Transcriptome Analysis of <i>Stephania yunnanensis</i> and Functional Validation of CYP80s Involved in Benzylisoquinoline Alkaloid Biosynthesis by Wenlong Shi, Qishuang Li, Xinyi Li, Linglong Luo, Jingyi Gan, Ying Ma, Jian Wang, Tong Chen, Yifeng Zhang, Ping Su, Xiaohui Ma, Juan Guo, Luqi Huang

“…Based on this analysis, we identified three CYP80 enzymes (SyCYP80Q5-1, SyCYP80Q5-3, and SyCYP80G6), which exhibited different activities toward (<i>S</i>)- and (<i>R</i>)-configured substrates in <i>S. yunnanensis</i> and demonstrated strict stereoselectivity enroute to aporphine. …”
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Dietary Capsaicin Supplementation Mitigates Calving-Induced Stress and Enhances Antioxidant Capacity, Immune Function, and Gut Microbiota in Periparturient Dairy Cows by Hangfan Li, Zibin Wu, Baisheng Yu, Jinyuan Chen, Chuang Yang, Yongqing Guo, Baoli Sun

“…Results showed that capsaicin significantly reduced milk somatic cell count and pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) while enhancing serum antioxidant enzymes (SOD, GSH-Px, and CAT) and immunoglobulin levels (IgG, IgA, and IgM). …”
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Clinical diagnosis of Q fever by targeted next-generation sequencing for identification of Coxiella burnetii by Shaohua Zhan, Haoyuan Jin, Hanbing Ji, Xin Hou, Jing Li, Ye Zhang, Jiajia Zheng, Liyan Cui

“…Although blood cultures were negative, elevated infection markers (CRP, PCT, and ferritin) and liver enzymes (ALT, AST, GGT, ALP, and LDH) were observed. …”
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X-linked ubiquitin-specific peptidase 11 (USP11) increases susceptibility to Cushing’s disease in women by Tao Zhang, Yanting Liu, Fang Liu, Kaiyu Guo, Runhua Tang, Jingwei Ye, Li Xue, Zhipeng Su, Zhe Bao Wu

“…In this study, we analyzed the expression of deubiquitinating enzymes in functioning ACTH PitNETs from both male and female subjects using RNA sequencing and identified USP11 as a potential susceptibility factor contributing to the higher prevalence of these PitNETs in females. …”
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Anti-Glycemic and Anti-Hepatotoxic Effects of Mangosteen Vinegar Rind from Garcinia mangostana Against HFD/STZ-Induced Type II Diabetes in Mice by Karim Naymul, Jeenduang Nutjaree, Tangpong Jitbanjong

“…After the treatment, lipid profile, glycogen and bilirubin contents, oxidative damage (malondialdehyde, MDA), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities, antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT) were measured in plasma and/or liver tissues. …”
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The Impact of Root Temperature on Photosynthesis and Isoprene Emission in Three Different Plant Species by Mauro Medori, Lucia Michelini, Isabel Nogues, Francesco Loreto, Carlo Calfapietra

“…In the green house experiments where the warming corresponded with high stress conditions, as confirmed by higher activities of the main antioxidant enzymes, we found that isoprene uncoupled from photosynthesis at a certain stage of the warming treatment and that even when photosynthesis approached to zero isoprene emission was still ongoing. …”
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Dietary Fiber with Functional Properties Counteracts the Thwarting Effects of Copper Nanoparticles on the Microbial Enzymatic Activity and Short-Chain Fatty Acid Production in the... by Jerzy Juśkiewicz, Bartosz Fotschki, Anna Stępniowska, Ewelina Cholewińska, Dorota Napiórkowska, Aleksandra Marzec, Łucja Brzuzan, Joanna Fotschki, Ewa Żary-Sikorska, Katarzyna Ognik

“…The activity of bacterial enzymes and short-chain fatty acids (SCFA) production were analyzed in the excreted feces collected on subsequent days of feeding. …”
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Metabolic and Genetic Determinants of Lipid Metabolism Disruption in Non-Alcoholic Fatty Liver Disease by O. Yu. Kytikova, T. P. Novgorodtseva, Yu. K. Denisenko, D. A. Kovalevsky

