Isolation and Identification of Lipase-producing Actinobacteria from the Lut Desert of Iran by Samira Abedi-Dolatabadi, Moj Khaleghi, Sedigheh Ghasemzadeh, Azadeh Lohrasbi-Nejad, Arastoo Badoei Delfard

“…Lipases are the third category of widely used hydrolytic enzymes that catalyze the hydrolysis of triacylglycerols, glycerol, and free fatty acids. …”
Get full text

Comparative effects of pravastatin and rosuvastatin on carbohydrate metabolism in an experimental diabetic rat model by Kaya Hacer Kayhan, Demirtas Berjan, Yokus Beran, Kesim Dilek Aygün, Tasdemir Ezel, Sermet Abdurrahman

“…Statin treatment may increase the risk of diabetes; there is insufficient data on how statins affect glucose regulation and glycemic control and the effects of statins on liver enzymes related to carbohydrate metabolism have not been fully studied. …”
Get full text

Polymorphism of genes and drug-induced liver injury by P. Ye. Tkachenko, M. V. Mayevskaya, V. T. Ivashkin

“…To analyze publications in the world scientific literature on relation between druginduced liver injury and genetic polymorphism of enzymes and transport systems, xenobiotics involved in metabolism.Key points. …”
Get full text

Dietary, Metabolic, and Potentially Environmental Modulation of the Lysine Acetylation Machinery by Go-Woon Kim, Goran Gocevski, Chao-Jung Wu, Xiang-Jiao Yang

“…These enzymes have been pursued by vigorous efforts for therapeutic development in the past 15 years or so. …”
Get full text

Peptidomic analysis of whey protein hydrolysates and prediction of their antioxidant peptides by Jesus Morales García, Chibuike C. Udenigwe, Jorge Duitama, Andrés Fernando González Barrios

“…A total of 2572 peptides were identified over three process conditions with two enzymes in duplicate. 499 peptides were classified and chosen as potential antioxidant peptides from whey proteins. …”
Get full text

Increasing experience in the use of papaya for burn injuries in an African context, potential and limitations by Helena W.C. Hofland, Edris W. Kalanzi, Emmie Viyuyi, Tilinde Chokotho, Titus M. Opegu, Eduard E. Zijlstra

“…The efficacy of papaya and pineapple is based on enzymes that have proteolytic activity and other compounds that have antimicrobial action. …”
Get full text

In Vitro Effect of Sodium Fluoride on Malondialdehyde Concentration and on Superoxide Dismutase, Catalase, and Glutathione Peroxidase in Human Erythrocytes by José Gutiérrez-Salinas, Liliana García-Ortíz, José A. Morales González, Sergio Hernández-Rodríguez, Sotero Ramírez-García, Norma R. Núñez-Ramos, Eduardo Madrigal-Santillán

“…The aim of this paper was to describe the in vitro effect of sodium fluoride (NaF) on the specific activity of the major erythrocyte antioxidant enzymes, as well as on the membrane malondialdehyde concentration, as indicators of oxidative stress. …”
Get full text

Identification of Family Specific Fingerprints in β-Lactamase Families by Abhishikha Srivastava, Neelja Singhal, Manisha Goel, Jugsharan Singh Virdi, Manish Kumar

“…Beta-lactamases are a superfamily of enzymes which degrade the β-lactam class of antibiotics. …”
Get full text

The contrasted impacts of grasshoppers on soil microbial activities in function of primary production and herbivore diet by Ibanez, Sébastien, Foulquier, Arnaud, Brun, Charles, Colace, Marie-Pascale, Piton, Gabin, Bernard, Lionel, Gallet, Christiane, Clément, Jean-Christophe

“…The least productive sites were characterized by conservative plants, high soil C content, and by microbes having a resource acquisition strategy (more extracellular enzymes, higher PNM). Herbivory decreased microbial biomass and increased the production of extracellular enzymes in those sites. …”
Get full text

Primary Roles of Branched Chain Amino Acids (BCAAs) and Their Metabolism in Physiology and Metabolic Disorders by Tomoki Bo, Junichi Fujii

“…The two consecutive initial reactions of BCAA catabolism are catalyzed by the common enzymes referred to as branched chain aminotransferase (BCAT) and branched chain α-keto acid dehydrogenase (BCKDH). …”
Get full text

Effect of Metformin and Sitagliptin on Doxorubicin-Induced Cardiotoxicity in Rats: Impact of Oxidative Stress, Inflammation, and Apoptosis by Mina Thabet Kelleni, Entesar Farghaly Amin, Aly Mohamed Abdelrahman

