Alchornea cordifolia leaf-extract ameliorates bisphenol A-induced obesity in male Wistar rats by Abdulhakeem Rotimi Agboola, Ako Hogan Itam, Chinedum Martins Ekeleme, Eyuwa Ignatius Agwupuye, Zuwairatu Oyiza Ahmed, Godswill Peter Igiakong, Gideon Bassey Agbor, Asmau Niwoye Abubakar, Zainab Adamu, Esien David-Oku, Item Justin Atangwho

“…Moreover, BPA treatment was found to alter measured serum biochemical indicators, (FBG, lipid profile, liver and kidney function indicators) and the lipid regulating enzymes (pancreatic lipase and HMG-CoA reductase activities), relative to the normal control (p < 0.05). …”
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The Role of Intravenous Selexipag in Managing PAH and Bridging Gaps in Oral Treatment: A Narrative Review by Goren S, Kidwai N, Aronow WS, Lanier GM

“…Additionally, selexipag should not be used with medications that block CYP enzymes. A phase III clinical trial reports that common side effects of the IV form of selexipag include headaches and irritation at the injection site. …”
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Recent progress on anti-cancer activity of thiadiazoles: A review by C.R. Santhosh, Sampath Chinnam, Nagaraju Kottam, S Amreen, Guddekoppa S. Ananthnag, G.M. Madhu, Samata Gadde, Viola Tressa Fernandes, Haritha Arnipalli

“…Thiadiazoles acts as inhibitors against several specific enzymes or signaling pathways. These compounds are frequently utilized when combined with other anti-cancer drugs to improve their efficacy. …”
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Design principles for engineering bacteria to maximise chemical production from batch cultures by Ahmad A. Mannan, Alexander P. S. Darlington, Reiko J. Tanaka, Declan G. Bates

“…Here, using a ‘host-aware’ computational framework which captures competition for both metabolic and gene expression resources, we uncover design principles for engineering the expression of host and production enzymes at the cell level which maximise volumetric productivity and yield from batch cultures. …”
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Clinical significance of lipid pathway-targeted therapy in breast cancer by Dan Li, Dan Li, Pengcheng Jin, Yiqi Cai, Yiqi Cai, Shijie Wu, Shijie Wu, Xianan Guo, Xianan Guo, Zhiyun Zhang, Zhiyun Zhang, Kexin Liu, Kexin Liu, Panni Li, Panni Li, Yue Hu, Yunxiang Zhou, Yunxiang Zhou

“…In this study, we delve into the clinical implications of lipid pathway-targeted therapy in breast cancer. We highlight key enzymes and potential therapeutic targets involved in lipid metabolism reprogramming, and their associations with cancer progression and treatment outcomes. …”
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Increased NOX-dependent ROS production and proportionally enhanced antioxidant response in white adipose tissue of male rats by Jessica de Freitas Nascimento, Keciany Alves de Oliveira, Paula Alexandre de Freitas, Júlia de Araújo Marques Falci, Renata Prado Vasconcelos, Saulo Chaves Magalhães, Talita Mendes Farias, Maria Isabel Cardoso Alonso-Vale, Adriano Cesar Carneiro Loureiro, Denise Pires de Carvalho, Rodrigo Soares Fortunato, Ariclécio Cunha de Oliveira

“…Materials and methods: The study analyzed the activity and gene expression of the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase, along with the production of NADPH oxidases dependent on H2O2 and gene expression of NOX1, NOX2, and NOX4. …”
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Evaluation of Colorimetric BCA-Based Quantification of Hydrazide Groups on Magnetic Particles by Zuzana Svobodova, Barbora Jankovicova, Zdenek Plichta, Daniel Horak, Zuzana Bilkova

“…Magnetic micro- and nanoparticles (MPs) are considered to provide excellent solid support for many immunoanalytical and bioaffinity applications, particularly when they contain hydrazide groups available for site-specific immobilization of various glycoproteins, such as immunoglobulin G and enzymes. To prepare a highly active bioaffinity carrier with sufficient binding capacity, knowledge as to the type and concentration of functional groups used for ligand binding is crucial. …”
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Isolation and characterization of ɸEcM-vB1 bacteriophage targeting multidrug-resistant Escherichia coli by Rania Abozahra, Dina Shlkamy, Sarah M. Abdelhamid

“…Methods done in this research are bacteriophage isolation, purification, titer determination, bacteriophage morphology, host range determination, bacteriophage latent period and burst size determination, genomic analysis by restriction enzymes, and bacteriophage total protein content determination. …”
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Insights into the relations between cell wall integrity and in vitro digestion properties of granular starches in pulse cotyledon cells after dry heat treatment by Ping Li, Bin Zhang, Rui Liu, Li Ding, Xiong Fu, Haiteng Li, Qiang Huang, Xiaowei He

“…DHT decreased the inhibitory effects of enzymes of both the soluble and insoluble components, but the digestion rate and extent of slightly and highly damaged cell samples did not exhibit significant differences compared with their native counterparts. …”
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Maintenance of Synaptic Stability Requires Calcium-Independent Phospholipase A2 Activity by Julie Allyson, Xiaoning Bi, Michel Baudry, Guy Massicotte