“…The regulation of fatty acid metabolism involves enzymes desaturase (FADS1, FADS2) and elongase (ELOVL2 and ELOVL5) fatty acids. …”
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Pomegranate Juices: Analytical and Bio-Toxicological Comparison of Pasteurization and High-Pressure Processing in the Development of Healthy Products by Francesco Cairone, Stefania Cesa, Irene Arpante, Simonetta Cristina Di Simone, Alejandro Han Mendez, Claudio Ferrante, Luigi Menghini, Antonello Filippi, Caterina Fraschetti, Gokhan Zengin, Simone Carradori, Marialucia Gallorini, Luisa Mannina, Mattia Spano

“…The potential inhibition of key enzymes of degenerative processes (cholinesterases, tyrosinase) and diabetes (amylase, glucosidase), the allelopathy toward <i>Cichorium intybus</i>, <i>Dicondra repens</i>, and <i>Diplotaxis tenuifolia</i>, and the in vivo toxicity on brine shrimp were also evaluated. …”
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Pretreatment of Small-for-Size Grafts In Vivo by γ-Aminobutyric Acid Receptor Regulation against Oxidative Stress-Induced Injury in Rat Split Orthotopic Liver Transplantation by Tomohide Hori, Shinji Uemoto, Lindsay B. Walden, Feng Chen, Ann-Marie T. Baine, Toshiyuki Hata, Justin H. Nguyen

“…Immunohistological assessment for apoptotic induction and western blotting for 4-hydroxynonenal, ataxia-telangiectasia mutated kinase (ATM), histone H2AX, phosphatidylinositol-3 kinase (PI3K), Akt, and free radical scavenging enzymes were performed. Results. Pretreatment by GABAR showed improvement in survival, histopathological assessment, and biochemical tests. …”
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Biochemical and histopathological profiling of Wistar rat treated with Brassica napus as a supplementary feed by Kazi Md. Mahmudul Hasan, Nasrin Tamanna, Md. Anwarul Haque

“…The use of Brassica napus as a supplementary feed ingredient should be, therefore, thoroughly considered Keywords: Rapeseed oil, Rattus norvegicus, Serum enzymes, Erucic acid, Tissue profiling…”
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Aggressive Recurrence of Primary Hepatic Epithelioid Haemangioendothelioma after Liver Transplantation by Qusay A. Abdoh, Asma M. Alnajjar, Faisal A. Abaalkhail, Mohammed Al Sebayel, Hussa F. Al-Hussaini, Waleed K. Al-Hamoudi, Hazem Helmy, Mohamad Almansour, Hussien A. Elsiesy

“…She underwent living related liver transplantation on June 2013 and was discharged after 20 days with normal liver enzymes. Four months later, she presented with diffuse disease recurrence. …”
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Screening for impact of popular herbs improving mental abilities on the transcriptional level of brain transporters by Mrozikiewicz Przemyslaw M., Bogacz Anna, Bartkowiak-Wieczorek Joanna, Kujawski Radoslaw, Mikolajczak Przemyslaw L., Ozarowski Marcin, Czerny Boguslaw, Mrozikiewicz-Rakowska Beata, Grzeskowiak Edmund

“…These findings suggest that herbs can play an important role in overcoming the BBB and multidrug resistance to pharmacotherapy of brain cancer and mental disorders, based on the activity of selected drug-metabolizing enzymes and transporters located in the BBB…”
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Improving Goat Meat (Longissimus Muscle) Tenderization by Using Moringa Oleifera Leaves by Hunin AbdElwhab Mohamed Tasnim, Sumarmono Juni, Fatoni Amin, Zeinalabdeen Abdelgadir Frah Amani, Fadhlurrohman Irfan, Muhammad Yusuf Hassan

“…The present results suggest that Moringa oleifera seems to be a promising source of exogenous enzymes for meat tenderization.…”
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Theoretical Investigation of the Structural, Spectroscopic, Electronic, and Pharmacological Properties of 4-Nerolidylcathecol, an Important Bioactive Molecule by Renyer A. Costa, Earle Silva A. Junior, Jaqueline de A. Bezerra, Josiana Moreira Mar, Emerson S. Lima, Maria Lucia B. Pinheiro, Diego V. C. Mendonça, Guilherme Braule P. Lopes, Adjane Dalvana S. Branches, Kelson M. T. Oliveira

