Oxygen versus Reactive Oxygen in the Regulation of HIF-1α: The Balance Tips by Thilo Hagen

“…It is composed of a constitutively expressed β subunit (HIF-1β) and an oxygen-regulated α subunit (HIF-1α and HIF-2α), whose stability is tightly controlled by a family of oxygen- and iron-dependent prolyl hydroxylase enzymes. Whether or not mitochondria-derived reactive oxygen species (ROS) are involved in the regulation of Hypoxia Inducible Factor-1α has been a matter of contention for the last 10 years, with equally compelling evidence in favor and against their contribution. …”
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Inositols in Insulin Signaling and Glucose Metabolism by Arturo Bevilacqua, Mariano Bizzarri

“…Furthermore, inositol, via its major isomers myo-inositol and D-chiro-inositol, and probably some of its phosphate intermediate metabolites and correlated enzymes (like inositol hexakisphosphate kinase) participate in both insulin signaling and glucose metabolism by influencing distinct pathways. …”
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The impact of revitalization treatments on biological activity of soil under afforestation on post-agricultural land by Anna Augustyniuk-Kram, Karol J. Kram

“…Biological activity of soil was measured with the activity of soil enzymes dehydrogenases and acid phosphatase, the biomass of microorganisms was measured and the content of total dissolved carbon and nitrogen was also determined.…”
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AMELIORATION POTATO PLANT PERFORMANCE UNDER DROUGHT CONDITIONS IN IRAQ BY USING TITANIUM DIOXIDE, AND BIODEGRADING, BIODEGRADABLE TREATMENTS by Aseel M.H. H. Al-Khafaji, Kadhim D. H. Al-jubouri, F. Y. Baktash, I. J. Abdul Rasool, Z. J. Al-Mousawi

“…Also the results revealed interaction treatment T1DBMX in producing significant results the entire vegetative growth traits and stress related enzymes concentrations in compare to control treatment T0D. …”
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Molecular and Cellular Pathways Contributing to Joint Damage in Rheumatoid Arthritis by Qinghua Fang, Chun Zhou, Kutty Selva Nandakumar

“…Although etiology of this disease is not clear, several immune pathways, involving immune (T cells, B cells, dendritic cells, macrophages, and neutrophils) and nonimmune (fibroblasts and chondrocytes) cells, participate in the secretion of many proinflammatory cytokines, chemokines, proteases (MMPs, ADAMTS), and other matrix lysing enzymes that could disturb the immune balance leading to cartilage and bone damage. …”
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Streptomyces at the Heart of Several Sectors to Support Practical and Sustainable Applications: A Review by Oumaima Beroigui, Faouzi Errachidi

“…In biotechnology, these totipotent microorganisms produce enzymes widely used in several industries, generating considerable revenue. …”
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Clinical Report of Probable Catastrophic Antiphospholipid Syndrome in Pregnancy by Eryk Hakman, Sasha Mikhael

“…Laboratory evaluation demonstrated microangiopathic disease with hemolysis (confirmed on peripheral smear), elevated liver enzymes, and abnormal 24-hour urine protein with vital signs within the normal range. …”
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Perceptions of Poultry Farmers on the Use of Growth Enhancers in Poultry Production in Rivers State, Nigeria by Favour Alapu, Angela Emodi

“…Results revealed that farmers (90.0%) were aware of the use of growth enhancers and pelleting additives (64.1%), feeding enzymes 64.1%, and antibiotics (51.3%) were the major growth enhancers used by poultry farmers. …”
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Dual targeting carbonic anhydrase inhibitors as promising therapeutic approach: a structural overview by Katia D’Ambrosio, Anna Di Fiore, Emma Langella

“…Human carbonic anhydrases (hCAs) have been recognized as suitable drug targets for this therapeutic approach. These enzymes play a key role in maintaining pH balance, ion transport, and fluid regulation across various tissues and organs and their dysregulation has been associated to a variety of human pathologies. …”
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Changes in Antioxidant and Photosynthetic Capacity in Rice Under Different Substrates by Hang Zhou, Liming Zhao, Yiwen Song, Xiaole Du, Jingxin Huo, Wanqi Mei, Xi Wang, Naijie Feng, Dianfeng Zheng, Zhaohui Wu

“…Rice in different substrates had various degrees of dependence on antioxidant enzymes and antioxidants. For example, seedlings in TT treatment may depend more on ascorbic acid (AsA) compared to T. …”
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Polyphenol Bioaccessibility and Sugar Reducing Capacity of Black, Green, and White Teas by Shelly Coe, Ann Fraser, Lisa Ryan

