Unraveling the Effect of Immunogenicity on the PK/PD, Efficacy, and Safety of Therapeutic Proteins by Alison Smith, Hugh Manoli, Stacey Jaw, Kimberley Frutoz, Alan L. Epstein, Leslie A. Khawli, Frank-Peter Theil

“…Biologics have emerged as a powerful and diverse class of molecular and cell-based therapies that are capable of replacing enzymes, editing genomes, targeting tumors, and more. …”
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Two-Component Signal Transduction System SaeRS Positively Regulates Staphylococcus epidermidis Glucose Metabolism by Qiang Lou, Yijun Qi, Yuanfang Ma, Di Qu

“…The downregulated proteins included enzymes related to glycolysis and TCA cycle, suggesting that glucose is not properly utilized in S. epidermidis when saeRS was deleted. …”
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Zinc Supplementation against Eimeria acervulina-Induced Oxidative Damage in Broiler Chickens by Nedyalka V. Georgieva, Margarita Gabrashanska, Ventsislav Koinarski, Zvezdelina Yaneva

“…The observed deviations in the studied enzymes and nonenzymatic parameters evidence the occurrence of oxidative stress following the infection and impaired antioxidant status of chickens, infected with Eimeria acervulina. …”
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New Insights into the Androgen-Targeted Therapies and Epigenetic Therapies in Prostate Cancer by Abhijit M. Godbole, Vincent C. O. Njar

“…Recent work has shed light on the importance of epigenetic events including facilitation of AR signaling by histone-modifying enzymes, posttranslational modifications of AR such as sumoylation. …”
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Intensification of Energy Production in the Anaerobic Digestion Process of Sewage Sludge Using Enzymatic Disintegration by Bartłomiej Macherzyński, Elżbieta Popowska-Nowak, Maria Włodarczyk-Makuła, Beata Bień, Małgorzata Wszelaka-Rylik

“…This paper presents results of a study on changes in the physical and chemical properties of papain-disintegrated sewage sludge subjected to methane fermentation and the effect of enzymes on the colony number of <i>Escherichia coli</i>, <i>Salmonella</i> spp. and <i>Legionella</i> spp. …”
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Angiogenesis in Spontaneous Tumors and Implications for Comparative Tumor Biology by C. Benazzi, A. Al-Dissi, C. H. Chau, W. D. Figg, G. Sarli, J. T. de Oliveira, F. Gärtner

“…Several molecules such as cell surface receptors, growth factors, and enzymes are involved in this process. While antiangiogenic therapy for cancer has been proposed over 20 years ago, it has garnered much controversy in recent years within the scientific community. …”
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Sulfurous Gases As Biological Messengers and Toxins: Comparative Genetics of Their Metabolism in Model Organisms by Neal D. Mathew, David I. Schlipalius, Paul R. Ebert

“…Interestingly, D. melanogaster and Arthropoda in general, lack a gene for 3-mercaptopyruvate sulfurtransferase, an enzym for H2S synthesis under reducing conditions.…”
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Cytological and biochemical markers of autophagy in wheat suspension culture cells under abiotic stress by A.B. Mazina, S.A. Dmitrieva, A.G. Renkova, J.N. Valitova, V.R. Khabibrakhmanova, F.V. Minibayeva

“…High activity of acid phosphatase and protease, the marker enzymes of lytic vesicles, and changes in the lipid composition were observed in the autophagosomes isolated from the sucrose-deficient cells. …”
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Current Perspective About the Effect of a Ketogenic Diet on Oxidative Stress – a Review by Natalia Drabińska

“…The shift in metabolism occurring in ketosis can affect the reactive oxygen species (ROS)-producing pathways and influence the expression of enzymes involved in redox homeostasis. Therefore, this review summarizes and discusses existing knowledge about KD and ROS homeostasis. …”
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A synthetic methylotroph achieves accelerated cell growth by alleviating transcription-replication conflicts by Xin Meng, Guipeng Hu, Xiaomin Li, Cong Gao, Wei Song, Wanqing Wei, Jing Wu, Liming Liu

“…In this study, we design a synthetic methanol assimilation (SMA) pathway containing only six enzymes linked to central carbon metabolism, which does not require energy and carbon emissions. …”
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Multivariate Analysis of Fruit Antioxidant Activities of Blackberry Treated with 1-Methylcyclopropene or Vacuum Precooling by Jian Li, Guowei Ma, Lin Ma, Xiaolin Bao, Liping Li, Qian Zhao, Yousheng Wang

