dominic Agyei

“…More peptides were released by enzymatic hydrolysis from the globulins than those from oleosins and conlinin. Compared with other enzymes studied, the plant proteases (papain, ficin, and bromelain) were found to be superior to releasing APs from the flaxseed proteins. …”
Get full text

Seroprevalence of Hepatitis C, Hepatitis B, Cytomegalovirus, and Human Immunodeficiency Viruses in Multitransfused Thalassemic Children in Upper Egypt by Ramadan A. Mahmoud, Abdel-Azeem M. El-Mazary, Ashraf Khodeary

“…Seropositivity for anti-HCV, HBsAg, and anti-CMV increased with increasing age of the patients, duration of the disease, serum ferritin level (ng/mL), and liver enzymes (U/L), while it was not significantly associated with gender, frequency of blood transfusion, or the status of splenectomy operation (P>0.05). …”
Get full text

Arabidopsis 3‐Deoxy‐d‐Arabino‐Heptulosonate 7‐Phosphate (DAHP) Synthases of the Shikimate Pathway Display Both Manganese‐ and Cobalt‐Dependent Activities by Ryo Yokoyama, Hiroshi A. Maeda

“…Previous biochemical studies suggested the presence of manganese‐ and cobalt‐dependent DHS enzymes (DHS‐Mn and DHS‐Co, respectively) in various plant species. …”
Get full text

Effect of Dietary Inclusion of Chitosan on Survival and Selected Cellular Antioxidants in <i>Drosophila melanogaster</i> by O.G. Igharo, L.I. Abadaike, J.O. Osunbor, I.C. Owie, A.I. Aruomaren, E.L. Igharo, K.I. Ikeke

“…These results have shown that dietary inclusions of chitosan in various concentrations increased the survival rate of the flies than in control which contained only water and also increase some antioxidant enzymes in the flies than in control. Reduced antioxidant levels have been linked to accelerated aging and conditions leading to death like cancer. …”
Get full text