“…While a number of studies have investigated the quantity and type of polyphenols present in different tea samples, no study has reported the potential effect of digestive enzymes on the availability of tea polyphenols for human absorption or the subsequent impact on glycaemic response. …”
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Cardioprotective Activity of N′′,N′′′-Bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide Derivative against Doxorubicin Induced Cardiotoxicity in Rats by Salma Tabassum, Kiran Gangarapu, Gouthami Thumma, Sarangapani Manda, Rama Narsimha Reddy Anreddy

“…The results showed the significant (P<0.05) dose dependent increase in antioxidant enzymes catalase and superoxide dismutase in heart tissue homogenates. …”
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Mechanistic Studies with DNA Polymerases Reveal Complex Outcomes following Bypass of DNA Damage by Robert L. Eoff, Jeong-Yun Choi, F. Peter Guengerich

“…Part of this so-called DNA damage tolerance pathway involves the recruitment of specialized DNA polymerases to sites of stalled or collapsed replication forks. These enzymes have unique structural and functional attributes that often allow bypass of adducted template DNA and successful completion of genomic replication. …”
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A High-Fat, High-Fructose Diet Induces Antioxidant Imbalance and Increases the Risk and Progression of Nonalcoholic Fatty Liver Disease in Mice by Kanokwan Jarukamjorn, Nattharat Jearapong, Charinya Pimson, Waranya Chatuphonprasert

“…In the present study, the effects of a high-fat, high-fructose diet (HFFD) on mRNA levels and activities of the antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), were determined in mouse livers and brains. …”
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Research Progress of Bacteriocin Combined with Physical Technology in the Prevention and Control of Foodborne Pathogens and Spoilage Microorganisms by Mingzhu WANG, Zihao TIAN, Zhongmei TAN, Jie REN, Gaoyun WU, Jinqi GUO, Yuchang YAO, Yuan YIN, Bailiang LI, Jiage MA, Wei YU

“…However, bacteriocins may have some limitations when used individually, such as the narrow inhibitory spectrum and easy degradation by enzymes. Previous studies found that the combined use of bacteriocins and physical technologies may exhibit synergistic antimicrobial effects. …”
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High-resolution fleezers reveal duplex opening and stepwise assembly by an oligomer of the DEAD-box helicase Ded1p by Eric M. Patrick, Rajeev Yadav, Kasun Senanayake, Kyle Cotter, Andrea A. Putnam, Eckhard Jankowsky, Matthew J. Comstock

“…DEAD-box ATPases with helicase activity unwind RNA duplexes by local opening of helical regions without directional movement through the duplexes and some of these enzymes, including Ded1p from Saccharomyces cerevisiae, oligomerize to effectively unwind RNA duplexes. …”
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Comparative Transcriptional Profiling of Two Contrasting Barley Genotypes under Salinity Stress during the Seedling Stage by Runhong Gao, Ke Duan, Guimei Guo, Zhizhao Du, Zhiwei Chen, Liang Li, Ting He, Ruiju Lu, Jianhua Huang

“…Notably, a LysM RLK was firstly found involved in salt stress response. Moreover, key enzymes in the pathways of jasmonic acid biosynthesis, lipid metabolism and indole-3-acetic acid homeostasis were specifically affected by salt stress in salt tolerance genotype. …”
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Targeting the Heart of Mycobacterium: Advances in Anti-Tubercular Agents Disrupting Cell Wall Biosynthesis by Ahmad Diab, Henry Dickerson, Othman Al Musaimi

“…Furthermore, ethambutol interferes with arabinogalactan synthesis by targeting arabinosyl transferase enzymes, particularly embB- and embC-encoded variants. …”
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Effect of High Hydrostatic Pressure Processing Strategies on Retention of Antioxidant Phenolic Bioactives in Foods and Beverages – a Review by Tokuşoğlu Özlem

“…High hydrostatic pressure processing (HHPP) conditions (300–700 MPa) at moderate initial temperatures (around ambient) are generally sufficient to inactivate vegetative pathogens for pasteurization processes, some enzymes, or spoilage organisms to extend the shelf-life. …”
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Impaired Resolution of Inflammation in the Endoglin Heterozygous Mouse Model of Chronic Colitis by Madonna R. Peter, Mirjana Jerkic, Valentin Sotov, David N. Douda, Daniela S. Ardelean, Niousha Ghamami, Flavia Lakschevitz, Meraj A. Khan, Susan J. Robertson, Michael Glogauer, Dana J. Philpott, Nades Palaniyar, Michelle Letarte

“…Interestingly, despite increased macrophage and neutrophil infiltration, a gut-specific reduction in expression of the key phagocytic respiratory burst enzymes, NADPH oxidase 2 (Nox-2) and myeloperoxidase, was seen in Eng+/− mice undergoing persistent inflammation. …”
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