E3 Ubiquitin Ligases: Potential Therapeutic Targets for Skeletal Pathology and Degeneration by Ruiyin Zeng, Yuan Xiong, Ze Lin, Adriana C. Panayi, Yun Sun, Faqi Cao, Guohui Liu

“…We review the classification of these E3 enzymes and the mechanisms that influence upstream and downstream molecules and transduction pathways. …”
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Metastatic Hepatocellular Carcinoma in a Patient with Crohn’s Disease Treated with Azathioprine and Infliximab: A Case Report and Literature Review by Kyle J. Fortinsky, Ali Alali, Khursheed Jeejeebhoy, Sandra Fischer, Morris Sherman, Scott Fung

“…Clinicians may consider early imaging in patients with Crohn’s disease presenting with concerning symptomatology or abnormal liver enzymes, especially in those being treated with azathioprine alone or in combination with infliximab. …”
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Biosynthesis and Role of N-Linked Glycosylation in Cell Surface Structures of Archaea with a Focus on Flagella and S Layers by Ken F. Jarrell, Gareth M. Jones, Divya B. Nair

“…These include many of the glycosyltransferases and the oligosaccharyltransferase needed to assemble the glycans as well as some of the genes encoding enzymes required for the biosynthesis of the sugars themselves. …”
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Palmitoylethanolamide: A Natural Body-Own Anti-Inflammatory Agent, Effective and Safe against Influenza and Common Cold by J. M. Keppel Hesselink, Tineke de Boer, Renger F. Witkamp

“…PEA is synthesized and metabolized in animal cells via a number of enzymes and exerts a multitude of physiological functions related to metabolic homeostasis. …”
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Laser-Based Propagation of Human iPS and ES Cells Generates Reproducible Cultures with Enhanced Differentiation Potential by Kristi A. Hohenstein Elliott, Cory Peterson, Anuradha Soundararajan, Natalia Kan, Brandon Nelson, Sean Spiering, Mark Mercola, Gary R. Bright

“…This study reports a novel approach for the efficient, consistent expansion of human ESCs and iPSCs using laser sectioning, instead of mechanical devices or enzymes, to divide cultures into defined size clumps for propagation. …”
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Role of 3-mercaptopyruvate sulfurtransferase in cancer: Molecular mechanisms and therapeutic perspectives by Ka Zhang, Yi-Wen Zhu, Ao-Qi Tang, Ze-Tao Zhou, Yi-Lun Yang, Zi-Hui Liu, Yan Li, Xiao-Yi Liang, Zhi-Fen Feng, Jun Wang, Tong Jiang, Qi-Ying Jiang, Dong-Dong Wu

“…As a result, the effects of H2S-catalyzing enzymes in cancers also attract widspread attention. 3-mercaptopyruvate sulfurtransferase (3-MST) is privileged to be one of them. …”
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Far beyond Phagocytosis: Phagocyte-Derived Extracellular Traps Act Efficiently against Protozoan Parasites In Vitro and In Vivo by Liliana M. R. Silva, Tamara Muñoz-Caro, Rafael A. Burgos, Maria A. Hidalgo, Anja Taubert, Carlos Hermosilla

“…Released ETs consist of nuclear DNA as backbone adorned with histones, antimicrobial peptides, and phagocyte-specific granular enzymes thereby producing a sticky extracellular matrix capable of entrapping and killing pathogens. …”
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Specialized Bacteroidetes dominate the Arctic Ocean during marine spring blooms by Álvaro Redondo-Río, Christopher J. Mundy, Javier Tamames, Carlos Pedrós-Alió

“…These proteins were used to identify polysaccharide-utilization loci that clustered transporters and polysaccharide-active enzymes, showing a higher level of specialization toward polysaccharide use. …”
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Protective mechanism of quercetin nanoliposomes on hydrogen peroxide-induced oxidative damage in 3D Caco-2 cell model by Xiaofeng Liu, Zhiyuan Zhou, Xiaoqin Lu, Hao Zhong, Rongjun He, Ziwei Feng, Rongfa Guan

“…Quercetin nanoliposomes can regulate the oxidative genes HO-1, Keap1, and Nrf2, activating downstream antioxidant enzymes and upregulating GST, NQO1, and Keap1 protein expression. …”
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Protective Role of Catechin and Quercetin in Sodium Benzoate-Induced Lipid Peroxidation and the Antioxidant System in Human Erythrocytes In Vitro by Gamze Yetuk, Dilek Pandir, Hatice Bas

“…Significantly higher LPO and lower activities of antioxidant enzymes were observed with the increasing concentrations of SB. …”
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Propofol Infusion Syndrome in Adults: A Clinical Update by Aibek E. Mirrakhimov, Prakruthi Voore, Oleksandr Halytskyy, Maliha Khan, Alaa M. Ali

“…The disease commonly presents as an otherwise unexplained high anion gap metabolic acidosis, rhabdomyolysis, hyperkalemia, acute kidney injury, elevated liver enzymes, and cardiac dysfunction. Management of overt propofol infusion syndrome requires immediate discontinuation of propofol infusion and supportive management, including hemodialysis, hemodynamic support, and extracorporeal membrane oxygenation in refractory cases. …”
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Anti-Inflammatory Effect of By-Products from Haliotis discus hannai in RAW 264.7 Cells by Ho-Seok Rho, Hyang Kim, Jung-Ae Kim, Fatih Karadeniz, Byul-Nim Ahn, Ki-Ho Nam, Youngwan Seo, Chang-Suk Kong

