Differences in hair cortisol to cortisone ratio between depressed and non-depressed adolescent women by Yasmine Zerroug, Marie-France Marin, Elyse Porter-Vignola, Patricia Garel, Catherine M. Herba

“…Although cross-sectional, our findings highlight the importance of future studies to test whether the group difference found in cortisol/cortisone ratio is the result of alterations in 11-beta-hydroxysteroid dehydrogenase enzymes (type 1 or 2) activity. Further research is thus needed to clarify the role of these enzymes in major depressive disorder in youth and to develop more targeted intervention strategies.…”
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Evaluating the Hepatoprotective Potential of Ginger Ethanolic Extract Against Lambda-Cyhalothrin-Induced Toxicity in Male Rats by Mustafa Q Mustafa, Zainab JM Jawad

“…Upon completion of the study, blood ‎samples were collected for liver ‎enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST)‎, ‎and alkaline phosphatase (ALP) ‎assessment. …”
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Molecular mechanisms and enhanced functions of Hibiscus sabdariffa L—nanoliposomes as an emerging therapeutic strategy in UV and galactosamine skin aging-induced model by Eptehal Nassar, Mai Rady, Heba Handousa

“…Compared with the aged group and the green tea extract-treated group, the Hs-liposome-treated group presented elevated reduced glutathione and decreased malondialdehyde levels and inhibited collagenase and elastase enzymes. This treatment also decreased the Bcl-2/Bax ratio and downregulated the expression of MMP-1, MMP-2, and MMP-9. …”
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Marine Macroalgae Display Bioreductant Efficacy for Fabricating Metallic Nanoparticles: Intra/Extracellular Mechanism and Potential Biomedical Applications by Sabiha Mahmood Ansari, Quaiser Saquib, Valeria De Matteis, Hend Awad Alwathnani, Sulaiman Ali Alharbi, Abdulaziz Ali Al-Khedhairy

“…However, microorganisms have an abundance of active compounds ranging from sugar molecules, enzymes, canonical membrane proteins, reductase enzymes (NADH and NADPH), membrane proteins to many more. …”
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Sphingolipid and Ceramide Homeostasis: Potential Therapeutic Targets by Simon A. Young, John G. Mina, Paul W. Denny, Terry K. Smith

“…Recent research has identified and characterised many of the key enzymes involved in sphingolipid metabolism and this has led to a heightened interest in the possibility of targeting these processes for therapies against cancers, Alzheimer's disease, and numerous important human pathogens. …”
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Are There Mutator Polymerases? by Miguel Garcia-Diaz, Jose F. Ruiz, Raquel Juarez, Gloria Terrados, Luis Blanco

“…The current view of these processes is reviewed, and the current understanding of DNA polymerases and their role as mutator enzymes is discussed.…”
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The Endoscopic Management of Pain in Chronic Pancreatitis by Adam J. Goodman, Frank G. Gress

“…Many approaches have been used to treat these patients, including narcotic analgesia, antidepressants, pancreatic enzymes, octreotide, denervation procedures, such as celiac plexus block, and various palliative, decompression, or drainage procedures. …”
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Acute Pancreatitis and Splenic Vein Thrombosis due to Hypertriglyceridemia by Ercan Gündüz, Recep Dursun, Mustafa İçer, Yılmaz Zengin, Cahfer Güloğlu

“…Acute pancreatitis (AP) is a condition characterised by the activation of the normally inactive digestive enzymes due to an etiological factor and digestion of the pancreatic tissues, resulting in extensive inflammation and leading to local, regional, and systemic complications in the organism. …”
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Genome sequence of Novosphingobium malaysiense strain MUSC 273T, novel alpha-proteobacterium isolated from intertidal soil by Hooi-Leng Ser, Wai-Fong Yin, Kok-Gan Chan, Nurul-Syakima Ab Mutalib, Learn-Han Lee

“…Knowledge of the genomic features of the strain may allow further biotechnological exploitation, particularly for production of secondary metabolites as well as production of industrially important enzymes…”
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Pharmacogenetics of Chronic Pain and Its Treatment by Svatopluk Světlík, Karolína Hronová, Hana Bakhouche, Olga Matoušková, Ondřej Slanař

“…This paper reviews the impact of genetic variability of drug metabolizing enzymes, transporters, receptors, and pathways involved in chronic pain perception on the efficacy and safety of analgesics and other drugs used for chronic pain treatment. …”
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Syphilitic hepatitis by Łukasz Supronowicz, Magdalena Rogalska

“…Given the significant morbidity associated with a missed diagnosis, syphilitic hepatitis should be taken into account as an element of differential diagnosis in patients with unexplained elevation of liver enzymes.…”
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Biochemical Properties of the Acid Ectophosphatase Activity of <i>Phytomonas serpens</i> Involved in Cell Proliferation by Luiz Fernando Carvalho-Kelly, Anita Leocadio Freitas-Mesquita, Thaís Souza Silveira Majerowicz, José Roberto Meyer-Fernandes

“…Ectophosphatases are cell surface enzymes involved in host–parasite interactions that are widely distributed among microorganisms. …”
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Preventive Effect of Cocoa Flavonoids via Suppression of Oxidative Stress-Induced Apoptosis in Auditory Senescent Cells by Luz del Mar Rivas-Chacón, Joaquín Yanes-Díaz, Beatriz de Lucas, Juan Ignacio Riestra-Ayora, Raquel Madrid-García, Ricardo Sanz-Fernández, Carolina Sánchez-Rodríguez