“…Phospholipases A2 (PLA2s) represent one of the largest groups of lipid-modifying enzymes. Over the years, significant advances have been made in understanding their potential physiological and pathological functions. …”
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Hematological and Serum Chemistry of Canine Parvoviral Enteritis in Diverse Breeds of Dogs by Olanrewaju Samuel Olaifa, Aderonke Rachel Kolawole, Olatunde Babatunde Akanbi, Christiana Ibironke Odita, Victor Taiwo

“…Biochemical changes included hyperproteinemia (26.7%), hyperalbuminemia, hyperglobulinemia, and elevated liver enzymes in some cases. Renal dysfunction was evident in 16.7% of dogs with elevated creatinine. …”
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Effects of seven days’ fasting on physical performance and metabolic adaptation during exercise in humans by Kristoffer J. Kolnes, Emelie T. F. Nilsen, Steffen Brufladt, Allison M. Meadows, Per B. Jeppesen, Øyvind Skattebo, Egil I. Johansen, Jesper B. Birk, Kurt Højlund, Janne Hingst, Bjørn S. Skålhegg, Rasmus Kjøbsted, Julian L. Griffin, Anders J. Kolnes, Stephen O’Rahilly, Jørgen F. P. Wojtaszewski, Jørgen Jensen

“…The participants maintained muscle strength and oxidative enzymes in skeletal muscle during fasting but carbohydrate oxidation and high-intensity endurance capacity were reduced.…”
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Microbes as Resources to Remove PPCPs and Improve Water Quality by Francesca Demaria, Marcel Suleiman, Philippe Corvini, Pilar Junier

“…To mitigate these risks, there is a growing interest in exploiting microorganisms and their enzymes for bioremediation purposes. By harnessing the metabolic capabilities of microbial communities, PPCPs can be efficiently degraded, transformed, or sequestered in water systems. …”
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Nutritional and Therapeutic Potential of Soursop by Muhammad Afzaal, Farhan Saeed, Aasma Asghar, Yasir Abbas Shah, Ali Ikram, Huda Ateeq, Muzzamal Hussain, Chigozie E. Ofoedu, James S. Chacha

“…Since soursop contains various phytochemicals, it can be used medicinally to treat a wide range of conditions, including diabetes (by inhibiting the enzymes α-glucosidase and α-amylase), tumor, cancer, oxidative stress, blood pressure, the induction of apoptosis in tumor cells as well as hemorrhagic disease and cholesterol lowering. …”
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Improving polyketide biosynthesis by rescuing the translation of truncated mRNAs into functional polyketide synthase subunits by Yan Liu, Chaoyi Song, Qingwen Cui, Hongluan Sun, Chanjuan Jiang, Ruofei Guo, Ruoting He, Zhen Li, Ji Luan, Hailong Wang

“…Abstract Modular polyketide synthases (mPKSs) are multidomain enzymes in bacteria that synthesize a variety of pharmaceutically important compounds. mPKS genes are usually longer than 10 kb and organized in operons. …”
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Theaflavin Ameliorates Cerebral Ischemia-Reperfusion Injury in Rats Through Its Anti-Inflammatory Effect and Modulation of STAT-1 by Fei Cai, Cai-Rong Li, Ji-Liang Wu, Jian-Guo Chen, Chao Liu, Qing Min, Wei Yu, Chang-Han Ouyang, Jin-He Chen

“…Our study demonstrated that theaflavin significantly protected neurons from cerebral ischemia-reperfusion injury by limiting leukocyte infiltration and expression of ICAM-1, and suppressing upregulation of inflammatory-related prooxidative enzymes (iNOS and COX-2) in ischemic brain via, at least in part, reducing the phosphorylation of STAT-1.…”
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Interplay between Extracellular Matrix and Neutrophils in Diseases by Yanyan Zhu, Yumeng Huang, Qian Ji, Shengqiao Fu, Jia Gu, Ningzheng Tai, Xu Wang

“…Neutrophils can also mediate ECM remodeling by providing specific matrix-remodeling enzymes (such as neutrophil elastase and metalloproteinases), generating neutrophil extracellular traps, and releasing exosomes. …”
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Bile Acids and Their Value for Central Nervous System by Yu. O. Shulpekova, P. E. Tkachenko, E. N. Shirokova, I. V. Damulin

“…The presence in CNS of various bile acid synthesis-related receptors and enzymes indicates their value in brain functioning and warrants research into their metabolism.…”
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Severe Vitamin B12 Deficiency in Pregnancy Mimicking HELLP Syndrome by Shravya Govindappagari, Michelle Nguyen, Megha Gupta, Ramy M. Hanna, Richard M. Burwick

“…Severe vitamin B12 deficiency may present with hematologic abnormalities that mimic thrombotic microangiopathy disorders such as hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. …”
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Characterization of eDNA from the Clinical Strain Acinetobacter baumannii AIIMS 7 and Its Role in Biofilm Formation by Praveen K. Sahu, Pavithra S. Iyer, Amrita M. Oak, Karishma R. Pardesi, Balu A. Chopade

“…An assessment of the characteristics of the eDNA with respect to size, digestion pattern by DNase I/restriction enzymes, and PCR-sequencing, indicates a high similarity with genomic DNA. …”
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