“…Molecular docking calculations with DNA topoisomerase I-DNA complex (TOPO-I), glyceraldehyde 3-phospate dehydrogenase (GAPDH), and Plasmodium falciparum lactate dehydrogenase (PfLDH) showed binding free energies of −6.3, −6.5, and −7.6 kcal/mol, respectively, which indicates that 4NRC is a good competitive inhibitor for these enzymes.…”
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Composition analysis of acid hydrolysates from Cucurbita moschata Duch. polysaccharides and their effect on oxidative stress resistance of Caenorhabditis elegans by Wen Jiang, Yakun Zhang, Jiangying Zeng, Jing Yao, Aoxue Lu, Zhiyu Fang, Ge Wang, Weimin Wang, Yongjun Zhang

“…The results showed that PPe-S-2 had a notable antioxidant effect, and could significantly enhance the activities of antioxidant enzymes including superoxide dismutase (SOD) (P < 0.01), catalase (CAT) (P < 0.01) and glutathione reductase (GR) (P < 0.05), and increase the level of glutathione (GSH) (P < 0.01), and decreased the content of malondialdehyde (MDA) (P < 0.05). …”
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Phosphodiesterase 10A Is a Mediator of Osteogenic Differentiation and Mechanotransduction in Bone Marrow-Derived Mesenchymal Stromal Cells by Sigrid Müller-Deubert, Carolin Ege, Melanie Krug, Jutta Meißner-Weigl, Maximilian Rudert, Oliver Bischof, Franz Jakob, Regina Ebert

“…The second messengers cAMP and cGMP are degraded by phosphodiesterase isoenzymes (PDE), but the role of these enzymes during osteogenic differentiation or mechanotransduction remains unclear. …”
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Biosynthesis of the Essential Fatty Acid Oxidation Cofactor Carnitine Is Stimulated in Heart and Liver after a Single Bout of Exercise in Mice by Tom L. Broderick, Frank A. Cusimano, Chelsea Carlson, Jeganathan Ramesh Babu

“…Liver and heart were removed under the same conditions for measurement of carnitine biosynthesis enzymes (liver butyrobetaine hydroxylase, γ-BBH; heart trimethyllysine dioxygenase, TMLD), organic cation transporter-2 (OCTN2, carnitine transporter), and liver peroxisome proliferator-activated receptor-alpha (PPARα, transcription factor for γ-BBH and OCTN2 synthesis). …”
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Antimalarial Efficacy and Antioxidant Activity of Lophira lanceolata Stem Bark Ethanol Extract Using Plasmodium berghei Induced-Malaria in Swiss Albino’s Mice by Mounvera Abdel Azizi, Noumedem Anangmo Christelle Nadia, Yamssi Cedric, Ngouyamsa Nsapkain Aboubakar Sidiki, Gamago Nkadeu Guy-Armand, Djeussi Doriane Esther, Tientcheu Noutong Jemimah Sandra, Tako Djimefo Alex Kevin, Vincent Khan Payne

“…The ethanol extract of L. lanceolata caused a reduction of tissue markers, such as hepatic oxidative stress, as it increased the enzymatic activity of antioxidant enzymes. Conclusion. The ethanol extract of L. lanceolata possesses both antimalarial and antioxidant activities. …”
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Antioxidant and hepatoprotective effects of Hypsizygus ulmarius polysaccharide on alcoholic liver injury in rats by Sudha Govindan, Angu Jayabal, Jayasakthi Shanmugam, Prasanna Ramani

“…Regarding in vivo hepatoprotective activity, compared with the ethanol induction group, pre-treatment of low and high doses of HUP significantly reduced the behaviours of serum enzymes, lowered the levels of hepatic oxidative stress markers, restored the levels of biochemical constituents, enhanced the levels of liver and serum enzymatic antioxidants and non-enzymatic antioxidants, and improved the serum lipid levels of alcohol-intoxicated rats. …”
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