“…Furthermore, in senescence cells, the activity of antioxidant enzymes (Superoxide dismutase, SOD; Catalase, CAT; and Glutathione peroxidase, GPx) was recovered after CPE treatment. …”
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Ultrasound May Suppress Tumor Growth, Inhibit Inflammation, and Establish Tolerogenesis by Remodeling Innatome via Pathways of ROS, Immune Checkpoints, Cytokines, and Trained Immun... by Qian Yang, Ruijing Zhang, Peng Tang, Yu Sun, Candice Johnson, Jason Saredy, Susu Wu, Jiwei Wang, Yifan Lu, Fatma Saaoud, Ying Shao, Charles Drummer, Keman Xu, Daohai Yu, Rongshan Li, Shuping Ge, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

“…We made the following findings: (1) LIUS upregulates proinflammatory IGs and downregulates metastasis genes in cancer cells, and LIUS upregulates adaptive immunity pathways but inhibits danger-sensing and inflammation pathways and promote tolerogenic differentiation in bone marrow (BM) cells. (2) LIUS upregulates IGs encoded for proteins localized in the cytoplasm, extracellular space, and others, but downregulates IG proteins localized in nuclear and plasma membranes, and LIUS downregulates phosphatases. (3) LIUS-modulated IGs act partially via several important pathways of reactive oxygen species (ROS), reverse signaling of immune checkpoint receptors B7-H4 and BTNL2, inflammatory cytokines, and static or oscillatory shear stress and heat generation, among which ROS is a dominant mechanism. (4) LIUS upregulates trained immunity enzymes in lymphoma cells and downregulates trained immunity enzymes and presumably establishes trained tolerance in BM cells. (5) LIUS modulates chromatin long-range interactions to differentially regulate IGs expression in cancer cells and noncancer cells. …”
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Unraveling nitrogen metabolism, cold and stress adaptation in polar Bosea sp. PAMC26642 through comparative genome analysis by Anamika Khanal, Anamika Khanal, So-Ra Han, So-Ra Han, So-Ra Han, Jun Hyuck Lee, Tae-Jin Oh, Tae-Jin Oh, Tae-Jin Oh, Tae-Jin Oh

“…PAMC26642, assimilatory nitrogen metabolic pathway and its associated enzymes such as nitrate reductase, NAD(P)H-nitrite reductase, ferredoxin-nitrite reductase, glutamine synthetase, glutamine synthase, and glutamate dehydrogenase were identified. …”
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Silicon-mediated modulation of maize growth, metabolic responses, and antioxidant mechanisms under saline conditions by Muhammad Saad Ullah, Athar Mahmood, Hussam F. Najeeb Alawadi, Mahmoud F. Seleiman, Bilal Ahmad Khan, Muhammad Mansoor Javaid, Abdul Wahid, Fnu Abdullah, Daniel O. Wasonga

“…Additionally, applying Si at 8 mM significantly enhanced antioxidant enzymes such as SOD (50.57%), POD (15.58%), CAT (10.06%) and chlorophyll ratio (21.32%). …”
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Bioactive potential and storage behavior of low molecular mass peptides in Pilsner and IPA style craft beers by Roberta Nogueira Pereira da Silva, Angelica Priscila Parussolo Tonin, Gabriela Soares Macello Ramos, Juliana Furtado Dias, Eduardo Cesar Meurer, Maria Gabriela Bello Koblitz

“…Given that beer production involves raw materials rich in both proteins and proteolytic enzymes, which may remain active throughout the product’s shelf life, beer holds potential as a source of bioactive peptides. …”
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Correlation of Clinical Severity and Laboratory Parameters with Various Serotypes in Dengue Virus: A Hospital-Based Study by Pooja Rao, Achappa Basavaprabhu, Suchitra Shenoy, Nikhil Victor Dsouza, Basavaiah Sridevi Hanaganahalli, Vaman Kulkarni

“…The clinical spectrum along with laboratory parameters such as ferritin, liver enzymes, platelet can be used as potential biomarkers in prediction of dengue severity. …”
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Genetic factors shaping the plasma lipidome and the relations to cardiometabolic risk in children and adolescentsResearch in context by Yun Huang, Sara Elizabeth Stinson, Malte Thodberg, Louise Aas Holm, Roman Thielemann, Karolina Sulek, Morten Asp Vonsild Lund, Cilius Esmann Fonvig, Min Kim, Kajetan Trost, Helene Bæk Juel, Trine Nielsen, Peter Rossing, Maja Thiele, Aleksander Krag, Cristina Legido-Quigley, Jens-Christian Holm, Torben Hansen

“…One-sample MR analysis identified positive causal associations between ceramides and liver enzymes, sphingomyelins and hemoglobin A1c (HbA1c), and phosphatidylethanolamines and high-sensitivity C-reactive protein in children and adolescents. …”
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SLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation by Izabella A. Pena, Jeffrey S. Shi, Sarah M. Chang, Jason Yang, Samuel Block, Charles H. Adelmann, Heather R. Keys, Preston Ge, Shveta Bathla, Isabella H. Witham, Grzegorz Sienski, Angus C. Nairn, David M. Sabatini, Caroline A. Lewis, Nora Kory, Matthew G. Vander Heiden, Myriam Heiman

“…Abstract Many essential proteins require pyridoxal 5’-phosphate, the active form of vitamin B6, as a cofactor for their activity. These include enzymes important for amino acid metabolism, one-carbon metabolism, polyamine synthesis, erythropoiesis, and neurotransmitter metabolism. …”
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