“…Results of our study revealed that pretreatment with metformin or sitagliptin produced significant (P<0.05) cardiac protection manifested by a significant decrease in serum levels of LDH and CK-MB enzymes and cardiac MDA and total nitrites and nitrates levels, a significant increase in cardiac SOD activity, and remarkable improvement in the histopathological features as well as a significant reduction in the immunohistochemical expression of COX-2, iNOS, and caspase-3 enzymes as compared to DOX group. …”
Get full text

A Novel Method of Imaging Lysosomes in Living Human Mammary Epithelial Cells by Kristine Glunde, Sandra E. Guggino, Yoshitaka Ichikawa, Zaver M. Bhujwalla

“…Cancer cells invade by secreting degradative enzymes which, under normal conditions, are sequestered in lysosomal vesicles. …”
Get full text

The effect of caloric restriction on genetical pathways by Mustafa Fevzi Karagöz, A. Gülçin Sağdıçoğlu Celep

“…The increase in NAD+ level stimulates sirtuin (SIRT) enzymes, and the increase in AMP level stimulates AMP-activated protein kinase (AMPK). …”
Get full text

Stability Constants of Mixed Ligand Complexes of Nickel(II) with Adenine and Some Amino Acids by Naciye Türkel

“…It is mostly found in nickel-based enzymes as an essential cofactor. It forms coordination complexes with amino acids within enzymes. …”
Get full text

Immune-Stimulatory and Therapeutic Activity of Tinospora cordifolia: Double-Edged Sword against Salmonellosis by Sultan Alsuhaibani, Masood A. Khan

“…The toxicity of AETC or METC was determined by measuring the levels of liver inflammation markers aspartate transaminase (AST) and alanine transaminase (ALT) and antioxidant enzymes. Macrophages treated with AETC or METC secreted greater levels of IFN-γ, TNF-α, and IL-1β. …”
Get full text

Optimization Conditions of Extracellular Proteases Production from a Newly Isolated Streptomyces Pseudogrisiolus NRC-15 by El-Sayed E. Mostafa, Moataza M. Saad, Hassan M. Awad, Mohsen H. Selim, Helmy M. Hassan

“…Microbial protease represents the most important industrial enzymes, which have an active role in biotechnological processes. …”
Get full text

Propionate metabolism in Desulfurella acetivorans by Eugenio Pettinato, Thomas M. Steiner, Eric A. Cassens, Thomas Geisberger, Christian Seitz, Simone König, Wolfgang Eisenreich, Ivan A. Berg

“…Here we show that D. acetivorans possesses a putative operon encoding enzymes of the methylcitrate cycle of propionate oxidation and demonstrate that this bacterium is capable of propionate growth. …”
Get full text

Variation in human gut microbiota impacts tamoxifen pharmacokinetics by Yasmine Alam, Sheron Hakopian, Lizett Ortiz de Ora, Ian Tamburini, Julio Avelar-Barragan, Sunhee Jung, Zane Long, Alina Chao, Katrine Whiteson, Cholsoon Jang, Elizabeth Bess

“…Tamoxifen is orally delivered and must be activated by metabolizing enzymes in the liver; however, clinical studies show that neither genotype nor hepatic metabolic enzymes are sufficient to predict why some patients have sub-therapeutic levels of the drug. …”
Get full text

Estimation of median LC50 and toxicity of environmentally relevant concentrations of thiram in Labeo rohita by Sana Alam, Gulnaz Afzal, Riaz Hussain, Hafiz Muhammad Ali, Amtul Sami, Rabbiah Manzoor Malik, Raheela Jabeen, Farid Shokry Ataya, Kun Li

“…Oxidative stress parameters; ROS and TBARS were increased significantly (p < 0.05) while antioxidant enzymes (CAT, SOD, POD, GSH) showed a significant (p < 0.05) decrease in the treated groups compared to the control. …”
Get full text

Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication by Mehrdad Rafati Rahimzadeh, Mehravar Rafati Rahimzadeh, Sohrab Kazemi, Roghayeh Jafarian Amiri, Marzieh Pirzadeh, Ali Akbar Moghadamnia

“…Aluminum poisoning has complex and multidimensional effects, such as disruption or inhibition of enzymes activities, changing protein synthesis, nucleic acid function, and cell membrane permeability, preventing DNA repair, altering the stability of DNA organization, inhibition of the protein phosphatase 2A (PP2A) activity, increasing reactive oxygen species (ROS) production, inducing oxidative stress, decreasing activity of antioxidant enzymes, altering cellular iron homeostasis, and changing NF-kB, p53, and JNK pathway leading to apoptosis. …”
Get full text