“…Results showed that the activities of antioxidant enzymes were enhanced by both 1-MCP treatment and vacuum precooling. …”
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Biological control of bacterial leaf blight (BLB) in rice–A sustainable approach by Bestha Sai Teja, Gayatri Jamwal, Vishal Gupta, Mansi Verma, Ayushi Sharma, Akash Sharma, Vinod Pandit

“…Additionally, the induction of plant immunity and defense-related enzymes in rice further enhances the resistance against the disease. …”
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Heat stable and intrinsically sterile liquid protein formulations by Atip Lawanprasert, Harminder Singh, Sopida Pimcharoen, Mariangely González Vargas, Arshiya Dewan, Girish S. Kirimanjeswara, Scott H. Medina

“…These non-aqueous formulations are impervious to contamination by microorganismal pathogens, degradative enzymes, and environmental impurities, and display comparable pre-clinical pharmacokinetics and safety profiles to standard saline protein samples. …”
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Androgen metabolism and inhibition of interleukin-1 synthesis in primary cultured human synovial macrophages by M. Cutolo, S. Accardo, B. Villaggio, A. Barone, A. Sulli, E. Balleari, C. Bason, L. Felli, O. M. Granata, R. Amodio, L. Castagnetta

“…Therefore, macrophages contain the key enzymes of steroidogenesis, in particular the 5α-treductase. …”
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The histone methyltransferase DOT1B is dispensable for stage differentiation and macrophage infection of Leishmania mexicana by Nicole Eisenhuth, Elisa Theres Rauh, Melina Mitnacht, Andrea Debus, Ulrike Schleicher, Falk Butter, Katerina Pruzinova, Petr Volf, Christian J. Janzen

“…However, the specific functions of these enzymes depend on the host evasion strategies of the parasites. …”
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Angelica acutiloba Kitagawa Extract Attenuates DSS-Induced Murine Colitis by Jong-Chan Jang, Kang Min Lee, Seong-Gyu Ko

“…Treatment improved the colonic mRNA expression of different inflammatory markers: cytokines, inducible enzymes, matrix metalloproteinases, and tight junction-related proteins. …”
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Therapeutic Potential of Clove Oil in Mitigating Cadmium-Induced Hepatorenal Toxicity Through Antioxidant, Anti-Inflammatory, and Antiapoptotic Mechanisms by Inas M. Elgharib, Fatma M. Abdelhamid, Gehad E. Elshopakey, Hatem Sembawa, Talat A. Albukhari, Waheed A. Filimban, Rehab M. Bagadood, Mohamed E. El-Boshy, Engy F. Risha

“…CLO ameliorated the oxidative effects of Cd through decreasing urea (27.4%), creatinine (41.6%), liver enzymes, and hepatic apoptotic markers while increasing levels of total protein, albumin, and hepatic values of SOD (60.37%), CAT (64.49%), GSH (50.41%), and GST (9.16%). …”
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Aetiology and Outcomes of Thrombocytopenia in Pregnancy: A Cross-Sectional Study in a University Hospital, India by Sudha V. Hooli, Neelima Shah, Prashant Shah, Shrradha Suresh, Bali Sukeshani Sunil

“…Twenty-eight percent of gestational TCP cases; 47.6% of PIH cases, both cases of haemolysis, elevated liver enzymes, and low platelets syndrome; 50.0% of dengue cases; and one COVID-19 positive case (33.0%) had moderate TCP. …”
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Pharmacological Correction of Stress-Induced Gastric Ulceration by Novel Small-Molecule Agents with Antioxidant Profile by Konstantin V. Kudryavtsev, Anna O. Markevich, Oleksandr V. Virchenko, Tetyana M. Falalyeyeva, Tetyana V. Beregova, Lyudmyla I. Ostapchenko, Dmitry V. Zabolotnev, Nikolay S. Zefirov

“…The levels of lipid peroxidation products and activities of antioxidative system enzymes were measured in gastric mucosa and correlated with the observed gastroprotective activity of the active compounds. …”
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An orally administered gold nanocluster with ROS scavenging for inflammatory bowel disease treatment by Fei Wang, Qianhui Li, Tingting Xu, Zhu Li, Yongxin Jiang, Yan Ma, Xiaohu Li, Wanni Wang, Haisheng Qian

“…Au25 NCs can eliminate ROS such as ABTS radicals, superoxide free radicals (•O2−), and hydroxyl free radicals (•OH), upregulate the expression level of antioxidant enzymes, inhibit the expression of proinflammatory cytokines, and finally interrupt the inflammatory circuit of IBD to achieve the effective prevention and delayed treatment of IBD. …”
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