Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver Disease by Roger F. Butterworth, Ali Canbay

“…L-ornithine L-aspartate (LOLA) has hepatoprotective properties in patients with fatty liver of diverse etiology and results of a multicenter randomized clinical trial reveal that 12 weeks treatment with oral LOLA (6–9 g/d) results in a dose-related reduction in activities of liver enzymes and triglycerides together with significant improvements of liver/spleen CT ratios. …”
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Understanding the impact of triazoles on female fertility and embryo development: Mechanisms and implications by Sonal Sharma, Geeta Pandey

“…The findings suggest that triazoles might negatively affect female fertility and embryonic development through multiple mechanisms including inhibition or interference with key enzymes such as CYP17A1 and CYP19A1 (aromatase) involved in steroid hormone synthesis, endocrine disruption, oxidative stress, disruption of signaling pathways, and apoptosis. …”
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Exploring the Potential of Postbiotics for Food Safety and Human Health Improvement by Folayemi Janet Isaac-Bamgboye, Chiamaka Linda Mgbechidinma, Helen Onyeaka, Ireoluwa Toluwalase Isaac-Bamgboye, Deborah C. Chukwugozie

“…Postbiotics, including organic acids, enzymes, and bacteriocins, exhibit antimicrobial and antioxidant properties that do not require live organisms, and this offers advantages over probiotics. …”
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Application of iron on improving antimony tolerance in Salvia spinosa by Shakiba Rajabpoor, Soghra Kiani, Shokoofeh Hajihashemi

“…The limitation of H2O2 generation in response to co-application of Fe with Sb was followed by counterbalancing the antioxidant enzymes (e.g. catalase, superoxide dismutase and ascorbate peroxidase), phenols, flavonoids, lipid membrane preservation, and increase of the carbohydrates and proteins contents, which altogether improved growth in Sb-stressed plants. …”
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Late-stage changes in the composition of cell walls of maize plants expressing an apoplast targeted, senescence enhanced fungal ferulic acid esterase, and the subsequent effects on... by Marcia M de O Buanafina, Phillip Morris, Sue Dalton, M Fernanda Buanafina, Yijuan Wang

“…The internodes of late stage and senescing FAEA-expressing plants exhibited significantly improved saccharification with a cocktail of cellulase and xylanase enzymes at both the R and R+ stages of development.…”
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Steatotic liver disease diagnosed in a 24-year-old woman with Rett syndrome: a case report by Larissa Albino, Adil Adatia, Aducio Thiesen, Brendan Halloran, Victor Dong, Carlos Moctezuma-Velázquez

“…We herein describe a 24-year-old woman with RTT who was evaluated for abnormal liver enzymes. Imaging revealed hepatic steatosis, and transient elastography showed a controlled attenuation parameter of 342 dB/m and stiffness of 7.1 kPa. …”
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Cytomegalovirus Associated Duodenal Ulcer and Duodenitis in a Malnourished Pediatric Patient by Rachel Bernard, Ghanim Aljomah, Emily Klepper, Elizabeth McDonough

“…While on antiviral treatment, her viral load of 1080 IU/mL trended to resolution and her liver enzymes normalized. The patient was ultimately discharged home demonstrating adequate weight gain via gastrostomy tube feeds. …”
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Implication of Fructans in Health: Immunomodulatory and Antioxidant Mechanisms by Elena Franco-Robles, Mercedes G. López

“…Additionally, fructans are resistant to hydrolysis by human digestive enzymes but can be fermented by the colonic microbiota to produce short chain fatty acids (SCFAs), metabolic by-products that possess immunomodulatory activity. …”
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Anti-Hyperlipidemic Effect of Zinc complex of Betulinic acid in High Fat Diet- Induced Hyperlipidemia by Mehwish Tayyab, Adnan Jehangir, Farhana Ayub, Nimra Ijaz, Sameer Ahmed`, Attiya Munir

“…On the final day terminal sampling was done and serum lipid profile (TG, TC, LDL, HDL) and hepatic enzymes (ALT) for assessing hepatotoxicity were estimated. …”
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The Activity of Metalloproteases and Serine Proteases in Various Organs after Leiurus macroctenus Envenomation by Valery Gunas, Oleksandr Maievskyi, Nataliia Raksha, Tetiana Vovk, Oleksiy Savchuk, Serhii Shchypanskyi, Igor Gunas

“…Scorpion stings may be life-threatening since their venoms are comprised of a wide range of toxins and other bioactive molecules, such as enzymes. At the same time, scorpion envenomation may increase matrix metalloproteases (MMPs) levels, which enhance proteolytic tissue destruction by venom. …”
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Differential Modulation of Annexin I Binding Sites on Monocytes and Neutrophils by H. S. Euzger, R. J. Flower, N. J. Goulding, M. Perretti