“…Results indicated that presence of H. discus hannai mucosubstance by-products (AM) significantly lowered the nitric oxide (NO) production along the expressional suppression of inflammatory mediators such as cytokines TNF-α, IL-1β, and IL-6 and enzymes iNOS and COX-2. Also, AM was shown to increase expression of anti-inflammatory response mediator HO-1. …”
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Mechanisms of recalcitrant fucoidan breakdown in marine Planctomycetota by Carla Pérez-Cruz, Alicia Moraleda-Montoya, Raquel Liébana, Oihana Terrones, Uxue Arrizabalaga, Mikel García-Alija, Maier Lorizate, Ana Martínez Gascueña, Isabel García-Álvarez, Jon Ander Nieto-Garai, June Olazar-Intxausti, Bárbara Rodríguez-Colinas, Enrique Mann, José Luis Chiara, Francesc-Xabier Contreras, Marcelo E. Guerin, Beatriz Trastoy, Laura Alonso-Sáez

“…Enzymatic assays and structural biology studies reveal how GH168 endo-fucanases degrade various fucoidan cores from brown algae, assisted by auxiliary hydrolytic enzymes. Overall, our results provide insights into fucoidan processing mechanisms in macroalgal-associated bacteria.…”
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Pexophagy: The Selective Degradation of Peroxisomes by Andreas Till, Ronak Lakhani, Sarah F. Burnett, Suresh Subramani

“…Despite the existence of great diversity among different species, cell types, and under different environmental conditions, peroxisomes contain enzymes involved in β-oxidation of fatty acids and the generation, as well as detoxification, of hydrogen peroxide. …”
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Early Primary Biliary Cirrhosis: A New Association with Erythema Nodosum of Unknown Origin by Nikolaos K. Gatselis, Kalliopi Zachou, George N. Dalekos

“…We report two females (42 and 44 years old) with low-grade fever, arthralgias, and elevated cholestatic enzymes in the first and fatigue in the second. Patients were also suffering from typical EN lesions characterized by multiple erythematous, painful nodules over the anterior portions of their lower extremities. …”
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Coordinated conformational changes in P450 decarboxylases enable hydrocarbons production from renewable feedstocks by Wesley Cardoso Generoso, Alana Helen Santana Alvarenga, Isabelle Taira Simões, Renan Yuji Miyamoto, Ricardo Rodrigues de Melo, Ederson Paulo Xavier Guilherme, Fernanda Mandelli, Clelton Aparecido Santos, Rafaela Prata, Camila Ramos dos Santos, Felippe Mariano Colombari, Mariana Abrahão Bueno Morais, Rodrigo Pimentel Fernandes, Gabriela Felix Persinoti, Mario Tyago Murakami, Leticia Maria Zanphorlin

“…Abstract Fatty acid peroxygenases have emerged as promising biocatalysts for hydrocarbon biosynthesis due to their ability to perform C-C scission, producing olefins - key building blocks for sustainable materials and fuels. These enzymes operate through non-canonical and complex mechanisms that yield a bifurcated chemoselectivity between hydroxylation and decarboxylation. …”
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Bioethanol production from coconut husk using DES-NADES pretreatment and enzymatic hydrolysis method by Yerizam, Muhammad, Jannah, Asyeni Miftahul, Aprianti, Nabila, Yandriani, Yandriani, Rendana, Muhammad, Ernas, Annisa Qonita, Tamba, Juice Lowise

“…The delignified samples were hydrolyzed using the 5% (w/w) of cellulase enzymes and fermented for seven days using Saccharomyces cerevisiae. …”
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A review on surface modification of nanofibrous textiles for diverse applications: Focus on medical uses by Rasool Shabanloo, Majid Montazer, Ali Farahani, Nesa Karimi

“…Chemical modification includes functionalization with chemical groups, while biological modification involves coating with proteins, enzymes, or antibodies. Nanotreatment approaches use nanomaterials to modify the surface of nanofibers. …”
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Adenosine deficiency facilitates CA1 synaptic hyperexcitability in the presymptomatic phase of a knockin mouse model of Alzheimer disease by Mattia Bonzanni, Alice Braga, Takashi Saito, Takaomi C. Saido, Giuseppina Tesco, Philip G. Haydon

“…We show that this aberrant excitability is associated with a deficient adenosine tone, an inhibitory neuromodulator, driven by reduced levels of CD39/73 enzymes, responsible for the extracellular ATP-to-adenosine conversion. …”
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Vasculopathy: a possible factor affecting hereditary angioedema by Anna Laura Colia, Alessandra Ranaldi, Rosa Santacroce, Giovanna D'Andrea, Angela Bruna Maffione, Maurizio Margaglione, Maria D'Apolito

“…The SERPING1 gene, encoding the C1-INH, determines the wide range of clinical symptoms associated with CI-INH deficient HAE. C1-INH regulates enzymes involved in bradykinin production, leading to increased vascular permeability and angioedema. …”
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