“…These binding sites are proteinaceous in nature and are sensitive to cleavage by the proteolytic enzymes trypsin, collagenase, elastase and cathepsin G. …”
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Whole-Body Cryotherapy Decreases the Levels of Inflammatory, Oxidative Stress, and Atherosclerosis Plaque Markers in Male Patients with Active-Phase Ankylosing Spondylitis in the A... by Agata Stanek, Armand Cholewka, Tomasz Wielkoszyński, Ewa Romuk, Aleksander Sieroń

“…Additionally, in the WBC group, we observed a decrease in oxidative stress markers, changes in the activity of some antioxidant enzymes and nonenzymatic antioxidant parameters. In both groups, the total cholesterol and LDL cholesterol, triglycerides, sCD40L, PAPP-A, and PLGF levels decreased, but the parameter changes were higher in the WBC group. …”
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Modulatory effects of Lactiplantibacillus plantarum on chronic metabolic diseases by Lei Tian, Ruixiang Zhao, Xinyi Xu, Zhiwei Zhou, Xiaofang Xu, Dongmei Luo, Zhiqiang Zhou, Yu Liu, Ariel Kushmaro, Robert S. Marks, András Dinnyés, Qun Sun

“…Ingesting L. plantarum demonstrated its ability to reduce inflammatory and oxidative stress levels by regulating the production of cytokines and short-chain fatty acids (SCFAs), the activity of antioxidant enzymes, and the balance of intestinal microbial communities to alleviate the symptoms of chronic metabolic diseases. …”
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Copolyamide-Based Modified Atmosphere Packaging Attenuates Phenolic Degradation and Maintains Postharvest Quality of <i>Rubus</i> Berries by Hafiz Muhammad Shoaib Shah, Zora Singh, Mahmood Ul Hasan, Eben Afrifa-Yamoah, Andrew Woodward

“…Relatively higher levels of glutathione and ascorbic acid as well as the activities of enzymes involved in the ascorbate-glutathione cycle in MA-packed <i>Rubus</i> berries were also observed. …”
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Biochemistry of Bacterial Biofilm: Insights into Antibiotic Resistance Mechanisms and Therapeutic Intervention by Kashish Azeem, Sadaf Fatima, Asghar Ali, Ayesha Ubaid, Fohad Mabood Husain, Mohammad Abid

“…The exploration of combination therapies, involving antimicrobial agents, biofilm-disrupting enzymes, and immunomodulators, is emphasized to enhance the efficacy of existing treatments and overcome biofilm resilience.…”
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Metabolomics combined with physiology and transcriptomics reveal the regulation of key nitrogen metabolic pathways in alfalfa by foliar spraying with nano-selenium by Pengbo Sun, Gentu Ge, Lin Sun, Jian Bao, Muqier Zhao, Junfeng Hao, Yuhan Zhang, Guoshun Liu, Zhijun Wang, Yushan Jia

“…In this study, using the 15N labeling method, it was found that nano-selenium could promote plant nitrogen metabolism and photosynthesis by increasing the light energy capture capacity and the activities of key enzymes of the nitrogen metabolism process, leading to an increase in alfalfa nitrogen accumulation and dry matter content. …”
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Role of proteases in oral carcinogenesis: Insights into the cancer degradome and therapeutic implications by Gargi S. Sarode, Sachin C. Sarode, Urmi Ghone, Rahul Anand

“…Proteases, essential enzymes regulating crucial cellular processes, emerge as promising targets and diagnostic markers in OSCC. …”
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Integration of metabolomic and transcriptomic analyses reveals regulatory functions of the ChREBP transcription factor in energy metabolism by Jie An, Inna Astapova, Guofang Zhang, Andrew L. Cangelosi, Olga Ilkayeva, Hannah Marchuk, Michael J. Muehlbauer, Tabitha George, Joseph Brozinick, Mark A. Herman, Christopher B. Newgard

“…In addition, expression of multiple anaplerotic enzymes is decreased by GalNac-siChREBP treatment, affecting TCA cycle intermediates. …”
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Bioactivity-guided isolation and molecular modeling of the anti-inflammatory constituents from the leaves of Duranta erecta Linn. by Marina Sobhy, Farid N. Kirollos, Sameh F. AbouZid, Nasser S. M. Ismail, Riham A. El-Shiekh, Essam Abdel-Sattar

“…This is the first report of metabolitrs from D. erecta inhibiting both LOX and COX enzymes. Furthermore, the isolated compounds were analyzed using computerized virtual screening, which enabled the modelling ADME characteristics, molecular docking, and dynamics simulation. …”
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The Difference a Year Can Make: How Antibiotic Resistance Mechanisms in <i>Pseudomonas aeruginosa</i> Have Changed in Northwestern Transylvania by Matei-Ștefan Dobrescu, Dan-Alexandru Țoc, Adrian-Gabriel Pană, Carmen Costache, Anca Butiuc-Keul

“…These include target protection and even more specific mechanisms, such as metallo-beta-lactamases or enzymes involved in the methylation of 23S rRNA. Statistical analysis further confirmed the correlation between Class I integrons and several ARGs, underscoring the role of horizontal gene transfer in the dissemination of resistance. …”
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